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Gene: Nelfe (negative elongation factor complex member E) Rattus norvegicus

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Symbol:

Nelfe

Name:

negative elongation factor complex member E

RGD ID:

1303325

Description:

Enables chromatin binding activity. Involved in positive regulation of ERK1 and ERK2 cascade; positive regulation of protein modification process; and regulation of transcription by RNA polymerase II. Predicted to be located in nuclear body and plasma membrane. Predicted to be part of NELF complex. Predicted to be active in chromatin and nucleus. Orthologous to human NELFE (negative elongation factor complex member E); PARTICIPATES IN RNA polymerase II transcription elongation pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

negative elongation factor E; Rd; RD RNA-binding protein; Rdbp

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	20	3,981,259 - 3,987,016 (-)	NCBI		GRCr8
mRatBN7.2	20	3,976,512 - 3,982,389 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	3,976,518 - 3,982,355 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	20	4,676,633 - 4,682,383 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	4,038,381 - 4,044,131 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	4,575,547 - 4,581,290 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	20	4,530,328 - 4,536,085 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	4,530,342 - 4,536,209 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	20	6,610,127 - 6,615,884 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	20	4,077,925 - 4,081,561 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	20	4,078,021 - 4,081,787 (-)	NCBI
Celera	20	4,048,306 - 4,054,061 (+)	NCBI		Celera
Cytogenetic Map	20	p12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

proteasome-associated autoinflammatory syndrome 1 (ISO)

trichohepatoenteric syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4,6-tribromophenol (ISO)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

3,3',5,5'-tetrabromobisphenol A (ISO)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

4-amino-2,6-dinitrotoluene (EXP)

acrolein (ISO)

aflatoxin B1 (EXP)

alpha-pinene (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

cadmium dichloride (ISO)

caffeine (ISO)

CGP 52608 (ISO)

chlorpyrifos (ISO)

cobalt dichloride (ISO)

coumarin (ISO)

cyclosporin A (ISO)

dibutyl phthalate (ISO)

dioxygen (ISO)

doxorubicin (ISO)

endosulfan (EXP)

enzyme inhibitor (ISO)

folic acid (ISO)

FR900359 (ISO)

genistein (ISO)

hexadecanoic acid (ISO)

hypochlorous acid (ISO)

isobutanol (ISO)

ivermectin (ISO)

lead(0) (ISO)

methyl methanesulfonate (ISO)

ozone (ISO)

paracetamol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenobarbital (ISO)

quercetin (ISO)

SB 431542 (ISO)

T-2 toxin (ISO)

tamoxifen (ISO)

temozolomide (ISO)

tetrahydropalmatine (ISO)

trichloroethene (ISO)

trimellitic anhydride (ISO)

triphenyl phosphate (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

negative regulation of transcription by RNA polymerase II (IMP)

negative regulation of transcription elongation by RNA polymerase II (IBA,ISO)

positive regulation of ERK1 and ERK2 cascade (IMP)

positive regulation of protein modification process (IMP)

positive regulation of transcription by RNA polymerase II (IMP)

Cellular Component

chromatin (ISO)

NELF complex (IBA,ISO)

nuclear body (IEA,ISO)

nucleoplasm (ISO)

nucleus (ISO)

plasma membrane (IEA,ISO)

Molecular Function

chromatin binding (IDA,IMP,ISO)

mRNA binding (ISO)

protein binding (ISO)

RNA binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

RNA polymerase II transcription elongation pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Negative elongation factor NELF controls transcription of immediate early genes in a stimulus-specific manner.	Fujita T, etal., Exp Cell Res. 2009 Jan 15;315(2):274-84. doi: 10.1016/j.yexcr.2008.10.032. Epub 2008 Nov 5.
2.	Transcription elongation factors are involved in programming hormone production in pituitary neuroendocrine GH4C1 cells.	Fujita T, etal., Mol Cell Endocrinol. 2010 May 5;319(1-2):63-70. doi: 10.1016/j.mce.2010.01.020. Epub 2010 Jan 25.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	Control of transcriptional elongation.	Kwak H and Lis JT, Annu Rev Genet. 2013;47:483-508. doi: 10.1146/annurev-genet-110711-155440. Epub 2013 Sep 11.
5.	GOA pipeline	RGD automated data pipeline
6.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
8.	Rapid activity-induced transcription of Arc and other IEGs relies on poised RNA polymerase II.	Saha RN, etal., Nat Neurosci. 2011 May 29;14(7):848-56. doi: 10.1038/nn.2839.
9.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:12612062	PMID:19575011	PMID:21670248	PMID:22658674	PMID:26480869

