Mdc1 (mediator of DNA damage checkpoint 1) - Rat Genome Database

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Gene: Mdc1 (mediator of DNA damage checkpoint 1) Rattus norvegicus
Analyze
Symbol: Mdc1
Name: mediator of DNA damage checkpoint 1
RGD ID: 1559468
Description: Predicted to enable histone reader activity. Predicted to be involved in DNA damage response; DNA replication checkpoint signaling; and protein localization to site of double-strand break. Predicted to act upstream of or within positive regulation of double-strand break repair via homologous recombination and protein K6-linked ubiquitination. Predicted to be located in chromosome and nucleus. Predicted to be active in site of double-strand break. Orthologous to human MDC1 (mediator of DNA damage checkpoint 1); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; histone modification pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: KIAA0170; mediator of DNA damage checkpoint protein 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8202,898,496 - 2,914,960 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl202,900,308 - 2,914,960 (-)EnsemblGRCr8
mRatBN7.2202,893,693 - 2,912,394 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl202,895,505 - 2,910,240 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx202,946,881 - 2,961,571 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0202,951,854 - 2,966,548 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0202,978,021 - 2,992,929 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0203,405,017 - 3,419,831 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl203,404,711 - 3,419,831 (-)Ensemblrn6Rnor6.0
Rnor_5.0205,502,120 - 5,516,934 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4203,042,953 - 3,057,607 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera20321,426 - 336,070 (-)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-alpha-phellandrene  (ISO)
17beta-estradiol  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-azacytidine  (ISO)
9-aminoacridine  (ISO)
acetamide  (EXP)
acrylamide  (EXP)
all-trans-retinoic acid  (ISO)
alpha-phellandrene  (ISO)
amphetamine  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
camptothecin  (ISO)
casticin  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
clozapine  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
Cuprizon  (EXP,ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
diazinon  (EXP)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
dieldrin  (EXP)
doxorubicin  (ISO)
Enterolactone  (ISO)
enzyme inhibitor  (ISO)
FR900359  (ISO)
genistein  (ISO)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
menadione  (ISO)
methyl methanesulfonate  (ISO)
miconazole  (ISO)
monocrotaline  (ISO)
n-propyl gallate  (ISO)
nickel atom  (EXP)
nickel dichloride  (EXP)
nickel sulfate  (EXP)
nitrates  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
paracetamol  (ISO)
paraquat  (ISO)
pentachlorophenol  (ISO)
pirinixic acid  (ISO)
quercetin  (ISO)
riddelliine  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (EXP,ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
chromosome  (IEA,ISO,ISS)
focal adhesion  (ISO)
nuclear body  (ISO)
nucleoplasm  (ISO)
nucleus  (IEA,ISO)
site of double-strand break  (ISO,ISS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. DNA damage response mediators MDC1 and 53BP1: constitutive activation and aberrant loss in breast and lung cancer, but not in testicular germ cell tumours. Bartkova J, etal., Oncogene. 2007 Nov 22;26(53):7414-22. Epub 2007 Jun 4.
2. ATM protein kinase: the linchpin of cellular defenses to stress. Bhatti S, etal., Cell Mol Life Sci. 2011 Sep;68(18):2977-3006. doi: 10.1007/s00018-011-0683-9. Epub 2011 May 2.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Push back to respond better: regulatory inhibition of the DNA double-strand break response. Panier S and Durocher D, Nat Rev Mol Cell Biol. 2013 Oct;14(10):661-72. doi: 10.1038/nrm3659. Epub 2013 Sep 4.
5. Readout of epigenetic modifications. Patel DJ and Wang Z, Annu Rev Biochem. 2013;82:81-118. doi: 10.1146/annurev-biochem-072711-165700.
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Comprehensive gene review and curation RGD comprehensive gene curation
10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
11. NFBD1/MDC1 is a protein of oncogenic potential in human cervical cancer. Yuan C, etal., Mol Cell Biochem. 2012 Jan;359(1-2):333-46. doi: 10.1007/s11010-011-1027-7. Epub 2011 Aug 19.
12. Loss of BRCA1 expression leads to worse survival in patients with gastric carcinoma. Zhang ZZ, etal., World J Gastroenterol. 2013 Mar 28;19(12):1968-74. doi: 10.3748/wjg.v19.i12.1968.
