Hspa1a (heat shock protein family A (Hsp70) member 1A) - Rat Genome Database

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Gene: Hspa1a (heat shock protein family A (Hsp70) member 1A) Rattus norvegicus
Symbol: Hspa1a (Ensembl: Hspa1b)
Name: heat shock protein family A (Hsp70) member 1A (Ensembl:heat shock protein family A (Hsp70) member 1B)
RGD ID: 2840
Description: Enables NF-kappaB binding activity and protease binding activity. Involved in several processes, including negative regulation of vasoconstriction; positive regulation of T cell mediated cytotoxicity; and response to unfolded protein. Located in apical plasma membrane; basolateral plasma membrane; and membrane raft. Part of protein-containing complex. Biomarker of graft-versus-host disease. Human ortholog(s) of this gene implicated in several diseases, including brain ischemia; obesity; toxic shock syndrome; type 2 diabetes mellitus; and urinary tract infection. Orthologous to human HSPA1B (heat shock protein family A (Hsp70) member 1B); PARTICIPATES IN antigen processing and presentation pathway; endocytosis pathway; Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH (+)-schisandrin B; (R,R,R)-alpha-tocopherol; 1-naphthyl isothiocyanate.
Type: protein-coding
Previously known as: Heat shock 70 kDa protein 1; heat shock 70 kDa protein 1/2; Heat shock 70 kDa protein 1A; heat shock 70 kDa protein 1A/1B; heat shock 70 kDa protein 1B; Heat shock 70 kDa protein 2; heat shock 70kD protein 1A; heat shock 70kD protein 1B; heat shock protein 1B; Heat shock protein 70-1; heat shock protein family A member 1B; Hsp70-1; HSP70-1/HSP70-2; Hsp70-2; HSP70.1; HSP70.1/2; HSP70.1/HSP70.2; HSP70.2; HSP72; Hspa1; Hspa1b; Hspa2
RGD Orthologs
Green Monkey
Alliance Genes
More Info more info ...
Is Marker For: Strains:   SHR-Hspa1em1Mcwi  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2203,855,104 - 3,859,148 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl203,856,006 - 3,873,227 (-)EnsemblmRatBN7.2 Ensembl
mRatBN7.2 Ensembl203,856,006 - 3,873,240 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx204,570,471 - 4,572,926 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0203,932,531 - 3,934,986 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0204,469,649 - 4,472,170 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0204,877,638 - 4,880,112 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl202,699,712 - 2,701,815 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0207,029,038 - 7,033,025 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0204,802,576 - 4,804,849 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4203,955,274 - 3,957,748 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera204,167,705 - 4,171,749 (-)NCBICelera
RH 3.4 Map20 RGD
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(R,R,R)-alpha-tocopherol  (EXP)
(S)-amphetamine  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (ISO)
1H-pyrazole  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,5-hexanedione  (EXP)
2-hydroxyethyl methacrylate  (ISO)
2-methoxyethanol  (EXP)
2-methylcholine  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
5-fluorouracil  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
adefovir pivoxil  (ISO)
aflatoxin B1  (ISO)
alpha-pinene  (ISO)
AM-251  (ISO)
ammonium chloride  (EXP)
amphotericin B  (ISO)
antimycin A  (ISO)
apigenin  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (ISO)
atrazine  (ISO)
azetidinecarboxylic acid  (ISO)
azoxystrobin  (EXP)
Benoxacor  (ISO)
benzene  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
bromobenzene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
cannabidiol  (ISO)
captan  (ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
carboplatin  (EXP)
carnosine  (EXP)
cefaloridine  (EXP)
celastrol  (ISO)
chloroacetaldehyde  (ISO)
chlorohydrocarbon  (EXP)
chloropicrin  (ISO)
chloroprene  (ISO)
chloroquine  (ISO)
chlorpyrifos  (EXP)
cidofovir anhydrous  (ISO)
cisplatin  (EXP,ISO)
cobalt dichloride  (ISO)
cocaine  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
coumarin  (EXP)
crocidolite asbestos  (ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (ISO)
deguelin  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
dieldrin  (ISO)
diethyl maleate  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (EXP,ISO)
diquat  (ISO)
disulfiram  (ISO)
doxorubicin  (ISO)
elesclomol  (ISO)
ethanol  (ISO)
fenpyroximate  (ISO)
fluoranthene  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
