Dna2 (DNA replication helicase/nuclease 2) - Rat Genome Database

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Gene: Dna2 (DNA replication helicase/nuclease 2) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Dna2
Name: DNA replication helicase/nuclease 2
RGD ID: 1306791
Description: Predicted to enable catalytic activity, acting on DNA and nucleic acid binding activity. Predicted to be involved in DNA metabolic process and DNA replication checkpoint signaling. Predicted to be located in mitochondrial inner membrane; mitochondrial nucleoid; and nucleoplasm. Predicted to be part of gamma DNA polymerase complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in Seckel syndrome 8; autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 6; isolated growth hormone deficiency type IA; and mitochondrial myopathy. Orthologous to human DNA2 (DNA replication helicase/nuclease 2); PARTICIPATES IN homologous recombination pathway of double-strand break repair; DNA replication pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; amphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: DNA replication ATP-dependent helicase-like homolog; DNA replication ATP-dependent helicase/nuclease DNA2; DNA replication helicase 2 homolog; DNA replication helicase 2 homolog (yeast); DNA2 DNA replication helicase 2-like; DNA2 DNA replication helicase 2-like (yeast); DNA2-like helicase; Dna2l; LOC309762; similar to DNA2 DNA replication helicase 2-like
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82025,660,339 - 25,689,285 (-)NCBIGRCr8
mRatBN7.22025,661,652 - 25,690,598 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2025,662,055 - 25,716,319 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2026,355,103 - 26,384,055 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02025,708,131 - 25,737,083 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02026,294,181 - 26,323,127 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_5.02029,093,620 - 29,123,086 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42025,288,326 - 25,316,851 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12025,302,172 - 25,363,960 (+)NCBI
Celera2026,956,734 - 26,986,153 (-)NCBICelera
Cytogenetic Map20q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Regulation of homologous recombination in eukaryotes. Heyer WD, etal., Annu Rev Genet. 2010;44:113-39. doi: 10.1146/annurev-genet-051710-150955.
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Comprehensive gene review and curation RGD comprehensive gene curation
8. Mutations in DNA2 link progressive myopathy to mitochondrial DNA instability. Ronchi D, etal., Am J Hum Genet. 2013 Feb 7;92(2):293-300. doi: 10.1016/j.ajhg.2012.12.014. Epub 2013 Jan 24.
9. Genomic analysis of primordial dwarfism reveals novel disease genes. Shaheen R, etal., Genome Res. 2014 Feb;24(2):291-9. doi: 10.1101/gr.160572.113. Epub 2014 Jan 3.
Additional References at PubMed
PMID:31904090  


Genomics

Variants

.
Variants in Dna2
18 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:73
Count of miRNA genes:72
Interacting mature miRNAs:72
Transcripts:ENSRNOT00000000438
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)201761783247606836Rat
2303587Bw93Body weight QTL 9313body mass (VT:0001259)body weight (CMO:0000012)202510672254435887Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20289259726381954Rat
4889870Pur30Proteinuria QTL 30190.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20804241029322208Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
2303626Vencon10Ventilatory control QTL 100.001respiration trait (VT:0001943)respiration rate (CMO:0000289)201919072154435887Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
7411652Foco24Food consumption QTL 240.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)201175751554435887Rat
1331747Hrtrt16Heart rate QTL 163.163heart pumping trait (VT:2000009)heart rate (CMO:0000002)202520973454435887Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
2303578Gluco50Glucose level QTL 502blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)202510672254435887Rat
2317880Alcrsp25Alcohol response QTL 252.3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)201769755054435887Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat
9590092Insglur9Insulin/glucose ratio QTL 918.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)201175751554435887Rat
2300188Bmd68Bone mineral density QTL 686.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)202510672254435887Rat

Markers in Region
RH128448  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22025,692,082 - 25,692,283 (+)MAPPERmRatBN7.2
Rnor_6.02027,283,901 - 27,284,101NCBIRnor6.0
Rnor_5.02029,124,544 - 29,124,744UniSTSRnor5.0
RGSC_v3.42025,286,626 - 25,286,826UniSTSRGSC3.4
Celera2026,987,633 - 26,987,833UniSTS
Cytogenetic Map20p11UniSTS
AU049833  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22025,685,479 - 25,685,664 (+)MAPPERmRatBN7.2
Rnor_6.02027,277,300 - 27,277,482NCBIRnor6.0
Rnor_5.02029,117,943 - 29,118,125UniSTSRnor5.0
RGSC_v3.42025,293,245 - 25,293,427UniSTSRGSC3.4
Celera2026,981,032 - 26,981,214UniSTS
Cytogenetic Map20p11UniSTS


