PSMB8 (proteasome 20S subunit beta 8) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: PSMB8 (proteasome 20S subunit beta 8) Sus scrofa
Analyze
Symbol: PSMB8
Name: proteasome 20S subunit beta 8
RGD ID: 13852132
Description: ENCODES a protein that exhibits peptidase activity (inferred); threonine-type endopeptidase activity (inferred); INVOLVED IN antigen processing and presentation (ortholog); fat cell differentiation (ortholog); ASSOCIATED WITH Chediak-Higashi syndrome (ortholog); COVID-19 (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN proteasome core complex (ortholog); proteasome core complex, beta-subunit complex (ortholog); spermatoproteasome complex (ortholog); INTERACTS WITH Estradiol 17beta-cyclopentylpropionate; zearalenone
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LMP7; low molecular mass protein 7; Macropain subunit C13; Multicatalytic endopeptidase complex subunit C13; proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7); proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional protease 7); proteasome beta 8 subunit; Proteasome component C13; proteasome subunit beta 8; proteasome subunit beta type-8; Proteasome subunit beta-5i; proteasome subunit LMP7
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl725,058,465 - 25,062,245 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1725,058,456 - 25,061,666 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2729,425,070 - 29,428,073 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:9811971   PMID:14681463   PMID:21140225   PMID:22301074  


Genomics

Comparative Map Data
PSMB8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl725,058,465 - 25,062,245 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1725,058,456 - 25,061,666 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2729,425,070 - 29,428,073 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PSMB8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38632,840,717 - 32,844,679 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl632,840,717 - 32,844,679 (-)EnsemblGRCh38hg38GRCh38
GRCh37632,808,494 - 32,812,456 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36632,916,472 - 32,920,690 (-)NCBINCBI36Build 36hg18NCBI36
Build 34632,916,472 - 32,919,792NCBI
Celera634,357,387 - 34,361,605 (-)NCBICelera
Cytogenetic Map6p21.32NCBI
HuRef632,550,700 - 32,554,918 (-)NCBIHuRef
CHM1_1632,809,321 - 32,813,539 (-)NCBICHM1_1
T2T-CHM13v2.0632,662,092 - 32,666,054 (-)NCBIT2T-CHM13v2.0
Psmb8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391734,417,169 - 34,420,428 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1734,416,695 - 34,420,428 (+)EnsemblGRCm39 Ensembl
GRCm381734,198,195 - 34,201,454 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1734,197,721 - 34,201,454 (+)EnsemblGRCm38mm10GRCm38
MGSCv371734,335,140 - 34,338,399 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361733,808,611 - 33,811,478 (+)NCBIMGSCv36mm8
Celera1736,951,781 - 36,955,036 (+)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1717.98NCBI
Psmb8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8204,654,068 - 4,657,049 (-)NCBIGRCr8
mRatBN7.2204,652,159 - 4,655,122 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl204,652,159 - 4,655,283 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx205,404,875 - 5,407,839 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0204,766,618 - 4,769,582 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0205,248,299 - 5,251,264 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0203,990,809 - 3,993,772 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl203,990,613 - 3,993,769 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0206,070,355 - 6,073,317 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0207,275,040 - 7,276,378 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4204,786,260 - 4,789,223 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1204,786,490 - 4,789,389 (-)NCBI
Celera206,253,214 - 6,256,177 (-)NCBICelera
Cytogenetic Map20p12NCBI
Psmb8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554371,500,477 - 1,504,072 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554371,500,477 - 1,504,072 (-)NCBIChiLan1.0ChiLan1.0
PSMB8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2547,315,792 - 47,319,753 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1643,187,339 - 43,191,304 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0632,410,172 - 32,414,136 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1633,525,681 - 33,529,897 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl633,525,681 - 33,529,897 (-)Ensemblpanpan1.1panPan2
PSMB8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1122,419,456 - 2,422,832 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl122,378,126 - 2,432,303 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha122,501,125 - 2,504,497 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0122,701,094 - 2,704,475 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl122,701,094 - 2,714,024 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1122,418,542 - 2,421,918 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0122,500,008 - 2,503,382 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0122,574,324 - 2,577,715 (-)NCBIUU_Cfam_GSD_1.0
Psmb8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494638,048,353 - 38,051,993 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647625,908,490 - 25,911,925 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647625,908,533 - 25,911,914 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PSMB8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11739,260,774 - 39,264,990 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1739,260,511 - 39,265,166 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604432,627,347 - 32,631,067 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Psmb8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475423,823,115 - 23,826,367 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475423,822,965 - 23,826,367 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PSMB8
52 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 8 2 5 2 3
Low 2 2 3 2 23 2 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000001622   ⟹   ENSSSCP00000001580
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl725,058,892 - 25,062,245 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000001623   ⟹   ENSSSCP00000001581
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl725,058,465 - 25,062,245 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000036366   ⟹   ENSSSCP00000029820
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl725,053,132 - 25,073,046 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000062286   ⟹   ENSSSCP00000037739
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl725,057,725 - 25,061,533 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000077519   ⟹   ENSSSCP00000074331
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl725,058,892 - 25,060,991 (-)Ensembl
RefSeq Acc Id: NM_213935   ⟹   NP_999100
RefSeq Status: VALIDATED
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1725,058,456 - 25,061,666 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_999100   ⟸   NM_213935
- UniProtKB: A5D9J4 (UniProtKB/TrEMBL),   A0A4X1UYA4 (UniProtKB/TrEMBL),   A0A480YVH7 (UniProtKB/TrEMBL),   A0A8D0M8J6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000001580   ⟸   ENSSSCT00000001622
RefSeq Acc Id: ENSSSCP00000001581   ⟸   ENSSSCT00000001623
RefSeq Acc Id: ENSSSCP00000029820   ⟸   ENSSSCT00000036366
RefSeq Acc Id: ENSSSCP00000037739   ⟸   ENSSSCT00000062286
RefSeq Acc Id: ENSSSCP00000074331   ⟸   ENSSSCT00000077519


