Sesn1 (sestrin 1) - Rat Genome Database

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Gene: Sesn1 (sestrin 1) Rattus norvegicus
Analyze
Symbol: Sesn1
Name: sestrin 1
RGD ID: 1307517
Description: Predicted to enable leucine binding activity and oxidoreductase activity, acting on peroxide as acceptor. Predicted to be involved in several processes, including cellular response to leucine; cellular response to starvation; and negative regulation of TORC1 signaling. Predicted to act upstream of or within regulation of protein kinase B signaling. Predicted to be located in cytoplasm; fibrillar center; and nucleoplasm. Predicted to be part of GATOR2 complex. Orthologous to human SESN1 (sestrin 1); PARTICIPATES IN p53 signaling pathway; INTERACTS WITH (S)-colchicine; 2,3,7,8-tetrachlorodibenzodioxine; 2-methoxyethanol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC294518; sestrin-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22045,294,876 - 45,387,698 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl2045,294,871 - 45,387,697 (+)Ensembl
Rnor_6.02046,667,116 - 46,758,306 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2046,667,121 - 46,758,305 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02048,347,213 - 48,437,687 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42045,786,623 - 45,877,856 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12045,879,708 - 45,900,868 (+)NCBI
Celera2054,572,050 - 54,662,230 (-)NCBICelera
Cytogenetic Map20q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(S)-colchicine  (EXP,ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-methoxyethanol  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
acrylamide  (EXP)
adefovir pivoxil  (ISO)
adenine  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
amphetamine  (EXP)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bilirubin IXalpha  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
Brusatol  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
celastrol  (ISO)
chloroacetaldehyde  (ISO)
chlorpromazine  (EXP)
cidofovir anhydrous  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (EXP,ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
dicrotophos  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
erastin  (ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
fenofibrate  (EXP)
fluoranthene  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
gedunin  (ISO)
genistein  (ISO)
gentamycin  (EXP)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
hydroxyurea  (ISO)
ibuprofen  (EXP)
ifosfamide  (ISO)
isoflavones  (ISO)
isoprenaline  (ISO)
ketamine  (EXP)
leflunomide  (ISO)
leptomycin B  (ISO)
lipopolysaccharide  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (EXP)
metformin  (EXP)
methapyrilene  (EXP)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
myristicin  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-nitrosodiethylamine  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
phenobarbital  (ISO)
picoxystrobin  (ISO)
piperonyl butoxide  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
potassium bromate  (ISO)
propanal  (ISO)
Ptaquiloside  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
succimer  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
tremolite asbestos  (ISO)
triphenyl phosphate  (EXP)
troglitazone  (EXP,ISO)
tungsten  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
vincristine  (EXP)
zoledronic acid  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:9926927   PMID:15105503   PMID:18692468   PMID:20203043   PMID:22958918   PMID:24315959   PMID:25259925   PMID:25263562   PMID:26449471   PMID:30835510   PMID:33883304  


