Egfl8 (EGF-like-domain, multiple 8) - Rat Genome Database

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Gene: Egfl8 (EGF-like-domain, multiple 8) Rattus norvegicus
Analyze
Symbol: Egfl8
Name: EGF-like-domain, multiple 8
RGD ID: 1549706
Description: Predicted to enable signaling receptor binding activity. Predicted to be active in cell surface and extracellular region. Orthologous to human EGFL8 (EGF like domain multiple 8); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 4-amino-2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: EGF-like domain 8; EGF-like domain-containing protein 8; EGF-like protein 8; epidermal growth factor-like protein 8; MGC156528; multiple EGF-like domain protein 8; Ng3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8204,137,531 - 4,140,632 (+)NCBIGRCr8
mRatBN7.2204,132,930 - 4,136,024 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl204,133,629 - 4,136,018 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx204,839,942 - 4,842,521 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0204,201,694 - 4,204,273 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0204,732,618 - 4,735,197 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0204,378,205 - 4,380,959 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl204,378,206 - 4,380,600 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0206,457,145 - 6,460,359 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4204,235,508 - 4,237,864 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera203,894,231 - 3,896,629 (-)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. The genomic sequence and comparative analysis of the rat major histocompatibility complex. Hurt P, etal., Genome Res 2004 Apr;14(4):631-9.
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:15162510  


Genomics

Comparative Map Data
Egfl8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8204,137,531 - 4,140,632 (+)NCBIGRCr8
mRatBN7.2204,132,930 - 4,136,024 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl204,133,629 - 4,136,018 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx204,839,942 - 4,842,521 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0204,201,694 - 4,204,273 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0204,732,618 - 4,735,197 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0204,378,205 - 4,380,959 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl204,378,206 - 4,380,600 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0206,457,145 - 6,460,359 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4204,235,508 - 4,237,864 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera203,894,231 - 3,896,629 (-)NCBICelera
Cytogenetic Map20p12NCBI
EGFL8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38632,164,595 - 32,168,281 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl632,164,595 - 32,168,281 (+)EnsemblGRCh38hg38GRCh38
GRCh37632,132,372 - 32,136,058 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36632,240,383 - 32,244,040 (+)NCBINCBI36Build 36hg18NCBI36
Build 34632,241,920 - 32,243,711NCBI
Celera633,699,452 - 33,703,109 (+)NCBICelera
Cytogenetic Map6p21.32NCBI
HuRef631,886,374 - 31,890,261 (+)NCBIHuRef
CHM1_1632,134,866 - 32,138,546 (+)NCBICHM1_1
T2T-CHM13v2.0632,017,785 - 32,021,472 (+)NCBIT2T-CHM13v2.0
Egfl8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391734,832,174 - 34,835,536 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1734,832,323 - 34,834,945 (-)EnsemblGRCm39 Ensembl
GRCm381734,613,349 - 34,616,562 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1734,613,349 - 34,615,971 (-)EnsemblGRCm38mm10GRCm38
MGSCv371734,750,295 - 34,752,916 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361734,221,410 - 34,224,027 (-)NCBIMGSCv36mm8
Celera1737,708,523 - 37,711,144 (-)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1718.19NCBI
Egfl8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955437631,619 - 633,315 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955437630,099 - 633,592 (+)NCBIChiLan1.0ChiLan1.0
EGFL8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2546,627,622 - 46,631,334 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1642,589,106 - 42,592,604 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0631,811,944 - 31,815,796 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1632,691,846 - 32,695,549 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl632,680,175 - 32,695,549 (+)Ensemblpanpan1.1panPan2
EGFL8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1121,558,069 - 1,561,566 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl121,559,384 - 1,561,580 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha121,691,756 - 1,695,261 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0121,696,259 - 1,699,764 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl121,697,579 - 1,699,467 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1121,559,296 - 1,562,799 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0121,624,911 - 1,628,412 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0121,691,223 - 1,694,727 (+)NCBIUU_Cfam_GSD_1.0
EGFL8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl724,201,632 - 24,204,971 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1724,201,129 - 24,205,133 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2728,021,599 - 28,025,803 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EGFL8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11739,864,006 - 39,867,730 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1739,864,328 - 39,876,947 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604432,063,973 - 32,067,726 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Egfl8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475424,152,811 - 24,155,240 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475424,152,544 - 24,155,271 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Egfl8
13 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:148
Count of miRNA genes:109
Interacting mature miRNAs:118
Transcripts:ENSRNOT00000000499, ENSRNOT00000068712
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125159026Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
2306850Pia40Pristane induced arthritis QTL 400.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2015279595304575Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
61448Ciaa1CIA Autoantibody QTL 1300.001blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)2026463954597031Rat
61472Aia1Adjuvant induced arthritis QTL 1180.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2026463954597031Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20289259726381954Rat
1300152Bp195Blood pressure QTL 1953.46arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2036216499243559Rat
1331772Cdexp2CD45RC expression in CD8 T cells QTL 25.7CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)20362164910078919Rat
737973Pia21Pristane induced arthritis QTL 214.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2036216564606812Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20362165614101050Rat

