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Gene: Traf3ip2 (Traf3 interacting protein 2) Rattus norvegicus

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Symbol:

Traf3ip2

Name:

Traf3 interacting protein 2

RGD ID:

1593240

Description:

Predicted to enable signaling receptor binding activity and ubiquitin protein ligase activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; hematopoietic or lymphoid organ development; and lymphocyte differentiation. Predicted to act upstream of or within B cell apoptotic process. Predicted to be active in cytoplasmic vesicle and nucleus. Human ortholog(s) of this gene implicated in chronic mucocutaneous candidiasis and psoriasis 13. Orthologous to human TRAF3IP2 (TRAF3 interacting protein 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; amphetamine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

adapter protein CIKS; chromosome 6 open reading frame 4; E3 ubiquitin ligase TRAF3IP2; LOC294437; MGC112844; RGD1304768; similar to Adapter protein CIKS (Connection to IKK and SAPK/JNK) (Nuclear factor NF-kappa-B activator 1) (ACT1)

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TRAF3IP2 (TRAF3 interacting protein 2)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Traf3ip2 (TRAF3 interacting protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Traf3ip2 (TRAF3 interacting protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	TRAF3IP2 (TRAF3 interacting protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	TRAF3IP2 (TRAF3 interacting protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Traf3ip2 (TRAF3 interacting protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	TRAF3IP2 (TRAF3 interacting protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	TRAF3IP2 (TRAF3 interacting protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Traf3ip2 (TRAF3 interacting protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	TRAF3IP2 (TRAF3 interacting protein 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Traf3ip2 (TRAF3 interacting protein 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	traf3ip2l (TRAF3 interacting protein 2-like)	Alliance	DIOPT (OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	traf3ip3	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	20	44,565,992 - 44,609,240 (+)	NCBI		GRCr8
mRatBN7.2	20	43,011,405 - 43,054,654 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	43,011,450 - 43,054,667 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	20	44,760,488 - 44,803,525 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	44,419,713 - 44,462,750 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	45,161,986 - 45,205,098 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	20	44,679,861 - 44,722,874 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	44,680,449 - 44,722,872 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	20	46,401,898 - 46,445,446 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	20	43,747,622 - 43,792,255 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	20	43,727,541 - 43,769,944 (+)	NCBI		Celera
Cytogenetic Map	20	q12	NCBI

JBrowse:

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Model

Annotation Click to see Annotation Detail View

Imported Disease Annotations - ClinVar

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Traf3ip2	Rat	Candidiasis, Familial, 8		ISO	RGD:1312403	8554872	ClinVar Annotator: match by term: Candidiasis, familial, 8 \| ClinVar Annotator: match by term: TRAF3IP2-related more ...	ClinVar	PMID:16199547\|PMID:17576681\|PMID:20953186\|PMID:20953188\|PMID:22513239\|PMID:22581863\|PMID:24033266\|PMID:24120361\|PMID:25741868\|PMID:28492532\|PMID:31292894\|PMID:9536098
Traf3ip2	Rat	Discoid Lupus Erythematosus		ISO	RGD:1312403	8554872	ClinVar Annotator: match by term: Discoid lupus erythematosus	ClinVar	PMID:25741868
Traf3ip2	Rat	psoriasis 13		ISO	RGD:1312403	8554872	ClinVar Annotator: match by term: Psoriasis 13, susceptibility to	ClinVar	PMID:20953186\|PMID:20953188\|PMID:22581863\|PMID:24033266\|PMID:24120361\|PMID:25741868\|PMID:28492532

Imported Disease Annotations - CTD

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Traf3ip2	Rat	psoriasis		ISO	RGD:1312403	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:20953186\|PMID:20953188\|PMID:20953190
Traf3ip2	Rat	psoriatic arthritis		ISO	RGD:1312403	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:20953186\|PMID:20953188