fructose  (EXP)
fulvestrant  (ISO)
furan  (EXP)
gedunin  (ISO)
genistein  (EXP)
gentamycin  (EXP)
glutathione  (EXP)
glyphosate  (EXP,ISO)
gold atom  (ISO)
gold(0)  (ISO)
hydrogen chloride  (EXP)
hydrogen peroxide  (ISO)
hypochlorous acid  (ISO)
ifosfamide  (ISO)
imidacloprid  (EXP)
ivermectin  (ISO)
L-serine  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
Licochalcone B  (ISO)
lidocaine  (EXP)
lithium atom  (EXP)
lithium hydride  (EXP)
LY294002  (ISO)
mancozeb  (ISO)
maneb  (ISO)
menadione  (ISO)
mercury atom  (ISO)
mercury dichloride  (EXP)
mercury(0)  (ISO)
methotrexate  (ISO)
methylarsonic acid  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (EXP,ISO)
methylparaben  (ISO)
microcystin RR  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
motexafin gadolinium  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methylformamide  (ISO)
N-nitrosodiethylamine  (ISO)
naphthalene  (ISO)
nickel dichloride  (ISO)
Niflumic acid  (ISO)
oleanolic acid  (ISO)
organoselenium compound  (ISO)
orphenadrine  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
parathion  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (EXP,ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
polaprezinc  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
propanil  (ISO)
propiconazole  (ISO)
pyrimidifen  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
resorcinol  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 203580  (ISO)
sertraline  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sinapic acid  (ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sodium dichromate  (ISO)
Sodium salicylate  (ISO)
Soman  (EXP)
succimer  (ISO)
sulfasalazine  (EXP)
sulforaphane  (ISO)
sulindac sulfide  (ISO)
tamoxifen  (ISO)
tanespimycin  (ISO)
tebufenpyrad  (ISO)
temozolomide  (ISO)
teprenone  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thiabendazole  (EXP)
thimerosal  (ISO)
titanium dioxide  (EXP,ISO)
triazines  (ISO)
tributylstannane  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
Triptolide  (EXP)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vanillin  (ISO)
zearalenone  (ISO)
zinc acetate  (ISO)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc sulfate  (EXP,ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
ATP metabolic process  (ISO)
binding of sperm to zona pellucida  (ISO)
cellular heat acclimation  (ISO)
cellular response to heat  (ISO)
cellular response to unfolded protein  (ISO)
chaperone cofactor-dependent protein refolding  (IBA)
chaperone-mediated protein complex assembly  (ISO)
defense response  (IDA)
lysosomal transport  (ISS)
mRNA catabolic process  (ISO,ISS)
negative regulation of apoptotic process  (IDA,ISO)
negative regulation of cell growth  (ISO,ISS)
negative regulation of cell population proliferation  (ISO,ISS)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  (IDA)
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  (ISO)
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
negative regulation of inclusion body assembly  (ISO)
negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway  (ISO)
negative regulation of myeloid cell apoptotic process  (IDA)
negative regulation of protein ubiquitination  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO,ISS)
negative regulation of transforming growth factor beta receptor signaling pathway  (ISO)
negative regulation of vasoconstriction  (IMP)
positive regulation of erythrocyte differentiation  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of interleukin-8 production  (ISO)
positive regulation of microtubule nucleation  (ISO,ISS)
positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway  (ISO)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (IBA,ISO)
positive regulation of RNA splicing  (ISO)
positive regulation of T cell mediated cytotoxicity  (IDA)
positive regulation of tumor necrosis factor-mediated signaling pathway  (ISO)
protein folding  (ISO)
protein refolding  (IBA,ISO,ISS)
protein stabilization  (ISO)
regulation of mitotic spindle assembly  (IBA,ISO,ISS)
regulation of protein ubiquitination  (ISO)
response to heat  (ISO)
response to unfolded protein  (IMP,ISO,ISS)
signal transduction  (IEA)

Cellular Component


References - curated
# Reference Title Reference Citation
1. Lipid peroxidation and the expressional regulation of the heat-shock response during ischemia-reperfusion of rat kidney. Akcetin Z, etal., Urol Int. 2000;65(1):32-9.
