Dna2 (DNA replication helicase/nuclease 2) - Rat Genome Database

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Gene: Dna2 (DNA replication helicase/nuclease 2) Rattus norvegicus
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Symbol: Dna2
Name: DNA replication helicase/nuclease 2
RGD ID: 1306791
Description: ENCODES a protein that exhibits 5'-3' DNA helicase activity (ortholog); 5'-flap endonuclease activity (ortholog); DNA binding (ortholog); INVOLVED IN base-excision repair (ortholog); DNA double-strand break processing (ortholog); DNA replication (ortholog); PARTICIPATES IN homologous recombination pathway of double-strand break repair; DNA replication pathway; ASSOCIATED WITH autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 6 (ortholog); congenital myopathy (ortholog); genetic disease (ortholog); FOUND IN chromosome, telomeric region (ortholog); gamma DNA polymerase complex (ortholog); mitochondrial nucleoid (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; amphetamine; bisphenol A
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: DNA replication ATP-dependent helicase-like homolog; DNA replication ATP-dependent helicase/nuclease DNA2; DNA replication helicase 2 homolog; DNA replication helicase 2 homolog (yeast); DNA2 DNA replication helicase 2-like; DNA2 DNA replication helicase 2-like (yeast); DNA2-like helicase; Dna2l; LOC309762; similar to DNA2 DNA replication helicase 2-like
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22025,661,652 - 25,690,598 (-)NCBImRatBN7.2
Rnor_5.02029,093,620 - 29,123,086 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42025,288,326 - 25,316,851 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12025,302,172 - 25,363,960 (+)NCBI
Celera2026,956,734 - 26,986,153 (-)NCBICelera
Cytogenetic Map20p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:31904090  


Genomics

Comparative Map Data
Dna2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22025,661,652 - 25,690,598 (-)NCBImRatBN7.2
Rnor_5.02029,093,620 - 29,123,086 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42025,288,326 - 25,316,851 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12025,302,172 - 25,363,960 (+)NCBI
Celera2026,956,734 - 26,986,153 (-)NCBICelera
Cytogenetic Map20p11NCBI
DNA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1068,414,064 - 68,472,121 (-)EnsemblGRCh38hg38GRCh38
GRCh381068,414,064 - 68,472,521 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371070,173,821 - 70,231,878 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361069,843,827 - 69,901,885 (-)NCBINCBI36hg18NCBI36
Build 341069,843,827 - 69,901,678NCBI
Celera1063,449,181 - 63,507,264 (-)NCBI
Cytogenetic Map10q21.3NCBI
HuRef1064,173,263 - 64,231,457 (-)NCBIHuRef
CHM1_11070,455,594 - 70,514,126 (-)NCBICHM1_1
Dna2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391062,782,762 - 62,809,967 (+)NCBIGRCm39mm39
GRCm39 Ensembl1062,782,805 - 62,809,964 (+)Ensembl
GRCm381062,946,983 - 62,974,188 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1062,947,026 - 62,974,185 (+)EnsemblGRCm38mm10GRCm38
MGSCv371062,409,777 - 62,436,936 (+)NCBIGRCm37mm9NCBIm37
MGSCv361062,342,410 - 62,369,534 (+)NCBImm8
Celera1064,048,162 - 64,075,318 (+)NCBICelera
Cytogenetic Map10B4NCBI
Dna2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542520,661,727 - 20,702,754 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542520,664,412 - 20,705,070 (-)NCBIChiLan1.0ChiLan1.0
DNA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11067,207,261 - 67,264,257 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1067,207,261 - 67,264,257 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01064,898,024 - 64,956,541 (-)NCBIMhudiblu_PPA_v0panPan3
DNA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1419,626,001 - 19,683,819 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl419,626,977 - 19,684,660 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha419,758,312 - 19,814,534 (-)NCBI
ROS_Cfam_1.0419,896,502 - 19,954,684 (-)NCBI
UMICH_Zoey_3.1419,798,388 - 19,856,607 (-)NCBI
UNSW_CanFamBas_1.0420,000,469 - 20,058,335 (-)NCBI
UU_Cfam_GSD_1.0420,343,723 - 20,401,576 (-)NCBI
Dna2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721361,351,058 - 61,392,148 (+)NCBI
SpeTri2.0NW_0049365219,843,867 - 9,884,248 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DNA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1471,549,815 - 71,651,089 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11471,550,405 - 71,607,067 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21477,609,353 - 77,643,988 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DNA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1962,926,221 - 62,985,843 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl962,926,674 - 62,985,842 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604823,687,256 - 23,749,223 (+)NCBIVero_WHO_p1.0
Dna2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247542,746,912 - 2,791,560 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
RH128448  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22025,692,082 - 25,692,283 (+)MAPPERmRatBN7.2
Rnor_6.02027,283,901 - 27,284,101NCBIRnor6.0
Rnor_5.02029,124,544 - 29,124,744UniSTSRnor5.0
RGSC_v3.42025,286,626 - 25,286,826UniSTSRGSC3.4
Celera2026,987,633 - 26,987,833UniSTS
Cytogenetic Map20p11UniSTS
AU049833  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22025,685,479 - 25,685,664 (+)MAPPERmRatBN7.2
Rnor_6.02027,277,300 - 27,277,482NCBIRnor6.0
Rnor_5.02029,117,943 - 29,118,125UniSTSRnor5.0
RGSC_v3.42025,293,245 - 25,293,427UniSTSRGSC3.4
Celera2026,981,032 - 26,981,214UniSTS
Cytogenetic Map20p11UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20289259726381954Rat
4889870Pur30Proteinuria QTL 30190.005total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20804241029322208Rat
7411652Foco24Food consumption QTL 240.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)201175751554435887Rat
9590092Insglur9Insulin/glucose ratio QTL 918.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)201175751554435887Rat
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)201761783247606836Rat
2317880Alcrsp25Alcohol response QTL 252.3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)201769755054435887Rat
2303626Vencon10Ventilatory control QTL 100.001respiration trait (VT:0001943)respiration rate (CMO:0000289)201919072154435887Rat
2303578Gluco50Glucose level QTL 502blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)202510672254435887Rat
2303587Bw93Body weight QTL 9313body mass (VT:0001259)body weight (CMO:0000012)202510672254435887Rat
2300188Bmd68Bone mineral density QTL 686.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)202510672254435887Rat
1331747Hrtrt16Heart rate QTL 163.163heart pumping trait (VT:2000009)heart rate (CMO:0000002)202520973454435887Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:73
Count of miRNA genes:72
Interacting mature miRNAs:72
Transcripts:ENSRNOT00000000438
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: NM_001389622   ⟹   NP_001376551
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22025,661,652 - 25,690,598 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001376551 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein D3ZG52 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001376551   ⟸   NM_001389622
Protein Domains
AAA_11   AAA_12   Dna2

