Glp1r (glucagon like peptide 1 receptor) - Rat Genome Database

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Gene: Glp1r (glucagon like peptide 1 receptor) Ictidomys tridecemlineatus
Analyze
Symbol: Glp1r
Name: glucagon like peptide 1 receptor
RGD ID: 12564916
Description: ENCODES a protein that exhibits G protein-coupled peptide receptor activity (ortholog); peptide hormone binding (ortholog); peptide receptor activity (ortholog); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); associative learning (ortholog); cAMP/PKA signal transduction (ortholog); PARTICIPATES IN protein kinase A (PKA) signaling pathway; ASSOCIATED WITH disease of cellular proliferation (ortholog); Experimental Diabetes Mellitus (ortholog); glucose intolerance (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: glucagon-like peptide 1 receptor
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494643,393,014 - 43,423,374 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647620,541,775 - 20,567,188 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647620,541,812 - 20,580,454 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Glp1rSquirreldisease of cellular proliferation  ISOGLP1R (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:23471186
Glp1rSquirrelHyperplasia  ISOGLP1R (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:23471186
Glp1rSquirrelhypertension  ISOGLP1R (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:22228705
Glp1rSquirreltype 2 diabetes mellitus  ISOGLP1R (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:30718926


Biological Process
1 to 20 of 36 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Glp1rSquirreladenylate cyclase-activating G protein-coupled receptor signaling pathway  ISOGlp1r (Rattus norvegicus)9068941 RGDPMID:8612565 and REF_RGD_ID:1598447
Glp1rSquirreladenylate cyclase-activating G protein-coupled receptor signaling pathway involved_inIEAUniProtKB:P43220 and ensembl:ENSP00000362353150520179 EnsemblGO_REF:0000107
Glp1rSquirreladenylate cyclase-activating G protein-coupled receptor signaling pathway involved_inIEAPANTHER:PTN000244467150520179 TreeGrafterGO_REF:0000118
Glp1rSquirreladenylate cyclase-modulating G protein-coupled receptor signaling pathway involved_inIEAPANTHER:PTN000244467150520179 TreeGrafterGO_REF:0000118
Glp1rSquirrelassociative learning  ISOGlp1r (Rattus norvegicus)9068941 RGDPMID:12925848 and REF_RGD_ID:1598440
Glp1rSquirrelcAMP/PKA signal transduction  ISOGlp1r (Rattus norvegicus)9068941 RGDPMID:10446905 and REF_RGD_ID:1598448
Glp1rSquirrelcell surface receptor signaling pathway involved_inIEAInterPro:IPR017981150520179 InterProGO_REF:0000002
Glp1rSquirrelcellular response to glucagon stimulus involved_inIEAGO:0004967150520179 GOCGO_REF:0000108
Glp1rSquirrelfeeding behavior  ISOGlp1r (Rattus norvegicus)9068941 RGDPMID:10933308 and REF_RGD_ID:1624355
Glp1rSquirrelG protein-coupled receptor signaling pathway involved_inIEAARBA:ARBA00029021150520179 UniProtGO_REF:0000117
Glp1rSquirrelG protein-coupled receptor signaling pathway involved_inIEAInterPro:IPR000832 more ...150520179 InterProGO_REF:0000002
Glp1rSquirrelG protein-coupled receptor signaling pathway involved_inIEAUniProtKB-KW:KW-0297150520179 UniProtGO_REF:0000043
Glp1rSquirrelhormone secretion involved_inISOGlp1r (Rattus norvegicus)9068941PMID:8828468UniProtPMID:8828468 and REF_RGD_ID:8554483
Glp1rSquirrelhormone secretion acts_upstream_of_or_within_positive_effectIEAUniProtKB:O35659 and ensembl:ENSMUSP00000110221150520179 EnsemblGO_REF:0000107
Glp1rSquirrelinsulin secretion involved_inISOGlp1r (Rattus norvegicus)9068941PMID:10362617UniProtPMID:10362617 and REF_RGD_ID:8553736
Glp1rSquirrellearning or memory involved_inIEAUniProtKB:O35659 and ensembl:ENSMUSP00000110221150520179 EnsemblGO_REF:0000107
Glp1rSquirrelmemory  ISOGlp1r (Rattus norvegicus)9068941 RGDPMID:12925848 and REF_RGD_ID:1598440
Glp1rSquirrelnegative regulation of apoptotic process  ISOGlp1r (Rattus norvegicus)9068941 RGDPMID:12409292 and REF_RGD_ID:728487
Glp1rSquirrelnegative regulation of blood pressure acts_upstream_ofIEAUniProtKB:O35659 and ensembl:ENSMUSP00000110221150520179 EnsemblGO_REF:0000107
Glp1rSquirrelnegative regulation of neuron apoptotic process  ISOGlp1r (Rattus norvegicus)9068941 RGDPMID:12925848 and REF_RGD_ID:1598440
1 to 20 of 36 rows

