HNRNPA0 (heterogeneous nuclear ribonucleoprotein A0) - Rat Genome Database
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Gene: HNRNPA0 (heterogeneous nuclear ribonucleoprotein A0) Homo sapiens
Analyze
Symbol: HNRNPA0
Name: heterogeneous nuclear ribonucleoprotein A0
RGD ID: 1318867
HGNC Page HGNC
Description: Exhibits mRNA 3'-UTR AU-rich region binding activity and protein kinase binding activity. Predicted to be involved in 3'-UTR-mediated mRNA stabilization; inflammatory response; and response to lipopolysaccharide. Localizes to nucleoplasm. Biomarker of gastric adenocarcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: hnRNA binding protein; hnRNP A0; HNRPA0
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl5137,745,651 - 137,754,363 (-)EnsemblGRCh38hg38GRCh38
GRCh385137,745,651 - 137,754,363 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh375137,087,073 - 137,090,039 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365137,114,972 - 137,117,938 (-)NCBINCBI36hg18NCBI36
Build 345137,114,973 - 137,117,938NCBI
Celera5133,208,508 - 133,211,474 (-)NCBI
Cytogenetic Map5q31.2NCBI
HuRef5132,277,733 - 132,280,699 (-)NCBIHuRef
CHM1_15136,519,671 - 136,522,637 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleoplasm  (IDA,TAS)
nucleus  (IBA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:1602151   PMID:7585247   PMID:8012384   PMID:8325628   PMID:8889548   PMID:8889549   PMID:11161817   PMID:12226669   PMID:12456657   PMID:12477932   PMID:12565831   PMID:15489334  
PMID:15592455   PMID:15635413   PMID:15782174   PMID:16169070   PMID:16196087   PMID:17215244   PMID:17314511   PMID:17620599   PMID:17643375   PMID:18029348   PMID:18457437   PMID:18816836  
PMID:19165527   PMID:19322201   PMID:19738201   PMID:20020773   PMID:20360068   PMID:20467437   PMID:20932473   PMID:21081503   PMID:21139048   PMID:21145461   PMID:21182205   PMID:21873635  
PMID:21890473   PMID:21900206   PMID:21906983   PMID:21963094   PMID:22199357   PMID:22365833   PMID:22412018   PMID:22505724   PMID:22623428   PMID:22658674   PMID:22681889   PMID:22863883  
PMID:22939629   PMID:23000965   PMID:23125841   PMID:23151878   PMID:23184937   PMID:23277564   PMID:23402259   PMID:24332808   PMID:24457600   PMID:24532040   PMID:24711643   PMID:24816145  
PMID:25147182   PMID:25324306   PMID:25437307   PMID:25515538   PMID:25798074   PMID:25852190   PMID:25900982   PMID:25921289   PMID:26167880   PMID:26318153   PMID:26496610   PMID:26514267  
PMID:26549023   PMID:26602816   PMID:26641092   PMID:26760575   PMID:26831064   PMID:26979993   PMID:27025967   PMID:27248496   PMID:27576135   PMID:27609421   PMID:27684187   PMID:27976729  
PMID:28225217   PMID:28431233   PMID:28515276   PMID:28977666   PMID:29053956   PMID:29117863   PMID:29229926   PMID:29298432   PMID:29467282   PMID:29478914   PMID:29511296   PMID:29653964  
PMID:29777862   PMID:29802200   PMID:29845934   PMID:29884807   PMID:29991511   PMID:30021884   PMID:30097533   PMID:30196744   PMID:30209976   PMID:30349055   PMID:30415952   PMID:30425250  
PMID:30463901   PMID:30532072   PMID:30804502   PMID:30833792   PMID:30940648   PMID:30948266   PMID:31048545   PMID:31059266   PMID:31091453   PMID:31180492   PMID:31239290   PMID:31586073  
PMID:31796584   PMID:31980649   PMID:32457219   PMID:32529326   PMID:32694731   PMID:32780723   PMID:32786267   PMID:32838362  