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSRNOG00000000387 UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000000438 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000000438 UniProtKB/TrEMBL
Gene3D-CATH 1.50.40.10 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Dna2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA2/NAM7-like_AAA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA2/NAM7_AAA_11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA_replication_fac_Dna2_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Graves_DC UniProtKB/TrEMBL
  Mit_carrier UniProtKB/TrEMBL
  Mitochondrial_sb/sol_carrier UniProtKB/TrEMBL
  Mt_carrier_dom_sf UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 309762 ENTREZGENE
PANTHER PTHR10887:SF433 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam AAA_11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AAA_12 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dna2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mito_carr UniProtKB/TrEMBL
PhenoGen Dna2 PhenoGen
PRINTS GRAVESDC UniProtKB/TrEMBL
  MITOCARRIER UniProtKB/TrEMBL
PROSITE SOLCAR UniProtKB/TrEMBL
Superfamily-SCOP SSF103506 UniProtKB/TrEMBL
  SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0H2UH92_RAT UniProtKB/TrEMBL
  D3ZG52 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-05-24 Dna2  DNA replication helicase/nuclease 2  LOC687919  similar to DNA2 DNA replication helicase 2-like  Data Merged 1643240 APPROVED
2013-05-22 Dna2  DNA replication helicase/nuclease 2  Dna2  DNA replication helicase 2 homolog (yeast)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-25 Dna2  DNA replication helicase 2 homolog (yeast)  Dna2l_predicted  DNA2 DNA replication helicase 2-like (yeast) (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC687919  similar to DNA2 DNA replication helicase 2-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-12 Dna2l_predicted  DNA2 DNA replication helicase 2-like (yeast) (predicted)      Symbol and Name status set to approved 70820 APPROVED