RGD Reference Report - Regulation of homologous recombination in eukaryotes. - Rat Genome Database

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Regulation of homologous recombination in eukaryotes.

Authors: Heyer, WD  Ehmsen, KT  Liu, J 
Citation: Heyer WD, etal., Annu Rev Genet. 2010;44:113-39. doi: 10.1146/annurev-genet-051710-150955.
RGD ID: 8662366
Pubmed: PMID:20690856   (View Abstract at PubMed)
PMCID: PMC4114321   (View Article at PubMed Central)
DOI: DOI:10.1146/annurev-genet-051710-150955   (Journal Full-text)

Homologous recombination (HR) is required for accurate chromosome segregation during the first meiotic division and constitutes a key repair and tolerance pathway for complex DNA damage, including DNA double-strand breaks, interstrand crosslinks, and DNA gaps. In addition, recombination and replication are inextricably linked, as recombination recovers stalled and broken replication forks, enabling the evolution of larger genomes/replicons. Defects in recombination lead to genomic instability and elevated cancer predisposition, demonstrating a clear cellular need for recombination. However, recombination can also lead to genome rearrangements. Unrestrained recombination causes undesired endpoints (translocation, deletion, inversion) and the accumulation of toxic recombination intermediates. Evidently, HR must be carefully regulated to match specific cellular needs. Here, we review the factors and mechanistic stages of recombination that are subject to regulation and suggest that recombination achieves flexibility and robustness by proceeding through metastable, reversible intermediates.



Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations


  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
BLMHumanhomologous recombination pathway of double-strand break repair   TAS  RGD 
BRCA2Humanhomologous recombination pathway of double-strand break repair   TAS  RGD 
BlmRathomologous recombination pathway of double-strand break repair   ISOBLM (Homo sapiens) RGD 
BlmMousehomologous recombination pathway of double-strand break repair   ISOBLM (Homo sapiens) RGD 
Brca2Rathomologous recombination pathway of double-strand break repair   ISOBRCA2 (Homo sapiens) RGD 
Brca2Mousehomologous recombination pathway of double-strand break repair   ISOBRCA2 (Homo sapiens) RGD 
DNA2Humanhomologous recombination pathway of double-strand break repair   TAS  RGD 
Dna2Rathomologous recombination pathway of double-strand break repair   ISODNA2 (Homo sapiens) RGD 
Dna2Mousehomologous recombination pathway of double-strand break repair   ISODNA2 (Homo sapiens) RGD 
EXO1Humanhomologous recombination pathway of double-strand break repair   TAS  RGD 
Exo1Rathomologous recombination pathway of double-strand break repair   ISOEXO1 (Homo sapiens) RGD 
Exo1Mousehomologous recombination pathway of double-strand break repair   ISOEXO1 (Homo sapiens) RGD 
MRE11Humanhomologous recombination pathway of double-strand break repair   TAS  RGD 
Mre11Rathomologous recombination pathway of double-strand break repair   ISOMRE11 (Homo sapiens) RGD 
Mre11aMousehomologous recombination pathway of double-strand break repair   ISOMRE11 (Homo sapiens) RGD 
NBNHumanhomologous recombination pathway of double-strand break repair   TAS  RGD 
NbnRathomologous recombination pathway of double-strand break repair   ISONBN (Homo sapiens) RGD 
NbnMousehomologous recombination pathway of double-strand break repair   ISONBN (Homo sapiens) RGD 
RAD50Humanhomologous recombination pathway of double-strand break repair   TAS  RGD 
RAD51Humanhomologous recombination pathway of double-strand break repair   TAS  RGD 
RAD51BHumanhomologous recombination pathway of double-strand break repair   TAS  RGD 
RAD51CHumanhomologous recombination pathway of double-strand break repair   TAS  RGD 
RAD51DHumanhomologous recombination pathway of double-strand break repair   TAS  RGD 
RAD54BHumanhomologous recombination pathway of double-strand break repair   TAS  RGD 
Rad50Rathomologous recombination pathway of double-strand break repair   ISORAD50 (Homo sapiens) RGD 
Rad50Mousehomologous recombination pathway of double-strand break repair   ISORAD50 (Homo sapiens) RGD 
Rad51Mousehomologous recombination pathway of double-strand break repair   ISORAD51 (Homo sapiens) RGD 
Rad51Rathomologous recombination pathway of double-strand break repair   ISORAD51 (Homo sapiens) RGD 
Rad51bMousehomologous recombination pathway of double-strand break repair   ISORAD51B (Homo sapiens) RGD 
Rad51bRathomologous recombination pathway of double-strand break repair   ISORAD51B (Homo sapiens) RGD 
Rad51cMousehomologous recombination pathway of double-strand break repair   ISORAD51C (Homo sapiens) RGD 
Rad51cRathomologous recombination pathway of double-strand break repair   ISORAD51C (Homo sapiens) RGD 
Rad51dRathomologous recombination pathway of double-strand break repair   ISORAD51D (Homo sapiens) RGD 
Rad51dMousehomologous recombination pathway of double-strand break repair   ISORAD51D (Homo sapiens) RGD 
Rad54bRathomologous recombination pathway of double-strand break repair   ISORAD54B (Homo sapiens) RGD 
Rad54bMousehomologous recombination pathway of double-strand break repair   ISORAD54B (Homo sapiens) RGD 
XRCC2Humanhomologous recombination pathway of double-strand break repair   TAS  RGD 
XRCC3Humanhomologous recombination pathway of double-strand break repair   TAS  RGD 
Xrcc2Mousehomologous recombination pathway of double-strand break repair   ISOXRCC2 (Homo sapiens) RGD 
Xrcc2Rathomologous recombination pathway of double-strand break repair   ISOXRCC2 (Homo sapiens) RGD 
Xrcc3Rathomologous recombination pathway of double-strand break repair   ISOXRCC3 (Homo sapiens) RGD 
Xrcc3Mousehomologous recombination pathway of double-strand break repair   ISOXRCC3 (Homo sapiens) RGD 
Objects Annotated