Expression


Sequence


Ensembl Acc Id: ENSRNOT00000000438   ⟹   ENSRNOP00000000438
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2025,663,299 - 25,716,319 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000056047   ⟹   ENSRNOP00000052899
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2025,691,567 - 25,716,319 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000102171   ⟹   ENSRNOP00000077473
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2025,663,299 - 25,707,418 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000103093   ⟹   ENSRNOP00000083522
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2025,662,055 - 25,690,593 (-)Ensembl
RefSeq Acc Id: NM_001389622   ⟹   NP_001376551
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82025,660,339 - 25,689,285 (-)NCBI
mRatBN7.22025,661,652 - 25,690,598 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001376551 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein D3ZG52 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000000438.6
  ENSRNOP00000077473.1
  ENSRNOP00000083522.1
RefSeq Acc Id: NP_001376551   ⟸   NM_001389622
- UniProtKB: D3ZG52 (UniProtKB/Swiss-Prot),   A0A8I5ZZI9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000000438   ⟸   ENSRNOT00000000438
Ensembl Acc Id: ENSRNOP00000052899   ⟸   ENSRNOT00000056047
Ensembl Acc Id: ENSRNOP00000077473   ⟸   ENSRNOT00000102171
Ensembl Acc Id: ENSRNOP00000083522   ⟸   ENSRNOT00000103093
Protein Domains
DNA replication factor Dna2 N-terminal   DNA2 rift barrel   DNA2/NAM7 helicase helicase   DNA2/NAM7 helicase-like C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZG52-F1-model_v2 AlphaFold D3ZG52 1-1059 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306791 AgrOrtholog
BioCyc Gene G2FUF-3807 BioCyc
Ensembl Genes ENSRNOG00000000387 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000000438.8 UniProtKB/TrEMBL
  ENSRNOT00000102171.1 UniProtKB/TrEMBL
  ENSRNOT00000103093.1 UniProtKB/TrEMBL
Gene3D-CATH 1.50.40.10 UniProtKB/TrEMBL
  2.40.30.270 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.90.320.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Dna2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA2/NAM7-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA2/NAM7-like_AAA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA2/NAM7_AAA_11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA2_Rift UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA_replication_fac_Dna2_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Graves_DC UniProtKB/TrEMBL
  Mit_carrier UniProtKB/TrEMBL
  Mitochondrial_sb/sol_carrier UniProtKB/TrEMBL
  Mt_carrier_dom_sf UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDDEXK-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SF1_C_Upf1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 309762 ENTREZGENE
PANTHER PTHR10887 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10887:SF433 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam AAA_11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AAA_12 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dna2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dna2_Rift UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mito_carr UniProtKB/TrEMBL
PhenoGen Dna2 PhenoGen
PRINTS GRAVESDC UniProtKB/TrEMBL
  MITOCARRIER UniProtKB/TrEMBL
PROSITE SOLCAR UniProtKB/TrEMBL
RatGTEx ENSRNOG00000000387 RatGTEx
Superfamily-SCOP SSF103506 UniProtKB/TrEMBL
  SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0H2UH92_RAT UniProtKB/TrEMBL
  A0A8I5Y1L7_RAT UniProtKB/TrEMBL
  A0A8I5ZZI9 ENTREZGENE, UniProtKB/TrEMBL
  D3ZG52 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-05-24 Dna2  DNA replication helicase/nuclease 2  LOC687919  similar to DNA2 DNA replication helicase 2-like  Data merged from RGD:1594929 1643240 APPROVED
2013-05-22 Dna2  DNA replication helicase/nuclease 2  Dna2  DNA replication helicase 2 homolog (yeast)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-25 Dna2  DNA replication helicase 2 homolog (yeast)  Dna2l_predicted  DNA2 DNA replication helicase 2-like (yeast) (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC687919  similar to DNA2 DNA replication helicase 2-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-12 Dna2l_predicted  DNA2 DNA replication helicase 2-like (yeast) (predicted)      Symbol and Name status set to approved 70820 APPROVED