Glp1r (glucagon-like peptide 1 receptor) - Rat Genome Database

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Gene: Glp1r (glucagon-like peptide 1 receptor) Rattus norvegicus
Analyze
Symbol: Glp1r
Name: glucagon-like peptide 1 receptor
RGD ID: 2703
Description: Enables glucagon-like peptide 1 receptor activity and peptide hormone binding activity. Involved in several processes, including cAMP/PKA signal transduction; learning or memory; and positive regulation of insulin secretion. Located in plasma membrane. Used to study hyperglycemia and hypertension. Biomarker of obesity. Human ortholog(s) of this gene implicated in obesity. Orthologous to human GLP1R (glucagon like peptide 1 receptor); PARTICIPATES IN protein kinase A (PKA) signaling pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Glip; GLP-1 receptor; GLP-1-R; GLP-1R; pancreatic beta cell receptor for the gluco-incretin hormone glucagon-like peptide 1; RATGL1RCP
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Glp1rem1Mcwi   Glp1rem2Mcwi   Glp1rem3Mcwi  
Genetic Models: Lew-Glp1rem1Mcwi Lew-Glp1rem3Mcwi Lew-Glp1rem2Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8208,973,393 - 9,011,622 (+)NCBIGRCr8
mRatBN7.2208,972,004 - 9,010,241 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl208,972,004 - 9,010,241 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx209,666,817 - 9,705,074 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0209,027,975 - 9,066,230 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0209,503,459 - 9,541,265 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0209,586,075 - 9,626,228 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl209,586,075 - 9,626,228 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02011,768,479 - 11,808,416 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4209,225,881 - 9,264,184 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1209,226,107 - 9,264,411 (+)NCBI
Celera2010,499,202 - 10,536,348 (+)NCBICelera
RH 3.4 Map20118.3RGD
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
plasma membrane  (IBA,IDA,IEA,ISO,TAS)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Central exendin-4 infusion reduces body weight without altering plasma leptin in (fa/fa) Zucker rats. Al-Barazanji KA, etal., Obes Res. 2000 Jul;8(4):317-23.
2. Hyperglycemia after protein ingestion concurrent with injection of a GLP-1 receptor agonist in rats: a possible role for dietary peptides. Aziz A, etal., Am J Physiol Regul Integr Comp Physiol. 2005 Sep;289(3):R688-94. Epub 2005 May 5.
3. Glucagon-like peptide-1 (GLP-1) releases thyrotropin (TSH): characterization of binding sites for GLP-1 on alpha-TSH cells. Beak SA, etal., Endocrinology. 1996 Oct;137(10):4130-8.
4. Expression levels of genes likely involved in glucose-sensing in the obese Zucker rat brain. Bogacka I, etal., Nutr Neurosci. 2004 Apr;7(2):67-74.
5. Over-expression of the glucagon-like peptide-1 receptor on INS-1 cells confers autocrine stimulation of insulin gene promoter activity: a strategy for production of pancreatic beta-cell lines for use in transplantation. Chepurny OG and Holz GG, Cell Tissue Res 2002 Feb;307(2):191-201.
6. The recombinant rat glucagon-like peptide-1 receptor, expressed in an alpha-cell line, is coupled to adenylyl cyclase activation and intracellular calcium release. Dillon JS, etal., Exp Clin Endocrinol Diabetes. 2005 Mar;113(3):182-9.
7. Glucagon-like peptide-1 receptor is involved in learning and neuroprotection. During MJ, etal., Nat Med. 2003 Sep;9(9):1173-9. Epub 2003 Aug 17.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Glucagon and glucagon-like peptide 1: selective receptor recognition via distinct peptide epitopes. Hjorth SA, etal., J Biol Chem. 1994 Dec 2;269(48):30121-4.
11. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