Additional References at PubMed
PMID:15060004   PMID:15489334   PMID:15604234   PMID:17577209   PMID:20008512   PMID:21293379   PMID:23039116   PMID:24217620   PMID:24550317   PMID:29656893  


Genomics

Comparative Map Data
Mdc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8202,898,496 - 2,914,960 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl202,900,308 - 2,914,960 (-)EnsemblGRCr8
mRatBN7.2202,893,693 - 2,912,394 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl202,895,505 - 2,910,240 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx202,946,881 - 2,961,571 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0202,951,854 - 2,966,548 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0202,978,021 - 2,992,929 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0203,405,017 - 3,419,831 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl203,404,711 - 3,419,831 (-)Ensemblrn6Rnor6.0
Rnor_5.0205,502,120 - 5,516,934 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4203,042,953 - 3,057,607 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera20321,426 - 336,070 (-)NCBICelera
Cytogenetic Map20p12NCBI
MDC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38630,699,807 - 30,717,281 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl630,699,807 - 30,717,562 (-)Ensemblhg38GRCh38
GRCh37630,667,584 - 30,685,058 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36630,775,563 - 30,793,437 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34630,775,563 - 30,790,934NCBI
Celera632,265,722 - 32,283,590 (-)NCBICelera
Cytogenetic Map6p21.33NCBI
HuRef630,467,532 - 30,485,406 (-)NCBIHuRef
CHM1_1630,669,686 - 30,687,581 (-)NCBICHM1_1
T2T-CHM13v2.0630,564,011 - 30,584,416 (-)NCBIT2T-CHM13v2.0
Mdc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391736,152,390 - 36,170,562 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1736,152,407 - 36,170,562 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381735,841,495 - 35,859,670 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1735,841,515 - 35,859,670 (+)Ensemblmm10GRCm38
MGSCv371735,978,443 - 35,996,615 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361735,449,706 - 35,467,725 (+)NCBIMGSCv36mm8
Celera1739,351,560 - 39,369,494 (+)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1718.7NCBI
Mdc1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955583688,288 - 722,393 (-)NCBIChiLan1.0ChiLan1.0
MDC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2545,260,018 - 45,278,434 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1641,223,716 - 41,241,276 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0630,444,570 - 30,462,432 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1631,313,898 - 31,329,246 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl631,314,560 - 31,329,243 (-)EnsemblpanPan2panpan1.1
MDC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.112496,353 - 509,812 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl12496,878 - 507,442 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha12633,666 - 647,122 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.012639,486 - 652,943 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl12639,486 - 652,569 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.112497,479 - 510,934 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.012566,333 - 579,790 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.012634,906 - 648,361 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Mdc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494633,998,611 - 34,015,580 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936837362,928 - 378,759 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936837363,870 - 379,406 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MDC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl723,229,508 - 23,247,641 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1723,229,508 - 23,247,739 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2726,951,468 - 26,969,675 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MDC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11741,735,584 - 41,754,618 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1741,739,419 - 41,755,141 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604430,396,343 - 30,414,913 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mdc1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475425,007,866 - 25,020,950 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Mdc1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1189,054,470 - 9,068,903 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Mdc1
91 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:65
Count of miRNA genes:62
Interacting mature miRNAs:64
Transcripts:ENSRNOT00000046798
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2306850Pia40Pristane induced arthritis QTL 400.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2015332005306452Rat
61474Eae1Experimental allergic encephalomyelitis QTL 13nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)2016693431Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20126925056Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20133724594Rat
7387283Uae44Urinary albumin excretion QTL 440.1712urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)20126128279Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600300Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20153308346533083Rat