Imported Disease Annotations - MGI

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Traf3ip2	Rat	atopic dermatitis		ISS	RGD:1312404	13592920	OMIM:603165	MouseDO
Traf3ip2	Rat	Sjogren's syndrome		ISS	RGD:1312404	13592920	OMIM:270150	MouseDO
Traf3ip2	Rat	systemic lupus erythematosus		ISS	RGD:1312404	13592920	OMIM:152700 \| OMIM:300809 \| OMIM:601744 \| OMIM:605218 \| OMIM:605480 \| OMIM:608437 \| OMIM:609903 \| OMIM:609939 more ...	MouseDO

Imported Disease Annotations - OMIM

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Traf3ip2	Rat	Candidiasis, Familial, 8	susceptibility	ISO	RGD:1312403	7240710		OMIM
Traf3ip2	Rat	psoriasis 13	susceptibility	ISO	RGD:1312403	7240710		OMIM

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Traf3ip2	Rat	(-)-epigallocatechin 3-gallate	multiple interactions	ISO	RGD:1312403	6480464	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of TRAF3IP2 mRNA	CTD	PMID:22079256
Traf3ip2	Rat	17beta-estradiol	increases expression	ISO	RGD:1312404	6480464	Estradiol results in increased expression of TRAF3IP2 mRNA	CTD	PMID:39298647
Traf3ip2	Rat	2,3,7,8-tetrachlorodibenzodioxine	affects expression	EXP		6480464	Tetrachlorodibenzodioxin affects the expression of TRAF3IP2 mRNA	CTD	PMID:22298810
Traf3ip2	Rat	2,3,7,8-tetrachlorodibenzodioxine	increases expression	EXP		6480464	Tetrachlorodibenzodioxin results in increased expression of TRAF3IP2 mRNA	CTD	PMID:33387578
Traf3ip2	Rat	2-butoxyethanol	decreases expression	ISO	RGD:1312404	6480464	n-butoxyethanol results in decreased expression of TRAF3IP2 mRNA	CTD	PMID:19812364
Traf3ip2	Rat	4,4'-sulfonyldiphenol	increases expression	ISO	RGD:1312404	6480464	bisphenol S results in increased expression of TRAF3IP2 mRNA	CTD	PMID:30951980\|PMID:39298647
Traf3ip2	Rat	4-hydroxynon-2-enal	decreases expression	ISO	RGD:1312404	6480464	4-hydroxy-2-nonenal results in decreased expression of TRAF3IP2 mRNA	CTD	PMID:19191707
Traf3ip2	Rat	4-hydroxyphenyl retinamide	increases expression	ISO	RGD:1312404	6480464	Fenretinide results in increased expression of TRAF3IP2 mRNA	CTD	PMID:28973697
Traf3ip2	Rat	5-aza-2'-deoxycytidine	affects expression	ISO	RGD:1312403	6480464	Decitabine affects the expression of TRAF3IP2 mRNA	CTD	PMID:23300844
Traf3ip2	Rat	6-propyl-2-thiouracil	decreases expression	EXP		6480464	Propylthiouracil results in decreased expression of TRAF3IP2 mRNA	CTD	PMID:24780913
Traf3ip2	Rat	6-propyl-2-thiouracil	multiple interactions	ISO	RGD:1312404	6480464	[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of TRAF3IP2 mRNA	CTD	PMID:36706583
Traf3ip2	Rat	acrolein	multiple interactions	ISO	RGD:1312403	6480464	[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of more ...	CTD	PMID:32699268
Traf3ip2	Rat	aflatoxin B1	increases methylation	ISO	RGD:1312403	6480464	Aflatoxin B1 results in increased methylation of TRAF3IP2 gene	CTD	PMID:27153756
Traf3ip2	Rat	all-trans-retinoic acid	increases expression	ISO	RGD:1312403	6480464	Tretinoin results in increased expression of TRAF3IP2 mRNA	CTD	PMID:33167477
Traf3ip2	Rat	alpha-pinene	multiple interactions	ISO	RGD:1312403	6480464	[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of more ...	CTD	PMID:32699268
