Mettl24 (methyltransferase like 24) - Rat Genome Database

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Gene: Mettl24 (methyltransferase like 24) Rattus norvegicus
Analyze
Symbol: Mettl24
Name: methyltransferase like 24
RGD ID: 1564857
Description: Predicted to enable methyltransferase activity. Predicted to be involved in methylation. Predicted to be located in extracellular region. Orthologous to human METTL24 (methyltransferase like 24); INTERACTS WITH atrazine; bisphenol A; glycidol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: hypothetical protein LOC499465; LOC499465; methyltransferase-like protein 24; probable methyltransferase-like protein 24; UPF0624 protein C6orf186 homolog
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82045,724,506 - 45,847,300 (+)NCBIGRCr8
mRatBN7.22044,142,126 - 44,264,651 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2044,142,396 - 44,261,310 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2045,932,198 - 46,045,829 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02045,591,333 - 45,704,981 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02046,298,848 - 46,427,592 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02048,586,322 - 48,706,793 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2048,586,325 - 48,706,793 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02050,231,661 - 50,352,320 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42044,820,310 - 44,940,706 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2044,950,242 - 45,068,427 (+)NCBICelera
Cytogenetic Map20q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
methylation  (IEA)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GOA pipeline RGD automated data pipeline
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Genomics

Comparative Map Data
Mettl24
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82045,724,506 - 45,847,300 (+)NCBIGRCr8
mRatBN7.22044,142,126 - 44,264,651 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2044,142,396 - 44,261,310 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2045,932,198 - 46,045,829 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02045,591,333 - 45,704,981 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02046,298,848 - 46,427,592 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02048,586,322 - 48,706,793 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2048,586,325 - 48,706,793 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02050,231,661 - 50,352,320 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42044,820,310 - 44,940,706 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2044,950,242 - 45,068,427 (+)NCBICelera
Cytogenetic Map20q12NCBI
METTL24
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386110,243,940 - 110,358,349 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6110,243,940 - 110,358,349 (-)EnsemblGRCh38hg38GRCh38
GRCh376110,565,143 - 110,679,552 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366110,673,842 - 110,786,168 (-)NCBINCBI36Build 36hg18NCBI36
Celera6111,313,748 - 111,426,096 (-)NCBICelera
Cytogenetic Map6q21NCBI
HuRef6108,133,908 - 108,246,389 (-)NCBIHuRef
CHM1_16110,830,351 - 110,942,668 (-)NCBICHM1_1
T2T-CHM13v2.06111,422,396 - 111,536,825 (-)NCBIT2T-CHM13v2.0
Mettl24
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391040,558,447 - 40,687,080 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1040,559,278 - 40,687,079 (+)EnsemblGRCm39 Ensembl
GRCm381040,682,445 - 40,812,733 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1040,683,282 - 40,811,083 (+)EnsemblGRCm38mm10GRCm38
MGSCv371040,403,088 - 40,530,889 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361040,371,739 - 40,499,498 (+)NCBIMGSCv36mm8
Celera1041,575,811 - 41,704,432 (+)NCBICelera
Cytogenetic Map10B1NCBI
cM Map1022.02NCBI
Mettl24
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495541135,009,910 - 35,114,710 (-)NCBIChiLan1.0ChiLan1.0
METTL24
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25130,240,731 - 130,372,588 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16128,126,636 - 128,258,479 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06108,051,029 - 108,166,932 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16112,121,747 - 112,235,538 (-)NCBIpanpan1.1PanPan1.1panPan2
METTL24
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11266,957,081 - 67,104,380 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1266,958,427 - 67,104,999 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1266,776,587 - 66,876,308 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01267,841,166 - 67,940,986 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1267,841,676 - 67,941,197 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11267,192,461 - 67,292,075 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01267,038,923 - 67,138,263 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01267,310,720 - 67,410,587 (-)NCBIUU_Cfam_GSD_1.0
Mettl24
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946101,877,949 - 101,973,149 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365646,154,643 - 6,247,721 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365646,154,576 - 6,247,733 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
METTL24
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl176,245,825 - 76,367,780 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1176,243,969 - 76,367,789 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2185,730,934 - 85,846,324 (-)NCBISscrofa10.2Sscrofa10.2susScr3
METTL24
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11363,538,648 - 63,652,808 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1363,584,079 - 63,652,504 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604035,829,601 - 35,943,399 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mettl24
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249161,366,395 - 1,464,593 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249161,338,038 - 1,464,667 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mettl24
1009 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:117
Count of miRNA genes:100
Interacting mature miRNAs:106
Transcripts:ENSRNOT00000036766
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
7411652Foco24Food consumption QTL 240.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)201175751554435887Rat
9590092Insglur9Insulin/glucose ratio QTL 918.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)201175751554435887Rat
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)201761783247606836Rat
2317880Alcrsp25Alcohol response QTL 252.3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)201769755054435887Rat
2303626Vencon10Ventilatory control QTL 100.001respiration trait (VT:0001943)respiration rate (CMO:0000289)201919072154435887Rat
2303578Gluco50Glucose level QTL 502blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)202510672254435887Rat
2303587Bw93Body weight QTL 9313body mass (VT:0001259)body weight (CMO:0000012)202510672254435887Rat
2300188Bmd68Bone mineral density QTL 686.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)202510672254435887Rat
1331747Hrtrt16Heart rate QTL 163.163heart pumping trait (VT:2000009)heart rate (CMO:0000002)202520973454435887Rat
1598869Memor6Memory QTL 63.1exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)202924438854435887Rat
70158Bp60Blood pressure QTL 603arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)203161428444396023Rat