2. Differential expression of heat shock proteins 70-1 and 70-2 mRNA after ischemia-reperfusion injury of rat kidney. Akcetin Z, etal., Urol Res. 1999 Oct;27(5):306-11.
3. Heat acclimation prolongs the time to central nervous system oxygen toxicity in the rat. Possible involvement of HSP72. Arieli Y, etal., Brain Res 2003 Feb 7;962(1-2):15-20.
4. Heat-shock protein gene polymorphisms and the risk of nephropathy in patients with Type 2 diabetes. Buraczynska M, etal., Clin Sci (Lond). 2009 Jan;116(1):81-6. doi: 10.1042/CS20070411.
5. In vivo heat shock protein assembles with septic liver NF-kappaB/I-kappaB complex regulating NF-kappaB activity. Chen HW, etal., Shock. 2005 Sep;24(3):232-8.
6. Heat shock protein 70 gene polymorphisms in sudden sensorineural hearing loss. Chien CY, etal., Audiol Neurootol. 2012;17(6):381-5. doi: 10.1159/000341815. Epub 2012 Aug 22.
7. Genetic variation in the stress protein hsp70-2 gene is highly associated with obesity. Chouchane L, etal., Int J Obes Relat Metab Disord. 2001 Apr;25(4):462-6.
8. HSP70-2 (HSPA1B) is associated with noncognitive symptoms in late-onset Alzheimer's disease. Clarimon J, etal., J Geriatr Psychiatry Neurol. 2003 Sep;16(3):146-50.
9. Hyperlipidemia induced by high cholesterol diet inhibits heat shock response in rat hearts. Csont T, etal., Biochem Biophys Res Commun 2002 Feb 8;290(5):1535-8.
10. Intracellular localization of constitutive and inducible heat shock protein 70 in rat liver after in vivo heat stress. Cvoro A, etal., Mol Cell Biochem. 2004 Oct;265(1-2):27-35.
11. Heat shock protein 70 is able to prevent heat shock-induced resistance of target cells to CTL. Dressel R, etal., J Immunol 2000 Mar 1;164(5):2362-71.
12. Sex differences in heat shock protein 72 expression and localization in rats following renal ischemia-reperfusion injury. Fekete A, etal., Am J Physiol Renal Physiol. 2006 Oct;291(4):F806-11. Epub 2006 Apr 11.
13. Heat-shock protein 70-2 (HSP70-2) expression in bladder urothelial carcinoma is associated with tumour progression and promotes migration and invasion. Garg M, etal., Eur J Cancer. 2010 Jan;46(1):207-15. doi: 10.1016/j.ejca.2009.10.020. Epub .
14. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
15. 1267 HSP70-2 polymorphism as a risk factor for carotid plaque rupture and cerebral ischaemia in old type 2 diabetes-atherosclerotic patients. Giacconi R, etal., Mech Ageing Dev. 2005 Aug;126(8):866-73. Epub 2005 Apr 18.
16. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
17. Association analysis of heat shock protein 70 gene polymorphisms in schizophrenia. Kim JJ, etal., Eur Arch Psychiatry Clin Neurosci. 2008 Jun;258(4):239-44.
18. Variations in HSP70 genes associated with noise-induced hearing loss in two independent populations. Konings A, etal., Eur J Hum Genet. 2009 Mar;17(3):329-35. doi: 10.1038/ejhg.2008.172. Epub 2008 Sep 24.
19. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
20. Proteomic characterisation of neuronal sphingolipid-cholesterol microdomains: role in plasminogen activation. Ledesma MD, etal., Brain Res. 2003 Oct 10;987(1):107-16.
21. Induction of molecular chaperones in carbon tetrachloride-treated rat liver: implications in protection against liver damage. Lee KJ, etal., Cell Stress Chaperones. 2004 Mar;9(1):58-68.