Genomics

Comparative Map Data
Sesn1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22045,294,876 - 45,387,698 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl2045,294,871 - 45,387,697 (+)Ensembl
Rnor_6.02046,667,116 - 46,758,306 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2046,667,121 - 46,758,305 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02048,347,213 - 48,437,687 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42045,786,623 - 45,877,856 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12045,879,708 - 45,900,868 (+)NCBI
Celera2054,572,050 - 54,662,230 (-)NCBICelera
Cytogenetic Map20q13NCBI
SESN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386108,984,309 - 109,094,846 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl6108,984,309 - 109,094,846 (-)EnsemblGRCh38hg38GRCh38
GRCh376109,305,512 - 109,416,049 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366109,414,338 - 109,521,970 (-)NCBINCBI36hg18NCBI36
Build 346109,414,339 - 109,521,970NCBI
Celera6110,053,551 - 110,161,184 (-)NCBI
Cytogenetic Map6q21NCBI
HuRef6106,874,235 - 106,981,304 (-)NCBIHuRef
CHM1_16109,570,466 - 109,678,815 (-)NCBICHM1_1
Sesn1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391041,686,570 - 41,784,432 (+)NCBIGRCm39mm39
GRCm39 Ensembl1041,685,931 - 41,784,420 (+)Ensembl
GRCm381041,810,574 - 41,908,436 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1041,809,935 - 41,908,424 (+)EnsemblGRCm38mm10GRCm38
MGSCv371041,530,380 - 41,628,242 (+)NCBIGRCm37mm9NCBIm37
MGSCv361041,575,864 - 41,596,839 (+)NCBImm8
Celera1042,690,911 - 42,787,751 (+)NCBICelera
Cytogenetic Map10B2NCBI
cM Map1022.77NCBI
Sesn1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541134,032,490 - 34,139,822 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541134,033,986 - 34,051,171 (-)NCBIChiLan1.0ChiLan1.0
SESN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.16110,839,631 - 110,945,723 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6110,839,631 - 110,946,276 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v06106,789,911 - 106,896,382 (-)NCBIMhudiblu_PPA_v0panPan3
SESN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11265,958,995 - 66,057,369 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1265,960,066 - 66,057,035 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1265,777,446 - 65,875,811 (-)NCBI
ROS_Cfam_1.01266,840,480 - 66,939,046 (-)NCBI
ROS_Cfam_1.0 Ensembl1266,840,487 - 66,939,038 (-)Ensembl
UMICH_Zoey_3.11266,191,015 - 66,289,363 (-)NCBI
UNSW_CanFamBas_1.01266,039,317 - 66,137,542 (-)NCBI
UU_Cfam_GSD_1.01266,311,345 - 66,409,780 (-)NCBI
Sesn1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946100,912,289 - 101,016,826 (-)NCBI
SpeTri2.0NW_0049365645,187,152 - 5,291,201 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SESN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl175,033,098 - 75,169,987 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1175,056,731 - 75,170,374 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2184,357,130 - 84,371,187 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SESN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11364,756,393 - 64,864,795 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1364,841,773 - 64,863,698 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604037,058,232 - 37,167,839 (+)NCBIVero_WHO_p1.0
Sesn1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624916231,168 - 332,423 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
RH130564  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22045,387,397 - 45,387,602 (+)MAPPERmRatBN7.2
Rnor_6.02046,758,006 - 46,758,210NCBIRnor6.0
Rnor_5.02048,437,387 - 48,437,591UniSTSRnor5.0
RGSC_v3.42045,877,557 - 45,877,761UniSTSRGSC3.4
Celera2054,572,145 - 54,572,349UniSTS
Cytogenetic Map20q13UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
7411652Foco24Food consumption QTL 240.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)201175751554435887Rat
9590092Insglur9Insulin/glucose ratio QTL 918.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)201175751554435887Rat
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)201761783247606836Rat
2317880Alcrsp25Alcohol response QTL 252.3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)201769755054435887Rat
2303626Vencon10Ventilatory control QTL 100.001respiration trait (VT:0001943)respiration rate (CMO:0000289)201919072154435887Rat
2303578Gluco50Glucose level QTL 502blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)202510672254435887Rat
2303587Bw93Body weight QTL 9313body mass (VT:0001259)body weight (CMO:0000012)202510672254435887Rat
2300188Bmd68Bone mineral density QTL 686.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)202510672254435887Rat
1331747Hrtrt16Heart rate QTL 163.163heart pumping trait (VT:2000009)heart rate (CMO:0000002)202520973454435887Rat
1598869Memor6Memory QTL 63.1exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)202924438854435887Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:155
Count of miRNA genes:104
Interacting mature miRNAs:130
Transcripts:ENSRNOT00000065890
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 39 56 40 19 40 8 11 68 35 39 11 8
Low 1 4 1 1 1 6 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000065890   ⟹   ENSRNOP00000060435
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2045,295,214 - 45,387,697 (+)Ensembl
Rnor_6.0 Ensembl2046,667,454 - 46,758,305 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000089611   ⟹   ENSRNOP00000073119
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2045,294,871 - 45,387,694 (+)Ensembl
Rnor_6.0 Ensembl2046,667,121 - 46,758,305 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000116987   ⟹   ENSRNOP00000090761
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2045,366,374 - 45,387,694 (+)Ensembl
RefSeq Acc Id: NM_001106396   ⟹   NP_001099866
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22045,295,214 - 45,387,697 (+)NCBI
Rnor_6.02046,667,454 - 46,758,305 (+)NCBI
Rnor_5.02048,347,213 - 48,437,687 (+)NCBI
RGSC_v3.42045,786,623 - 45,877,856 (+)RGD
Celera2054,572,050 - 54,662,230 (-)RGD
Sequence:
RefSeq Acc Id: XM_006256560   ⟹   XP_006256622
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22045,294,876 - 45,387,698 (+)NCBI
Rnor_6.02046,667,116 - 46,758,306 (+)NCBI
Rnor_5.02048,347,213 - 48,437,687 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006256561   ⟹   XP_006256623
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22045,366,393 - 45,387,543 (+)NCBI
Rnor_6.02046,736,633 - 46,758,151 (+)NCBI
Rnor_5.02048,347,213 - 48,437,687 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001099866 (Get FASTA)   NCBI Sequence Viewer  
  XP_006256622 (Get FASTA)   NCBI Sequence Viewer  
  XP_006256623 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL99717 (Get FASTA)   NCBI Sequence Viewer  
  EDL99718 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001099866   ⟸   NM_001106396
- UniProtKB: D3ZJU4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256622   ⟸   XM_006256560
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K4P1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256623   ⟸   XM_006256561
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000073119   ⟸   ENSRNOT00000089611
RefSeq Acc Id: ENSRNOP00000060435   ⟸   ENSRNOT00000065890
RefSeq Acc Id: ENSRNOP00000090761   ⟸   ENSRNOT00000116987

