RT1-CE13 (RT1 class I, locus CE13) - Rat Genome Database

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Gene: RT1-CE13 (RT1 class I, locus CE13) Rattus norvegicus
Analyze
No known orthologs.
Symbol: RT1-CE13
Name: RT1 class I, locus CE13
RGD ID: 1359196
Description: PARTICIPATES IN allograft rejection pathway; antigen processing and presentation pathway; autoimmune thyroiditis pathway; ASSOCIATED WITH acute retinal necrosis syndrome (ortholog); alopecia (ortholog); ankylosing spondylitis (ortholog)
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: RT1 class I, CE13
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8203,314,491 - 3,322,815 (-)NCBIGRCr8
mRatBN7.2203,314,830 - 3,318,106 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx204,217,490 - 4,220,703 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0203,579,551 - 3,582,764 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0203,645,154 - 3,950,323 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

References - curated
# Reference Title Reference Citation
1. Human leukocyte antigen (HLA)-B, DRB1, and DQB1 allotypes associated with disease and protection of trachoma endemic villagers. Abbas M, etal., Invest Ophthalmol Vis Sci. 2009 Apr;50(4):1734-8. doi: 10.1167/iovs.08-2053. Epub 2008 Sep 29.
2. AIDS-associated Reiter's syndrome. Altman EM, etal., Ann Allergy. 1994 Apr;72(4):307-16.
3. HLA class I polymorphisms in Tunisian patients with otosclerosis. Bel Hadj Ali I, etal., Ann Hum Biol. 2012 May;39(3):190-4. doi: 10.3109/03014460.2012.671849. Epub 2012 Apr 4.
4. Profiling of human leukocyte antigens in Eales' disease. Biswas J, etal., Int Ophthalmol. 1997-1998;21(5):277-81.
5. Human leukocyte antigen class I expression. Marker of poor prognosis in uveal melanoma. Blom DJ, etal., Invest Ophthalmol Vis Sci. 1997 Aug;38(9):1865-72.
6. HLA class I associations of ankylosing spondylitis in the white population in the United Kingdom. Brown MA, etal., Ann Rheum Dis. 1996 Apr;55(4):268-70.
7. HLA-B alleles associated with severe cutaneous reactions to antiepileptic drugs in Han Chinese. Cheung YK, etal., Epilepsia. 2013 Jul;54(7):1307-14. doi: 10.1111/epi.12217. Epub 2013 May 20.
8. HLA-B phenotype modifies the course of Behcet's disease in Moroccan patients. Choukri F, etal., Tissue Antigens. 2003 Jan;61(1):92-6.
9. Association of the HLA-DR15/HLA-DQ6 haplotype with development of choroidal neovascular lesions in presumed ocular histoplasmosis syndrome. Dabil H, etal., Hum Immunol. 2003 Oct;64(10):960-4.
10. [Characteristics of the distribution of major histocompatibility system antigens in retinal vasculitis in patients with Behcet's disease]. Ermakova NA Vestn Oftalmol. 2003 Jan-Feb;119(1):31-3.
11. The role of the human leukocyte antigen system in retinopathy of prematurity: a pilot study. Flor-de-Lima F, etal., Acta Paediatr. 2013 Aug 29. doi: 10.1111/apa.12410.
12. Lack of association of HLA-B*51 with a severe disease course in Behcet's disease. Gul A, etal., Rheumatology (Oxford). 2001 Jun;40(6):668-72.
13. Spontaneous inflammatory disease in transgenic rats expressing HLA-B27 and human beta 2m: an animal model of HLA-B27-associated human disorders. Hammer RE, etal., Cell. 1990 Nov 30;63(5):1099-112.
14. An association between acute retinal necrosis syndrome and HLA-DQw7 and phenotype Bw62, DR4. Holland GN, etal., Am J Ophthalmol. 1989 Oct 15;108(4):370-4.
15. The association of HLA -A, -B, and -DRB1 genotypes with Graves' disease in Taiwanese people. Huang SM, etal., Tissue Antigens. 2003 Feb;61(2):154-8.
16. Associations of major histocompatibility complex class I chain-related molecule polymorphisms with Behcet's disease in Caucasian patients. Hughes EH, etal., Tissue Antigens. 2005 Sep;66(3):195-9.
17. Genetic and non-genetic factors affecting the visual outcome of ocular Behcet's disease. Kang EH, etal., Hum Immunol. 2013 Oct;74(10):1363-7. doi: 10.1016/j.humimm.2013.06.036. Epub 2013 Jul 2.
