Hdac2 (histone deacetylase 2) - Rat Genome Database

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Gene: Hdac2 (histone deacetylase 2) Rattus norvegicus
Analyze
Symbol: Hdac2
Name: histone deacetylase 2
RGD ID: 619976
Description: Enables several functions, including deacetylase activity; heat shock protein binding activity; and promoter-specific chromatin binding activity. Involved in several processes, including positive regulation of cell differentiation; positive regulation of macromolecule metabolic process; and response to alkaloid. Located in chromatin; cytoplasm; and nucleus. Used to study Peyronie's disease; alcohol use disorder; and anxiety disorder. Biomarker of bronchitis; chronic obstructive pulmonary disease; endometriosis; pulmonary emphysema; and visual epilepsy. Human ortholog(s) of this gene implicated in stomach cancer. Orthologous to human HDAC2 (histone deacetylase 2); PARTICIPATES IN CHD family mediated chromatin remodeling pathway; Hedgehog signaling pathway; histone modification pathway; INTERACTS WITH (S)-nicotine; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 1,2-dimethylhydrazine.
Type: protein-coding
RefSeq Status: VALIDATED
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22040,548,250 - 40,571,609 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl2040,548,250 - 40,571,609 (+)Ensembl
Rnor_6.02043,084,870 - 43,108,198 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2043,084,870 - 43,108,198 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02044,811,967 - 44,835,337 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42041,162,093 - 41,186,492 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12041,204,917 - 41,209,275 (+)NCBI
Celera2041,298,790 - 41,322,159 (+)NCBICelera
Cytogenetic Map20q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(20S)-ginsenoside Rh2  (ISO)
(S)-nicotine  (EXP,ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,2-dimethylhydrazine  (EXP)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3',5'-cyclic AMP  (EXP)
3,3'-diindolylmethane  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
aconitine  (EXP)
acrolein  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antimycin A  (ISO)
aristolochic acid  (ISO)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (ISO)
berberine  (ISO)
biphenyl-4-amine  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
Brodifacoum  (EXP)
butanal  (ISO)
C60 fullerene  (EXP)
caffeine  (EXP)
capsaicin  (EXP)
choline  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (ISO)
diuron  (EXP)
doxorubicin  (EXP,ISO)
endosulfan  (ISO)
enzyme inhibitor  (ISO)
fenpyroximate  (ISO)
fluoxetine  (EXP,ISO)
folic acid  (ISO)
furan  (EXP)
genistein  (ISO)
glafenine  (EXP)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
hydroxamic acid  (ISO)
hydroxyurea  (ISO)
indole-3-methanol  (ISO)
isoprenaline  (EXP,ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lead(0)  (EXP,ISO)
lead(2+)  (EXP,ISO)
manganese(II) chloride  (EXP)
mechlorethamine  (EXP)
menadione  (ISO)
methoxyacetic acid  (ISO)
mifepristone  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
nefazodone  (EXP)
nickel subsulfide  (EXP)
nicotine  (EXP,ISO)
nimesulide  (EXP)
oxybenzone  (EXP)
pelargonidin  (ISO)
perfluorooctanoic acid  (ISO)
picoxystrobin  (ISO)
Plantamajoside  (EXP,ISO)
resveratrol  (EXP,ISO)
romidepsin  (EXP)
rotenone  (ISO)
sevoflurane  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sulforaphane  (ISO)
tamoxifen  (ISO)
tebufenpyrad  (ISO)
tetrachloromethane  (ISO)
theophylline  (ISO)
trichostatin A  (ISO)
Triptolide  (EXP)
triptonide  (ISO)
valdecoxib  (EXP)
valproic acid  (EXP,ISO)
valsartan  (EXP,ISO)
vorinostat  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
behavioral response to ethanol  (IEP)
cardiac muscle cell development  (ISO)
cardiac muscle cell proliferation  (ISO)
cardiac muscle hypertrophy  (IEP)
cellular response to dopamine  (IEP)
cellular response to heat  (IEP)
cellular response to hydrogen peroxide  (IDA)
cellular response to retinoic acid  (IEP)
cellular response to transforming growth factor beta stimulus  (IEP)
cellular response to trichostatin A  (ISO)
chromatin remodeling  (ISO)
circadian regulation of gene expression  (ISO)
dendrite development  (ISO)
embryonic digit morphogenesis  (ISO)
epidermal cell differentiation  (ISO)
eyelid development in camera-type eye  (ISO)
fungiform papilla formation  (ISO)
hair follicle placode formation  (ISO)
heterochromatin organization  (ISO)
hippocampus development  (ISO)
histone deacetylation  (ISO)
histone H3 deacetylation  (IMP,ISO)
histone H3-K27 methylation  (ISO)
histone H4 deacetylation  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of canonical Wnt signaling pathway  (ISO)
negative regulation of cardiac muscle cell proliferation  (ISO)
negative regulation of dendritic spine development  (IMP)
negative regulation of DNA binding  (IMP)
negative regulation of DNA-binding transcription factor activity  (ISO)
negative regulation of intrinsic apoptotic signaling pathway  (ISO)
negative regulation of miRNA transcription  (ISO)
negative regulation of neuron projection development  (IMP,ISO)
negative regulation of peptidyl-lysine acetylation  (IMP)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of transcription, DNA-templated  (IMP,ISO)
neuron differentiation  (ISO)
odontogenesis of dentin-containing tooth  (ISO)
oligodendrocyte differentiation  (ISO)
positive regulation of cell population proliferation  (IMP,ISO)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of epithelial to mesenchymal transition  (IMP)
positive regulation of interleukin-1 production  (IMP)
positive regulation of male mating behavior  (IMP)
positive regulation of oligodendrocyte differentiation  (IMP,ISO)
positive regulation of proteolysis  (ISO)
positive regulation of signaling receptor activity  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of tumor necrosis factor production  (IMP)
positive regulation of tyrosine phosphorylation of STAT protein  (IMP)
protein deacetylation  (ISO)
regulation of protein deacetylation  (ISO)
regulation of protein kinase B signaling  (ISO)
regulation of sarcomere organization  (ISO)
regulation of transcription by RNA polymerase II  (IBA)
response to amphetamine  (IEP)
response to caffeine  (IEP)
response to cocaine  (IEP)
response to hyperoxia  (IEP)
response to lipopolysaccharide  (IEP)
response to nicotine  (IEP)
response to xenobiotic stimulus  (IEP)