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K4P1-F1-model_v2 AlphaFold A0A0G2K4P1 1-551 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701671
Promoter ID:EPDNEW_R12192
Type:single initiation site
Name:Sesn1_1
Description:sestrin 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02046,667,101 - 46,667,161EPDNEW

Strain Variation

Strain Sequence Variants (MRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
Damaging Variants


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
20 46716263 46716264 C G snv MR/N (MCW)
20 46745121 46745122 C T snv MNS/Gib (RGD)


Assembly: Rnor_5.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
20 48395630 48395631 C A snv COP/CrCrl (MCW & UW), GK/Ox (KNAW), WKY/NHsd (KNAW), WKY/NCrl (KNAW), MNS/Gib (KNAW)


Assembly: RGSC_v3.4

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
20 45835688 45835689 C G snv WKY/NCrl (ICL), WKY/NHsd (ICL)
20 45835706 45835707 C A snv WKY/NCrl (ICL), MNS/Gib (ICL), GK/Ox (ICL), WKY/NHsd (ICL)
20 45835720 45835721 C G snv MR/N (KNAW)


Assembly: mRatBN7.2

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
20 45345192 45345193 C G snv GK/FarMcwi (2019), WKY/NCrl (2019)
20 45345210 45345211 C A snv BXH2/CubMcwi (2020), LEXF4/Stm (2020), M520/NRrrcMcwi (2019), WKY/NCrl (2019), BN/NHsdMcwi (2019), BN/SsN (2020)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307517 AgrOrtholog
BioCyc Gene G2FUF-3388 BioCyc
Ensembl Genes ENSRNOG00000000302 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000060435 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000073119 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000090761 ENTREZGENE
Ensembl Transcript ENSRNOT00000065890 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000089611 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000116987 ENTREZGENE
Gene3D-CATH 1.20.1290.10 UniProtKB/TrEMBL
InterPro AhpD-like UniProtKB/TrEMBL
  PA26 UniProtKB/TrEMBL
KEGG Report rno:294518 UniProtKB/TrEMBL
NCBI Gene 294518 ENTREZGENE
PANTHER PTHR12474 UniProtKB/TrEMBL
Pfam PA26 UniProtKB/TrEMBL
PhenoGen Sesn1 PhenoGen
Superfamily-SCOP SSF69118 UniProtKB/TrEMBL
UniProt A0A0G2K4P1 ENTREZGENE, UniProtKB/TrEMBL
  D3ZJU4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Sesn1  sestrin 1   Sesn1_predicted  sestrin 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Sesn1_predicted  sestrin 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED