Glp1r (glucagon-like peptide 1 receptor) - Rat Genome Database

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Gene: Glp1r (glucagon-like peptide 1 receptor) Rattus norvegicus
Analyze
Symbol: Glp1r
Name: glucagon-like peptide 1 receptor
RGD ID: 2703
Description: Exhibits G protein-coupled peptide receptor activity and peptide hormone binding activity. Involved in several processes, including cAMP-mediated signaling; learning or memory; and regulation of ion transport. Localizes to integral component of plasma membrane. Used to study hyperglycemia and hypertension. Biomarker of obesity. Orthologous to human GLP1R (glucagon like peptide 1 receptor); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 6-propyl-2-thiouracil; aldehydo-D-glucose.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Glip; GLP-1 receptor; GLP-1-R; GLP-1R; pancreatic beta cell receptor for the gluco-incretin hormone glucagon-like peptide 1; RATGL1RCP
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Glp1rem1Mcwi   Glp1rem2Mcwi   Glp1rem3Mcwi  
Genetic Models: Lew-Glp1rem1Mcwi Lew-Glp1rem3Mcwi Lew-Glp1rem2Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2208,972,004 - 9,010,241 (+)NCBI
Rnor_6.0 Ensembl209,586,075 - 9,626,228 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0209,586,075 - 9,626,228 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02011,768,479 - 11,808,416 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4209,225,881 - 9,264,184 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1209,226,107 - 9,264,411 (+)NCBI
Celera2010,499,202 - 10,536,348 (+)NCBICelera
RH 3.4 Map20118.3RGD
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
1. Al-Barazanji KA, etal., Obes Res. 2000 Jul;8(4):317-23.
2. Aziz A, etal., Am J Physiol Regul Integr Comp Physiol. 2005 Sep;289(3):R688-94. Epub 2005 May 5.
3. Beak SA, etal., Endocrinology. 1996 Oct;137(10):4130-8.
4. Bogacka I, etal., Nutr Neurosci. 2004 Apr;7(2):67-74.
5. Chepurny OG and Holz GG, Cell Tissue Res 2002 Feb;307(2):191-201.
6. Dillon JS, etal., Exp Clin Endocrinol Diabetes. 2005 Mar;113(3):182-9.
7. During MJ, etal., Nat Med. 2003 Sep;9(9):1173-9. Epub 2003 Aug 17.
8. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. GOA data from the GO Consortium
10. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
11. Li Y, etal., J Biol Chem 2003 Jan 3;278(1):471-8.
12. MGD data from the GO Consortium
13. NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. RGD automated data pipeline
15. RGD automated import pipeline for gene-chemical interactions
16. Roger B, etal., Diabetologia. 2011 Feb;54(2):390-402. doi: 10.1007/s00125-010-1955-x. Epub 2010 Nov 3.
17. Salapatek AM, etal., Mol Endocrinol. 1999 Aug;13(8):1305-17.
18. Scrocchi LA, etal., Nat Med. 1996 Nov;2(11):1254-8.
19. Takhar S, etal., Endocrinology. 1996 May;137(5):2175-8.
20. Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
21. Thorens B Proc Natl Acad Sci U S A 1992 Sep 15;89(18):8641-5.
22. Tseng CC, etal., Am J Physiol. 1999 Jun;276(6 Pt 1):E1049-54.
23. Vazquez P, etal., J Endocrinol. 2005 Jul;186(1):221-31.
24. Xu G, etal., Diabetes. 1999 Dec;48(12):2270-6.
25. Yamamoto H, etal., J Clin Invest 2002 Jul;110(1):43-52.
Additional References at PubMed
PMID:7589461   PMID:7813606   PMID:10650957   PMID:12746281   PMID:14766323   PMID:14965273   PMID:14965274   PMID:15670850   PMID:17322063   PMID:17360984   PMID:17584962   PMID:17629357  
PMID:17631146   PMID:17898126   PMID:18078857   PMID:18420740   PMID:18541709   PMID:19264875   PMID:19453518   PMID:19474324   PMID:20589757   PMID:20649595   PMID:20799012   PMID:21356521  
PMID:21745271   PMID:21810595   PMID:21917638   PMID:21945929   PMID:22105074   PMID:22128031   PMID:22960405   PMID:23019232   PMID:23033273   PMID:23302777   PMID:23338623   PMID:23354098  
PMID:23612998   PMID:24048027   PMID:24217090   PMID:24425760   PMID:24601880   PMID:24681814   PMID:24879927   PMID:24944243   PMID:25012114   PMID:25035078   PMID:25114295   PMID:25177707  
PMID:25202980   PMID:25483438   PMID:25656368   PMID:25793511   PMID:25893200   PMID:25915883   PMID:26098939   PMID:26211731   PMID:26302449   PMID:26470787   PMID:26655814   PMID:26675243  
PMID:26850848   PMID:26947974   PMID:26975347   PMID:27013681   PMID:27372651   PMID:27782127   PMID:28242257   PMID:28514449   PMID:28599244   PMID:28920591   PMID:29247677   PMID:29263141  
PMID:29412813   PMID:29434185   PMID:29510158   PMID:29650350   PMID:29813107   PMID:29959973   PMID:30195035   PMID:30637442   PMID:30770099   PMID:31468622   PMID:31537818   PMID:31581176  
PMID:31795376   PMID:31828140   PMID:32013667  


Genomics

Comparative Map Data
Glp1r
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2208,972,004 - 9,010,241 (+)NCBI
Rnor_6.0 Ensembl209,586,075 - 9,626,228 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0209,586,075 - 9,626,228 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02011,768,479 - 11,808,416 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4209,225,881 - 9,264,184 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1209,226,107 - 9,264,411 (+)NCBI
Celera2010,499,202 - 10,536,348 (+)NCBICelera
RH 3.4 Map20118.3RGD
Cytogenetic Map20p12NCBI
GLP1R
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl639,048,781 - 39,091,303 (+)EnsemblGRCh38hg38GRCh38
GRCh38639,048,781 - 39,091,303 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37639,016,557 - 39,059,079 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36639,124,595 - 39,163,498 (+)NCBINCBI36hg18NCBI36
Build 34639,124,594 - 39,163,497NCBI
Celera640,569,967 - 40,608,942 (+)NCBI
Cytogenetic Map6p21.2NCBI
HuRef638,734,906 - 38,773,876 (+)NCBIHuRef
CHM1_1639,019,249 - 39,061,774 (+)NCBICHM1_1
Glp1r
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391731,120,841 - 31,155,484 (+)NCBIGRCm39mm39
GRCm39 Ensembl1731,120,791 - 31,159,765 (+)Ensembl
GRCm381730,901,867 - 30,936,510 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1730,901,817 - 30,940,791 (+)EnsemblGRCm38mm10GRCm38
MGSCv371731,038,812 - 31,073,455 (+)NCBIGRCm37mm9NCBIm37
MGSCv361730,628,889 - 30,663,545 (+)NCBImm8
Celera1731,818,203 - 31,852,564 (+)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1715.8NCBI
Glp1r
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554374,395,039 - 4,418,186 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554374,394,088 - 4,418,172 (-)NCBIChiLan1.0ChiLan1.0
GLP1R
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1639,818,361 - 39,860,999 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl639,823,373 - 39,855,784 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0638,637,838 - 38,680,423 (+)NCBIMhudiblu_PPA_v0panPan3
GLP1R
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1127,999,963 - 8,030,335 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl127,999,997 - 8,025,048 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha128,007,600 - 8,053,911 (+)NCBI
ROS_Cfam_1.0128,461,837 - 8,508,323 (+)NCBI
UMICH_Zoey_3.1127,989,087 - 8,035,354 (+)NCBI
UNSW_CanFamBas_1.0128,066,878 - 8,113,116 (+)NCBI
UU_Cfam_GSD_1.0128,172,302 - 8,218,559 (+)NCBI
Glp1r
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494643,393,014 - 43,423,374 (+)NCBI
SpeTri2.0NW_00493647620,541,812 - 20,580,454 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GLP1R
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl734,497,759 - 34,534,629 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1734,497,779 - 34,534,356 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2739,595,524 - 39,623,438 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GLP1R
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11733,053,442 - 33,092,806 (-)NCBI
ChlSab1.1 Ensembl1733,054,574 - 33,091,422 (-)Ensembl
Glp1r
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475419,214,547 - 19,245,030 (-)NCBI

Position Markers
D20Wox7  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0209,624,640 - 9,624,908NCBIRnor6.0
Rnor_5.02011,806,828 - 11,807,096UniSTSRnor5.0
RGSC_v3.4209,262,596 - 9,262,864UniSTSRGSC3.4
Cytogenetic Map20p12UniSTS
D20Got6  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0209,614,983 - 9,615,225NCBIRnor6.0
Rnor_5.02011,797,171 - 11,797,413UniSTSRnor5.0
RGSC_v3.4209,254,993 - 9,255,234RGDRGSC3.4
RGSC_v3.4209,254,992 - 9,255,234UniSTSRGSC3.4
RGSC_v3.1209,255,220 - 9,255,461RGD
Celera2010,527,243 - 10,527,485UniSTS
RH 3.4 Map20123.6RGD
RH 3.4 Map20123.6UniSTS
RH 2.0 Map20134.1RGD
Cytogenetic Map20p12UniSTS
Glp1r  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0209,624,612 - 9,624,808NCBIRnor6.0
Rnor_5.02011,806,800 - 11,806,996UniSTSRnor5.0
RGSC_v3.4209,262,568 - 9,262,764UniSTSRGSC3.4
Cytogenetic Map20p12UniSTS
RH94780  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0209,624,894 - 9,625,126NCBIRnor6.0
Rnor_5.02011,807,082 - 11,807,314UniSTSRnor5.0
RGSC_v3.4209,262,850 - 9,263,082UniSTSRGSC3.4
Celera2010,535,014 - 10,535,246UniSTS
RH 3.4 Map20118.3UniSTS
Cytogenetic Map20p12UniSTS
RH138657  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0209,625,939 - 9,626,105NCBIRnor6.0
Rnor_5.02011,808,127 - 11,808,293UniSTSRnor5.0
RGSC_v3.4209,263,895 - 9,264,061UniSTSRGSC3.4
Celera2010,536,059 - 10,536,225UniSTS
RH 3.4 Map20119.3UniSTS
Cytogenetic Map20p12UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124652101Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125653396Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20126305996Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20126305996Rat
7387283Uae44Urinary albumin excretion QTL 440.1712urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)20127357423Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20128375393Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20128375393Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20128375393Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20128375393Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20128375393Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20133300419Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20137550487Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20137550487Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20201865447018654Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20299970747999707Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20340211127968216Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20403911318872273Rat
4889857Pur27Proteinuria QTL 2712.20.001total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20403911318872273Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance in proximity to the target during voluntary locomotion in an experimental apparatus (CMO:0002674)20410895649108956Rat
1300152Bp195Blood pressure QTL 1953.46arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2048554689899946Rat
1331772Cdexp2CD45RC expression in CD8 T cells QTL 25.7CD8-positive T cell quantity (VT:0008077)blood CD45RChigh CD8 T cell count to CD45RClow CD8 T cell count ratio (CMO:0001990)20485546810800530Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20485547515050565Rat
70154Insul2Insulin level QTL 23.75blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20587544818739210Rat
1581577Pur15Proteinuria QTL 154.380.0002total urine protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)20865434118872273Rat
4889870Pur30Proteinuria QTL 30190.005total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20865434130991290Rat


Genetic Models
This gene Glp1r is modified in the following models/strains
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:186
Count of miRNA genes:131
Interacting mature miRNAs:158
Transcripts:ENSRNOT00000001527
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 10
Low 2 6 20 24 16 1
Below cutoff 2 25 22 8 12 8 8 8 34 11 20 8

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000001527   ⟹   ENSRNOP00000001527
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl209,586,075 - 9,626,228 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000079509   ⟹   ENSRNOP00000069480
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl209,586,091 - 9,624,571 (+)Ensembl
RefSeq Acc Id: NM_012728   ⟹   NP_036860
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2208,972,004 - 9,010,241 (+)NCBI
Rnor_6.0209,586,075 - 9,626,228 (+)NCBI
Rnor_5.02011,768,479 - 11,808,416 (+)NCBI
RGSC_v3.4209,225,881 - 9,264,184 (+)RGD
Celera2010,499,202 - 10,536,348 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_036860 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA73377 (Get FASTA)   NCBI Sequence Viewer  
  AAP31860 (Get FASTA)   NCBI Sequence Viewer  
  CAB58595 (Get FASTA)   NCBI Sequence Viewer  
  P32301 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_036860   ⟸   NM_012728
- Peptide Label: precursor
- Sequence:
RefSeq Acc Id: ENSRNOP00000069480   ⟸   ENSRNOT00000079509
RefSeq Acc Id: ENSRNOP00000001527   ⟸   ENSRNOT00000001527
Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701468
Promoter ID:EPDNEW_R11992
Type:single initiation site
Name:Glp1r_1
Description:glucagon-like peptide 1 receptor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0209,586,034 - 9,586,094EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2703 AgrOrtholog
Ensembl Genes ENSRNOG00000001152 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000001527 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000069480 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000001527 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000079509 UniProtKB/TrEMBL
Gene3D-CATH 4.10.1240.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GPCR_2-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_extracell_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_extracellular_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_GLP1/glucagon_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_GLP1_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_secretin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_secretin-like_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25051 UniProtKB/Swiss-Prot
NCBI Gene 25051 ENTREZGENE
PANTHER PTHR45620:SF25 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HRM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Glp1r PhenoGen
PRINTS GLUCAGNFAMLY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLUCAGNLIKER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRSECRETIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F2_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F2_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F2_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F2_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HormR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF111418 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC226578
UniProt F1LRH2_RAT UniProtKB/TrEMBL
  GLP1R_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q64073 UniProtKB/Swiss-Prot
  Q6LD83 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2001-10-23 Glp1r  glucagon-like peptide 1 receptor      Name updated to reflect Human and Mouse nomenclature 68913 APPROVED
2001-10-23 Glp1r  Pancreatic beta cell receptor for the gluco-incretin hormone glucagon-like peptide 1      Name withdrawn 68913 WITHDRAWN

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in brain 625448
gene_function receptor for glucagon-like peptide-1 625448
gene_process activation induces c-fos expression and increases blood pressure and heart rate 625448
gene_process plays a role in autonomic and neuroendocrine responses 625448
gene_process mediates sympathetic outflow leading to activation of cardiovascular responses 625448