Markers in Region
D20Rat56  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22044,234,153 - 44,234,298 (-)MAPPERmRatBN7.2
Rnor_6.02048,611,203 - 48,611,345NCBIRnor6.0
Rnor_5.02050,256,542 - 50,256,684UniSTSRnor5.0
RGSC_v3.42044,914,394 - 44,914,536RGDRGSC3.4
RGSC_v3.12044,937,405 - 44,937,547RGD
RH 3.4 Map20485.21RGD
RH 3.4 Map20485.21UniSTS
SHRSP x BN Map2036.6899RGD
SHRSP x BN Map2036.6899UniSTS
Cytogenetic Map20q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 10
Low 3 28 32 16 19 16 8 8 39 35 38 1 8
Below cutoff 15 24 24 24 3 33

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000036766   ⟹   ENSRNOP00000038872
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2044,142,396 - 44,261,310 (+)Ensembl
Rnor_6.0 Ensembl2048,586,325 - 48,706,793 (-)Ensembl
RefSeq Acc Id: NM_001025038   ⟹   NP_001020209
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82045,725,055 - 45,843,962 (+)NCBI
mRatBN7.22044,142,396 - 44,261,313 (+)NCBI
Rnor_6.02048,586,322 - 48,706,793 (-)NCBI
Rnor_5.02050,231,661 - 50,352,320 (-)NCBI
RGSC_v3.42044,820,310 - 44,940,706 (+)RGD
Celera2044,950,242 - 45,068,427 (+)RGD
Sequence:
RefSeq Acc Id: XM_039099027   ⟹   XP_038954955
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82045,724,506 - 45,813,635 (+)NCBI
mRatBN7.22044,142,126 - 44,230,984 (+)NCBI
RefSeq Acc Id: XM_039099028   ⟹   XP_038954956
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82045,724,519 - 45,813,635 (+)NCBI
mRatBN7.22044,142,127 - 44,230,984 (+)NCBI
RefSeq Acc Id: XM_039099029   ⟹   XP_038954957
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82045,724,524 - 45,818,021 (+)NCBI
mRatBN7.22044,142,128 - 44,236,001 (+)NCBI
RefSeq Acc Id: XM_039099030   ⟹   XP_038954958
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82045,763,347 - 45,847,300 (+)NCBI
mRatBN7.22044,180,691 - 44,264,651 (+)NCBI
RefSeq Acc Id: XR_005497329
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82045,724,519 - 45,813,635 (+)NCBI
mRatBN7.22044,142,127 - 44,230,984 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001020209   ⟸   NM_001025038
- Peptide Label: precursor
- UniProtKB: Q5BK01 (UniProtKB/Swiss-Prot),   A6KTC3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000038872   ⟸   ENSRNOT00000036766
RefSeq Acc Id: XP_038954955   ⟸   XM_039099027
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038954956   ⟸   XM_039099028
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038954957   ⟸   XM_039099029
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038954958   ⟸   XM_039099030
- Peptide Label: isoform X4
Protein Domains
Methyltransferase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5BK01-F1-model_v2 AlphaFold Q5BK01 1-363 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701679
Promoter ID:EPDNEW_R12203
Type:single initiation site
Name:Mettl24_1
Description:methyltransferase like 24
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02048,706,878 - 48,706,938EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1564857 AgrOrtholog
BioCyc Gene G2FUF-3419 BioCyc
Ensembl Genes ENSRNOG00000024221 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00065008749 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000036766 ENTREZGENE
  ENSRNOT00000036766.6 UniProtKB/Swiss-Prot
  ENSRNOT00065013924 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7377954 IMAGE-MGC_LOAD
InterPro Methyltranfer_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  METTL24 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:499465 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:109097 IMAGE-MGC_LOAD
NCBI Gene 499465 ENTREZGENE
PANTHER METHYLTRANSFERASE-LIKE PROTEIN 24 UniProtKB/TrEMBL
  METHYLTRANSFERASE-LIKE PROTEIN 24-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR32026 UniProtKB/Swiss-Prot
Pfam Methyltransf_22 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mettl24 PhenoGen
RatGTEx ENSRNOG00000024221 RatGTEx
  ENSRNOG00065008749 RatGTEx
UniProt A6KTC3 ENTREZGENE, UniProtKB/TrEMBL
  MET24_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-09-18 Mettl24  methyltransferase like 24  LOC499465  hypothetical protein LOC499465  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-02-09 LOC499465  hypothetical protein LOC499465      Symbol and Name status set to provisional 70820 PROVISIONAL