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Gene: Psmb8 (proteasome 20S subunit beta 8) Rattus norvegicus
Symbol: Psmb8
Name: proteasome 20S subunit beta 8
Description: Predicted to have endopeptidase activity. Predicted to be involved in several processes, including fat cell differentiation; proteasomal protein catabolic process; and regulation of endopeptidase activity. Predicted to localize to cytoplasm; nucleus; and proteasome complex. Human ortholog(s) of this gene implicated in JMP syndrome. Orthologous to human PSMB8 (proteasome 20S subunit beta 8); PARTICIPATES IN ubiquitin/proteasome degradation pathway; INTERACTS WITH 1,3-dinitrobenzene; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: large multifunctional protease 7; Lmp7; low molecular mass polypeptide 7; macropain subunit C13; MGC124945; multicatalytic endopeptidase complex subunit C13; proteasome (prosome macropain) subunit beta type 8 (low molecular mass polypeptide 7); proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7); proteasome (prosome, macropain) subunit, beta type, 8; proteasome component C13; proteasome subunit beta 8; proteasome subunit beta type-8; proteasome subunit beta-5i; proteosome (prosome macropain) subunit beta type 8 (large multifunctional protease 7); proteosome (prosome, macropain) subunit, beta type 8; Ring10
Homo sapiens (human) : PSMB8 (proteasome 20S subunit beta 8)  HGNC  Alliance
Mus musculus (house mouse) : Psmb8 (proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7))  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Psmb8 (proteasome 20S subunit beta 8)
Pan paniscus (bonobo/pygmy chimpanzee) : PSMB8 (proteasome 20S subunit beta 8)
Canis lupus familiaris (dog) : PSMB8 (proteasome 20S subunit beta 8)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Psmb8 (proteasome 20S subunit beta 8)
Sus scrofa (pig) : PSMB8 (proteasome 20S subunit beta 8)
Chlorocebus sabaeus (African green monkey) : PSMB8 (proteasome 20S subunit beta 8)
Heterocephalus glaber (naked mole-rat) : Psmb8 (proteasome 20S subunit beta 8)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0203,990,809 - 3,993,772 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl203,990,613 - 3,993,769 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0207,275,040 - 7,276,378 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0206,070,355 - 6,073,317 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4204,786,260 - 4,789,223 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1204,786,490 - 4,789,389 (-)NCBI
Celera206,253,214 - 6,256,177 (-)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Psmb8
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3426
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.