Sesn1 (sestrin 1) - Rat Genome Database

Name: Sesn1
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Sesn1 (sestrin 1) Rattus norvegicus

Analyze

Symbol:

Sesn1

Name:

sestrin 1

RGD ID:

1307517

Description:

Predicted to enable leucine binding activity and oxidoreductase activity, acting on peroxide as acceptor. Predicted to be involved in several processes, including cellular response to leucine; cellular response to starvation; and negative regulation of TORC1 signaling. Predicted to act upstream of or within regulation of protein kinase B signaling. Predicted to be located in cytoplasm; fibrillar center; and nucleoplasm. Predicted to be part of GATOR2 complex. Orthologous to human SESN1 (sestrin 1); PARTICIPATES IN p53 signaling pathway; INTERACTS WITH (S)-colchicine; 2,3,7,8-tetrachlorodibenzodioxine; 2-methoxyethanol.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC294518; sestrin-1

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SESN1 (sestrin 1)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther
Mus musculus (house mouse):	Sesn1 (sestrin 1)	HGNC	NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):	Sesn1 (sestrin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SESN1 (sestrin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SESN1 (sestrin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Sesn1 (sestrin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SESN1 (sestrin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SESN1 (sestrin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Sesn1 (sestrin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	SESN1 (sestrin 1)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|sonicParanoid)
Mus musculus (house mouse):	Sesn1 (sestrin 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|sonicParanoid)
Danio rerio (zebrafish):	sesn1 (sestrin 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|sonicParanoid)
Caenorhabditis elegans (roundworm):	sesn-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|sonicParanoid)
Drosophila melanogaster (fruit fly):	Sesn	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|sonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	20	45,294,876 - 45,387,698 (+)	NCBI	mRatBN7.2
mRatBN7.2 Ensembl	20	45,294,871 - 45,387,697 (+)	Ensembl
Rnor_6.0	20	46,667,116 - 46,758,306 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	46,667,121 - 46,758,305 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	20	48,347,213 - 48,437,687 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	20	45,786,623 - 45,877,856 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	20	45,879,708 - 45,900,868 (+)	NCBI
Celera	20	54,572,050 - 54,662,230 (-)	NCBI		Celera
Cytogenetic Map	20	q13	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-demecolcine (ISO)

(S)-colchicine (EXP,ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

17beta-hydroxy-17-methylestra-4,9,11-trien-3-one (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-methoxyethanol (EXP)

4-hydroxyphenyl retinamide (ISO)

5-aza-2'-deoxycytidine (ISO)

5-fluorouracil (ISO)

acrylamide (EXP)

adefovir pivoxil (ISO)

adenine (ISO)

afimoxifene (ISO)

aflatoxin B1 (ISO)

amphetamine (EXP)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bilirubin IXalpha (ISO)

bis(2-chloroethyl) sulfide (ISO)

bisphenol A (EXP,ISO)

Brusatol (ISO)

cadmium dichloride (ISO)

calcitriol (ISO)

carbamazepine (ISO)

carbon nanotube (ISO)

celastrol (ISO)

chloroacetaldehyde (ISO)

chlorpromazine (EXP)

cidofovir anhydrous (ISO)

cisplatin (ISO)

cobalt dichloride (ISO)

colforsin daropate hydrochloride (ISO)

copper(II) sulfate (ISO)

cyclosporin A (EXP,ISO)

dexamethasone (EXP,ISO)

diarsenic trioxide (ISO)

dicrotophos (ISO)

dioxygen (ISO)

disodium selenite (ISO)

diuron (EXP)

dorsomorphin (ISO)

doxorubicin (ISO)

endosulfan (EXP)

erastin (ISO)

ethyl methanesulfonate (ISO)

etoposide (ISO)

fenofibrate (EXP)

fluoranthene (ISO)

folpet (ISO)

formaldehyde (ISO)

gedunin (ISO)

genistein (ISO)

gentamycin (EXP)

hydrogen peroxide (ISO)

hydroquinone (ISO)

hydroxyurea (ISO)

ibuprofen (EXP)

ifosfamide (ISO)

isoflavones (ISO)

isoprenaline (ISO)

ketamine (EXP)

leflunomide (ISO)

leptomycin B (ISO)

lipopolysaccharide (ISO)

mercury dibromide (ISO)

mercury dichloride (EXP)

metformin (EXP)

methapyrilene (EXP)

methyl methanesulfonate (ISO)

methylisothiazolinone (ISO)

myristicin (ISO)

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine (ISO)

N-nitrosodiethylamine (ISO)

nickel atom (ISO)

nickel dichloride (EXP)

ozone (ISO)

paracetamol (EXP,ISO)

paraquat (ISO)

phenobarbital (ISO)

picoxystrobin (ISO)

piperonyl butoxide (ISO)

pirinixic acid (ISO)

piroxicam (ISO)

potassium bromate (ISO)

propanal (ISO)

Ptaquiloside (ISO)

quercetin (ISO)

resveratrol (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenite (ISO)

succimer (ISO)

sunitinib (ISO)

tamoxifen (ISO)

testosterone (EXP,ISO)

tetrachloromethane (EXP,ISO)

tremolite asbestos (ISO)

triphenyl phosphate (EXP)

troglitazone (EXP,ISO)

tungsten (ISO)

valdecoxib (EXP)

valproic acid (ISO)

vinclozolin (EXP)

vincristine (EXP)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular oxidant detoxification (ISO)

cellular response to amino acid starvation (ISO)

cellular response to amino acid stimulus (ISO)

cellular response to glucose starvation (ISO)

cellular response to leucine (IBA)

cellular response to leucine starvation (IBA)

negative regulation of cell growth (ISO)

negative regulation of TORC1 signaling (IBA,ISO)

positive regulation of macroautophagy (IBA)

reactive oxygen species metabolic process (ISO)

regulation of protein kinase B signaling (ISO)

regulation of response to reactive oxygen species (IEA)