Traf3ip2	Rat	amphetamine	decreases expression	EXP		6480464	Amphetamine results in decreased expression of TRAF3IP2 mRNA	CTD	PMID:30779732
Traf3ip2	Rat	antirheumatic drug	decreases expression	ISO	RGD:1312403	6480464	Antirheumatic Agents results in decreased expression of TRAF3IP2 mRNA	CTD	PMID:24449571
Traf3ip2	Rat	arsane	multiple interactions	ISO	RGD:1312403	6480464	[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of TRAF3IP2 more ...	CTD	PMID:39836092
Traf3ip2	Rat	arsenic atom	multiple interactions	ISO	RGD:1312403	6480464	[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of TRAF3IP2 more ...	CTD	PMID:39836092
Traf3ip2	Rat	arsenous acid	increases expression	ISO	RGD:1312403	6480464	Arsenic Trioxide results in increased expression of TRAF3IP2 mRNA	CTD	PMID:15761015
Traf3ip2	Rat	azoxystrobin	multiple interactions	EXP		6480464	[azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with more ...	CTD	PMID:33854195
Traf3ip2	Rat	benzo[a]pyrene	increases methylation	ISO	RGD:1312403	6480464	Benzo(a)pyrene results in increased methylation of TRAF3IP2 promoter	CTD	PMID:27901495
Traf3ip2	Rat	benzo[a]pyrene	decreases methylation	ISO	RGD:1312403	6480464	Benzo(a)pyrene results in decreased methylation of TRAF3IP2 3' UTR	CTD	PMID:27901495
Traf3ip2	Rat	bisphenol A	increases expression	EXP		6480464	bisphenol A results in increased expression of TRAF3IP2 mRNA	CTD	PMID:25181051
Traf3ip2	Rat	bisphenol A	decreases expression	EXP		6480464	bisphenol A results in decreased expression of TRAF3IP2 mRNA	CTD	PMID:35192832
Traf3ip2	Rat	bisphenol A	increases expression	ISO	RGD:1312404	6480464	bisphenol A results in increased expression of TRAF3IP2 mRNA	CTD	PMID:30951980
Traf3ip2	Rat	bisphenol F	increases expression	ISO	RGD:1312404	6480464	bisphenol F results in increased expression of TRAF3IP2 mRNA	CTD	PMID:30951980
Traf3ip2	Rat	bleomycin A2	multiple interactions	ISO	RGD:1312404	6480464	Calcitriol inhibits the reaction [Bleomycin results in increased phosphorylation of ACT1 protein]	CTD	PMID:26520185
Traf3ip2	Rat	cadmium dichloride	decreases expression	ISO	RGD:1312403	6480464	Cadmium Chloride results in decreased expression of TRAF3IP2 mRNA	CTD	PMID:38568856
Traf3ip2	Rat	calcitriol	multiple interactions	ISO	RGD:1312404	6480464	Calcitriol inhibits the reaction [Bleomycin results in increased phosphorylation of ACT1 protein]	CTD	PMID:26520185
Traf3ip2	Rat	CGP 52608	multiple interactions	ISO	RGD:1312403	6480464	CGP 52608 promotes the reaction [RORA protein binds to TRAF3IP2 gene]	CTD	PMID:28238834
Traf3ip2	Rat	chlorpyrifos	multiple interactions	EXP		6480464	[azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with more ...	CTD	PMID:33854195
Traf3ip2	Rat	chlorpyrifos	decreases expression	ISO	RGD:1312404	6480464	Chlorpyrifos results in decreased expression of TRAF3IP2 mRNA	CTD	PMID:37019170
Traf3ip2	Rat	ciglitazone	multiple interactions	ISO	RGD:1312403	6480464	[ciglitazone binds to PPARG protein alternative form] which results in increased expression of TRAF3IP2 mRNA	CTD	PMID:16197558
Traf3ip2	Rat	cisplatin	multiple interactions	ISO	RGD:1312403	6480464	[Piroxicam co-treated with Cisplatin] results in decreased expression of TRAF3IP2 mRNA	CTD	PMID:21858171