References

References - curated
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Additional References at PubMed
PMID:8889548   PMID:10431247   PMID:10888872   PMID:11062478   PMID:11641274   PMID:12007404   PMID:12403844   PMID:12477932   PMID:12975471   PMID:14519686   PMID:14643676   PMID:14966270  
PMID:15051733   PMID:15226430   PMID:16217013   PMID:17182846   PMID:17322895   PMID:17392792   PMID:17785205   PMID:17827154   PMID:18316616   PMID:18347167   PMID:18458156   PMID:18768922  
PMID:19041327   PMID:19139378   PMID:19276356   PMID:19372552   PMID:19380719   PMID:19503085   PMID:19644445   PMID:20075857   PMID:20720167   PMID:20833366   PMID:20972425   PMID:21093383  
PMID:21166804   PMID:21177534   PMID:22391310   PMID:22681889   PMID:22770845   PMID:22926524   PMID:23516383   PMID:23980619   PMID:24111946   PMID:24137001   PMID:24675724   PMID:24936141  
PMID:24970816   PMID:25241747   PMID:25380525   PMID:26962001   PMID:26998823   PMID:28046085   PMID:28053041   PMID:28177689   PMID:29257262   PMID:30177751   PMID:30213210   PMID:30452948  
PMID:30483749   PMID:31022463   PMID:31108155   PMID:31493239   PMID:32847971   PMID:33378103   PMID:33750441   PMID:35263606  


Genomics

Comparative Map Data
Hdac2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22040,548,250 - 40,571,609 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl2040,548,250 - 40,571,609 (+)Ensembl
Rnor_6.02043,084,870 - 43,108,198 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2043,084,870 - 43,108,198 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02044,811,967 - 44,835,337 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42041,162,093 - 41,186,492 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12041,204,917 - 41,209,275 (+)NCBI
Celera2041,298,790 - 41,322,159 (+)NCBICelera
Cytogenetic Map20q12NCBI
HDAC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386113,933,028 - 113,971,148 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl6113,933,028 - 114,011,308 (-)EnsemblGRCh38hg38GRCh38
GRCh376114,254,192 - 114,292,312 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366114,364,019 - 114,399,047 (-)NCBINCBI36hg18NCBI36
Build 346114,368,619 - 114,398,967NCBI
Celera6114,998,693 - 115,033,733 (-)NCBI
Cytogenetic Map6q21NCBI
HuRef6111,834,121 - 111,869,161 (-)NCBIHuRef
CHM1_16114,520,179 - 114,555,225 (-)NCBICHM1_1
T2T-CHM13v2.06115,116,117 - 115,154,233 (-)NCBI
Hdac2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391036,850,293 - 36,877,885 (+)NCBIGRCm39mm39
GRCm39 Ensembl1036,850,540 - 36,877,885 (+)Ensembl
GRCm381036,974,297 - 37,001,889 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1036,974,544 - 37,001,889 (+)EnsemblGRCm38mm10GRCm38
MGSCv371036,694,350 - 36,721,694 (+)NCBIGRCm37mm9NCBIm37
MGSCv361036,663,960 - 36,691,304 (+)NCBImm8
Celera1037,867,952 - 37,895,247 (+)NCBICelera
Cytogenetic Map10B1NCBI
cM Map1019.44NCBI
Hdac2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555262,728,377 - 2,759,707 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555262,739,099 - 2,759,640 (+)NCBIChiLan1.0ChiLan1.0
HDAC2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.16115,802,367 - 115,833,004 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6115,802,367 - 115,833,004 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v06111,731,139 - 111,761,826 (-)NCBIMhudiblu_PPA_v0panPan3
HDAC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11270,053,822 - 70,083,491 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1270,053,297 - 70,103,578 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1269,799,259 - 69,828,714 (-)NCBI
ROS_Cfam_1.01270,933,049 - 70,962,557 (-)NCBI
ROS_Cfam_1.0 Ensembl1270,932,535 - 70,961,523 (-)Ensembl
UMICH_Zoey_3.11270,285,352 - 70,314,769 (-)NCBI
UNSW_CanFamBas_1.01270,123,758 - 70,153,135 (-)NCBI
UU_Cfam_GSD_1.01270,454,633 - 70,484,021 (-)NCBI
Hdac2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946105,216,548 - 105,242,461 (-)NCBI
SpeTri2.0NW_0049366792,448,676 - 2,474,641 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HDAC2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl179,863,094 - 79,901,585 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1179,867,713 - 79,901,597 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2189,929,206 - 89,962,996 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HDAC2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11359,873,248 - 59,904,542 (+)NCBIChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604032,233,290 - 32,264,328 (+)NCBIVero_WHO_p1.0
Hdac2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248564,834,217 - 4,861,592 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046248564,834,197 - 4,861,546 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
RH127658  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map4649.61UniSTS
Cytogenetic Map20q12UniSTS
RH136178  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22040,571,152 - 40,571,386 (-)MAPPERmRatBN7.2
Rnor_6.02043,085,093 - 43,085,326NCBIRnor6.0
Rnor_5.02044,812,190 - 44,812,423UniSTSRnor5.0
Cytogenetic Map20q12UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
7411652Foco24Food consumption QTL 240.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)201175751554435887Rat
9590092Insglur9Insulin/glucose ratio QTL 918.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)201175751554435887Rat
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)201761783247606836Rat
2317880Alcrsp25Alcohol response QTL 252.3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)201769755054435887Rat
2303626Vencon10Ventilatory control QTL 100.001respiration trait (VT:0001943)respiration rate (CMO:0000289)201919072154435887Rat
2303578Gluco50Glucose level QTL 502blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)202510672254435887Rat
2303587Bw93Body weight QTL 9313body mass (VT:0001259)body weight (CMO:0000012)202510672254435887Rat
2300188Bmd68Bone mineral density QTL 686.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)202510672254435887Rat
1331747Hrtrt16Heart rate QTL 163.163heart pumping trait (VT:2000009)heart rate (CMO:0000002)202520973454435887Rat
1598869Memor6Memory QTL 63.1exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)202924438854435887Rat
70158Bp60Blood pressure QTL 603arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)203161428444396023Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:382
Count of miRNA genes:232
Interacting mature miRNAs:261
Transcripts:ENSRNOT00000000742
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000000742   ⟹   ENSRNOP00000000742
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2040,548,250 - 40,571,609 (+)Ensembl
Rnor_6.0 Ensembl2043,084,870 - 43,108,198 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000100766   ⟹   ENSRNOP00000094992
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2040,548,250 - 40,568,854 (+)Ensembl
RefSeq Acc Id: NM_053447   ⟹   NP_445899
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22040,548,250 - 40,571,609 (+)NCBI
Rnor_6.02043,084,870 - 43,108,198 (-)NCBI
Rnor_5.02044,811,967 - 44,835,337 (-)NCBI
RGSC_v3.42041,162,093 - 41,186,492 (+)RGD
Celera2041,298,790 - 41,322,159 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_445899 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI61939 (Get FASTA)   NCBI Sequence Viewer  
  AAK11183 (Get FASTA)   NCBI Sequence Viewer  
  EDL87791 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_445899   ⟸   NM_053447
- UniProtKB: B1WBY8 (UniProtKB/TrEMBL),   F7ENH8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000000742   ⟸   ENSRNOT00000000742
RefSeq Acc Id: ENSRNOP00000094992   ⟸   ENSRNOT00000100766
Protein Domains
Hist_deacetyl

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F7ENH8-F1-model_v2 AlphaFold F7ENH8 1-488 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701645
Promoter ID:EPDNEW_R12169
Type:multiple initiation site
Name:Hdac2_1
Description:histone deacetylase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02043,108,204 - 43,108,264EPDNEW

Strain Variation

Strain Sequence Variants (MRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
Damaging Variants


Assembly: Rnor_6.0
Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
20 43092609 43092610 A C snv Buf/N (MCW), F344/NRrrc (MCW), WN/N (MCW), WKY/N (MCW), M520/N (MCW)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619976 AgrOrtholog
BioCyc Gene G2FUF-3523 BioCyc
Ensembl Genes ENSRNOG00000000604 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000000742 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000000742 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 3.40.800.20 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:9023326 IMAGE-MGC_LOAD
InterPro His_deacetylse UniProtKB/TrEMBL
  His_deacetylse_1 UniProtKB/TrEMBL
  His_deacetylse_dom UniProtKB/TrEMBL
  His_deacetylse_dom_sf UniProtKB/TrEMBL
  Ureohydrolase_domain UniProtKB/TrEMBL
KEGG Report rno:84577 UniProtKB/TrEMBL
MGC_CLONE MGC:187727 IMAGE-MGC_LOAD
NCBI Gene 84577 ENTREZGENE
Pfam Hist_deacetyl UniProtKB/TrEMBL
PhenoGen Hdac2 PhenoGen
PIRSF His_deacetylse_1 UniProtKB/TrEMBL
PRINTS HDASUPER UniProtKB/TrEMBL
  HISDACETLASE UniProtKB/TrEMBL
Superfamily-SCOP SSF52768 UniProtKB/TrEMBL
UniProt B1WBY8 ENTREZGENE, UniProtKB/TrEMBL
  F7ENH8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-08-07 Hdac2  histone deacetylase 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in embryonic rat hippocampal progenitors 704464