Dna2 (DNA replication helicase/nuclease 2) - Rat Genome Database
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Gene: Dna2 (DNA replication helicase/nuclease 2) Rattus norvegicus
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Symbol: Dna2
Name: DNA replication helicase/nuclease 2
RGD ID: 1306791
Description: ENCODES a protein that exhibits 5'-3' DNA helicase activity (ortholog); 5'-flap endonuclease activity (ortholog); DNA binding (ortholog); INVOLVED IN base-excision repair (ortholog); DNA double-strand break processing (ortholog); DNA replication (ortholog); PARTICIPATES IN homologous recombination pathway of double-strand break repair; DNA replication pathway; ASSOCIATED WITH autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 6 (ortholog); congenital myopathy (ortholog); genetic disease (ortholog); FOUND IN chromosome, telomeric region (ortholog); gamma DNA polymerase complex (ortholog); mitochondrial nucleoid (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; amphetamine; bisphenol A
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: DNA replication ATP-dependent helicase-like homolog; DNA replication ATP-dependent helicase/nuclease DNA2; DNA replication helicase 2 homolog; DNA replication helicase 2 homolog (yeast); DNA2 DNA replication helicase 2-like; DNA2 DNA replication helicase 2-like (yeast); DNA2-like helicase; Dna2l; LOC309762; similar to DNA2 DNA replication helicase 2-like
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22025,661,652 - 25,690,598 (-)NCBI
Rnor_5.02029,093,620 - 29,123,086 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42025,288,326 - 25,316,851 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12025,302,172 - 25,363,960 (+)NCBI
Celera2026,956,734 - 26,986,153 (-)NCBICelera
Cytogenetic Map20p11NCBI


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:31904090  


Genomics

Comparative Map Data
Dna2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22025,661,652 - 25,690,598 (-)NCBI
Rnor_5.02029,093,620 - 29,123,086 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42025,288,326 - 25,316,851 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12025,302,172 - 25,363,960 (+)NCBI
Celera2026,956,734 - 26,986,153 (-)NCBICelera
Cytogenetic Map20p11NCBI
DNA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1068,414,064 - 68,472,121 (-)EnsemblGRCh38hg38GRCh38
GRCh381068,414,064 - 68,472,521 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371070,173,821 - 70,231,878 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361069,843,827 - 69,901,885 (-)NCBINCBI36hg18NCBI36
Build 341069,843,827 - 69,901,678NCBI
Celera1063,449,181 - 63,507,264 (-)NCBI
Cytogenetic Map10q21.3NCBI
HuRef1064,173,263 - 64,231,457 (-)NCBIHuRef
CHM1_11070,455,594 - 70,514,126 (-)NCBICHM1_1
Dna2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391062,782,762 - 62,809,967 (+)NCBIGRCm39mm39
GRCm381062,946,983 - 62,974,188 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1062,947,026 - 62,974,185 (+)EnsemblGRCm38mm10GRCm38
MGSCv371062,409,777 - 62,436,936 (+)NCBIGRCm37mm9NCBIm37
MGSCv361062,342,410 - 62,369,534 (+)NCBImm8
Celera1064,048,162 - 64,075,318 (+)NCBICelera
Cytogenetic Map10B4NCBI
Dna2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542520,661,727 - 20,702,754 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542520,664,412 - 20,705,070 (-)NCBIChiLan1.0ChiLan1.0
DNA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11067,207,261 - 67,264,257 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1067,207,261 - 67,264,257 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01064,898,024 - 64,956,541 (-)NCBIMhudiblu_PPA_v0panPan3
DNA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl419,626,977 - 19,684,660 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1419,626,001 - 19,683,819 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dna2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365219,843,867 - 9,884,248 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DNA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1471,549,815 - 71,651,089 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11471,550,405 - 71,607,067 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21477,609,353 - 77,643,988 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DNA2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1962,926,221 - 62,985,843 (+)NCBI
ChlSab1.1 Ensembl962,926,674 - 62,985,842 (+)Ensembl
Dna2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247542,746,912 - 2,791,560 (-)NCBI