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Glp1rSquirrelmembrane located_inIEAInterPro:IPR000832 more ...150520179 InterProGO_REF:0000002
Glp1rSquirrelmembrane located_inIEAUniProtKB-KW:KW-0472150520179 UniProtGO_REF:0000043
Glp1rSquirrelplasma membrane located_inIEAPANTHER:PTN000244467150520179 TreeGrafterGO_REF:0000118
Glp1rSquirrelplasma membrane located_inIEAUniProtKB-KW:KW-1003150520179 UniProtGO_REF:0000043
Glp1rSquirrelplasma membrane located_inIEAUniProtKB:P43220 and ensembl:ENSP00000362353150520179 EnsemblGO_REF:0000107
Glp1rSquirrelplasma membrane located_inIEAUniProtKB-SubCell:SL-0039150520179 UniProtGO_REF:0000044

Molecular Function
1 to 16 of 16 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Glp1rSquirrelG protein-coupled peptide receptor activity  ISOUniProtKB:P012759068941 RGDPMID:8612565 and REF_RGD_ID:1598447
Glp1rSquirrelG protein-coupled peptide receptor activity enablesIEAInterPro:IPR003292150520179 InterProGO_REF:0000002
Glp1rSquirrelG protein-coupled peptide receptor activity enablesIEAPANTHER:PTN000244467150520179 TreeGrafterGO_REF:0000118
Glp1rSquirrelG protein-coupled receptor activity enablesIEAUniProtKB-KW:KW-0297150520179 UniProtGO_REF:0000043
Glp1rSquirrelG protein-coupled receptor activity enablesIEAInterPro:IPR000832 more ...150520179 InterProGO_REF:0000002
Glp1rSquirrelglucagon receptor activity enablesIEAPANTHER:PTN000244467150520179 TreeGrafterGO_REF:0000118
Glp1rSquirrelglucagon receptor activity enablesIEAInterPro:IPR003290150520179 InterProGO_REF:0000002
Glp1rSquirrelglucagon-like peptide 1 receptor activity enablesIEAPANTHER:PTN000244467150520179 TreeGrafterGO_REF:0000118
Glp1rSquirrelglucagon-like peptide 1 receptor activity enablesIEAUniProtKB:P43220 and ensembl:ENSP00000362353150520179 EnsemblGO_REF:0000107
Glp1rSquirrelpeptide hormone binding enablesIEAPANTHER:PTN000244467150520179 TreeGrafterGO_REF:0000118
Glp1rSquirrelpeptide hormone binding  ISOGlp1r (Rattus norvegicus)9068941 RGDPMID:1326760 and REF_RGD_ID:727535
Glp1rSquirrelpeptide receptor activity  ISOGlp1r (Rattus norvegicus)9068941 RGDPMID:15789279 and REF_RGD_ID:1598438
Glp1rSquirrelprotein binding enablesISOUniProtKB:P60409 more ...9068941 PMID:25416956IntActPMID:25416956
Glp1rSquirrelprotein binding enablesISOUniProtKB:A8MQ03 more ...9068941 PMID:32296183IntActPMID:32296183
Glp1rSquirrelsignaling receptor activity enablesIEAARBA:ARBA00027254150520179 UniProtGO_REF:0000117
Glp1rSquirreltransmembrane signaling receptor activity enablesIEAInterPro:IPR017981150520179 InterProGO_REF:0000002
1 to 16 of 16 rows

RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Glp1rSquirrelprotein kinase A (PKA) signaling pathway   ISOGlp1r (Rattus norvegicus)9068941 RGDPMID:10446905 and REF_RGD_ID:1598448
PMID:22301074   PMID:30032202  