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000026951 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005045769 UniProtKB/TrEMBL
  ENSSSCG00055009110 UniProtKB/TrEMBL
  ENSSSCG00070021116 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000001622.5 UniProtKB/TrEMBL
  ENSSSCT00000001623 ENTREZGENE
  ENSSSCT00000001623.5 UniProtKB/TrEMBL
  ENSSSCT00000077519.1 UniProtKB/TrEMBL
  ENSSSCT00005074062.1 UniProtKB/TrEMBL
  ENSSSCT00005074067.1 UniProtKB/TrEMBL
  ENSSSCT00055018400.1 UniProtKB/TrEMBL
  ENSSSCT00070041946.1 UniProtKB/TrEMBL
  ENSSSCT00070041981.1 UniProtKB/TrEMBL
  ENSSSCT00070041987.1 UniProtKB/TrEMBL
  ENSSSCT00070041998.1 UniProtKB/TrEMBL
  ENSSSCT00070042085.1 UniProtKB/TrEMBL
  ENSSSCT00070042169.1 UniProtKB/TrEMBL
Gene3D-CATH 3.60.20.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ntn_hydrolases_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_T1A_subB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Proteasome_bsu_CS UniProtKB/TrEMBL
  Proteasome_sua/b UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Proteasome_suB-type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:396975 UniProtKB/TrEMBL
NCBI Gene PSMB8 ENTREZGENE
PANTHER METALLOPROTEASE TLDD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEASOME SUBUNIT BETA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Proteasome UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS PROTEASOME UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PROTEASOME_BETA_1 UniProtKB/TrEMBL
  PROTEASOME_BETA_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56235 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A480YVH7 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1UYA4 ENTREZGENE
  A0A4X1V0V1_PIG UniProtKB/TrEMBL
  A0A4X1V170_PIG UniProtKB/TrEMBL
  A0A4X1V1W8_PIG UniProtKB/TrEMBL
  A0A4X1V2U6_PIG UniProtKB/TrEMBL
  A0A4X1V3H8_PIG UniProtKB/TrEMBL
  A0A5G2RD01_PIG UniProtKB/TrEMBL
  A0A8D0M7U8_PIG UniProtKB/TrEMBL
  A0A8D0M8J6 ENTREZGENE, UniProtKB/TrEMBL
  A5D9J4 ENTREZGENE, UniProtKB/TrEMBL
  A5D9J5_PIG UniProtKB/TrEMBL
  A5D9J6_PIG UniProtKB/TrEMBL
  PSB8_PIG UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A0A287A1Z0 UniProtKB/TrEMBL
  A0A4X1UYA4 UniProtKB/TrEMBL
  I6L5M4 UniProtKB/TrEMBL
VGNC ID VGNC:91910 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-09-03 PSMB8  proteasome 20S subunit beta 8  PSMB8  proteasome subunit beta 8  Symbol and/or name change 5135510 APPROVED