Markers in Region
RH135211  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2204,136,183 - 4,136,397 (-)MAPPERmRatBN7.2
Rnor_6.0204,377,832 - 4,378,045NCBIRnor6.0
Rnor_5.0206,457,188 - 6,457,401UniSTSRnor5.0
RGSC_v3.4204,238,025 - 4,238,238UniSTSRGSC3.4
Celera203,893,857 - 3,894,070UniSTS
RH 3.4 Map2053.33UniSTS
Cytogenetic Map20p12UniSTS
RH139384  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2204,135,796 - 4,136,000 (-)MAPPERmRatBN7.2
Rnor_6.0204,378,229 - 4,378,432NCBIRnor6.0
Rnor_5.0206,457,585 - 6,457,788UniSTSRnor5.0
RGSC_v3.4204,237,638 - 4,237,841UniSTSRGSC3.4
Celera203,894,254 - 3,894,457UniSTS
Cytogenetic Map20p12UniSTS
RH140482  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2204,132,361 - 4,132,493 (-)MAPPERmRatBN7.2
Rnor_6.0204,381,736 - 4,381,867NCBIRnor6.0
Rnor_5.0206,461,092 - 6,461,223UniSTSRnor5.0
RGSC_v3.4204,234,241 - 4,234,372UniSTSRGSC3.4
Celera203,897,765 - 3,897,896UniSTS
Cytogenetic Map20p12UniSTS
RH124332  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2204,132,455 - 4,132,618 (-)MAPPERmRatBN7.2
Rnor_6.0204,381,611 - 4,381,773NCBIRnor6.0
Rnor_5.0206,460,967 - 6,461,129UniSTSRnor5.0
RGSC_v3.4204,234,335 - 4,234,497UniSTSRGSC3.4
Celera203,897,640 - 3,897,802UniSTS
Cytogenetic Map20p12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 4 5 1 1 6 25 15 1 1
Low 3 43 53 41 14 41 7 10 68 10 26 10 7
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000000499   ⟹   ENSRNOP00000000499
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl204,133,629 - 4,136,018 (+)Ensembl
Rnor_6.0 Ensembl204,378,211 - 4,380,084 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000068712   ⟹   ENSRNOP00000063796
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl204,133,629 - 4,136,018 (+)Ensembl
Rnor_6.0 Ensembl204,378,206 - 4,380,600 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000107302   ⟹   ENSRNOP00000093713
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl204,133,629 - 4,136,018 (+)Ensembl
RefSeq Acc Id: NM_001004070   ⟹   NP_001004070
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8204,138,053 - 4,140,632 (+)NCBI
mRatBN7.2204,133,445 - 4,136,024 (+)NCBI
Rnor_6.0204,378,206 - 4,380,084 (-)NCBI
Rnor_5.0206,457,145 - 6,460,359 (-)NCBI
RGSC_v3.4204,235,508 - 4,237,864 (+)RGD
Celera203,894,231 - 3,896,113 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001165880   ⟹   NP_001159352
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8204,138,053 - 4,140,632 (+)NCBI
mRatBN7.2204,133,445 - 4,136,024 (+)NCBI
Rnor_6.0204,378,206 - 4,380,600 (-)NCBI
Rnor_5.0206,457,145 - 6,460,359 (-)NCBI
RGSC_v3.4204,235,508 - 4,237,864 (+)RGD
Celera203,894,231 - 3,896,629 (-)RGD
Sequence:
RefSeq Acc Id: XM_006255978   ⟹   XP_006256040
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8204,137,531 - 4,140,632 (+)NCBI
mRatBN7.2204,132,930 - 4,136,024 (+)NCBI
Rnor_6.0204,378,206 - 4,380,956 (-)NCBI
Rnor_5.0206,457,145 - 6,460,359 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039098934   ⟹   XP_038954862
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8204,137,531 - 4,140,632 (+)NCBI
mRatBN7.2204,132,930 - 4,136,024 (+)NCBI
RefSeq Acc Id: XM_039098935   ⟹   XP_038954863
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8204,137,531 - 4,140,632 (+)NCBI
mRatBN7.2204,132,930 - 4,136,024 (+)NCBI
RefSeq Acc Id: XM_063279353   ⟹   XP_063135423
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8204,137,531 - 4,140,632 (+)NCBI
RefSeq Acc Id: XM_063279354   ⟹   XP_063135424
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8204,137,531 - 4,140,632 (+)NCBI
RefSeq Acc Id: NP_001004070   ⟸   NM_001004070
- Peptide Label: isoform 1 precursor
- UniProtKB: A0JPK1 (UniProtKB/Swiss-Prot),   Q6MG84 (UniProtKB/Swiss-Prot),   A6KTH6 (UniProtKB/TrEMBL),   A0A8I6AMC1 (UniProtKB/TrEMBL),   A6KTH4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001159352   ⟸   NM_001165880
- Peptide Label: isoform 2 precursor
- UniProtKB: A6KTH7 (UniProtKB/TrEMBL),   A0A8I6AMC1 (UniProtKB/TrEMBL),   A6KTH4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256040   ⟸   XM_006255978
- Peptide Label: isoform X1
- UniProtKB: A0JPK1 (UniProtKB/Swiss-Prot),   Q6MG84 (UniProtKB/Swiss-Prot),   A6KTH6 (UniProtKB/TrEMBL),   A0A8I6AMC1 (UniProtKB/TrEMBL),   A6KTH4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000000499   ⟸   ENSRNOT00000000499
RefSeq Acc Id: ENSRNOP00000063796   ⟸   ENSRNOT00000068712
RefSeq Acc Id: XP_038954862   ⟸   XM_039098934
- Peptide Label: isoform X1
- UniProtKB: Q6MG84 (UniProtKB/Swiss-Prot),   A0JPK1 (UniProtKB/Swiss-Prot),   A6KTH6 (UniProtKB/TrEMBL),   A0A8I6AMC1 (UniProtKB/TrEMBL),   A6KTH4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038954863   ⟸   XM_039098935
- Peptide Label: isoform X1
- UniProtKB: Q6MG84 (UniProtKB/Swiss-Prot),   A0JPK1 (UniProtKB/Swiss-Prot),   A6KTH6 (UniProtKB/TrEMBL),   A0A8I6AMC1 (UniProtKB/TrEMBL),   A6KTH4 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000093713   ⟸   ENSRNOT00000107302
RefSeq Acc Id: XP_063135424   ⟸   XM_063279354
- Peptide Label: isoform X1
- UniProtKB: Q6MG84 (UniProtKB/Swiss-Prot),   A0JPK1 (UniProtKB/Swiss-Prot),   A0A8I6AMC1 (UniProtKB/TrEMBL),   A6KTH4 (UniProtKB/TrEMBL),   A6KTH6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063135423   ⟸   XM_063279353
- Peptide Label: isoform X1
- UniProtKB: Q6MG84 (UniProtKB/Swiss-Prot),   A0JPK1 (UniProtKB/Swiss-Prot),   A0A8I6AMC1 (UniProtKB/TrEMBL),   A6KTH4 (UniProtKB/TrEMBL),   A6KTH6 (UniProtKB/TrEMBL)
Protein Domains
EGF-like   EMI

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6MG84-F1-model_v2 AlphaFold Q6MG84 1-291 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701344
Promoter ID:EPDNEW_R11868
Type:single initiation site
Name:Egfl8_1
Description:EGF-like-domain, multiple 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0204,380,597 - 4,380,657EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1549706 AgrOrtholog
BioCyc Gene G2FUF-4587 BioCyc
Ensembl Genes ENSRNOG00000000436 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055006708 UniProtKB/Swiss-Prot
  ENSRNOG00060007400 UniProtKB/Swiss-Prot
  ENSRNOG00065027817 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000000499.7 UniProtKB/Swiss-Prot
  ENSRNOT00000068712 ENTREZGENE
  ENSRNOT00000068712.5 UniProtKB/Swiss-Prot
  ENSRNOT00000107302 ENTREZGENE
  ENSRNOT00000107302.1 UniProtKB/TrEMBL
  ENSRNOT00055010956 UniProtKB/Swiss-Prot
  ENSRNOT00060012199 UniProtKB/Swiss-Prot
  ENSRNOT00065047989 UniProtKB/Swiss-Prot
Gene3D-CATH Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:8362353 IMAGE-MGC_LOAD
InterPro EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EMI_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NOTCH1_EGF-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:406166 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:156528 IMAGE-MGC_LOAD
NCBI Gene 406166 ENTREZGENE
PANTHER EGF-LIKE-DOMAIN, MULTIPLE 7, 8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EPIDERMAL GROWTH FACTOR-LIKE PROTEIN 8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EMI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Egfl8 PhenoGen
PROSITE ASX_HYDROXYL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EMI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000000436 RatGTEx
  ENSRNOG00055006708 RatGTEx
  ENSRNOG00060007400 RatGTEx
  ENSRNOG00065027817 RatGTEx
SMART EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57184 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6AMC1 ENTREZGENE, UniProtKB/TrEMBL
  A0JPK1 ENTREZGENE
  A6KTH4 ENTREZGENE, UniProtKB/TrEMBL
  A6KTH6 ENTREZGENE, UniProtKB/TrEMBL
  A6KTH7 ENTREZGENE, UniProtKB/TrEMBL
  EGFL8_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A0JPK1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-11-25 Egfl8  EGF-like-domain, multiple 8  Egfl8  EGF-like domain 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-06 Egfl8  EGF-like domain 8  Ng3  Ng3 protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Ng3  Ng3 protein      Symbol and Name updated 1559027 APPROVED
2005-09-15 Ng3  Ng3 protein      Symbol and Name status set to provisional 70820 PROVISIONAL