Glp1r
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494643,393,014 - 43,423,374 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647620,541,775 - 20,567,188 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647620,541,812 - 20,580,454 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GLP1R
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38639,048,781 - 39,091,303 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl639,048,781 - 39,091,303 (+)EnsemblGRCh38hg38GRCh38
GRCh37639,016,557 - 39,059,079 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36639,124,595 - 39,163,498 (+)NCBINCBI36Build 36hg18NCBI36
Build 34639,124,594 - 39,163,497NCBI
Celera640,569,967 - 40,608,942 (+)NCBICelera
Cytogenetic Map6p21.2NCBI
HuRef638,734,906 - 38,773,876 (+)NCBIHuRef
CHM1_1639,019,249 - 39,058,215 (+)NCBICHM1_1
T2T-CHM13v2.0638,873,166 - 38,915,730 (+)NCBIT2T-CHM13v2.0
Glp1r
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391731,120,841 - 31,155,484 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1731,120,791 - 31,159,765 (+)EnsemblGRCm39 Ensembl
GRCm381730,901,867 - 30,936,510 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1730,901,817 - 30,940,791 (+)EnsemblGRCm38mm10GRCm38
MGSCv371731,038,812 - 31,073,455 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361730,628,889 - 30,663,545 (+)NCBIMGSCv36mm8
Celera1731,818,203 - 31,852,564 (+)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1715.8NCBI
Glp1r
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8208,973,393 - 9,011,622 (+)NCBIGRCr8
mRatBN7.2208,972,004 - 9,010,241 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl208,972,004 - 9,010,241 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx209,666,817 - 9,705,074 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0209,027,975 - 9,066,230 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0209,503,459 - 9,541,265 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0209,586,075 - 9,626,228 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl209,586,075 - 9,626,228 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02011,768,479 - 11,808,416 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4209,225,881 - 9,264,184 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1209,226,107 - 9,264,411 (+)NCBI
Celera2010,499,202 - 10,536,348 (+)NCBICelera
RH 3.4 Map20118.3RGD
Cytogenetic Map20p12NCBI
Glp1r
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554374,395,039 - 4,418,186 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554374,394,088 - 4,418,172 (-)NCBIChiLan1.0ChiLan1.0
GLP1R
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2553,545,422 - 53,595,309 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1649,415,037 - 49,470,541 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0638,637,838 - 38,680,423 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1639,818,361 - 39,860,999 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl639,823,373 - 39,855,784 (+)Ensemblpanpan1.1panPan2
GLP1R
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1127,999,963 - 8,030,335 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl127,999,997 - 8,025,048 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha128,007,600 - 8,053,911 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0128,461,837 - 8,508,323 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl128,469,301 - 8,503,729 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1127,989,087 - 8,035,354 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0128,066,878 - 8,113,116 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0128,172,302 - 8,218,559 (+)NCBIUU_Cfam_GSD_1.0
GLP1R
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl734,497,759 - 34,534,627 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1734,497,779 - 34,534,356 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2739,595,524 - 39,623,438 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GLP1R
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11733,053,442 - 33,092,806 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1733,054,574 - 33,091,422 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604439,051,279 - 39,092,487 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Glp1r
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475419,215,829 - 19,244,987 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475419,214,547 - 19,245,030 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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RefSeq Transcripts XM_021721778 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_040282014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010000005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSSTOT00000006617   ⟹   ENSSTOP00000005917
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493647620,541,775 - 20,567,188 (-)Ensembl
RefSeq Acc Id: XM_040282014   ⟹   XP_040137948
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494643,393,014 - 43,423,374 (+)NCBI
Protein RefSeqs XP_040137948 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000005917.3
RefSeq Acc Id: XP_040137948   ⟸   XM_040282014
- UniProtKB: I3M889 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSSTOP00000005917   ⟸   ENSSTOT00000006617


1 to 29 of 29 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSSTOG00000006609 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000006617.3 UniProtKB/TrEMBL
Gene3D-CATH 4.10.1240.10 UniProtKB/TrEMBL
  Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro 7tmB1_GLP1R UniProtKB/TrEMBL
  GPCR_2 UniProtKB/TrEMBL
  GPCR_2-like UniProtKB/TrEMBL
  GPCR_2_extracell_dom_sf UniProtKB/TrEMBL
  GPCR_2_extracellular_dom UniProtKB/TrEMBL
  GPCR_2_GLP1/glucagon_rcpt UniProtKB/TrEMBL
  GPCR_2_GLP1_rcpt UniProtKB/TrEMBL
  GPCR_2_secretin-like UniProtKB/TrEMBL
  GPCR_2_secretin-like_CS UniProtKB/TrEMBL
NCBI Gene Glp1r ENTREZGENE
PANTHER PDF RECEPTOR-LIKE PROTEIN-RELATED UniProtKB/TrEMBL
  PTHR45620:SF25 UniProtKB/TrEMBL
Pfam 7tm_2 UniProtKB/TrEMBL
  HRM UniProtKB/TrEMBL
PRINTS GLUCAGNFAMLY UniProtKB/TrEMBL
  GLUCAGNLIKER UniProtKB/TrEMBL
  GPCRSECRETIN UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F2_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F2_2 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F2_3 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F2_4 UniProtKB/TrEMBL
SMART HormR UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
  SSF111418 UniProtKB/TrEMBL
UniProt I3M889 ENTREZGENE, UniProtKB/TrEMBL
1 to 29 of 29 rows