Cellular Component

cytoplasm (ISO)

fibrillar center (IEA,ISO)

GATOR2 complex (IEA,ISO)

nucleoplasm (IEA,ISO)

nucleus (ISO)

Molecular Function

leucine binding (IBA,ISO)

oxidoreductase activity, acting on peroxide as acceptor (IBA)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

p53 signaling pathway (IEA)

References

References - curated


1.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA data from the GO Consortium
3.	Pipeline to import KEGG annotations from KEGG into RGD
4.	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:9926927	PMID:15105503	PMID:18692468	PMID:20203043	PMID:22958918	PMID:24315959	PMID:25259925	PMID:25263562	PMID:26449471	PMID:30835510	PMID:33883304

Genomics

Comparative Map Data

Sesn1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	20	45,294,876 - 45,387,698 (+)	NCBI	mRatBN7.2
mRatBN7.2 Ensembl	20	45,294,871 - 45,387,697 (+)	Ensembl
Rnor_6.0	20	46,667,116 - 46,758,306 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	46,667,121 - 46,758,305 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	20	48,347,213 - 48,437,687 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	20	45,786,623 - 45,877,856 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	20	45,879,708 - 45,900,868 (+)	NCBI
Celera	20	54,572,050 - 54,662,230 (-)	NCBI		Celera
Cytogenetic Map	20	q13	NCBI

SESN1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	108,984,309 - 109,094,846 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	6	108,984,309 - 109,094,846 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	109,305,512 - 109,416,049 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	109,414,338 - 109,521,970 (-)	NCBI	NCBI36		hg18	NCBI36
Build 34	6	109,414,339 - 109,521,970	NCBI
Celera	6	110,053,551 - 110,161,184 (-)	NCBI
Cytogenetic Map	6	q21	NCBI
HuRef	6	106,874,235 - 106,981,304 (-)	NCBI		HuRef
CHM1_1	6	109,570,466 - 109,678,815 (-)	NCBI		CHM1_1

Sesn1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	41,686,570 - 41,784,432 (+)	NCBI	GRCm39		mm39
GRCm39 Ensembl	10	41,685,931 - 41,784,420 (+)	Ensembl
GRCm38	10	41,810,574 - 41,908,436 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	41,809,935 - 41,908,424 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	41,530,380 - 41,628,242 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	10	41,575,864 - 41,596,839 (+)	NCBI			mm8
Celera	10	42,690,911 - 42,787,751 (+)	NCBI		Celera
Cytogenetic Map	10	B2	NCBI
cM Map	10	22.77	NCBI

Sesn1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955411	34,032,490 - 34,139,822 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955411	34,033,986 - 34,051,171 (-)	NCBI	ChiLan1.0	ChiLan1.0

SESN1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	6	110,839,631 - 110,945,723 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	110,839,631 - 110,946,276 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	6	106,789,911 - 106,896,382 (-)	NCBI	Mhudiblu_PPA_v0		panPan3

SESN1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	12	65,958,995 - 66,057,369 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	12	65,960,066 - 66,057,035 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	12	65,777,446 - 65,875,811 (-)	NCBI
ROS_Cfam_1.0	12	66,840,480 - 66,939,046 (-)	NCBI
ROS_Cfam_1.0 Ensembl	12	66,840,487 - 66,939,038 (-)	Ensembl
UMICH_Zoey_3.1	12	66,191,015 - 66,289,363 (-)	NCBI
UNSW_CanFamBas_1.0	12	66,039,317 - 66,137,542 (-)	NCBI
UU_Cfam_GSD_1.0	12	66,311,345 - 66,409,780 (-)	NCBI

Sesn1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	100,912,289 - 101,016,826 (-)	NCBI
SpeTri2.0	NW_004936564	5,187,152 - 5,291,201 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SESN1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	75,033,098 - 75,169,987 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	75,056,731 - 75,170,374 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	84,357,130 - 84,371,187 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SESN1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	13	64,756,393 - 64,864,795 (+)	NCBI	ChlSab1.1		chlSab2
ChlSab1.1 Ensembl	13	64,841,773 - 64,863,698 (+)	Ensembl	ChlSab1.1		chlSab2
Vero_WHO_p1.0	NW_023666040	37,058,232 - 37,167,839 (+)	NCBI	Vero_WHO_p1.0

Sesn1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624916	231,168 - 332,423 (-)	NCBI	HetGla_female_1.0		hetGla2

Position Markers

RH130564

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	20	45,387,397 - 45,387,602 (+)	MAPPER	mRatBN7.2
Rnor_6.0	20	46,758,006 - 46,758,210	NCBI	Rnor6.0
Rnor_5.0	20	48,437,387 - 48,437,591	UniSTS	Rnor5.0
RGSC_v3.4	20	45,877,557 - 45,877,761	UniSTS	RGSC3.4
Celera	20	54,572,145 - 54,572,349	UniSTS
Cytogenetic Map	20	q13	UniSTS