18. HLA-B locus in Japanese patients with anti-epileptics and allopurinol-related Stevens-Johnson syndrome and toxic epidermal necrolysis. Kaniwa N, etal., Pharmacogenomics. 2008 Nov;9(11):1617-22. doi: 10.2217/14622416.9.11.1617.
19. Association of class I HLA antigens with the clinical manifestations of Turkish patients with Behcet's disease. Kaya TI, etal., Clin Exp Dermatol. 2002 Sep;27(6):498-501.
20. Evaluation of HLA-A, -B, -Cw, and -DRB1 alleles frequency in Turkish patients with nasal polyposis. Keles B, etal., Otolaryngol Head Neck Surg. 2008 Oct;139(4):580-5. doi: 10.1016/j.otohns.2008.07.002.
21. Frequency of HLA antigens in Graves' hyperthyroidism and mitral valve prolapse. Kontopoulos A, etal., J Heart Valve Dis. 1996 Sep;5(5):543-7.
22. Audio-vestibular disturbances in Behcet's patients: report of 62 cases. Kulahli I, etal., Hear Res. 2005 May;203(1-2):28-31.
23. Association between HLA-B*46 allele and Graves disease in Asian populations: a meta-analysis. Li Y, etal., Int J Med Sci. 2013;10(2):164-70. doi: 10.7150/ijms.5158. Epub 2013 Jan 3.
24. [Association of HLA antigens with thyrotoxic periodic paralysis]. Liu WH, etal., Zhonghua Nei Ke Za Zhi. 1991 Jul;30(7):395-8, 454.
25. Human leukocyte antigen in childhood unilateral deafness. Matsuki K, etal., Arch Otolaryngol Head Neck Surg. 1989 Jan;115(1):46-7.
26. Synthetic MHC class I peptide prolongs cardiac survival and attenuates transplant arteriosclerosis in the Lewis-->Fischer 344 model of chronic allograft rejection. Murphy B, etal., Transplantation. 1997 Jul 15;64(1):14-9.
27. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
28. Clinical phenotype is related to HLA genotype in the peripheral arthropathies of inflammatory bowel disease. Orchard TR, etal., Gastroenterology. 2000 Feb;118(2):274-8.
29. Uveitis and erythema nodosum in inflammatory bowel disease: clinical features and the role of HLA genes. Orchard TR, etal., Gastroenterology. 2002 Sep;123(3):714-8.
30. HLA-B27-associated acute anterior uveitis in the University Referral Centre in North Thailand: clinical presentation and visual prognosis. Pathanapitoon K, etal., Br J Ophthalmol. 2006 Dec;90(12):1448-50. Epub 2006 Aug 9.
31. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
32. Immune dysfunction and immune restoration disease in HIV patients given highly active antiretroviral therapy. Price P, etal., J Clin Virol. 2001 Oct;22(3):279-87.
33. HLA typing in birdshot chorioretinopathy. Priem HA, etal., Am J Ophthalmol. 1988 Feb 15;105(2):182-5.
34. [Susceptibility genes, HLA and diabetic retinopathy in the Algerian population]. Raache R, etal., J Fr Ophtalmol. 2013 Mar;36(3):247-54. doi: 10.1016/j.jfo.2012.01.008. Epub 2012 Sep 14.
35. MHC-extended haplotypes in families of patients with Graves' disease. Ratanachaiyavong S, etal., Hum Immunol. 1993 Feb;36(2):99-111.
36. [Features of clinical manifestations of the globe, adnexal and orbital sarcoidosis]. Razumova IIu, etal., Vestn Oftalmol. 2013 Mar-Apr;129(2):35-40.
37. GOA pipeline RGD automated data pipeline
38. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
39. HLA antigens in Asian Indian patients with Graves' disease. Tandon N, etal., Clin Endocrinol (Oxf). 1990 Jul;33(1):21-6.
40. Molecular mimicry as a therapeutic approach for an autoimmune disease: oral treatment of uveitis-patients with an MHC-peptide crossreactive with autoantigen--first results. Thurau SR, etal., Immunol Lett. 1997 Jun 1;57(1-3):193-201.
41. HLA B27 as predisposition factor to suffer age related macular degeneration. Villegas Becerril E, etal., Cell Mol Immunol. 2009 Aug;6(4):303-7. doi: 10.1038/cmi.2009.40.
42. Gamma-delta T cells as orally induced suppressor cells in rats: in vitro characterization. Wildner G, etal., Ann N Y Acad Sci. 2004 Dec;1029:416-21.
43. Characterization of psoriasiform and alopecic skin lesions in HLA-B27 transgenic rats. Yanagisawa H, etal., Am J Pathol. 1995 Oct;147(4):955-64.
44. Influence of human leukocyte antigen in the pathogenesis of Meniere's disease in the South Korean population. Yeo SW, etal., Acta Otolaryngol. 2002 Dec;122(8):851-6.
Additional References at PubMed
PMID:29531166  


