Psmb8 (proteasome 20S subunit beta 8) - Rat Genome Database

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Gene: Psmb8 (proteasome 20S subunit beta 8) Rattus norvegicus
Analyze
Symbol: Psmb8
Name: proteasome 20S subunit beta 8
RGD ID: 3426
Description: Predicted to have endopeptidase activity. Predicted to be involved in several processes, including fat cell differentiation; proteasomal protein catabolic process; and regulation of endopeptidase activity. Predicted to localize to cytoplasm; nucleus; and proteasome complex. Human ortholog(s) of this gene implicated in JMP syndrome. Orthologous to human PSMB8 (proteasome 20S subunit beta 8); PARTICIPATES IN ubiquitin/proteasome degradation pathway; INTERACTS WITH 1,3-dinitrobenzene; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: large multifunctional protease 7; Lmp7; LOC103690099; low molecular mass polypeptide 7; macropain subunit C13; MGC124945; multicatalytic endopeptidase complex subunit C13; proteasome (prosome macropain) subunit beta type 8 (low molecular mass polypeptide 7); proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7); proteasome (prosome, macropain) subunit, beta type, 8; proteasome component C13; proteasome subunit beta 8; proteasome subunit beta type-8; proteasome subunit beta type-8-like; proteasome subunit beta-5i; proteosome (prosome macropain) subunit beta type 8 (large multifunctional protease 7); proteosome (prosome, macropain) subunit, beta type 8; Ring10
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2204,652,159 - 4,655,122 (-)NCBI
Rnor_6.0 Ensembl203,990,613 - 3,993,769 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0203,990,809 - 3,993,772 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0206,070,355 - 6,073,317 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0207,275,040 - 7,276,378 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4204,786,260 - 4,789,223 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1204,786,490 - 4,789,389 (-)NCBI
Celera206,253,214 - 6,256,177 (-)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrobenzenesulfonic acid  (ISO)
2-hydroxypropanoic acid  (ISO)
2-nitrofluorene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-dihydrocoumarin  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (EXP)
4-hydroxyphenyl retinamide  (ISO)
acetamide  (EXP)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP)
bisphenol F  (ISO)
buspirone  (EXP)
C60 fullerene  (EXP)
cadmium dichloride  (EXP)
cannabidiol  (ISO)
carbon nanotube  (ISO)
chloroprene  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
deoxynivalenol  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dichlorine  (EXP)
diethylstilbestrol  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
Genipin  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
ionomycin  (ISO)
lactacystin  (ISO)
leflunomide  (EXP)
lipopolysaccharide  (ISO)
mercury dibromide  (ISO)
methotrexate  (ISO)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
N-nitrosodimethylamine  (EXP)
nefazodone  (EXP)
nickel atom  (ISO)
nickel dichloride  (EXP)
nickel sulfate  (ISO)
nimesulide  (EXP)
ozone  (EXP)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenformin  (EXP)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
picrotoxin  (EXP)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
SB 431542  (ISO)
sibutramine  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sulforaphane  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
theophylline  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triclosan  (ISO)
trimellitic anhydride  (EXP)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:12477932   PMID:15060004   PMID:15356141   PMID:16769238   PMID:16857966   PMID:17540904   PMID:19032866   PMID:20458337   PMID:20888554   PMID:21881205   PMID:23376485   PMID:23706739  
PMID:24586191   PMID:26524591   PMID:32255680  