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2305926	Iddm37	Insulin dependent diabetes mellitus QTL 37	6		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	20	1527842	46527842	Rat
1641915	Colcr9	Colorectal carcinoma resistance QTL 9	2.97	0.0024	intestine integrity trait (VT:0010554)	benign colorectal tumor number (CMO:0001795)	20	1530655	46530655	Rat
1598816	Memor12	Memory QTL 12	2.4		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	20	2606836	47606836	Rat
7411652	Foco24	Food consumption QTL 24		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	20	11757515	54435887	Rat
9590092	Insglur9	Insulin/glucose ratio QTL 9	18.38	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	20	11757515	54435887	Rat
4889610	Pancm3	Pancreatic morphology QTL 3	3.75	0.001	pancreas mass (VT:0010144)	pancreas wet weight (CMO:0000626)	20	17617832	47606836	Rat
2317880	Alcrsp25	Alcohol response QTL 25	2.3		response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	20	17697550	54435887	Rat
2303626	Vencon10	Ventilatory control QTL 10		0.001	respiration trait (VT:0001943)	respiration rate (CMO:0000289)	20	19190721	54435887	Rat
2303578	Gluco50	Glucose level QTL 50	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	20	25106722	54435887	Rat
2303587	Bw93	Body weight QTL 93	13		body mass (VT:0001259)	body weight (CMO:0000012)	20	25106722	54435887	Rat
2300188	Bmd68	Bone mineral density QTL 68	6.4	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	20	25106722	54435887	Rat
1331747	Hrtrt16	Heart rate QTL 16	3.163		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	20	25209734	54435887	Rat
1598869	Memor6	Memory QTL 6	3.1		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	20	29244388	54435887	Rat

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	155
Count of miRNA genes:	104
Interacting mature miRNAs:	130
Transcripts:	ENSRNOT00000065890
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	2	39	56	40	19	40	8	11	68	35	39	11	8
Low	1	4	1	1		1			6		2
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001106396	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006256560	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006256561	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH474025	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000330	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000065890 ⟹ ENSRNOP00000060435

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	20	45,295,214 - 45,387,697 (+)	Ensembl
Rnor_6.0 Ensembl	20	46,667,454 - 46,758,305 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000089611 ⟹ ENSRNOP00000073119

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	20	45,294,871 - 45,387,694 (+)	Ensembl
Rnor_6.0 Ensembl	20	46,667,121 - 46,758,305 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000116987 ⟹ ENSRNOP00000090761

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	20	45,366,374 - 45,387,694 (+)	Ensembl

RefSeq Acc Id:

NM_001106396 ⟹ NP_001099866

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	20	45,295,214 - 45,387,697 (+)	NCBI
Rnor_6.0	20	46,667,454 - 46,758,305 (+)	NCBI
Rnor_5.0	20	48,347,213 - 48,437,687 (+)	NCBI
RGSC_v3.4	20	45,786,623 - 45,877,856 (+)	RGD
Celera	20	54,572,050 - 54,662,230 (-)	RGD

Sequence:

show sequence

CAGACAAAAAATAAAAAAATCGAATGGCTGGAGAACCTTCTACTGTTACCAGCCTTTTGGGACC
AAGCACGGATTTGACAGCTCCACAACGCGAGGATATCCGCTGACCCTGCGACACCGAGAGCACT
TCCCCGAGACTCCCTGTCCAGCTAACCAGCTCTGTGAGATTGCAACTTTCCAAGTTGGTTCTTT
TCCATCTCTGTCAGAAGACTGCCCTTTCGTGTGGGAGAGGGTGCCTGGGTGAACCGCCTTGTGG
ATCGATTTGAAAGCATCAACTTTAAAAAAGCACGTGTGATTCCCAGTGCCATCCAGACGCCTGC
TTTCGTGACCGCTGGATTTTTCTGACTTTATTCTTAACCAATCTCTCTCTCAAAAAGACTGAAA
AAGAAAAAGCTCACGATTGTCAGTCATGGCCGAAGGAGAGAATGAAGTGAGGTGGGAGGGTCTG
TGCAGTAGAGACCCAACTACTAGAGAGACAGCACTGGAAAGCGTTAGGCAGATTGTTCTGAGAA
AAACCGAGTACCTTCGTTCTGCCAAAGAGACACTTTCTCGACCTTCGGACGGGCTTTCAAATGG
TGTTTCTTTGGATGGGATGAATAAACTTCTTGCCCATCTGCTTATGCTGTCCAAGAGATGTCCC
TTTAAAGACGTGAGAGAGAGAAGCGGGTTCATTCTGAAGAGCGTCGAGGCGGCAGCCAGGCATC
AGTGTTCCTACCTGGTGAATCTACACGTCAGTGACTTTCTTCATGTTGGTGGGGACCCCAAGTG
GCTCAATGGTTTAGAGAATGCTCCTCAGAAACTGCAGAATTTAGGAGAACTTAACAAAGTGTTA
GCCCACAGGCCTTGGCTAATCACCAAAGAACACATCGAGGGGCTGCTGAAGGCTGAGGAGCACA
GCTGGTCTCTTGCGGAGCTGGTCCACGCTGTGGTTCTGCTCACACACTACCACTCTCTTGCCTC
CTTCACATTTGGCTGTGGAATTAGTCCAGAGATCCACTGTGACGGTGGCCACACCTTCAGACCT
CCTTCTGTCAGTAACTACTGCATCTGCGACATTACGAATGGCAACCACAGTGTGGAGGAGACGC
CAGTCCCCTCAGCAGGAAGTGCCTTGGTGAGTGACTCCTTCTTTGAGGTCGAAGCCCTCATGGA
AAAGATGAAGCAGTTACAGGAGTGCCGGGAGGAGGAGGAGGCCAGCCAGGAGGAGATGGCCTCG
AGGTTTGAAATGGAGAAGAGAGATAGCATGTTTGTCTTCTCTTCAGATGATGATGAAGTTACAC
CAGCGAGAGATGTGTCTCGGCACTTTGAGGACACTAGTTATGGCTACAAGGATTTCTCCAGGCA
TGGGATGCATGTTCCAACATTTCGTGTCCAGGACTACTGCTGGGAGGACCATGGTTATTCTCTG
GTGAATCGTCTTTATCCGGATGTGGGACAGTTAATCGATGAGAAATTTCACATTGCTTACAACC
TTACTTACAATACCATGGCAATGCACAAAGATGTTGATACCTCAATGCTGCGACGGGCTATCTG
GAACTATATCCACTGCATGTTCGGAATACGATACGATGACTATGACTACGGGGAGATTAACCAG
CTGTTGGATCGTAGCTTTAAAGTTTATATCAAAACTGTCGTGTGCACTCCTGAAAAGGTCACCA
AAAGAATGTATGATAGCTTCTGGAGGCAGTTCAAGCACTCTGAGAAGGTTCATGTTAATCTGCT
TCTTATAGAAGCGAGGATGCAAGCGGAGCTCCTGTATGCTCTGAGAGCCATTACCCGGTATATG
ACCTGATGCCCCTCCTCCACTGAGGATGACCCTGCAGTGAACAGCAAACTTAGTCTCCACGGGG
ATGGAACCAAGCCCCAGGACCAATGGTAGATAAAAAGAATTCAGAAATGCGTGTGCCATGATTC
CTGCTATTTTCCTGTGTCTGCTCTCACTGCTGTCAGCAGTGGGCACTTGGCAGCCTCAGTGTTA
GAGCTGTGAAGAAAGGCTGTGGCCACAGTGTCTGCTTTGTGACAGTGTGAGGTGCTGTGAACTT
GTTTCAGTACAGCAACTAGTAATTCTCCAGATCCCCTGCTCCGCTGTGACAGGGTGACGGACAG
GAGAGTAGAGGCTGGACTTGGGCACCAAGTTCACCCGTAGGGAGCCGAGCGGATTGGAGCTCGG
TGCTGCTGTGGCTGAGGACAAGCGCACGGCTGTTCCTGCCAAGCGCTGCTGCCACCTGAGCCCG
CACCACACCGTCTTCGTGTGGTTTTCAGTTGAACTCGTGCGCATTTCTTCTTGCATCTAAAAGA
GCATAGAATTATTACTCAGCTCAGCGAAGACCGTGTTGGTGGTGACAGTTTGTTTCTTTCATTA
CAGTTTAAAATTCAGTTGCTGGAGGAAATTACAGTGGCATTCTTAAGATTTCCTCCAAAGAGCA
ATCTTAAAATAATAGTGTGTTAATTATAAGAAAAACAAGCTATCTTTCGACATGCTGTTTTCCA
ACATCCTCTCATCCTGGAGGGCAGCTATCTTGTGCGGGATTTTTGTTTCCAGCACCAACAATGT
GGTTTCCAGTGTTGCTGCAAACTGACGCCCAGGGAGTGCCGGGTGCATTCTGCCCCGTGCTCCT
GCTGACCTCGTGACCCTGACTTTGAAGGTATACAGCTCCTTAAAGAATAAAGCTGGAAAATGTT
TTATTGAAGTTATCGGATTTGTATCTTGATTTACAGAAATGCTAACCTTGAGATGCAAACAGGT
TTGGGGTAAATGAGCTAAGCGCTTTGTACTCTGGGACAGTAACTGCTTTTGGAATCTGTCAGTA
TTATTGGTATTTTTCAATAAAGAATAATTTCCAC

hide sequence

RefSeq Acc Id:

XM_006256560 ⟹ XP_006256622

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	20	45,294,876 - 45,387,698 (+)	NCBI
Rnor_6.0	20	46,667,116 - 46,758,306 (+)	NCBI
Rnor_5.0	20	48,347,213 - 48,437,687 (+)	NCBI

Sequence:

show sequence

AGCCCGGGGCTCGATGACTGCTGGGTCGCTGGGTGCCCTCTGGCTTGGCGGAGGTGGGCGAGGA
CAGAGGGGTAAGAGAAGCACGGCGTACCCCGGAAGACAGGAACCGGCAGGGTCGGCGACGCTGC
CCTCTGTCGCCGCTGACACAGTGACTGGTGGGCACTGGAGTCCCCGGAGCACCGGAGCCTCAGG
CCCCAGCAGCTAAGGGCCAGGGTCTACCGCCTACCCCCGCCAGCAGCCCGCCCGCTGCCCTGCC
GAGGCGCTAGGAGGAGCCGACAGGGGCGGAGACTGGTGTCGGAGGAGGGCGGGGTGGGAACACT
AGAAAACTGGCCGCTGCACAGACAAAAAATAAAAAAATCGAATGGCTGGAGAACCTTCTACTGT
TACCAGCCTTTTGGGACCAAGCACGGATTTGACAGCTCCACAACGCGAGGATATCCGCTGACCC
TGCGACACCGAGAGCACTTCCCCGAGACTCCCTGTCCAGCTAACCAGCTCTGTGAGATTGCAAC
TTTCCAAGTTGGTTCTTTTCCATCTCTGTCAGAAGACTGCCCTTTCGTGTGGGAGAGGGTGCCT
GGGTGAACCGCCTTGTGGATCGATTTGAAAGCATCAACTTTAAAAAAGCACGTGTGATTCCCAG
TGCCATCCAGACGCCTGCTTTCGTGACCGCTGGATTTTTCTGACTTTATTCTTAACCAATCTCT
CTCTCAAAAAGACTGAAAAAGAAAAAGCTCACGATTGTCAGTCATGGCCGAAGGAGAGAATGAA
GTGAGGTGGGAGGGTCTGTGCAGTAGAGACCCAACTACTAGAGAGACAGCACTGGAAAGCGTTA
GGCAGATTGTTCTGAGAAAAACCGAGTACCTTCGTTCTGCCAAAGAGACACTTTCTCGACCTTC
GGACGGGCTTTCAAATGGTGTTTCTTTGGATGGGATGAATAAACTTCTTGCCCATCTGCTTATG
CTGTCCAAGAGATGTCCCTTTAAAGACGTGAGAGAGAGAAGCGGGTTCATTCTGAAGAGCGTCG
AGGAACTTGGAATCAGAATCCCTCGGCCACTAGGACACGGACCAAGCAGGTTCATCCCAGAGAA
GGAGATGCTGCAGGTGGGCAGCGAGGACGCACAGATGCACACTCTGTTTGCCGACTCTTTCGCT
GCTTTGGGTCGTTTGGATAACATTACACTAGTGATGGTTTTTCATCCACAATATCTAGAAAGTT
TCTTAAAGACACAACACTACCTACTGCAGATGGACGGGCCGTTGCCCCTCCATTATCGCCACTA
CATTGGCATCATGGCGGCAGCCAGGCATCAGTGTTCCTACCTGGTGAATCTACACGTCAGTGAC
TTTCTTCATGTTGGTGGGGACCCCAAGTGGCTCAATGGTTTAGAGAATGCTCCTCAGAAACTGC
AGAATTTAGGAGAACTTAACAAAGTGTTAGCCCACAGGCCTTGGCTAATCACCAAAGAACACAT
CGAGGGGCTGCTGAAGGCTGAGGAGCACAGCTGGTCTCTTGCGGAGCTGGTCCACGCTGTGGTT
CTGCTCACACACTACCACTCTCTTGCCTCCTTCACATTTGGCTGTGGAATTAGTCCAGAGATCC
ACTGTGACGGTGGCCACACCTTCAGACCTCCTTCTGTCAGTAACTACTGCATCTGCGACATTAC
GAATGGCAACCACAGTGTGGAGGAGACGCCAGTCCCCTCAGCAGGAAGTGCCTTGGTGAGTGAC
TCCTTCTTTGAGGTCGAAGCCCTCATGGAAAAGATGAAGCAGTTACAGGAGTGCCGGGAGGAGG
AGGAGGCCAGCCAGGAGGAGATGGCCTCGAGGTTTGAAATGGAGAAGAGAGATAGCATGTTTGT
CTTCTCTTCAGATGATGATGAAGTTACACCAGCGAGAGATGTGTCTCGGCACTTTGAGGACACT
AGTTATGGCTACAAGGATTTCTCCAGGCATGGGATGCATGTTCCAACATTTCGTGTCCAGGACT
ACTGCTGGGAGGACCATGGTTATTCTCTGGTGAATCGTCTTTATCCGGATGTGGGACAGTTAAT
CGATGAGAAATTTCACATTGCTTACAACCTTACTTACAATACCATGGCAATGCACAAAGATGTT
GATACCTCAATGCTGCGACGGGCTATCTGGAACTATATCCACTGCATGTTCGGAATACGATACG
ATGACTATGACTACGGGGAGATTAACCAGCTGTTGGATCGTAGCTTTAAAGTTTATATCAAAAC
TGTCGTGTGCACTCCTGAAAAGGTCACCAAAAGAATGTATGATAGCTTCTGGAGGCAGTTCAAG
CACTCTGAGAAGGTTCATGTTAATCTGCTTCTTATAGAAGCGAGGATGCAAGCGGAGCTCCTGT
ATGCTCTGAGAGCCATTACCCGGTATATGACCTGATGCCCCTCCTCCACTGAGGATGACCCTGC
AGTGAACAGCAAACTTAGTCTCCACGGGGATGGAACCAAGCCCCAGGACCAATGGTAGATAAAA
AGAATTCAGAAATGCGTGTGCCATGATTCCTGCTATTTTCCTGTGTCTGCTCTCACTGCTGTCA
GCAGTGGGCACTTGGCAGCCTCAGTGTTAGAGCTGTGAAGAAAGGCTGTGGCCACAGTGTCTGC
TTTGTGACAGTGTGAGGTGCTGTGAACTTGTTTCAGTACAGCAACTAGTAATTCTCCAGATCCC
CTGCTCCGCTGTGACAGGGTGACGGACAGGAGAGTAGAGGCTGGACTTGGGCACCAAGTTCACC
CGTAGGGAGCCGAGCGGATTGGAGCTCGGTGCTGCTGTGGCTGAGGACAAGCGCACGGCTGTTC
CTGCCAAGCGCTGCTGCCACCTGAGCCCGCACCACACCGTCTTCGTGTGGTTTTCAGTTGAACT
CGTGCGCATTTCTTCTTGCATCTAAAAGAGCATAGAATTATTACTCAGCTCAGCGAAGACCGTG
TTGGTGGTGACAGTTTGTTTCTTTCATTACAGTTTAAAATTCAGTTGCTGGAGGAAATTACAGT
GGCATTCTTAAGATTTCCTCCAAAGAGCAATCTTAAAATAATAGTGTGTTAATTATAAGAAAAA
CAAGCTATCTTTCGACATGCTGTTTTCCAACATCCTCTCATCCTGGAGGGCAGCTATCTTGTGC
GGGATTTTTGTTTCCAGCACCAACAATGTGGTTTCCAGTGTTGCTGCAAACTGACGCCCAGGGA
GTGCCGGGTGCATTCTGCCCCGTGCTCCTGCTGACCTCGTGACCCTGACTTTGAAGGTATACAG
CTCCTTAAAGAATAAAGCTGGAAAATGTTTTATTGAAGTTATCGGATTTGTATCTTGATTTACA
GAAATGCTAACCTTGAGATGCAAACAGGTTTGGGGTAAATGAGCTAAGCGCTTTGTACTCTGGG
ACAGTAACTGCTTTTGGAATCTGTCAGTATTATTGGTATTTTTCAATAAAGAATAATTTCCACA

hide sequence

RefSeq Acc Id:

XM_006256561 ⟹ XP_006256623

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	20	45,366,393 - 45,387,543 (+)	NCBI
Rnor_6.0	20	46,736,633 - 46,758,151 (+)	NCBI
Rnor_5.0	20	48,347,213 - 48,437,687 (+)	NCBI

Sequence:

show sequence

TGCCCCGCCCCCGCCGTGTGCAGACTGAAGCTGTGCAGCGACTGACTGCGGCCGCAGCCGTCCC
TCCGACATGCGCCTGGCCGCCGCGGCGAACGAGGCGTACGCAGCCTCGCTGGCTGTCTCGGAGC
TGCTGGGCTGCCACCAGTGCGGCGGTGGCCGCGGCCAGGACGAGGAACTTGGAATCAGAATCCC
TCGGCCACTAGGACACGGACCAAGCAGGTTCATCCCAGAGAAGGAGATGCTGCAGGTGGGCAGC
GAGGACGCACAGATGCACACTCTGTTTGCCGACTCTTTCGCTGCTTTGGGTCGTTTGGATAACA
TTACACTAGTGATGGTTTTTCATCCACAATATCTAGAAAGTTTCTTAAAGACACAACACTACCT
ACTGCAGATGGACGGGCCGTTGCCCCTCCATTATCGCCACTACATTGGCATCATGGCGGCAGCC
AGGCATCAGTGTTCCTACCTGGTGAATCTACACGTCAGTGACTTTCTTCATGTTGGTGGGGACC
CCAAGTGGCTCAATGGTTTAGAGAATGCTCCTCAGAAACTGCAGAATTTAGGAGAACTTAACAA
AGTGTTAGCCCACAGGCCTTGGCTAATCACCAAAGAACACATCGAGGGGCTGCTGAAGGCTGAG
GAGCACAGCTGGTCTCTTGCGGAGCTGGTCCACGCTGTGGTTCTGCTCACACACTACCACTCTC
TTGCCTCCTTCACATTTGGCTGTGGAATTAGTCCAGAGATCCACTGTGACGGTGGCCACACCTT
CAGACCTCCTTCTGTCAGTAACTACTGCATCTGCGACATTACGAATGGCAACCACAGTGTGGAG
GAGACGCCAGTCCCCTCAGCAGGAAGTGCCTTGGTGAGTGACTCCTTCTTTGAGGTCGAAGCCC
TCATGGAAAAGATGAAGCAGTTACAGGAGTGCCGGGAGGAGGAGGAGGCCAGCCAGGAGGAGAT
GGCCTCGAGGTTTGAAATGGAGAAGAGAGATAGCATGTTTGTCTTCTCTTCAGATGATGATGAA
GTTACACCAGCGAGAGATGTGTCTCGGCACTTTGAGGACACTAGTTATGGCTACAAGGATTTCT
CCAGGCATGGGATGCATGTTCCAACATTTCGTGTCCAGGACTACTGCTGGGAGGACCATGGTTA
TTCTCTGGTGAATCGTCTTTATCCGGATGTGGGACAGTTAATCGATGAGAAATTTCACATTGCT
TACAACCTTACTTACAATACCATGGCAATGCACAAAGATGTTGATACCTCAATGCTGCGACGGG
CTATCTGGAACTATATCCACTGCATGTTCGGAATACGATACGATGACTATGACTACGGGGAGAT
TAACCAGCTGTTGGATCGTAGCTTTAAAGTTTATATCAAAACTGTCGTGTGCACTCCTGAAAAG
GTCACCAAAAGAATGTATGATAGCTTCTGGAGGCAGTTCAAGCACTCTGAGAAGGTTCATGTTA
ATCTGCTTCTTATAGAAGCGAGGATGCAAGCGGAGCTCCTGTATGCTCTGAGAGCCATTACCCG
GTATATGACCTGATGCCCCTCCTCCACTGAGGATGACCCTGCAGTGAACAGCAAACTTAGTCTC
CACGGGGATGGAACCAAGCCCCAGGACCAATGGTAGATAAAAAGAATTCAGAAATGCGTGTGCC
ATGATTCCTGCTATTTTCCTGTGTCTGCTCTCACTGCTGTCAGCAGTGGGCACTTGGCAGCCTC
AGTGTTAGAGCTGTGAAGAAAGGCTGTGGCCACAGTGTCTGCTTTGTGACAGTGTGAGGTGCTG
TGAACTTGTTTCAGTACAGCAACTAGTAATTCTCCAGATCCCCTGCTCCGCTGTGACAGGGTGA
CGGACAGGAGAGTAGAGGCTGGACTTGGGCACCAAGTTCACCCGTAGGGAGCCGAGCGGATTGG
AGCTCGGTGCTGCTGTGGCTGAGGACAAGCGCACGGCTGTTCCTGCCAAGCGCTGCTGCCACCT
GAGCCCGCACCACACCGTCTTCGTGTGGTTTTCAGTTGAACTCGTGCGCATTTCTTCTTGCATC
TAAAAGAGCATAGAATTATTACTCAGCTCAGCGAAGACCGTGTTGGTGGTGACAGTTTGTTTCT
TTCATTACAGTTTAAAATTCAGTTGCTGGAGGAAATTACAGTGGCATTCTTAAGATTTCCTCCA
AAGAGCAATCTTAAAATAATAGTGTGTTAATTATAAGAAAAACAAGCTATCTTTCGACATGCTG
TTTTCCAACATCCTCTCATCCTGGAGGGCAGCTATCTTGTGCGGGATTTTTGTTTCCAGCACCA
ACAATGTGGTTTCCAGTGTTGCTGCAAACTGACGCCCAGGGAGTGCCGGGTGCATTCTGCCCCG
TGCTCCTGCTGACCTCGTGACCCTGACTTTGAAGGTATACAGCTCCTTAAAGAATAAAGCTGGA
AAATGTTTTATTGAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001099866	(Get FASTA)	NCBI Sequence Viewer
	XP_006256622	(Get FASTA)	NCBI Sequence Viewer
	XP_006256623	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL99717	(Get FASTA)	NCBI Sequence Viewer
	EDL99718	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_001099866 ⟸ NM_001106396