Genomics

Comparative Map Data
HNRNPA0
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl5137,745,651 - 137,754,363 (-)EnsemblGRCh38hg38GRCh38
GRCh385137,745,651 - 137,754,363 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh375137,087,073 - 137,090,039 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365137,114,972 - 137,117,938 (-)NCBINCBI36hg18NCBI36
Build 345137,114,973 - 137,117,938NCBI
Celera5133,208,508 - 133,211,474 (-)NCBI
Cytogenetic Map5q31.2NCBI
HuRef5132,277,733 - 132,280,699 (-)NCBIHuRef
CHM1_15136,519,671 - 136,522,637 (-)NCBICHM1_1
Hnrnpa0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391358,273,693 - 58,276,370 (-)NCBIGRCm39mm39
GRCm381358,125,879 - 58,128,556 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1358,125,879 - 58,128,556 (-)EnsemblGRCm38mm10GRCm38
MGSCv371358,227,240 - 58,229,917 (-)NCBIGRCm37mm9NCBIm37
MGSCv361358,135,497 - 58,138,179 (-)NCBImm8
Celera1359,188,312 - 59,191,005 (-)NCBICelera
Cytogenetic Map13B1NCBI
Hnrnpa0
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
RGSC_v3.41712,452,030 - 12,452,914 (+)NCBIRGSC3.4rn4RGSC3.4
Celera176,617,417 - 6,618,097 (+)NCBICelera
Cytogenetic Map17p14NCBI
Hnrnpa0
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495540832,718,736 - 32,719,409 (-)NCBIChiLan1.0ChiLan1.0
HNRNPA0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.15139,275,249 - 139,278,250 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5139,277,004 - 139,277,939 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v05133,132,030 - 133,140,771 (-)NCBIMhudiblu_PPA_v0panPan3
HNRNPA0
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1125,466,185 - 25,467,117 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11125,464,601 - 25,467,460 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Hnrnpa0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365974,712,201 - 4,714,949 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HNRNPA0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2139,779,867 - 139,783,159 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12139,779,865 - 139,783,016 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22145,501,462 - 145,504,543 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HNRNPA0
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12340,433,429 - 40,436,188 (-)NCBI
ChlSab1.1 Ensembl2340,435,002 - 40,435,913 (-)Ensembl
Hnrnpa0
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247339,265,784 - 9,271,559 (+)NCBI

Position Markers
RH12646  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375137,087,101 - 137,087,243UniSTSGRCh37
Build 365137,115,000 - 137,115,142RGDNCBI36
Celera5133,208,536 - 133,208,678RGD
Cytogenetic Map5q31UniSTS
HuRef5132,277,761 - 132,277,903UniSTS
GeneMap99-GB4 RH Map5520.62UniSTS
RH70163  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375137,089,263 - 137,089,394UniSTSGRCh37
Build 365137,117,162 - 137,117,293RGDNCBI36
Celera5133,210,698 - 133,210,829RGD
Cytogenetic Map5q31UniSTS
HuRef5132,279,923 - 132,280,054UniSTS
GeneMap99-GB4 RH Map5520.52UniSTS
RH79130  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375137,088,407 - 137,088,533UniSTSGRCh37
Build 365137,116,306 - 137,116,432RGDNCBI36
Celera5133,209,842 - 133,209,968RGD
Cytogenetic Map5q31UniSTS
HuRef5132,279,067 - 132,279,193UniSTS
GeneMap99-GB4 RH Map5520.39UniSTS
D5F121S1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375137,088,897 - 137,089,147UniSTSGRCh37
Build 365137,116,796 - 137,117,046RGDNCBI36
Celera5133,210,332 - 133,210,582RGD
Cytogenetic Map5q31UniSTS
HuRef5132,279,557 - 132,279,807UniSTS
G20772  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375137,087,356 - 137,087,479UniSTSGRCh37
Build 365137,115,255 - 137,115,378RGDNCBI36
Celera5133,208,791 - 133,208,914RGD
Cytogenetic Map5q31UniSTS
HuRef5132,278,016 - 132,278,139UniSTS
A006F37  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375137,087,356 - 137,087,479UniSTSGRCh37
Build 365137,115,255 - 137,115,378RGDNCBI36
Celera5133,208,791 - 133,208,914RGD
Cytogenetic Map5q31UniSTS
HuRef5132,278,016 - 132,278,139UniSTS
GeneMap99-GB4 RH Map5520.62UniSTS
HNRPA0_2045  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375137,088,216 - 137,089,104UniSTSGRCh37
Build 365137,116,115 - 137,117,003RGDNCBI36
Celera5133,209,651 - 133,210,539RGD
HuRef5132,278,876 - 132,279,764UniSTS
AA858784  
Human AssemblyChrPosition (strand)SourceJBrowse
HuRef5132,279,098 - 132,279,242UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:574
Count of miRNA genes:450
Interacting mature miRNAs:485
Transcripts:ENST00000314940
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 9
Medium 2436 2289 1604 502 1514 344 4268 1874 3062 395 1450 1613 174 1 1204 2699 5 2
Low 3 702 122 122 437 121 89 323 672 24 1 1 89 1
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_006805 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA081021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AA442538 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC106791 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC001008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC007271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC009284 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC011972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC012490 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC012980 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC018800 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC018949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC019271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC028976 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC030249 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF445078 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM968394 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471062 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR456986 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB887001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC944410 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KT584573 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L10372 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U23803 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z61116 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000314940   ⟹   ENSP00000316042
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl5137,745,651 - 137,754,363 (-)Ensembl
RefSeq Acc Id: NM_006805   ⟹   NP_006796
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385137,745,651 - 137,754,363 (-)NCBI
GRCh375137,087,073 - 137,090,039 (-)RGD
Build 365137,114,972 - 137,117,938 (-)NCBI Archive
Celera5133,208,508 - 133,211,474 (-)RGD
HuRef5132,277,733 - 132,280,699 (-)ENTREZGENE
CHM1_15136,519,671 - 136,522,637 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_006796   ⟸   NM_006805
- UniProtKB: Q13151 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000316042   ⟸   ENST00000314940
Protein Domains
RRM


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 5q23.3-33.2(chr5:130860928-155321811)x3 copy number gain See cases [RCV000051193] Chr5:130860928..155321811 [GRCh38]
Chr5:130196621..154701371 [GRCh37]
Chr5:130224520..154681564 [NCBI36]
Chr5:5q23.3-33.2
pathogenic
GRCh38/hg38 5q31.1-31.2(chr5:133401565-138437038)x1 copy number loss See cases [RCV000052114] Chr5:133401565..138437038 [GRCh38]
Chr5:132737257..137772727 [GRCh37]
Chr5:132765156..137800626 [NCBI36]
Chr5:5q31.1-31.2
pathogenic
GRCh38/hg38 5q21.3-33.2(chr5:106619588-156124387)x1 copy number loss See cases [RCV000053524] Chr5:106619588..156124387 [GRCh38]
Chr5:105955289..155551397 [GRCh37]
Chr5:105983188..155483975 [NCBI36]
Chr5:5q21.3-33.2
pathogenic
GRCh38/hg38 5q31.1-31.3(chr5:135297294-140106003)x3 copy number gain See cases [RCV000133750] Chr5:135297294..140106003 [GRCh38]
Chr5:134632984..139485588 [GRCh37]
Chr5:134660883..139465772 [NCBI36]
Chr5:5q31.1-31.3
pathogenic
GRCh38/hg38 5q23.3-33.2(chr5:129847794-153353546)x3 copy number gain See cases [RCV000138808] Chr5:129847794..153353546 [GRCh38]
Chr5:129183487..152733106 [GRCh37]
Chr5:129211386..152713299 [NCBI36]
Chr5:5q23.3-33.2
pathogenic
GRCh37/hg19 5q15-35.3(chr5:94844077-178830410)x3 copy number gain not provided [RCV000487658] Chr5:94844077..178830410 [GRCh37]
Chr5:5q15-35.3
likely benign
GRCh37/hg19 5q23.3-33.3(chr5:130125085-157574910)x3 copy number gain See cases [RCV000449349] Chr5:130125085..157574910 [GRCh37]
Chr5:5q23.3-33.3
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789) copy number gain See cases [RCV000510723] Chr5:113577..180719789 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
GRCh37/hg19 5q21.3-35.3(chr5:106716357-180687338)x3 copy number gain See cases [RCV000448245] Chr5:106716357..180687338 [GRCh37]
Chr5:5q21.3-35.3
pathogenic
GRCh37/hg19 5q31.2(chr5:136667092-137380603)x3 copy number gain See cases [RCV000447839] Chr5:136667092..137380603 [GRCh37]
Chr5:5q31.2
uncertain significance
NC_000005.9:g.(?_86400000)_(154000000_?)del deletion Hereditary cancer-predisposing syndrome [RCV000554476] Chr5:86400000..154000000 [GRCh37]
Chr5:5q14.3-33.2
pathogenic
GRCh37/hg19 5p15.1-q35.2(chr5:17628741-176575720)x1 copy number loss See cases [RCV000511978] Chr5:17628741..176575720 [GRCh37]
Chr5:5p15.1-q35.2
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789)x3 copy number gain See cases [RCV000512039] Chr5:113577..180719789 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:25328-180693344)x3 copy number gain not provided [RCV000744323] Chr5:25328..180693344 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:13648-180905029)x3 copy number gain not provided [RCV000744317] Chr5:13648..180905029 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
Single allele deletion Neurodevelopmental disorder [RCV000787436] Chr5:14685137..149511942 [GRCh37]
Chr5:5p15.2-q32
uncertain significance
NM_006805.4(HNRNPA0):c.516A>G (p.Lys172=) single nucleotide variant not provided [RCV000880786] Chr5:137753551 [GRCh38]
Chr5:137089240 [GRCh37]
Chr5:5q31.2
benign

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:5030 AgrOrtholog
COSMIC HNRNPA0 COSMIC
Ensembl Genes ENSG00000177733 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000316042 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000314940 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.70.330 UniProtKB/Swiss-Prot
GTEx ENSG00000177733 GTEx
HGNC ID HGNC:5030 ENTREZGENE
Human Proteome Map HNRNPA0 Human Proteome Map
InterPro hnRNPA0_RRM1 UniProtKB/Swiss-Prot
  Nucleotide-bd_a/b_plait_sf UniProtKB/Swiss-Prot
  RBD_domain_sf UniProtKB/Swiss-Prot
  RRM_dom UniProtKB/Swiss-Prot
KEGG Report hsa:10949 UniProtKB/Swiss-Prot
NCBI Gene 10949 ENTREZGENE
OMIM 609409 OMIM
Pfam RRM_1 UniProtKB/Swiss-Prot
PharmGKB PA162391106 PharmGKB
PROSITE RRM UniProtKB/Swiss-Prot
SMART RRM UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54928 UniProtKB/Swiss-Prot
UniGene Hs.645902 ENTREZGENE
  Hs.96996 ENTREZGENE
UniProt Q13151 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q6IB18 UniProtKB/Swiss-Prot