Rab44 (RAB44, member RAS oncogene family) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Rab44 (RAB44, member RAS oncogene family) Rattus norvegicus
Analyze
Symbol: Rab44
Name: RAB44, member RAS oncogene family
RGD ID: 1560150
Description: Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in vesicle-mediated transport. Predicted to act upstream of or within histamine secretion by mast cell and histamine secretion mediated by IgE immunoglobulin. Orthologous to human RAB44 (RAB44, member RAS oncogene family); INTERACTS WITH 1-naphthyl isothiocyanate; amphetamine; bisphenol A.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC309649; ras-related protein Rab-44; RGD1560150; similar to RIKEN cDNA 9830134C10 gene
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8207,166,219 - 7,200,114 (+)NCBIGRCr8
mRatBN7.2207,164,576 - 7,198,473 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl207,164,720 - 7,198,468 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0206,363,839 - 6,410,878 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl206,397,022 - 6,410,191 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0208,607,880 - 8,656,089 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4207,332,351 - 7,452,568 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera208,714,633 - 8,748,437 (+)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Rab44
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8207,166,219 - 7,200,114 (+)NCBIGRCr8
mRatBN7.2207,164,576 - 7,198,473 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl207,164,720 - 7,198,468 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0206,363,839 - 6,410,878 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl206,397,022 - 6,410,191 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0208,607,880 - 8,656,089 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4207,332,351 - 7,452,568 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera208,714,633 - 8,748,437 (+)NCBICelera
Cytogenetic Map20p12NCBI
RAB44
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38636,697,826 - 36,733,184 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl636,697,826 - 36,733,184 (+)EnsemblGRCh38hg38GRCh38
GRCh37636,665,603 - 36,700,961 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36636,779,991 - 36,813,461 (+)NCBINCBI36Build 36hg18NCBI36
Celera638,227,044 - 38,260,526 (+)NCBICelera
Cytogenetic Map6p21.2NCBI
HuRef636,383,845 - 36,419,250 (+)NCBIHuRef
CHM1_1636,667,541 - 36,702,900 (+)NCBICHM1_1
T2T-CHM13v2.0636,518,456 - 36,553,808 (+)NCBIT2T-CHM13v2.0
Rab44
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391729,333,102 - 29,367,966 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1729,333,119 - 29,367,954 (+)EnsemblGRCm39 Ensembl
GRCm381729,114,128 - 29,148,980 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1729,114,145 - 29,148,980 (+)EnsemblGRCm38mm10GRCm38
MGSCv371729,272,001 - 29,285,921 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361728,862,339 - 28,876,259 (+)NCBIMGSCv36mm8
Celera1729,686,716 - 29,699,710 (+)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1715.14NCBI
Rab44
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554376,220,228 - 6,246,898 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554376,223,281 - 6,250,068 (-)NCBIChiLan1.0ChiLan1.0
RAB44
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2551,166,628 - 51,202,259 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1647,036,220 - 47,071,882 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0636,260,088 - 36,295,723 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1637,455,996 - 37,491,424 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl637,462,355 - 37,490,330 (+)Ensemblpanpan1.1panPan2
RAB44
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1125,769,056 - 5,804,963 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl125,770,882 - 5,804,949 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha125,787,999 - 5,823,996 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0126,117,999 - 6,154,011 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl126,121,446 - 6,154,014 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1125,772,503 - 5,808,609 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0125,852,102 - 5,888,147 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0125,950,333 - 5,986,288 (+)NCBIUU_Cfam_GSD_1.0
Rab44
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494641,248,071 - 41,278,972 (+)NCBIHiC_Itri_2
SpeTri2.0NW_00493647622,681,324 - 22,706,897 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RAB44
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl732,372,600 - 32,402,736 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1732,372,606 - 32,402,282 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2737,276,005 - 37,305,389 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RAB44
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11735,399,866 - 35,435,599 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604436,644,658 - 36,680,296 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rab44
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475421,072,113 - 21,092,517 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rab44
340 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:75
Count of miRNA genes:67
Interacting mature miRNAs:68
Transcripts:ENSRNOT00000002553
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125159026Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20289259726381954Rat
1300152Bp195Blood pressure QTL 1953.46arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2036216499243559Rat
1331772Cdexp2CD45RC expression in CD8 T cells QTL 25.7CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)20362164910078919Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20362165614101050Rat
4889857Pur27Proteinuria QTL 2712.20.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20460660717617956Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20460660717617956Rat
70154Insul2Insulin level QTL 23.75blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20669170617489458Rat

Markers in Region
RH132286  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2207,198,039 - 7,198,231 (+)MAPPERmRatBN7.2
Rnor_6.0206,410,325 - 6,410,516NCBIRnor6.0
Rnor_5.0208,655,536 - 8,655,727UniSTSRnor5.0
RGSC_v3.4207,444,935 - 7,445,126UniSTSRGSC3.4
Celera208,747,884 - 8,748,075UniSTS
RH 3.4 Map2094.2UniSTS
Cytogenetic Map20p12UniSTS
BF403662  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2207,190,606 - 7,190,698 (+)MAPPERmRatBN7.2
Rnor_6.0206,402,802 - 6,402,893NCBIRnor6.0
Rnor_5.0208,648,013 - 8,648,104UniSTSRnor5.0
RGSC_v3.4207,436,800 - 7,436,891UniSTSRGSC3.4
Celera208,740,004 - 8,740,095UniSTS
Cytogenetic Map20p12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2
Low 1 30 26 12 26 1 1 10 16 9 1
Below cutoff 2 18 14 3 5 3 7 8 20 17 22 2 7

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000002553   ⟹   ENSRNOP00000002553
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl207,164,720 - 7,198,468 (+)Ensembl
Rnor_6.0 Ensembl206,397,022 - 6,410,191 (+)Ensembl
RefSeq Acc Id: XM_006256153   ⟹   XP_006256215
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8207,166,239 - 7,200,114 (+)NCBI
mRatBN7.2207,164,597 - 7,198,473 (+)NCBI
Rnor_6.0206,363,839 - 6,410,878 (+)NCBI
Rnor_5.0208,607,880 - 8,656,089 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017601867   ⟹   XP_017457356
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8207,166,479 - 7,200,114 (+)NCBI
mRatBN7.2207,164,899 - 7,198,473 (+)NCBI
Rnor_6.0206,364,086 - 6,410,878 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039099145   ⟹   XP_038955073
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8207,166,219 - 7,194,668 (+)NCBI
mRatBN7.2207,164,576 - 7,191,519 (+)NCBI
RefSeq Acc Id: XM_039099146   ⟹   XP_038955074
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8207,166,244 - 7,200,114 (+)NCBI
mRatBN7.2207,164,606 - 7,198,473 (+)NCBI
Protein Sequences
Protein RefSeqs XP_006256215 (Get FASTA)   NCBI Sequence Viewer  
  XP_017457356 (Get FASTA)   NCBI Sequence Viewer  
  XP_038955073 (Get FASTA)   NCBI Sequence Viewer  
  XP_038955074 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL96956 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000002553
  ENSRNOP00000002553.7
Reference Protein Sequences
RefSeq Acc Id: XP_006256215   ⟸   XM_006256153
- Peptide Label: isoform X1
- UniProtKB: F1M8M0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017457356   ⟸   XM_017601867
- Peptide Label: isoform X1
- UniProtKB: F1M8M0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000002553   ⟸   ENSRNOT00000002553
RefSeq Acc Id: XP_038955073   ⟸   XM_039099145
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038955074   ⟸   XM_039099146
- Peptide Label: isoform X3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M8M0-F1-model_v2 AlphaFold F1M8M0 1-722 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560150 AgrOrtholog
BioCyc Gene G2FUF-4390 BioCyc
Ensembl Genes ENSRNOG00000001869 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000002553.7 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
InterPro EF-hand-dom_pair UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  Small_GTP-bd_dom UniProtKB/TrEMBL
  Small_GTPase UniProtKB/TrEMBL
KEGG Report rno:309649 UniProtKB/TrEMBL
NCBI Gene 309649 ENTREZGENE
PANTHER RAS-RELATED PROTEIN RAB UniProtKB/TrEMBL
  RAS-RELATED PROTEIN RAB-44 UniProtKB/TrEMBL
Pfam Ras UniProtKB/TrEMBL
PhenoGen Rab44 PhenoGen
PRINTS RASTRNSFRMNG UniProtKB/TrEMBL
PROSITE RAB UniProtKB/TrEMBL
  RAS UniProtKB/TrEMBL
RatGTEx ENSRNOG00000001869 RatGTEx
SMART RAB UniProtKB/TrEMBL
  RAN UniProtKB/TrEMBL
  RAS UniProtKB/TrEMBL
  RHO UniProtKB/TrEMBL
Superfamily-SCOP SSF47473 UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
UniProt F1M8M0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-06-12 Rab44  RAB44, member RAS oncogene family  RGD1560150  similar to RIKEN cDNA 9830134C10 gene   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1560150  similar to RIKEN cDNA 9830134C10 gene   RGD1560150_predicted  similar to RIKEN cDNA 9830134C10 gene (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1560150_predicted  similar to RIKEN cDNA 9830134C10 gene (predicted)  LOC309649  similar to RIKEN cDNA 9830134C10 gene  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC309649  similar to RIKEN cDNA 9830134C10 gene      Symbol and Name status set to provisional 70820 PROVISIONAL