22. Construction of cDNA library from liver RNA of heat shocked rats and DNA sequence analysis of the clone containing the 3'-end untranslated region (3'UTR) of the heat inducible gene hsp70.2. Lisowska K, etal., Acta Biochim Pol 1996;43(2):313-7.
23. Cloning, nucleotide sequence and expression of rat heat inducible hsp70 gene. Lisowska K, etal., Biochim Biophys Acta 1994 Sep 13;1219(1):64-72.
24. cDNA cloning and expression of stress-inducible rat hsp70 in normal and injured rat brain. Longo FM, etal., J Neurosci Res 1993 Oct 15;36(3):325-35.
25. Inhibition of cellular proliferation by the Wilms tumor suppressor WT1 requires association with the inducible chaperone Hsp70. Maheswaran S, etal., Genes Dev. 1998 Apr 15;12(8):1108-20.
26. Reduction of caspase-8 and -9 cleavage is associated with increased c-FLIP and increased binding of Apaf-1 and Hsp70 after neonatal hypoxic/ischemic injury in mice overexpressing Hsp70. Matsumori Y, etal., Stroke. 2006 Feb;37(2):507-12. Epub 2006 Jan 5.
27. Isolation of a novel inducible rat heat-shock protein (HSP70) gene and its expression during ischaemia/hypoxia and heat shock. Mestril R, etal., Biochem J 1994 Mar 15;298 Pt 3:561-9.
28. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
29. Heat-shock protein 70 gene polymorphism is associated with the severity of diabetic foot ulcer and the outcome of surgical treatment. Mir KA, etal., Br J Surg. 2009 Oct;96(10):1205-9. doi: 10.1002/bjs.6689.
30. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
31. Potential role for heat shock protein 72 in antagonizing cerebral vasospasm after rat subarachnoid hemorrhage. Nikaido H, etal., Circulation. 2004 Sep 28;110(13):1839-46. Epub 2004 Sep 20.
32. Correlation of Hsp70-1 and Hsp70-2 gene expression with the degree of graft-versus-host reaction in a rat skin explant model. Novota P, etal., Transplantation. 2008 Jun 27;85(12):1809-16. doi: 10.1097/TP.0b013e31817753f7.
33. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
34. GOA pipeline RGD automated data pipeline
35. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
36. Heat shock protein polymorphism predisposes to urinary tract malformations and renal transplantation in children. Rusai K, etal., Transplant Proc. 2010 Jul-Aug;42(6):2309-11. doi: 10.1016/j.transproceed.2010.05.010.
37. Comparative analysis of the three major histocompatibility complex-linked heat shock protein 70 (Hsp70) genes of the rat. Walter L, etal., Immunogenetics 1994;40(5):325-30.
38. Heat shock protein 70-2+1267 AA homozygotes have an increased risk of septic shock in adults with community-acquired pneumonia. Waterer GW, etal., Crit Care Med. 2003 May;31(5):1367-72.
39. Genetic risk for recurrent urinary tract infections in humans: a systematic review. Zaffanello M, etal., J Biomed Biotechnol. 2010;2010:321082. doi: 10.1155/2010/321082. Epub 2010 Mar 30.
40. Genetic polymorphisms of HSP70 in age-related cataract. Zhang Y, etal., Cell Stress Chaperones. 2013 Nov;18(6):703-9. doi: 10.1007/s12192-013-0420-4. Epub 2013 May 11.
41. Polymorphism of stress protein HSP70-2 gene in Tunisians: susceptibility implications in type 2 diabetes and obesity. Zouari Bouassida K, etal., Diabetes Metab. 2004 Apr;30(2):175-80.
Additional References at PubMed
PMID:9122205   PMID:9499401   PMID:10205060   PMID:10811660   PMID:10859165   PMID:11785981   PMID:11879190   PMID:12070193   PMID:12150907   PMID:12397389   PMID:12399251   PMID:12654467  
PMID:12791594   PMID:12842450   PMID:14697321   PMID:15060004   PMID:15528251   PMID:15603737   PMID:15632090   PMID:15809055   PMID:15885686   PMID:15919508   PMID:16081876   PMID:16207717  
PMID:16252069   PMID:16394269   PMID:16679378   PMID:16690792   PMID:16809764   PMID:16945336   PMID:17069463   PMID:17167422   PMID:17182002   PMID:17240064   PMID:17289661   PMID:17376863  
PMID:17569768   PMID:18242848   PMID:18302488   PMID:18755693   PMID:18850735   PMID:18931043   PMID:19103603   PMID:19190083   PMID:19199708   PMID:19546256   PMID:19945465   PMID:20235222  
PMID:20458337   PMID:20625543   PMID:20809232   PMID:20817947   PMID:20853596   PMID:21231916   PMID:21311744   PMID:21423176   PMID:21789629   PMID:21880732   PMID:21909508   PMID:22319056  
PMID:22516433   PMID:22526757   PMID:22658674   PMID:22681889   PMID:22763123   PMID:23000394   PMID:23047067   PMID:23180211   PMID:23206709   PMID:23303413   PMID:23349634   PMID:23372380  
PMID:23533145   PMID:23816752   PMID:23851625   PMID:23902977   PMID:23904609   PMID:23921388   PMID:24061851   PMID:24186360   PMID:24325467   PMID:24442868   PMID:24613385   PMID:24790089  
PMID:25096025   PMID:25259839   PMID:25281747   PMID:25334068   PMID:25394481   PMID:25468996   PMID:25863030   PMID:26073348   PMID:26279425   PMID:26488549   PMID:26851345   PMID:27137183  
PMID:27279016   PMID:27288968   PMID:27435079   PMID:27496612   PMID:27708256   PMID:28205128   PMID:28393561   PMID:28637952   PMID:28755400   PMID:30343606   PMID:30596969   PMID:31233366  
PMID:31904090   PMID:32199935   PMID:33546324   PMID:33573715   PMID:35457282   PMID:36538982  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2203,855,104 - 3,859,148 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl203,856,006 - 3,873,227 (-)EnsemblmRatBN7.2 Ensembl
mRatBN7.2 Ensembl203,856,006 - 3,873,240 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx204,570,471 - 4,572,926 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0203,932,531 - 3,934,986 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0204,469,649 - 4,472,170 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0204,877,638 - 4,880,112 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl202,699,712 - 2,701,815 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0207,029,038 - 7,033,025 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0204,802,576 - 4,804,849 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4203,955,274 - 3,957,748 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera204,167,705 - 4,171,749 (-)NCBICelera
RH 3.4 Map20 RGD
Cytogenetic Map20p12NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38631,827,738 - 31,830,254 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl631,827,738 - 31,830,254 (+)EnsemblGRCh38hg38GRCh38
GRCh37631,795,515 - 31,798,031 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36631,903,503 - 31,906,010 (+)NCBINCBI36Build 36hg18NCBI36
Build 34631,903,502 - 31,906,010NCBI
Celera633,393,763 - 33,396,281 (+)NCBICelera
Cytogenetic Map6p21.33NCBI
HuRef631,582,004 - 31,584,555 (+)NCBIHuRef
CHM1_1631,797,655 - 31,800,174 (+)NCBICHM1_1
T2T-CHM13v2.0631,680,802 - 31,683,317 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391735,175,405 - 35,178,214 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1735,175,412 - 35,178,214 (-)EnsemblGRCm39 Ensembl
GRCm381734,956,429 - 34,959,238 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1734,956,436 - 34,959,238 (-)EnsemblGRCm38mm10GRCm38
MGSCv371735,093,374 - 35,096,183 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361734,564,485 - 34,567,642 (-)NCBIMGSCv36mm8
Celera1738,052,658 - 38,055,467 (-)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1718.5NCBI
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1642,260,625 - 42,268,770 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0631,488,882 - 31,491,412 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1632,377,194 - 32,377,967 (+)NCBIpanpan1.1PanPan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1121,285,282 - 1,287,670 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha121,420,953 - 1,423,341 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0121,428,137 - 1,430,527 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl121,428,127 - 1,443,998 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1121,287,147 - 1,289,536 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0121,354,295 - 1,356,685 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0121,418,720 - 1,421,109 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440494635,839,910 - 35,842,392 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049367271,718,952 - 1,721,691 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11740,191,695 - 40,194,459 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1740,203,936 - 40,205,858 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604431,739,056 - 31,744,444 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Variants in Hspa1a
31 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:24
Count of miRNA genes:24
Interacting mature miRNAs:24
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125159026Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
2306850Pia40Pristane induced arthritis QTL 400.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2015279595304575Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
61448Ciaa1CIA Autoantibody QTL 1300.001blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)2026463954597031Rat
61472Aia1Adjuvant induced arthritis QTL 1180.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2026463954597031Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20289259726381954Rat
1300152Bp195Blood pressure QTL 1953.46arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2036216499243559Rat
1331772Cdexp2CD45RC expression in CD8 T cells QTL 25.7CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)20362164910078919Rat
737973Pia21Pristane induced arthritis QTL 214.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2036216564606812Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20362165614101050Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2203,868,847 - 3,869,052 (-)MAPPERmRatBN7.2
Rnor_6.0204,881,491 - 4,881,693NCBIRnor6.0
Rnor_5.0206,961,891 - 6,962,093UniSTSRnor5.0
Cytogenetic Map20p12UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map20p12UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2203,872,885 - 3,873,070 (-)MAPPERmRatBN7.2
Rnor_6.0204,877,475 - 4,877,659NCBIRnor6.0
Rnor_5.0206,957,875 - 6,958,059UniSTSRnor5.0
RGSC_v3.4203,957,727 - 3,957,911UniSTSRGSC3.4
Celera204,154,211 - 4,154,395UniSTS
RH 3.4 Map2051.62UniSTS
Cytogenetic Map20p12UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2203,858,636 - 3,858,854 (-)MAPPERmRatBN7.2
Rnor_6.0204,955,962 - 4,956,179NCBIRnor6.0
Rnor_5.0207,029,332 - 7,029,549UniSTSRnor5.0
Celera204,167,999 - 4,168,216UniSTS
RH 3.4 Map2052.42UniSTS
Cytogenetic Map20p12UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2203,872,918 - 3,873,105 (-)MAPPERmRatBN7.2
Rnor_6.0204,877,440 - 4,877,626NCBIRnor6.0
Rnor_5.0206,957,840 - 6,958,026UniSTSRnor5.0
RGSC_v3.4203,957,760 - 3,957,946UniSTSRGSC3.4
Celera204,154,176 - 4,154,362UniSTS
RH 3.4 Map2052.22UniSTS
Cytogenetic Map20p12UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2203,871,310 - 3,871,800 (-)MAPPERmRatBN7.2
mRatBN7.2203,856,718 - 3,857,207 (-)MAPPERmRatBN7.2
Rnor_6.0204,878,745 - 4,879,233NCBIRnor6.0
Rnor_6.0202,700,781 - 2,701,269NCBIRnor6.0
Rnor_5.0204,803,650 - 4,804,138UniSTSRnor5.0
Rnor_5.0206,959,145 - 6,959,633UniSTSRnor5.0
RGSC_v3.4203,956,153 - 3,956,641UniSTSRGSC3.4
Celera204,155,481 - 4,155,969UniSTS
Celera204,169,646 - 4,170,134UniSTS
Cytogenetic Map20p12UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2203,868,846 - 3,869,052 (-)MAPPERmRatBN7.2
Rnor_6.0204,881,491 - 4,881,694NCBIRnor6.0
Rnor_5.0206,961,891 - 6,962,094UniSTSRnor5.0
Cytogenetic Map20p12UniSTS

Related Rat Strains
The following Strains have been annotated to Hspa1a


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 1 3
Low 3 10 12 1 9 1 7 9 29 31 24 8 7
Below cutoff 33 42 37 10 37 1 2 43 4 16 1


RefSeq Acc Id: ENSRNOT00000049667   ⟹   ENSRNOP00000050605
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl203,856,006 - 3,873,227 (-)Ensembl