Genomics

Candidate Gene Status
Psmb8 is a candidate Gene for QTL Pur27
Psmb8 is a candidate Gene for QTL Pur30
Comparative Map Data
Psmb8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2204,652,159 - 4,655,122 (-)NCBI
Rnor_6.0 Ensembl203,990,613 - 3,993,769 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0203,990,809 - 3,993,772 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0206,070,355 - 6,073,317 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0207,275,040 - 7,276,378 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4204,786,260 - 4,789,223 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1204,786,490 - 4,789,389 (-)NCBI
Celera206,253,214 - 6,256,177 (-)NCBICelera
Cytogenetic Map20p12NCBI
PSMB8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl632,840,717 - 32,844,679 (-)EnsemblGRCh38hg38GRCh38
GRCh38632,840,717 - 32,844,679 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37632,808,494 - 32,812,456 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36632,916,472 - 32,920,690 (-)NCBINCBI36hg18NCBI36
Build 34632,916,472 - 32,919,792NCBI
Celera634,357,387 - 34,361,605 (-)NCBI
Cytogenetic Map6p21.32NCBI
HuRef632,550,700 - 32,554,918 (-)NCBIHuRef
CHM1_1632,809,321 - 32,813,539 (-)NCBICHM1_1
Psmb8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391734,417,169 - 34,420,428 (+)NCBIGRCm39mm39
GRCm39 Ensembl1734,416,695 - 34,420,428 (+)Ensembl
GRCm381734,198,195 - 34,201,454 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1734,197,721 - 34,201,454 (+)EnsemblGRCm38mm10GRCm38
MGSCv371734,335,140 - 34,338,399 (+)NCBIGRCm37mm9NCBIm37
MGSCv361733,808,611 - 33,811,478 (+)NCBImm8
Celera1736,951,781 - 36,955,036 (+)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1717.98NCBI
Psmb8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554371,500,477 - 1,504,072 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554371,500,477 - 1,504,072 (-)NCBIChiLan1.0ChiLan1.0
PSMB8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1633,525,681 - 33,529,897 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl633,525,681 - 33,529,897 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0632,410,172 - 32,414,136 (-)NCBIMhudiblu_PPA_v0panPan3
PSMB8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1122,419,456 - 2,422,832 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl122,378,126 - 2,432,303 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha122,501,125 - 2,504,497 (-)NCBI
ROS_Cfam_1.0122,701,094 - 2,704,475 (-)NCBI
UMICH_Zoey_3.1122,418,542 - 2,421,918 (-)NCBI
UNSW_CanFamBas_1.0122,500,008 - 2,503,382 (-)NCBI
UU_Cfam_GSD_1.0122,574,324 - 2,577,715 (-)NCBI
Psmb8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494638,048,353 - 38,051,993 (-)NCBI
SpeTri2.0NW_00493647625,908,533 - 25,911,914 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PSMB8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl725,053,132 - 25,073,046 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1725,058,456 - 25,061,666 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2729,425,070 - 29,428,073 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PSMB8
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11739,260,774 - 39,264,990 (+)NCBI
ChlSab1.1 Ensembl1739,260,511 - 39,265,166 (+)Ensembl
Vero_WHO_p1.0NW_02366604432,627,347 - 32,631,067 (-)NCBI
Psmb8
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475423,822,965 - 23,826,367 (+)NCBI

Position Markers
RH132773  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2204,652,206 - 4,653,401 (-)MAPPER
mRatBN7.2204,652,206 - 4,653,401 (+)MAPPER
Rnor_6.0205,214,027 - 5,215,221NCBIRnor6.0
Rnor_6.0203,992,530 - 3,993,724NCBIRnor6.0
Rnor_5.0206,072,078 - 6,073,272UniSTSRnor5.0
Rnor_5.0207,275,088 - 7,276,282UniSTSRnor5.0
RGSC_v3.4204,786,308 - 4,787,502UniSTSRGSC3.4
Celera206,253,262 - 6,254,456UniSTS
RH 3.4 Map2072.0UniSTS
Cytogenetic Map20p12UniSTS
RH139398  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2204,656,317 - 4,656,544 (-)MAPPER
Rnor_6.0203,989,387 - 3,989,613NCBIRnor6.0
Rnor_5.0206,068,935 - 6,069,161UniSTSRnor5.0
RGSC_v3.4204,790,419 - 4,790,645UniSTSRGSC3.4
Celera206,257,373 - 6,257,599UniSTS
RH 3.4 Map2064.6UniSTS
Cytogenetic Map20p12UniSTS
RH139868  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2204,656,365 - 4,656,556 (-)MAPPER
Rnor_6.0203,989,375 - 3,989,565NCBIRnor6.0
Rnor_5.0206,068,923 - 6,069,113UniSTSRnor5.0
RGSC_v3.4204,790,467 - 4,790,657UniSTSRGSC3.4
Celera206,257,421 - 6,257,611UniSTS
RH 3.4 Map2060.7UniSTS
Cytogenetic Map20p12UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724519Bp144Blood pressure QTL 1440.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2015192000Rat
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124652101Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125653396Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20126305996Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20126305996Rat
7387283Uae44Urinary albumin excretion QTL 440.1712urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)20127357423Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20128375393Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20128375393Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20128375393Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20128375393Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20128375393Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20133300419Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20137550487Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20137550487Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20201865447018654Rat
2306850Pia40Pristane induced arthritis QTL 400.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2020187706567419Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20299970747999707Rat
61472Aia1Adjuvant induced arthritis QTL 1180.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2031518156896013Rat
61448Ciaa1CIA Autoantibody QTL 1300.001blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)2031518156896013Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20340211127968216Rat
7175096Tcs1T cell selection QTL 1T cell selectionexpression2039105555533640Rat
7175099Tcs2T cell selection QTL 2T cell selectionexpression2039453834156365Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:90
Count of miRNA genes:70
Interacting mature miRNAs:80
Transcripts:ENSRNOT00000000528
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 1 28 12 19 12 7 10
Low 1 26 29 29 29 8 11 33 29 29 1 8
Below cutoff 14 39 6 5