Genomics

Variants

.
Variants in RT1-CE13
563 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61472Aia1Adjuvant induced arthritis QTL 1180.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2026463954597031Rat
2306850Pia40Pristane induced arthritis QTL 400.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2015279595304575Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20289259726381954Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125159026Rat
61448Ciaa1CIA Autoantibody QTL 1300.001blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)2026463954597031Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
724519Bp144Blood pressure QTL 1440.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2013624629Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat


Expression


Sequence


RefSeq Acc Id: NM_001008836   ⟹   NP_001008836
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8203,319,525 - 3,322,799 (-)NCBI
mRatBN7.2203,314,830 - 3,318,106 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063279405   ⟹   XP_063135475
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8203,319,942 - 3,322,815 (-)NCBI
RefSeq Acc Id: XM_063279406   ⟹   XP_063135476
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8203,314,491 - 3,322,815 (-)NCBI
RefSeq Acc Id: XM_063279407   ⟹   XP_063135477
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8203,314,491 - 3,322,815 (-)NCBI
RefSeq Acc Id: XM_063279408   ⟹   XP_063135478
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8203,314,491 - 3,322,815 (-)NCBI
RefSeq Acc Id: XR_010060748
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8203,314,491 - 3,322,815 (-)NCBI
RefSeq Acc Id: NP_001008836   ⟸   NM_001008836
- Peptide Label: precursor
- UniProtKB: Q6MG31 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_063135476   ⟸   XM_063279406
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063135477   ⟸   XM_063279407
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063135478   ⟸   XM_063279408
- Peptide Label: isoform X4
- UniProtKB: A0A2P1NRY3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063135475   ⟸   XM_063279405
- Peptide Label: isoform X1
Protein Domains
Ig-like


Additional Information

Database Acc Id Source(s)
BioCyc Gene G2FUF-4713 BioCyc
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
  3.30.500.10 UniProtKB/TrEMBL
InterPro Ig-like UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig/MHC_CS UniProtKB/TrEMBL
  Ig_C1-set UniProtKB/TrEMBL
  MHC_class-I_related UniProtKB/TrEMBL
  MHC_I-like_Ag-recog UniProtKB/TrEMBL
  MHC_I-like_Ag-recog_sf UniProtKB/TrEMBL
  MHC_I/II-like_Ag-recog UniProtKB/TrEMBL
  MHC_I_a_a1/a2 UniProtKB/TrEMBL
  MHC_I_a_C UniProtKB/TrEMBL
KEGG Report rno:414790 UniProtKB/TrEMBL
NCBI Gene 414790 ENTREZGENE
PANTHER CLASS IB MHC ANTIGEN QA-2-RELATED UniProtKB/TrEMBL
  MHC CLASS I-RELATED UniProtKB/TrEMBL
Pfam C1-set UniProtKB/TrEMBL
  MHC_I UniProtKB/TrEMBL
  MHC_I_C UniProtKB/TrEMBL
PhenoGen RT1-CE13 PhenoGen
PRINTS MHCCLASSI UniProtKB/TrEMBL
PROSITE IG_LIKE UniProtKB/TrEMBL
  IG_MHC UniProtKB/TrEMBL
SMART IGc1 UniProtKB/TrEMBL
Superfamily-SCOP MHC_I/II-like_Ag-recog UniProtKB/TrEMBL
  SSF48726 UniProtKB/TrEMBL
UniProt A0A2P1NRY3 ENTREZGENE, UniProtKB/TrEMBL
  Q6MG31 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-09-15 RT1-CE13  RT1 class I, locus CE13  RT1-CE13  RT1 class I, CE13  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 RT1-CE13  RT1 class I, CE13      Symbol and Name updated 1559027 APPROVED
2005-07-29 RT1-CE13  RT1 class I, CE13      Symbol and Name status set to provisional 70820 PROVISIONAL