Genomics

Comparative Map Data

Nelfe
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	20	3,981,259 - 3,987,016 (-)	NCBI		GRCr8
mRatBN7.2	20	3,976,512 - 3,982,389 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	3,976,518 - 3,982,355 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	20	4,676,633 - 4,682,383 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	4,038,381 - 4,044,131 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	4,575,547 - 4,581,290 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	20	4,530,328 - 4,536,085 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	4,530,342 - 4,536,209 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	20	6,610,127 - 6,615,884 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	20	4,077,925 - 4,081,561 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	20	4,078,021 - 4,081,787 (-)	NCBI
Celera	20	4,048,306 - 4,054,061 (+)	NCBI		Celera
Cytogenetic Map	20	p12	NCBI

NELFE
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	31,952,087 - 31,958,971 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	31,952,087 - 31,959,038 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	31,919,864 - 31,926,748 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	32,027,843 - 32,034,843 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	6	32,027,843 - 32,034,747	NCBI
Celera	6	33,519,627 - 33,526,530 (-)	NCBI		Celera
Cytogenetic Map	6	p21.33	NCBI
HuRef	6	31,706,833 - 31,713,834 (-)	NCBI		HuRef
CHM1_1	6	31,921,945 - 31,928,945 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	6	31,805,292 - 31,812,176 (-)	NCBI		T2T-CHM13v2.0

Nelfe
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	35,069,367 - 35,075,348 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	35,069,367 - 35,075,348 (+)	Ensembl		GRCm39 Ensembl
GRCm38	17	34,850,391 - 34,856,372 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	34,850,391 - 34,856,372 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	34,987,336 - 34,993,317 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	34,458,975 - 34,464,214 (+)	NCBI		MGSCv36	mm8
Celera	17	37,945,699 - 37,951,680 (+)	NCBI		Celera
Cytogenetic Map	17	B1	NCBI
cM Map	17	18.4	NCBI

Nelfe
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955437	466,690 - 473,084 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955437	467,018 - 473,084 (-)	NCBI	ChiLan1.0	ChiLan1.0

NELFE
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	46,428,781 - 46,435,590 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	42,390,268 - 42,397,077 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	31,612,924 - 31,619,732 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	32,499,538 - 32,506,382 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	32,499,540 - 32,506,382 (-)	Ensembl	panpan1.1		panPan2

NELFE
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	12	1,406,411 - 1,412,387 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	12	1,406,271 - 1,412,324 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	12	1,541,468 - 1,547,598 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	12	1,548,568 - 1,554,700 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	12	1,548,568 - 1,554,605 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	12	1,405,843 - 1,411,974 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	12	1,474,213 - 1,480,345 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	12	1,539,542 - 1,546,943 (-)	NCBI		UU_Cfam_GSD_1.0

Nelfe
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	35,965,333 - 35,971,346 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936727	1,589,942 - 1,598,182 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936727	1,589,942 - 1,596,009 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

NELFE
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	24,040,525 - 24,047,025 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	24,040,525 - 24,046,932 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	27,765,281 - 27,771,676 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

