Psmb8 (proteasome 20S subunit beta 8)

Gene: Psmb8 (proteasome 20S subunit beta 8) Rattus norvegicus

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Symbol:

Psmb8

Name:

proteasome 20S subunit beta 8

Description:

Predicted to have endopeptidase activity. Predicted to be involved in several processes, including fat cell differentiation; proteasomal protein catabolic process; and regulation of endopeptidase activity. Predicted to localize to the cytoplasm; nucleus; and proteasome complex. Human ortholog(s) of this gene implicated in JMP syndrome. Orthologous to human PSMB8 (proteasome subunit beta 8); PARTICIPATES IN ubiquitin/proteasome degradation pathway; INTERACTS WITH 1,3-dinitrobenzene; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Also known as:

large multifunctional protease 7; Lmp7; low molecular mass polypeptide 7; macropain subunit C13; MGC124945; multicatalytic endopeptidase complex subunit C13; proteasome (prosome macropain) subunit beta type 8 (low molecular mass polypeptide 7); proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7); proteasome (prosome, macropain) subunit, beta type, 8; proteasome component C13; proteasome subunit beta 8; proteasome subunit beta type-8; proteasome subunit beta-5i; proteosome (prosome macropain) subunit beta type 8 (large multifunctional protease 7); proteosome (prosome, macropain) subunit, beta type 8; Ring10

Orthologs:

Homo sapiens (human) : PSMB8 (proteasome 20S subunit beta 8) HGNC Alliance
Mus musculus (house mouse) : Psmb8 (proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)) MGI Alliance
Chinchilla lanigera (long-tailed chinchilla) : Psmb8 (proteasome 20S subunit beta 8)
Pan paniscus (bonobo/pygmy chimpanzee) : PSMB8 (proteasome 20S subunit beta 8)
Canis lupus familiaris (dog) : PSMB8 (proteasome 20S subunit beta 8)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Psmb8 (proteasome 20S subunit beta 8)
Sus scrofa (pig) : PSMB8 (proteasome 20S subunit beta 8)

more info ...

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PSMB8 (proteasome 20S subunit beta 8)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Psmb8 (proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7))	HGNC	Treefam, OrthoMCL, NCBI, HomoloGene, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):	Psmb8 (proteasome 20S subunit beta 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PSMB8 (proteasome 20S subunit beta 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PSMB8 (proteasome 20S subunit beta 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Psmb8 (proteasome 20S subunit beta 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PSMB8 (proteasome 20S subunit beta 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	PSMB8 (proteasome 20S subunit beta 8)	Alliance	DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Mus musculus (house mouse):	Psmb8 (proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7))	Alliance	DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Danio rerio (zebrafish):	psmb8a (proteasome subunit beta 8A)	Alliance	DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Saccharomyces cerevisiae (baker's yeast):	PRE2	Alliance	DIOPT (Ensembl Compara, Hieranoid, InParanoid, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Drosophila melanogaster (fruit fly):	Prosbeta5R1	Alliance	DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Drosophila melanogaster (fruit fly):	Prosbeta5R2	Alliance	DIOPT (Ensembl Compara, Hieranoid, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Caenorhabditis elegans (roundworm):	pbs-5	Alliance	DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rnor_6.0	20	3,990,809 - 3,993,772 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	20	7,275,040 - 7,276,378 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Rnor_5.0	20	6,070,355 - 6,073,317 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	20	4,786,260 - 4,789,223 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	20	4,786,490 - 4,789,389 (-)	NCBI
Celera	20	6,253,214 - 6,256,177 (-)	NCBI		Celera
Cytogenetic Map	20	p12	NCBI

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Comparative Map Data

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Strain Sequence Variants (Rnor 5.0)

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Nomenclature History

RGD Curation Notes

More on Psmb8
	Alliance Gene
	NCBI Gene
	Ensembl Gene
	JBrowse: rn5 rn6
	NCBI Genome Data Viewer

RGD Object Information
RGD ID:	3426
Created:	2000-05-25
Species:	Rattus norvegicus
Last Modified:	2019-08-20
Status:	ACTIVE

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.

Functional Annotation unavailable	Annotation Distribution unavailable	Genomic Variants unavailble for Mouse Genomic Variants unavailable
Functional Annotation	Annotation Distribution	Genomic Variants

Protein-Protein Interactions unavailable	Genome Viewer unavailable	Damaging Variants unavailble for Mouse Damaging Variants unavailable
Protein-Protein Interactions	Genome Viewer	Damaging Variants

Annotation Comparison unavailable	OLGA unavailable
Annotation Comparison	OLGA	Excel (Download)

Gene Enrichment unavailable	Ortholog Finder unavailable
Gene Enrichment	Ortholog Finder

Imported Annotations - ClinVar

Imported Annotations - CTD

Imported Annotations - Genetic Association Database

Imported Annotations - OMIM

Imported Annotations - KEGG (archival)