12. Genetic association analysis of 30 genes related to obesity in a European American population. Li P, etal., Int J Obes (Lond). 2014 May;38(5):724-9. doi: 10.1038/ijo.2013.140. Epub 2013 Jul 31.
13. Glucagon-like peptide-1 receptor signaling modulates beta cell apoptosis. Li Y, etal., J Biol Chem 2003 Jan 3;278(1):471-8.
14. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
15. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
16. GOA pipeline RGD automated data pipeline
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Adenylyl cyclase 8 is central to glucagon-like peptide 1 signalling and effects of chronically elevated glucose in rat and human pancreatic beta cells. Roger B, etal., Diabetologia. 2011 Feb;54(2):390-402. doi: 10.1007/s00125-010-1955-x. Epub 2010 Nov 3.
19. Mutations to the third cytoplasmic domain of the glucagon-like peptide 1 (GLP-1) receptor can functionally uncouple GLP-1-stimulated insulin secretion in HIT-T15 cells. Salapatek AM, etal., Mol Endocrinol. 1999 Aug;13(8):1305-17.
20. Glucose intolerance but normal satiety in mice with a null mutation in the glucagon-like peptide 1 receptor gene. Scrocchi LA, etal., Nat Med. 1996 Nov;2(11):1254-8.
21. The third cytoplasmic domain of the GLP-1[7-36 amide] receptor is required for coupling to the adenylyl cyclase system. Takhar S, etal., Endocrinology. 1996 May;137(5):2175-8.
22. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
23. Expression cloning of the pancreatic beta cell receptor for the gluco-incretin hormone glucagon-like peptide 1. Thorens B Proc Natl Acad Sci U S A 1992 Sep 15;89(18):8641-5.
24. Effect of GIP and GLP-1 antagonists on insulin release in the rat. Tseng CC, etal., Am J Physiol. 1999 Jun;276(6 Pt 1):E1049-54.
25. The cytoplasmic domain close to the transmembrane region of the glucagon-like peptide-1 receptor contains sequence elements that regulate agonist-dependent internalisation. Vazquez P, etal., J Endocrinol. 2005 Jul;186(1):221-31.
26. Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats. Xu G, etal., Diabetes. 1999 Dec;48(12):2270-6.
27. Glucagon-like peptide-1 receptor stimulation increases blood pressure and heart rate and activates autonomic regulatory neurons. Yamamoto H, etal., J Clin Invest 2002 Jul;110(1):43-52.
Additional References at PubMed
PMID:7589461   PMID:7813606   PMID:10650957   PMID:12746281   PMID:14766323   PMID:14965273   PMID:14965274   PMID:15670850   PMID:17322063   PMID:17360984   PMID:17584962   PMID:17629357  
PMID:17631146   PMID:17898126   PMID:18078857   PMID:18420740   PMID:18541709   PMID:19264875   PMID:19453518   PMID:19474324   PMID:20589757   PMID:20649595   PMID:20799012   PMID:21356521  
PMID:21745271   PMID:21810595   PMID:21917638   PMID:21945929   PMID:22105074   PMID:22128031   PMID:22960405   PMID:23019232   PMID:23033273   PMID:23302777   PMID:23338623   PMID:23354098  
PMID:23612998   PMID:24048027   PMID:24217090   PMID:24425760   PMID:24601880   PMID:24681814   PMID:24879927   PMID:24944243   PMID:25012114   PMID:25035078   PMID:25114295   PMID:25177707  
PMID:25202980   PMID:25483438   PMID:25656368   PMID:25793511   PMID:25893200   PMID:25915883   PMID:26098939   PMID:26211731   PMID:26302449   PMID:26470787   PMID:26655814   PMID:26675243  
PMID:26850848   PMID:26947974   PMID:26975347   PMID:27013681   PMID:27372651   PMID:27782127   PMID:28242257   PMID:28514449   PMID:28599244   PMID:28920591   PMID:29247677   PMID:29263141  
PMID:29412813   PMID:29434185   PMID:29510158   PMID:29650350   PMID:29813107   PMID:29959973   PMID:30195035   PMID:30637442   PMID:30770099   PMID:31468622   PMID:31537818   PMID:31581176  
PMID:31795376   PMID:31828140   PMID:32010959   PMID:32013667   PMID:32132220   PMID:32563174   PMID:33341919   PMID:33611845   PMID:33804063   PMID:34512747   PMID:34713714   PMID:34943934  
PMID:35618993   PMID:36599141   PMID:38069998  


Genomics

Comparative Map Data
Glp1r
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8208,973,393 - 9,011,622 (+)NCBIGRCr8
mRatBN7.2208,972,004 - 9,010,241 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl208,972,004 - 9,010,241 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx209,666,817 - 9,705,074 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0209,027,975 - 9,066,230 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0209,503,459 - 9,541,265 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0209,586,075 - 9,626,228 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl209,586,075 - 9,626,228 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02011,768,479 - 11,808,416 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4209,225,881 - 9,264,184 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1209,226,107 - 9,264,411 (+)NCBI
Celera2010,499,202 - 10,536,348 (+)NCBICelera
RH 3.4 Map20118.3RGD
Cytogenetic Map20p12NCBI
GLP1R
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38639,048,781 - 39,091,303 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl639,048,781 - 39,091,303 (+)EnsemblGRCh38hg38GRCh38
GRCh37639,016,557 - 39,059,079 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36639,124,595 - 39,163,498 (+)NCBINCBI36Build 36hg18NCBI36
Build 34639,124,594 - 39,163,497NCBI
Celera640,569,967 - 40,608,942 (+)NCBICelera
Cytogenetic Map6p21.2NCBI
HuRef638,734,906 - 38,773,876 (+)NCBIHuRef
CHM1_1639,019,249 - 39,058,215 (+)NCBICHM1_1
T2T-CHM13v2.0638,873,166 - 38,915,730 (+)NCBIT2T-CHM13v2.0
Glp1r
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391731,120,841 - 31,155,484 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1731,120,791 - 31,159,765 (+)EnsemblGRCm39 Ensembl
GRCm381730,901,867 - 30,936,510 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1730,901,817 - 30,940,791 (+)EnsemblGRCm38mm10GRCm38
MGSCv371731,038,812 - 31,073,455 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361730,628,889 - 30,663,545 (+)NCBIMGSCv36mm8
Celera1731,818,203 - 31,852,564 (+)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1715.8NCBI
Glp1r
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554374,395,039 - 4,418,186 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554374,394,088 - 4,418,172 (-)NCBIChiLan1.0ChiLan1.0
GLP1R
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2553,545,422 - 53,595,309 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1649,415,037 - 49,470,541 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0638,637,838 - 38,680,423 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1639,818,361 - 39,860,999 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl639,823,373 - 39,855,784 (+)Ensemblpanpan1.1panPan2
GLP1R
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1127,999,963 - 8,030,335 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl127,999,997 - 8,025,048 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha128,007,600 - 8,053,911 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0128,461,837 - 8,508,323 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl128,469,301 - 8,503,729 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1127,989,087 - 8,035,354 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0128,066,878 - 8,113,116 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0128,172,302 - 8,218,559 (+)NCBIUU_Cfam_GSD_1.0
Glp1r
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494643,393,014 - 43,423,374 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647620,541,775 - 20,567,188 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647620,541,812 - 20,580,454 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GLP1R
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl734,497,759 - 34,534,627 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1734,497,779 - 34,534,356 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2739,595,524 - 39,623,438 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GLP1R
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11733,053,442 - 33,092,806 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1733,054,574 - 33,091,422 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604439,051,279 - 39,092,487 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Glp1r
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475419,215,829 - 19,244,987 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475419,214,547 - 19,245,030 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Glp1r
452 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:186
Count of miRNA genes:131
Interacting mature miRNAs:158
Transcripts:ENSRNOT00000001527
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4889870Pur30Proteinuria QTL 30190.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20804241029322208Rat
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
4889857Pur27Proteinuria QTL 2712.20.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20460660717617956Rat
70154Insul2Insulin level QTL 23.75blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20669170617489458Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
1581577Pur15Proteinuria QTL 154.380.0002urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)20804241017617956Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20289259726381954Rat
7387283Uae44Urinary albumin excretion QTL 440.1712urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)20126123605Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125159026Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20460660717617956Rat
1331772Cdexp2CD45RC expression in CD8 T cells QTL 25.7CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)20362164910078919Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
1300152Bp195Blood pressure QTL 1953.46arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2036216499243559Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20362165614101050Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat

Markers in Region
D20Wox7  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2209,008,652 - 9,008,921 (+)MAPPERmRatBN7.2
Rnor_6.0209,624,640 - 9,624,908NCBIRnor6.0
Rnor_5.02011,806,828 - 11,807,096UniSTSRnor5.0
RGSC_v3.4209,262,596 - 9,262,864UniSTSRGSC3.4
Cytogenetic Map20p12UniSTS
D20Got6  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2209,000,904 - 9,001,147 (+)MAPPERmRatBN7.2
Rnor_6.0209,614,983 - 9,615,225NCBIRnor6.0
Rnor_5.02011,797,171 - 11,797,413UniSTSRnor5.0
RGSC_v3.4209,254,993 - 9,255,234RGDRGSC3.4
RGSC_v3.4209,254,992 - 9,255,234UniSTSRGSC3.4
RGSC_v3.1209,255,220 - 9,255,461RGD
Celera2010,527,243 - 10,527,485UniSTS
RH 3.4 Map20123.6UniSTS
RH 3.4 Map20123.6RGD
RH 2.0 Map20134.1RGD
Cytogenetic Map20p12UniSTS
Glp1r  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2209,008,624 - 9,008,821 (+)MAPPERmRatBN7.2
Rnor_6.0209,624,612 - 9,624,808NCBIRnor6.0
Rnor_5.02011,806,800 - 11,806,996UniSTSRnor5.0
RGSC_v3.4209,262,568 - 9,262,764UniSTSRGSC3.4
Cytogenetic Map20p12UniSTS
RH94780  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2209,008,906 - 9,009,139 (+)MAPPERmRatBN7.2
Rnor_6.0209,624,894 - 9,625,126NCBIRnor6.0
Rnor_5.02011,807,082 - 11,807,314UniSTSRnor5.0
RGSC_v3.4209,262,850 - 9,263,082UniSTSRGSC3.4
Celera2010,535,014 - 10,535,246UniSTS
RH 3.4 Map20118.3UniSTS
Cytogenetic Map20p12UniSTS
RH138657  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2209,009,951 - 9,010,118 (+)MAPPERmRatBN7.2
Rnor_6.0209,625,939 - 9,626,105NCBIRnor6.0
Rnor_5.02011,808,127 - 11,808,293UniSTSRnor5.0
RGSC_v3.4209,263,895 - 9,264,061UniSTSRGSC3.4
Celera2010,536,059 - 10,536,225UniSTS
RH 3.4 Map20119.3UniSTS
Cytogenetic Map20p12UniSTS