NELFE
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	17	40,063,298 - 40,069,714 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	17	40,063,755 - 40,198,451 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666044	31,868,805 - 31,875,524 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Nelfe
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624754	24,300,602 - 24,310,671 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624754	24,300,012 - 24,310,777 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	29
Count of miRNA genes:	28
Interacting mature miRNAs:	29
Transcripts:	ENSRNOT00000000478
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2306850	Pia40	Pristane induced arthritis QTL 40		0.0001	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	20	1533200	5306452	Rat
61474	Eae1	Experimental allergic encephalomyelitis QTL 1	3		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis severity score (CMO:0001419)	20	1	6693431	Rat
2317057	Aia27	Adjuvant induced arthritis QTL 27	2.83		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	20	1	26925056	Rat
1641915	Colcr9	Colorectal carcinoma resistance QTL 9	2.97	0.0024	intestine integrity trait (VT:0010554)	benign colorectal tumor number (CMO:0001795)	20	1	33724594	Rat
7411668	Foco32	Food consumption QTL 32	8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	20	1	36600300	Rat
2305926	Iddm37	Insulin dependent diabetes mellitus QTL 37	6		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	20	1533083	46533083	Rat
1354642	Despr15	Despair related QTL 15		0.0027	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	20	1	24164241	Rat
1558640	Prcs2	Prostate cancer susceptibility QTL 2	3.3		prostate integrity trait (VT:0010571)	percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)	20	1	34066551	Rat
1331772	Cdexp2	CD45RC expression in CD8 T cells QTL 2	5.7		CD8-positive T cell quantity (VT:0008077)	blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)	20	3626323	10078622	Rat
8694189	Bw153	Body weight QTL 153	3.13	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	20	1	29193376	Rat
70154	Insul2	Insulin level QTL 2	3.75		blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	20	1	6693431	Rat
4889857	Pur27	Proteinuria QTL 27	12.2	0.001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	20	1	27341128	Rat
1300152	Bp195	Blood pressure QTL 195	3.46		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	20	3626323	9244918	Rat
9590109	Sffal8	Serum free fatty acids level QTL 8	5.32	0.01	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	20	1	29193376	Rat
9589155	Insul32	Insulin level QTL 32	6.38	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	20	1	29193376	Rat
9590275	Scort15	Serum corticosterone level QTL 15	3.48	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	20	1	29193376	Rat
7411650	Foco23	Food consumption QTL 23	20.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	20	1	29193376	Rat
61432	Cia1	Collagen induced arthritis QTL 1			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	20	1	14100378	Rat
2317851	Alcrsp22	Alcohol response QTL 22	3.2	0.05	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	20	1	27341128	Rat
1641893	Alcrsp7	Alcohol response QTL 7			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	20	1	27341128	Rat
6893685	Bw111	Body weight QTL 111	2.7	0.004	body mass (VT:0001259)	body weight (CMO:0000012)	20	1	32578510	Rat
9590252	Scort12	Serum corticosterone level QTL 12	20.46	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	20	1	36600300	Rat

Markers in Region

AI255840

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	20	3,976,300 - 3,976,398 (-)	MAPPER	mRatBN7.2
Rnor_6.0	20	4,536,318 - 4,536,415	NCBI	Rnor6.0
Rnor_5.0	20	6,616,117 - 6,616,214	UniSTS	Rnor5.0
RGSC_v3.4	20	4,077,593 - 4,077,690	UniSTS	RGSC3.4
Celera	20	4,054,296 - 4,054,393	UniSTS
Cytogenetic Map	20	p12	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001165901	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_212548	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006255921	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006255922	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC079427	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BX883045	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474121	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CO401737	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000020	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000000478 ⟹ ENSRNOP00000000478

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	20	3,976,518 - 3,982,355 (-)	Ensembl
Rnor_6.0 Ensembl	20	4,530,344 - 4,536,209 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000075925 ⟹ ENSRNOP00000068302

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	20	4,530,365 - 4,533,928 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000076352 ⟹ ENSRNOP00000068403

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	20	4,530,342 - 4,536,084 (+)	Ensembl

RefSeq Acc Id:

NM_001165901 ⟹ NP_001159373

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	3,981,261 - 3,987,016 (-)	NCBI
mRatBN7.2	20	3,976,633 - 3,982,389 (-)	NCBI
Rnor_6.0	20	4,530,328 - 4,536,083 (+)	NCBI
Rnor_5.0	20	6,610,127 - 6,615,884 (+)	NCBI
RGSC_v3.4	20	4,077,925 - 4,081,561 (-)	RGD
Celera	20	4,048,306 - 4,054,061 (+)	RGD