Genes (Rattus norvegicus)
Blm  (BLM RecQ like helicase)
Brca2  (BRCA2, DNA repair associated)
Dna2  (DNA replication helicase/nuclease 2)
Exo1  (exonuclease 1)
Mre11  (MRE11 homolog, double strand break repair nuclease)
Nbn  (nibrin)
Rad50  (RAD50 double strand break repair protein)
Rad51  (RAD51 recombinase)
Rad51b  (RAD51 paralog B)
Rad51c  (RAD51 paralog C)
Rad51d  (RAD51 paralog D)
Rad54b  (RAD54 homolog B)
Xrcc2  (X-ray repair cross complementing 2)
Xrcc3  (X-ray repair cross complementing 3)

Genes (Mus musculus)
Blm  (Bloom syndrome, RecQ like helicase)
Brca2  (breast cancer 2, early onset)
Dna2  (DNA replication helicase/nuclease 2)
Exo1  (exonuclease 1)
Mre11a  (MRE11A homolog A, double strand break repair nuclease)
Nbn  (nibrin)
Rad50  (RAD50 double strand break repair protein)
Rad51  (RAD51 recombinase)
Rad51b  (RAD51 paralog B)
Rad51c  (RAD51 paralog C)
Rad51d  (RAD51 paralog D)
Rad54b  (RAD54 homolog B (S. cerevisiae))
Xrcc2  (X-ray repair complementing defective repair in Chinese hamster cells 2)
Xrcc3  (X-ray repair complementing defective repair in Chinese hamster cells 3)

Genes (Homo sapiens)
BLM  (BLM RecQ like helicase)
BRCA2  (BRCA2 DNA repair associated)
DNA2  (DNA replication helicase/nuclease 2)
EXO1  (exonuclease 1)
MRE11  (MRE11 homolog, double strand break repair nuclease)
NBN  (nibrin)
RAD50  (RAD50 double strand break repair protein)
RAD51  (RAD51 recombinase)
RAD51B  (RAD51 paralog B)
RAD51C  (RAD51 paralog C)
RAD51D  (RAD51 paralog D)
RAD54B  (RAD54 homolog B)
XRCC2  (X-ray repair cross complementing 2)
XRCC3  (X-ray repair cross complementing 3)


Additional Information