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_080767 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC098547 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC092567 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC107946 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX883043 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D10729 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232382 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234493 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ235267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC222892 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC222893 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC222894 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC222895 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC222896 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000000528   ⟹   ENSRNOP00000000528
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl203,990,820 - 3,993,769 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000082047   ⟹   ENSRNOP00000073470
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl203,992,496 - 3,992,959 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000083291
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl203,990,613 - 3,993,769 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000089996
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl203,990,853 - 3,993,769 (+)Ensembl
RefSeq Acc Id: NM_080767   ⟹   NP_542945
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2204,652,159 - 4,655,122 (-)NCBI
Rnor_6.0203,990,809 - 3,993,772 (+)NCBI
Rnor_5.0207,275,040 - 7,276,378 (-)NCBI
RGSC_v3.4204,786,260 - 4,789,223 (-)RGD
Celera206,253,214 - 6,256,177 (-)RGD
Sequence:
Reference Sequences
RefSeq Acc Id: NP_542945   ⟸   NM_080767
- UniProtKB: P28064 (UniProtKB/Swiss-Prot),   A0A023IMI6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000073470   ⟸   ENSRNOT00000082047
RefSeq Acc Id: ENSRNOP00000000528   ⟸   ENSRNOT00000000528

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701325
Promoter ID:EPDNEW_R11848
Type:initiation region
Name:Psmb8_1
Description:proteasome subunit beta 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0203,990,820 - 3,990,880EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3426 AgrOrtholog
Ensembl Genes ENSRNOG00000000456 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00000059927 ENTREZGENE
Ensembl Protein ENSRNOP00000000528 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000073470 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000000528 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000082047 UniProtKB/TrEMBL
Gene3D-CATH 3.60.20.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7387376 IMAGE-MGC_LOAD
InterPro Ntn_hydrolases_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_T1A_subB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Proteasome_beta8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Proteasome_bsu_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Proteasome_sua/b UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Proteasome_suB-type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24968 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:124945 IMAGE-MGC_LOAD
NCBI Gene 24968 ENTREZGENE
PANTHER PTHR11599:SF53 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Proteasome UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Psmb8 PhenoGen
PRINTS PROTEASOME UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PROTEASOME_BETA_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEASOME_BETA_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56235 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A023IKI3_RAT UniProtKB/TrEMBL
  A0A023IM45_RAT UniProtKB/TrEMBL
  A0A023IMI6 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2K5L5_RAT UniProtKB/TrEMBL
  P28064 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q6MGA4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Psmb8  proteasome 20S subunit beta 8  LOC103690099  proteasome subunit beta type-8-like  Data Merged 737654 PROVISIONAL
2019-09-13 Psmb8  proteasome 20S subunit beta 8  Psmb8  proteasome subunit beta 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-08-19 Psmb8  proteasome subunit beta 8  Psmb8  proteasome (prosome, macropain) subunit, beta type, 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-08-25 LOC103690099  proteasome subunit beta type-8-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2013-04-04 Psmb8  proteasome (prosome, macropain) subunit, beta type, 8  Psmb8  proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-15 Psmb8  proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)  Psmb8  proteosome (prosome, macropain) subunit, beta type 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Psmb8  proteasome (prosome, macropain) subunit, beta type, 8 (low molecular mass polypeptide 7)      Symbol and Name status set to approved 70586 APPROVED
2001-06-20 Lmp7  Low molecular mass polypeptide 7      Symbol withdrawn, duplicate of Psmb8 (RGD:3246) 67952 WITHDRAWN

RGD Curation Notes
Note Type Note Reference
gene_mapping found in the major histocompatibility RT1 complex 1300431