Position Markers
RH128448  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.02027,283,901 - 27,284,101NCBIRnor6.0
Rnor_5.02029,124,544 - 29,124,744UniSTSRnor5.0
RGSC_v3.42025,286,626 - 25,286,826UniSTSRGSC3.4
Celera2026,987,633 - 26,987,833UniSTS
Cytogenetic Map20p11UniSTS
AU049833  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.02027,277,300 - 27,277,482NCBIRnor6.0
Rnor_5.02029,117,943 - 29,118,125UniSTSRnor5.0
RGSC_v3.42025,293,245 - 25,293,427UniSTSRGSC3.4
Celera2026,981,032 - 26,981,214UniSTS
Cytogenetic Map20p11UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:73
Count of miRNA genes:72
Interacting mature miRNAs:72
Transcripts:ENSRNOT00000000438
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001389622 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JACYVU010000324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: NM_001389622   ⟹   NP_001376551
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22025,661,652 - 25,690,598 (-)NCBI
RefSeq Acc Id: XM_002725830   ⟹   XP_002725876
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Celera2026,956,734 - 26,986,153 (-)NCBI
RefSeq Acc Id: XM_006223878   ⟹   XP_006223940
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Celera2026,956,734 - 26,986,153 (-)NCBI
RefSeq Acc Id: XM_006256397   ⟹   XP_006256459
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_5.02029,093,620 - 29,123,086 (-)NCBI
RefSeq Acc Id: XM_241671   ⟹   XP_241671
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_5.02029,093,620 - 29,123,086 (-)NCBI
RGSC_v3.42025,288,326 - 25,316,851 (+)RGD
Protein Sequences
Protein RefSeqs NP_001376551 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein D3ZG52 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_002725876   ⟸   XM_002725830
- Peptide Label: isoform X1
RefSeq Acc Id: XP_241671   ⟸   XM_241671
- Peptide Label: isoform X2
RefSeq Acc Id: XP_006223940   ⟸   XM_006223878
RefSeq Acc Id: XP_006256459   ⟸   XM_006256397
RefSeq Acc Id: NP_001376551   ⟸   NM_001389622
Protein Domains
AAA_11   AAA_12   Dna2

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSRNOG00000000387 UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000000438 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000000438 UniProtKB/TrEMBL
Gene3D-CATH 1.50.40.10 UniProtKB/TrEMBL
InterPro Dna2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA2/NAM7-like_AAA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA2/NAM7_AAA_11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA_replication_fac_Dna2_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Graves_DC UniProtKB/TrEMBL
  Mit_carrier UniProtKB/TrEMBL
  Mitochondrial_sb/sol_carrier UniProtKB/TrEMBL
  Mt_carrier_dom_sf UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 309762 ENTREZGENE
PANTHER PTHR10887:SF433 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam AAA_11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AAA_12 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dna2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mito_carr UniProtKB/TrEMBL
PhenoGen Dna2 PhenoGen
PRINTS GRAVESDC UniProtKB/TrEMBL
  MITOCARRIER UniProtKB/TrEMBL
PROSITE SOLCAR UniProtKB/TrEMBL
Superfamily-SCOP SSF103506 UniProtKB/TrEMBL
  SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0H2UH92_RAT UniProtKB/TrEMBL
  D3ZG52 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-05-24 Dna2  DNA replication helicase/nuclease 2  LOC687919  similar to DNA2 DNA replication helicase 2-like  Data Merged 1643240 APPROVED
2013-05-22 Dna2  DNA replication helicase/nuclease 2  Dna2  DNA replication helicase 2 homolog (yeast)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-25 Dna2  DNA replication helicase 2 homolog (yeast)  Dna2l_predicted  DNA2 DNA replication helicase 2-like (yeast) (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC687919  similar to DNA2 DNA replication helicase 2-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-12 Dna2l_predicted  DNA2 DNA replication helicase 2-like (yeast) (predicted)      Symbol and Name status set to approved 70820 APPROVED