Rnor_6.0 Ensembl202,699,712 - 2,701,637 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000061950   ⟹   ENSRNOP00000067749
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl203,856,023 - 3,858,948 (+)Ensembl
Rnor_6.0 Ensembl202,699,715 - 2,701,815 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000081924   ⟹   ENSRNOP00000075599
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl203,856,006 - 3,873,240 (+)Ensembl
Rnor_6.0 Ensembl204,877,324 - 4,879,779 (-)Ensembl
RefSeq Acc Id: NM_031971   ⟹   NP_114177
Rat AssemblyChrPosition (strand)Source
mRatBN7.2203,855,104 - 3,859,148 (+)NCBI
Rnor_6.0204,877,638 - 4,880,112 (-)NCBI
Rnor_5.0204,802,576 - 4,804,849 (-)NCBI
Rnor_5.0207,029,038 - 7,033,025 (-)NCBI
RGSC_v3.4203,955,274 - 3,957,748 (+)RGD
Celera204,167,705 - 4,171,749 (-)RGD
Protein Sequences
Protein RefSeqs NP_114177 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA54423 (Get FASTA)   NCBI Sequence Viewer  
  CAA99320 (Get FASTA)   NCBI Sequence Viewer  
  CAE83978 (Get FASTA)   NCBI Sequence Viewer  
  EDL83473 (Get FASTA)   NCBI Sequence Viewer  
  P0DMW0 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_114177   ⟸   NM_031971
- UniProtKB: Q07439 (UniProtKB/Swiss-Prot),   P42853 (UniProtKB/Swiss-Prot),   Q63256 (UniProtKB/Swiss-Prot),   P0DMW1 (UniProtKB/Swiss-Prot),   P0DMW0 (UniProtKB/Swiss-Prot),   A6KTP2 (UniProtKB/TrEMBL),   A0A8L2RAM6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000067749   ⟸   ENSRNOT00000061950
RefSeq Acc Id: ENSRNOP00000050605   ⟸   ENSRNOT00000049667
RefSeq Acc Id: ENSRNOP00000075599   ⟸   ENSRNOT00000081924

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P0DMW0-F1-model_v2 AlphaFold P0DMW0 1-641 view protein structure
AF-P0DMW1-F1-model_v2 AlphaFold P0DMW1 1-641 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2840 AgrOrtholog
BioCyc Gene G2FUF-4621 BioCyc
Ensembl Genes ENSRNOG00000045654 Ensembl
  ENSRNOG00000050647 Ensembl, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000075599.2 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000081924.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1270.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.420.40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ATPase_NBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Heat_shock_70_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP70_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP70_peptide-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hsp_70_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:108348108 UniProtKB/Swiss-Prot
  rno:24472 UniProtKB/Swiss-Prot
  PTHR19375 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam HSP70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hspa1a PhenoGen
PROSITE HSP70_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP70_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP70_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF100920 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF100934 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF53067 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HS71A_RAT UniProtKB/Swiss-Prot
  HS71B_RAT UniProtKB/Swiss-Prot
UniProt Secondary P42853 UniProtKB/Swiss-Prot
  Q07439 UniProtKB/Swiss-Prot
  Q63256 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-10-14 Hspa1a  heat shock protein family A (Hsp70) member 1A  Hspa1b  heat shock protein family A member 1B  Nomenclature updated 625702 APPROVED
2016-10-12 Hspa1b  heat shock protein family A (Hsp70) member 1B  Hspa1b  heat shock protein family A member 1B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-09-09 Hspa1b  heat shock protein family A member 1B  Hspa1b  heat shock protein 1B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-12 Hspa1b  heat shock 70kD protein 1B  Hspa1a  heat shock 70kD protein 1A  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2008-03-12 Hspa1b  heat shock protein 1B  Hspa1b  heat shock 70kD protein 1B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Hspa1a  heat shock 70kD protein 1A    Heat shock protein 70-1  Name updated 625702 APPROVED
2002-06-10 Hspa1a  Heat shock protein 70-1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_regulation induced by heat 1298960
gene_regulation induced in rat brain 8 hours following global ischemia and kainic acid-induced seizures 1298961