Genetic Models
This gene Glp1r is modified in the following models/strains:
Lew-Glp1rem1Mcwi     Lew-Glp1rem3Mcwi     Lew-Glp1rem2Mcwi    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
8 8 31 90 53 52 21 24 21 6 157 75 70 45 55 31

Sequence


Ensembl Acc Id: ENSRNOT00000001527   ⟹   ENSRNOP00000001527
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl208,972,004 - 9,010,241 (+)Ensembl
Rnor_6.0 Ensembl209,586,075 - 9,626,228 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000079509   ⟹   ENSRNOP00000069480
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl208,977,604 - 9,010,241 (+)Ensembl
Rnor_6.0 Ensembl209,586,091 - 9,624,571 (+)Ensembl
RefSeq Acc Id: NM_012728   ⟹   NP_036860
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8208,973,393 - 9,011,622 (+)NCBI
mRatBN7.2208,972,004 - 9,010,241 (+)NCBI
Rnor_6.0209,586,075 - 9,626,228 (+)NCBI
Rnor_5.02011,768,479 - 11,808,416 (+)NCBI
RGSC_v3.4209,225,881 - 9,264,184 (+)RGD
Celera2010,499,202 - 10,536,348 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_036860 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA73377 (Get FASTA)   NCBI Sequence Viewer  
  AAP31860 (Get FASTA)   NCBI Sequence Viewer  
  CAB58595 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000001527.5
  ENSRNOP00000069480.2
GenBank Protein P32301 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036860   ⟸   NM_012728
- Peptide Label: precursor
- UniProtKB: Q6LD83 (UniProtKB/Swiss-Prot),   Q64073 (UniProtKB/Swiss-Prot),   P32301 (UniProtKB/Swiss-Prot),   F1LRH2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000069480   ⟸   ENSRNOT00000079509
Ensembl Acc Id: ENSRNOP00000001527   ⟸   ENSRNOT00000001527
Protein Domains
G-protein coupled receptors family 2 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P32301-F1-model_v2 AlphaFold P32301 1-463 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701468
Promoter ID:EPDNEW_R11992
Type:single initiation site
Name:Glp1r_1
Description:glucagon-like peptide 1 receptor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0209,586,034 - 9,586,094EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2703 AgrOrtholog
BioCyc Gene G2FUF-4335 BioCyc
Ensembl Genes ENSRNOG00000001152 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000001527.7 UniProtKB/TrEMBL
  ENSRNOT00000079509.2 UniProtKB/TrEMBL
Gene3D-CATH 4.10.1240.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 7tmB1_GLP1R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_extracell_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_extracellular_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_GLP1/glucagon_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_GLP1_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_secretin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_secretin-like_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25051 UniProtKB/Swiss-Prot
NCBI Gene 25051 ENTREZGENE
PANTHER PDF RECEPTOR-LIKE PROTEIN-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR45620:SF25 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HRM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Glp1r PhenoGen
PRINTS GLUCAGNFAMLY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLUCAGNLIKER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRSECRETIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F2_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F2_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F2_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F2_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000001152 RatGTEx
SMART HormR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF111418 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC226578
UniProt A0A0G2JVG9_RAT UniProtKB/TrEMBL
  F1LRH2 ENTREZGENE, UniProtKB/TrEMBL
  GLP1R_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q64073 ENTREZGENE
  Q6LD83 ENTREZGENE
UniProt Secondary Q64073 UniProtKB/Swiss-Prot
  Q6LD83 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2001-10-23 Glp1r  glucagon-like peptide 1 receptor      Name updated to reflect Human and Mouse nomenclature 68913 APPROVED
2001-10-23 Glp1r  Pancreatic beta cell receptor for the gluco-incretin hormone glucagon-like peptide 1      Name withdrawn 68913 WITHDRAWN

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in brain 625448
gene_function receptor for glucagon-like peptide-1 625448
gene_process activation induces c-fos expression and increases blood pressure and heart rate 625448
gene_process plays a role in autonomic and neuroendocrine responses 625448
gene_process mediates sympathetic outflow leading to activation of cardiovascular responses 625448