Sequence:

show sequence

CCGCGAGCCCGCGCGCAGCAGCCCGCGCGGCGGCGCCGGAGACCGCGGGCCCGGGCGCCGCCCC
CTCAGGAGCCAACATGTTGGTGATACCTCCGGGGCTGAGTGAAGAGGAAGAGGCACTACAGAAG
AAATTCAACAAACTCAAGAAAAAGAAAAAGGCGTTGCTGGCTCTGAAGAAGCAAAGCAGCAGTG
GTACAGCGAGCCAGGGCGGTGTCAAGCGCTCACTGTCAGAGCAGCCTGTGGTGGATACTGCCAC
AGCAACAGAACAGGCCAAACAGCTGGTGAAGTCAGGAGCTATCAGTGCCATCAAGGCTGAAACT
AAGAACTCAGGCTTCAAACGTTCTCGGACCCTGGAAGGGAAGTTAAAGGACCCAGAGAAGGGGC
CTGTCCCCACCTTCCAGCCGTTCCAGAGGAGCATGTCTGCTGACGAGGACCTACAGGAGCCATC
CAGACGGCCCCAAAGGAAATCTCTGTATGAAAGCTTTGTGTCTTCTAGTGATCGGCTTCGGGAA
CTGGGACAAGATGGAGAAGAAGCAGAGGCCCCTGGGGCTGGTGAAGGCCCACCTCGAGGTTTTG
ACTGGAGCTATGAAGAACACAGCGGTGCCCGATCCTCAGCCTCCCCTCCCCGAAGCCGCAGCCG
GGACAGAAGTCATGATCGGAGCCGAGATAGGGACCGGGACAAAGAACGAGACAGAGACCGGGAT
CGAGACAGAGAACGGGACAAAGACAAAGACAGAGACCGGGACCGGGACAGAGACAAAGAGCGGG
ACAGAGACAGGGACCGGGAGCGAGACCGAGAGGGCCCTTTCCGTAGGTCAGACTCATTCCCCGA
ACGGAGGGCCCCTCGAAAGGGGAACACTCTGTATGTGTATGGAGAGGACATGACGCCCACCCTC
CTCCGAGGGGCCTTCTCTCCCTTTGGAAATATCATCGACCTCTCCATGGACCCACCCAGAAACT
GTGCCTTCGTCACCTACGAGAAGATGGAGTCAGCAGATCAGGCTGTTGCTGAGCTCAATGGGAC
CCAGGTGGAATCTGTGCAGCTCAAAGTCAACATAGCCCGAAAACAGCCCATGCTGGACGCTGCT
ACTGGCAAATCTGTCTGGGGCTCCCTTGCTGTCCAGAACAGCCCCAAGGGTTGCCACCGGGACA
AGAGGACCCAGATTGTGTACAGTGACGATCTATAGGAAACCTTGTGGATGGCTTCTAGGACATG
AAGCTGGATTCCTTGTGCCTCATATGCCCCCAAGCTGGTCTCAGTAAAATCCTGGGGTAGAAGC
TTTTAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

NM_212548 ⟹ NP_997713

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	3,981,261 - 3,986,922 (-)	NCBI
mRatBN7.2	20	3,976,633 - 3,982,295 (-)	NCBI
Rnor_6.0	20	4,530,422 - 4,536,083 (+)	NCBI
Rnor_5.0	20	6,610,127 - 6,615,884 (+)	NCBI
RGSC_v3.4	20	4,077,925 - 4,081,561 (-)	RGD
Celera	20	4,048,400 - 4,054,061 (+)	NCBI

Sequence:

show sequence

GCGCCTTCCCCGCGCGGCCCCTGGTTCTTCTTCCTCCTCCTCTGGTTGCCCAGATAGCGCTGCG
CGGGCCCGGCCGCCTTCTCTGCCCACCGGACCCCGAGGAGCCAACATGTTGGTGATACCTCCGG
GGCTGAGTGAAGAGGAAGAGGCACTACAGAAGAAATTCAACAAACTCAAGAAAAAGAAAAAGGC
GTTGCTGGCTCTGAAGAAGCAAAGCAGCAGTGGTACAGCGAGCCAGGGCGGTGTCAAGCGCTCA
CTGTCAGAGCAGCCTGTGGTGGATACTGCCACAGCAACAGAACAGGCCAAACAGCTGGTGAAGT
CAGGAGCTATCAGTGCCATCAAGGCTGAAACTAAGAACTCAGGCTTCAAACGTTCTCGGACCCT
GGAAGGGAAGTTAAAGGACCCAGAGAAGGGGCCTGTCCCCACCTTCCAGCCGTTCCAGAGGAGC
ATGTCTGCTGACGAGGACCTACAGGAGCCATCCAGACGGCCCCAAAGGAAATCTCTGTATGAAA
GCTTTGTGTCTTCTAGTGATCGGCTTCGGGAACTGGGACAAGATGGAGAAGAAGCAGAGGCCCC
TGGGGCTGGTGAAGGCCCACCTCGAGGTTTTGACTGGAGCTATGAAGAACACAGCGGTGCCCGA
TCCTCAGCCTCCCCTCCCCGAAGCCGCAGCCGGGACAGAAGTCATGATCGGAGCCGAGATAGGG
ACCGGGACAAAGAACGAGACAGAGACCGGGATCGAGACAGAGAACGGGACAAAGACAAAGACAG
AGACCGGGACCGGGACAGAGACAAAGAGCGGGACAGAGACAGGGACCGGGAGCGAGACCGAGAG
GGCCCTTTCCGTAGGTCAGACTCATTCCCCGAACGGAGGGCCCCTCGAAAGGGGAACACTCTGT
ATGTGTATGGAGAGGACATGACGCCCACCCTCCTCCGAGGGGCCTTCTCTCCCTTTGGAAATAT
CATCGACCTCTCCATGGACCCACCCAGAAACTGTGCCTTCGTCACCTACGAGAAGATGGAGTCA
GCAGATCAGGCTGTTGCTGAGCTCAATGGGACCCAGGTGGAATCTGTGCAGCTCAAAGTCAACA
TAGCCCGAAAACAGCCCATGCTGGACGCTGCTACTGGCAAATCTGTCTGGGGCTCCCTTGCTGT
CCAGAACAGCCCCAAGGGTTGCCACCGGGACAAGAGGACCCAGATTGTGTACAGTGACGATCTA
TAGGAAACCTTGTGGATGGCTTCTAGGACATGAAGCTGGATTCCTTGTGCCTCATATGCCCCCA
AGCTGGTCTCAGTAAAATCCTGGGGTAGAAGCTTTTAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_006255922 ⟹ XP_006255984

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	3,981,259 - 3,986,997 (-)	NCBI
mRatBN7.2	20	3,976,512 - 3,982,360 (-)	NCBI
Rnor_6.0	20	4,530,335 - 4,536,085 (+)	NCBI
Rnor_5.0	20	6,610,127 - 6,615,884 (+)	NCBI

Sequence:

show sequence

CCCGCGCGCAGCAGCCCGCGCGGCGGCGCCGGAGACCGCGGGCCCGGGCGCCGCCCCCTCAGGT
GAGGGCTTCGTCTCACATCCTTCGCGCCTTCCCCGCGCGGCCCCTGGTTCTTCTTCCTCCTCCT
CTGGTTGCCCAGATAGCGCTGCGCGGGCCCGGCCGCCTTCTCTGCCCACCGGACCCCGAGGTTG
GCTGACCTAACCCCATTGGGCATGGGGGTCGGGAGCCATCGCCTTGGCGTCGCAGGGAGTGCTT
TTCCTTCTCCGGGCTGAGGAGCCAACATGTTGGTGATACCTCCGGGGCTGAGTGAAGAGGAAGA
GGCACTACAGAAGAAATTCAACAAACTCAAGAAAAAGAAAAAGGCGTTGCTGGCTCTGAAGAAG
CAAAGCAGCAGTGGTACAGCGAGCCAGGGCGGTGTCAAGCGCTCACTGTCAGAGCAGCCTGTGG
TGGATACTGCCACAGCAACAGAACAGGCCAAACAGCTGGTGAAGTCAGGAGCTATCAGTGCCAT
CAAGGCTGAAACTAAGAACTCAGGCTTCAAACGTTCTCGGACCCTGGAAGGGAAGTTAAAGGAC
CCAGAGAAGGGGCCTGTCCCCACCTTCCAGCCGTTCCAGAGGAGCATGTCTGCTGACGAGGACC
TACAGGAGCCATCCAGACGGCCCCAAAGGAAATCTCTGTATGAAAGCTTTGTGTCTTCTAGTGA
TCGGCTTCGGGAACTGGGACAAGATGGAGAAGAAGCAGAGGCCCCTGGGGCTGGTGAAGGCCCA
CCTCGAGGTTTTGACTGGAGCTATGAAGAACACAGCGGTGCCCGATCCTCAGCCTCCCCTCCCC
GAAGCCGCAGCCGGGACAGAAGTCATGATCGGAGCCGAGATAGGGACCGGGACAAAGAACGAGA
CAGAGACCGGGATCGAGACAGAGAACGGGACAAAGACAAAGACAGAGACCGGGACCGGGACAGA
GACAAAGAGCGGGACAGAGACAGGGACCGGGAGCGAGACCGAGAGGGCCCTTTCCGTAGGTCAG
ACTCATTCCCCGAACGGAGGGCCCCTCGAAAGGGGAACACTCTGTATGTGTATGGAGAGGACAT
GACGCCCACCCTCCTCCGAGGGGCCTTCTCTCCCTTTGGAAATATCATCGACCTCTCCATGGAC
CCACCCAGAAACTGTGCCTTCGTCACCTACGAGAAGATGGAGTCAGCAGATCAGGCTGTTGCTG
AGCTCAATGGGACCCAGGTGGAATCTGTGCAGCTCAAAGTCAACATAGCCCGAAAACAGCCCAT
GCTGGACGCTGCTACTGGCAAATCTGTCTGGGGCTCCCTTGCTGTCCAGAACAGCCCCAAGGGT
TGCCACCGGGACAAGAGGACCCAGATTGTGTACAGTGACGATCTATAGGAAACCTTGTGGATGG
CTTCTAGGACATGAAGCTGGATTCCTTGTGCCTCATATGCCCCCAAGCTGGTCTCAGTAAAATC
CTGGGGTAGAAGCTTTTCA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001159373	(Get FASTA)	NCBI Sequence Viewer
	NP_997713	(Get FASTA)	NCBI Sequence Viewer
	XP_006255984	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH79427	(Get FASTA)	NCBI Sequence Viewer
	CAE83971	(Get FASTA)	NCBI Sequence Viewer
	EDL83439	(Get FASTA)	NCBI Sequence Viewer
	EDL83441	(Get FASTA)	NCBI Sequence Viewer
	EDL83444	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000000478.6

RefSeq Acc Id:

NP_997713 ⟸ NM_212548

- UniProtKB:

Q6MG75 (UniProtKB/TrEMBL), F1LP40 (UniProtKB/TrEMBL), Q6AXP2 (UniProtKB/TrEMBL), A0A8J8XR86 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MLVIPPGLSEEEEALQKKFNKLKKKKKALLALKKQSSSGTASQGGVKRSLSEQPVVDTATATEQ
AKQLVKSGAISAIKAETKNSGFKRSRTLEGKLKDPEKGPVPTFQPFQRSMSADEDLQEPSRRPQ
RKSLYESFVSSSDRLRELGQDGEEAEAPGAGEGPPRGFDWSYEEHSGARSSASPPRSRSRDRSH
DRSRDRDRDKERDRDRDRDRERDKDKDRDRDRDRDKERDRDRDRERDREGPFRRSDSFPERRAP
RKGNTLYVYGEDMTPTLLRGAFSPFGNIIDLSMDPPRNCAFVTYEKMESADQAVAELNGTQVES
VQLKVNIARKQPMLDAATGKSVWGSLAVQNSPKGCHRDKRTQIVYSDDL

hide sequence

RefSeq Acc Id:

NP_001159373 ⟸ NM_001165901

- UniProtKB:

Q6MG75 (UniProtKB/TrEMBL), F1LP40 (UniProtKB/TrEMBL), Q6AXP2 (UniProtKB/TrEMBL), A0A8J8XR86 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MLVIPPGLSEEEEALQKKFNKLKKKKKALLALKKQSSSGTASQGGVKRSLSEQPVVDTATATEQ
AKQLVKSGAISAIKAETKNSGFKRSRTLEGKLKDPEKGPVPTFQPFQRSMSADEDLQEPSRRPQ
RKSLYESFVSSSDRLRELGQDGEEAEAPGAGEGPPRGFDWSYEEHSGARSSASPPRSRSRDRSH
DRSRDRDRDKERDRDRDRDRERDKDKDRDRDRDRDKERDRDRDRERDREGPFRRSDSFPERRAP
RKGNTLYVYGEDMTPTLLRGAFSPFGNIIDLSMDPPRNCAFVTYEKMESADQAVAELNGTQVES
VQLKVNIARKQPMLDAATGKSVWGSLAVQNSPKGCHRDKRTQIVYSDDL

hide sequence

RefSeq Acc Id:	XP_006255984 ⟸ XM_006255922
- Peptide Label:	isoform X1
- UniProtKB:	Q6MG75 (UniProtKB/TrEMBL), F1LP40 (UniProtKB/TrEMBL), Q6AXP2 (UniProtKB/TrEMBL), A0A8J8XR86 (UniProtKB/TrEMBL)
- Sequence:	show sequence MLVIPPGLSEEEEALQKKFNKLKKKKKALLALKKQSSSGTASQGGVKRSLSEQPVVDTATATEQ AKQLVKSGAISAIKAETKNSGFKRSRTLEGKLKDPEKGPVPTFQPFQRSMSADEDLQEPSRRPQ RKSLYESFVSSSDRLRELGQDGEEAEAPGAGEGPPRGFDWSYEEHSGARSSASPPRSRSRDRSH DRSRDRDRDKERDRDRDRDRERDKDKDRDRDRDRDKERDRDRDRERDREGPFRRSDSFPERRAP RKGNTLYVYGEDMTPTLLRGAFSPFGNIIDLSMDPPRNCAFVTYEKMESADQAVAELNGTQVES VQLKVNIARKQPMLDAATGKSVWGSLAVQNSPKGCHRDKRTQIVYSDDL hide sequence

Ensembl Acc Id:

ENSRNOP00000068302 ⟸ ENSRNOT00000075925

Ensembl Acc Id:

ENSRNOP00000000478 ⟸ ENSRNOT00000000478

Ensembl Acc Id:

ENSRNOP00000068403 ⟸ ENSRNOT00000076352

Protein Domains

RRM

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q6MG75-F1-model_v2	AlphaFold	Q6MG75	1-369	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13701355

Promoter ID:

EPDNEW_R11878

Type:

initiation region

Name:

Nelfe_1

Description:

negative elongation factor complex member E

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	20	4,530,344 - 4,530,404	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1303325	AgrOrtholog
BioCyc Gene	G2FUF-4601	BioCyc
Ensembl Genes	ENSRNOG00000000420	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000000478.8	UniProtKB/TrEMBL
Gene3D-CATH	3.30.70.330	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7114415	IMAGE-MGC_LOAD
InterPro	NELFE	UniProtKB/TrEMBL
	NELFE_RRM	UniProtKB/TrEMBL
	Nucleotide-bd_a/b_plait_sf	UniProtKB/TrEMBL
	RBD_domain_sf	UniProtKB/TrEMBL
	RRM_dom	UniProtKB/TrEMBL
KEGG Report	rno:294258	UniProtKB/TrEMBL
MGC_CLONE	MGC:94972	IMAGE-MGC_LOAD
NCBI Gene	294258	ENTREZGENE
PANTHER	NEGATIVE ELONGATION FACTOR E	UniProtKB/TrEMBL
	PTHR17250	UniProtKB/TrEMBL
Pfam	RRM_1	UniProtKB/TrEMBL
PhenoGen	Nelfe	PhenoGen
PROSITE	RRM	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000000420	RatGTEx
SMART	RRM	UniProtKB/TrEMBL
Superfamily-SCOP	SSF54928	UniProtKB/TrEMBL
UniProt	A0A8J8XR86	ENTREZGENE, UniProtKB/TrEMBL
	F1LP40	ENTREZGENE
	Q6AXP2	ENTREZGENE, UniProtKB/TrEMBL
	Q6MG75	ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary	F1LP40	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2013-02-06	Nelfe	negative elongation factor complex member E	Rdbp	RD RNA-binding protein	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-11-17	Rdbp	RD RNA-binding protein			Symbol and Name status set to approved	1299863	APPROVED
2005-10-12	Rdbp				Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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