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124164241Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20134066551Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129193376Rat
70154Insul2Insulin level QTL 23.75blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)2016693431Rat
4889857Pur27Proteinuria QTL 2712.20.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20127341128Rat
724519Bp144Blood pressure QTL 1440.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2013629303Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129193376Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129193376Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129193376Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129193376Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20114100378Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127341128Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127341128Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578510Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600300Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000046798   ⟹   ENSRNOP00000049009
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl202,900,308 - 2,914,960 (-)Ensembl
mRatBN7.2 Ensembl202,895,505 - 2,910,160 (-)Ensembl
Rnor_6.0 Ensembl203,405,018 - 3,419,831 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000077632
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl203,417,061 - 3,419,551 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000081676
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl202,900,308 - 2,914,960 (-)Ensembl
mRatBN7.2 Ensembl202,895,505 - 2,910,160 (-)Ensembl
Rnor_6.0 Ensembl203,405,017 - 3,419,831 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000086914
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl202,900,308 - 2,914,676 (-)Ensembl
mRatBN7.2 Ensembl202,895,505 - 2,910,240 (-)Ensembl
Rnor_6.0 Ensembl203,408,116 - 3,409,862 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000087638
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl203,404,711 - 3,405,285 (-)Ensembl
RefSeq Acc Id: NM_001166275   ⟹   NP_001159747
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8202,900,307 - 2,914,960 (-)NCBI
mRatBN7.2202,895,504 - 2,910,160 (-)NCBI
Rnor_6.0203,405,017 - 3,419,831 (-)NCBI
Rnor_5.0205,502,120 - 5,516,934 (-)NCBI
RGSC_v3.4203,042,953 - 3,057,607 (-)RGD
Celera20321,426 - 336,070 (-)RGD
Sequence:
RefSeq Acc Id: XM_039098643   ⟹   XP_038954571
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8202,898,496 - 2,914,790 (-)NCBI
mRatBN7.2202,893,693 - 2,909,897 (-)NCBI
RefSeq Acc Id: XM_039098645   ⟹   XP_038954573
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8202,898,496 - 2,914,925 (-)NCBI
mRatBN7.2202,893,693 - 2,912,394 (-)NCBI
RefSeq Acc Id: XM_039098647   ⟹   XP_038954575
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8202,898,496 - 2,914,697 (-)NCBI
mRatBN7.2202,893,693 - 2,909,897 (-)NCBI
RefSeq Acc Id: NP_001159747   ⟸   NM_001166275
- UniProtKB: Q6MG15 (UniProtKB/Swiss-Prot),   Q5U2M8 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000049009   ⟸   ENSRNOT00000046798
RefSeq Acc Id: XP_038954573   ⟸   XM_039098645
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AKS9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038954575   ⟸   XM_039098647
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038954571   ⟸   XM_039098643
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GIV7 (UniProtKB/TrEMBL)
Protein Domains
BRCT   FHA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5U2M8-F1-model_v2 AlphaFold Q5U2M8 1-1279 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1559468 AgrOrtholog
BioCyc Gene G2FUF-4778 BioCyc
Ensembl Genes ENSRNOG00000032813 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000046798 ENTREZGENE
  ENSRNOT00000046798.5 UniProtKB/Swiss-Prot
  ENSRNOT00000081676 ENTREZGENE
  ENSRNOT00000086914 ENTREZGENE
Gene3D-CATH 2.60.200.20 UniProtKB/Swiss-Prot
  3.40.50.10190 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7134653 IMAGE-MGC_LOAD
InterPro BRCT_dom UniProtKB/Swiss-Prot
  BRCT_dom_sf UniProtKB/Swiss-Prot
  DDR_Transcriptional_Reg UniProtKB/Swiss-Prot
  FHA_dom UniProtKB/Swiss-Prot
  SMAD_FHA_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:309595 UniProtKB/Swiss-Prot
MGC_CLONE MGC:95298 IMAGE-MGC_LOAD
NCBI Gene 309595 ENTREZGENE
PANTHER MEDIATOR OF DNA DAMAGE CHECKPOINT PROTEIN 1 UniProtKB/Swiss-Prot
  PAX TRANSCRIPTION ACTIVATION DOMAIN INTERACTING PROTEIN UniProtKB/Swiss-Prot
Pfam BRCT_2 UniProtKB/Swiss-Prot
  FHA UniProtKB/Swiss-Prot
  RTT107_BRCT_5 UniProtKB/Swiss-Prot
PhenoGen Mdc1 PhenoGen
PROSITE BRCT UniProtKB/Swiss-Prot
  FHA_DOMAIN UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000032813 RatGTEx
SMART BRCT UniProtKB/Swiss-Prot
  FHA UniProtKB/Swiss-Prot
Superfamily-SCOP SSF49879 UniProtKB/Swiss-Prot
  SSF52113 UniProtKB/Swiss-Prot
UniProt A0A8I6AKS9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GIV7 ENTREZGENE, UniProtKB/TrEMBL
  A6KT84_RAT UniProtKB/TrEMBL
  MDC1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q6MG15 ENTREZGENE
UniProt Secondary Q6MG15 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-02-09 Mdc1  mediator of DNA damage checkpoint 1      Symbol and Name status set to provisional 70820 PROVISIONAL