- UniProtKB:

D3ZJU4 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAEGENEVRWEGLCSRDPTTRETALESVRQIVLRKTEYLRSAKETLSRPSDGLSNGVSLDGMNK
LLAHLLMLSKRCPFKDVRERSGFILKSVEAAARHQCSYLVNLHVSDFLHVGGDPKWLNGLENAP
QKLQNLGELNKVLAHRPWLITKEHIEGLLKAEEHSWSLAELVHAVVLLTHYHSLASFTFGCGIS
PEIHCDGGHTFRPPSVSNYCICDITNGNHSVEETPVPSAGSALVSDSFFEVEALMEKMKQLQEC
REEEEASQEEMASRFEMEKRDSMFVFSSDDDEVTPARDVSRHFEDTSYGYKDFSRHGMHVPTFR
VQDYCWEDHGYSLVNRLYPDVGQLIDEKFHIAYNLTYNTMAMHKDVDTSMLRRAIWNYIHCMFG
IRYDDYDYGEINQLLDRSFKVYIKTVVCTPEKVTKRMYDSFWRQFKHSEKVHVNLLLIEARMQA
ELLYALRAITRYMT

hide sequence

RefSeq Acc Id:	XP_006256622 ⟸ XM_006256560
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2K4P1 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAEGENEVRWEGLCSRDPTTRETALESVRQIVLRKTEYLRSAKETLSRPSDGLSNGVSLDGMNK LLAHLLMLSKRCPFKDVRERSGFILKSVEELGIRIPRPLGHGPSRFIPEKEMLQVGSEDAQMHT LFADSFAALGRLDNITLVMVFHPQYLESFLKTQHYLLQMDGPLPLHYRHYIGIMAAARHQCSYL VNLHVSDFLHVGGDPKWLNGLENAPQKLQNLGELNKVLAHRPWLITKEHIEGLLKAEEHSWSLA ELVHAVVLLTHYHSLASFTFGCGISPEIHCDGGHTFRPPSVSNYCICDITNGNHSVEETPVPSA GSALVSDSFFEVEALMEKMKQLQECREEEEASQEEMASRFEMEKRDSMFVFSSDDDEVTPARDV SRHFEDTSYGYKDFSRHGMHVPTFRVQDYCWEDHGYSLVNRLYPDVGQLIDEKFHIAYNLTYNT MAMHKDVDTSMLRRAIWNYIHCMFGIRYDDYDYGEINQLLDRSFKVYIKTVVCTPEKVTKRMYD SFWRQFKHSEKVHVNLLLIEARMQAELLYALRAITRYMT hide sequence

RefSeq Acc Id:

XP_006256623 ⟸ XM_006256561

- Peptide Label:

isoform X2

- Sequence:

show sequence

MRLAAAANEAYAASLAVSELLGCHQCGGGRGQDEELGIRIPRPLGHGPSRFIPEKEMLQVGSED
AQMHTLFADSFAALGRLDNITLVMVFHPQYLESFLKTQHYLLQMDGPLPLHYRHYIGIMAAARH
QCSYLVNLHVSDFLHVGGDPKWLNGLENAPQKLQNLGELNKVLAHRPWLITKEHIEGLLKAEEH
SWSLAELVHAVVLLTHYHSLASFTFGCGISPEIHCDGGHTFRPPSVSNYCICDITNGNHSVEET
PVPSAGSALVSDSFFEVEALMEKMKQLQECREEEEASQEEMASRFEMEKRDSMFVFSSDDDEVT
PARDVSRHFEDTSYGYKDFSRHGMHVPTFRVQDYCWEDHGYSLVNRLYPDVGQLIDEKFHIAYN
LTYNTMAMHKDVDTSMLRRAIWNYIHCMFGIRYDDYDYGEINQLLDRSFKVYIKTVVCTPEKVT
KRMYDSFWRQFKHSEKVHVNLLLIEARMQAELLYALRAITRYMT

hide sequence

RefSeq Acc Id:

ENSRNOP00000073119 ⟸ ENSRNOT00000089611

RefSeq Acc Id:

ENSRNOP00000060435 ⟸ ENSRNOT00000065890

RefSeq Acc Id:

ENSRNOP00000090761 ⟸ ENSRNOT00000116987

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A0A0G2K4P1-F1-model_v2	AlphaFold	A0A0G2K4P1	1-551	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13701671

Promoter ID:

EPDNEW_R12192

Type:

single initiation site

Name:

Sesn1_1

Description:

sestrin 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	20	46,667,101 - 46,667,161	EPDNEW

Strain Variation

Strain Sequence Variants (MRatBN7.2)

ACI/EurMcwi (2019)

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CSV

TAB

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

ACI/N (2020)

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CSV

TAB

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BN-Lx/CubMcwi (2019)

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CSV

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BN/NHsdMcwi (2019)

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CSV

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BN/NHsdMcwi (2020)

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CSV

TAB

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BN/SsN (2020)

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CSV

TAB

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BUF/N (2020)

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CSV

TAB

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BXH2/CubMcwi (2020)

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CSV

TAB

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BXH3/CubMcwi (2020)

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CSV

TAB

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

DA/OlaHsd (2019)

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CSV

TAB

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Envigo
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

F344/DuCrl (2019)

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CSV

TAB

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

F344/N (2020)

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CSV

TAB

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

F344/NCrl (2019)

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CSV

TAB

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

F344/Stm (2019)

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CSV

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

FHH/EurMcwi (2019)

Visual

CSV

TAB

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

FXLE16/Stm (2020)

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CSV

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

FXLE18/Stm (2020)

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CSV

TAB

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

GK/FarMcwi (2019)

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CSV

TAB

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

HXB10/IpcvMcwi (2019)

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CSV

TAB

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

HXB2/IpcvMcwi (2019)

Visual

CSV

TAB

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

HXB20/IpcvMcwi (2020)

Visual

CSV

TAB

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

HXB31/IpcvMcwi (2019)

Visual

CSV

TAB

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

HXB4/IpcvMcwi (2020)

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CSV

TAB

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LE/Stm (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEW/Crl (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF10A/StmMcwi (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF11/Stm (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF1A/Stm (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF1C/Stm (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF2B/Stm (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF3/Stm (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF4/Stm (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LH/MavRrrcAek (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Kwitek
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LL/MavRrrcAek (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Kwitek
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LN/MavRrrcAek (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Kwitek
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

M520/N (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

M520/NRrrcMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

MR/N (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

MWF/Hsd (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

PVG/Seac (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

SHR/OlalpcvMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

SHRSP/A3NCrl (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

SR/JrHsd (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Envigo
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

SS/JrHsdMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

WAG/RijCrl (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

WKY/N (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

WKY/NCrl (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

WN/N (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

Damaging Variants

Assembly: Rnor_6.0

Chromosome	Start Pos	End Pos	Reference Nucleotide	Variant Nucleotide	Variant Type	Strain
20	46716263	46716264	C	G	snv	MR/N (MCW)
20	46745121	46745122	C	T	snv	MNS/Gib (RGD)

Assembly: Rnor_5.0

Chromosome	Start Pos	End Pos	Reference Nucleotide	Variant Nucleotide	Variant Type	Strain
20	48395630	48395631	C	A	snv	COP/CrCrl (MCW & UW), GK/Ox (KNAW), WKY/NHsd (KNAW), WKY/NCrl (KNAW), MNS/Gib (KNAW)

Assembly: RGSC_v3.4

Chromosome	Start Pos	End Pos	Reference Nucleotide	Variant Nucleotide	Variant Type	Strain
20	45835688	45835689	C	G	snv	WKY/NCrl (ICL), WKY/NHsd (ICL)
20	45835706	45835707	C	A	snv	WKY/NCrl (ICL), MNS/Gib (ICL), GK/Ox (ICL), WKY/NHsd (ICL)
20	45835720	45835721	C	G	snv	MR/N (KNAW)

Assembly: mRatBN7.2

Chromosome	Start Pos	End Pos	Reference Nucleotide	Variant Nucleotide	Variant Type	Strain
20	45345192	45345193	C	G	snv	GK/FarMcwi (2019), WKY/NCrl (2019)
20	45345210	45345211	C	A	snv	BXH2/CubMcwi (2020), LEXF4/Stm (2020), M520/NRrrcMcwi (2019), WKY/NCrl (2019), BN/NHsdMcwi (2019), BN/SsN (2020)

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1307517	AgrOrtholog
BioCyc Gene	G2FUF-3388	BioCyc
Ensembl Genes	ENSRNOG00000000302	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000060435	ENTREZGENE, UniProtKB/TrEMBL
	ENSRNOP00000073119	ENTREZGENE, UniProtKB/TrEMBL
	ENSRNOP00000090761	ENTREZGENE
Ensembl Transcript	ENSRNOT00000065890	ENTREZGENE, UniProtKB/TrEMBL
	ENSRNOT00000089611	ENTREZGENE, UniProtKB/TrEMBL
	ENSRNOT00000116987	ENTREZGENE
Gene3D-CATH	1.20.1290.10	UniProtKB/TrEMBL
InterPro	AhpD-like	UniProtKB/TrEMBL
	PA26	UniProtKB/TrEMBL
KEGG Report	rno:294518	UniProtKB/TrEMBL
NCBI Gene	294518	ENTREZGENE
PANTHER	PTHR12474	UniProtKB/TrEMBL
Pfam	PA26	UniProtKB/TrEMBL
PhenoGen	Sesn1	PhenoGen
Superfamily-SCOP	SSF69118	UniProtKB/TrEMBL
UniProt	A0A0G2K4P1	ENTREZGENE, UniProtKB/TrEMBL
	D3ZJU4	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-04-30	Sesn1	sestrin 1	Sesn1_predicted	sestrin 1 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Sesn1_predicted	sestrin 1 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Annotations - KEGG (archival)