Traf3ip2	Rat	cisplatin	increases expression	ISO	RGD:1312403	6480464	Cisplatin results in increased expression of TRAF3IP2 mRNA	CTD	PMID:27392435
Traf3ip2	Rat	cisplatin	affects expression	ISO	RGD:1312403	6480464	Cisplatin affects the expression of TRAF3IP2 mRNA	CTD	PMID:23300844
Traf3ip2	Rat	copper(II) sulfate	decreases expression	ISO	RGD:1312403	6480464	Copper Sulfate results in decreased expression of TRAF3IP2 mRNA	CTD	PMID:19549813
Traf3ip2	Rat	cyclosporin A	increases expression	ISO	RGD:1312403	6480464	Cyclosporine results in increased expression of TRAF3IP2 mRNA	CTD	PMID:25562108
Traf3ip2	Rat	diarsenic trioxide	increases expression	ISO	RGD:1312403	6480464	Arsenic Trioxide results in increased expression of TRAF3IP2 mRNA	CTD	PMID:15761015
Traf3ip2	Rat	diiodine	multiple interactions	ISO	RGD:1312404	6480464	[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of TRAF3IP2 mRNA	CTD	PMID:36706583
Traf3ip2	Rat	dorsomorphin	multiple interactions	ISO	RGD:1312403	6480464	[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ...	CTD	PMID:27188386
Traf3ip2	Rat	ethanol	increases expression	ISO	RGD:1312404	6480464	Ethanol results in increased expression of TRAF3IP2 mRNA	CTD	PMID:19167417
Traf3ip2	Rat	glyphosate	multiple interactions	EXP		6480464	[azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with more ...	CTD	PMID:33854195
Traf3ip2	Rat	imidacloprid	multiple interactions	EXP		6480464	[azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with more ...	CTD	PMID:33854195
Traf3ip2	Rat	indole-3-methanol	affects expression	EXP		6480464	indole-3-carbinol affects the expression of TRAF3IP2 mRNA	CTD	PMID:21396975
Traf3ip2	Rat	lead(0)	decreases expression	ISO	RGD:1312403	6480464	Lead results in decreased expression of TRAF3IP2 mRNA	CTD	PMID:19921347
Traf3ip2	Rat	lipopolysaccharide	increases expression	ISO	RGD:1312403	6480464	Lipopolysaccharides results in increased expression of TRAF3IP2 mRNA	CTD	PMID:31059760\|PMID:35811015
Traf3ip2	Rat	lipopolysaccharide	multiple interactions	ISO	RGD:1312403	6480464	[S-(1,2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of TRAF3IP2 mRNA	CTD	PMID:35811015
Traf3ip2	Rat	maneb	multiple interactions	ISO	RGD:1312404	6480464	[Maneb co-treated with Paraquat] results in increased expression of ACT1 protein	CTD	PMID:23562983
Traf3ip2	Rat	menadione	affects expression	ISO	RGD:1312403	6480464	Vitamin K 3 affects the expression of TRAF3IP2 mRNA	CTD	PMID:20044591
Traf3ip2	Rat	monosodium L-glutamate	decreases expression	ISO	RGD:1312404	6480464	Sodium Glutamate results in decreased expression of TRAF3IP2 mRNA	CTD	PMID:22078008
Traf3ip2	Rat	oxaliplatin	multiple interactions	EXP		6480464	[oxaliplatin co-treated with Topotecan] results in increased expression of TRAF3IP2 mRNA	CTD	PMID:25729387
Traf3ip2	Rat	ozone	multiple interactions	ISO	RGD:1312403	6480464	[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of more ...	CTD	PMID:32699268
Traf3ip2	Rat	paracetamol	decreases expression	ISO	RGD:1312403	6480464	Acetaminophen results in decreased expression of TRAF3IP2 mRNA	CTD	PMID:21420995
Traf3ip2	Rat	paracetamol	decreases expression	EXP		6480464	Acetaminophen results in decreased expression of TRAF3IP2 mRNA	CTD	PMID:33387578
Traf3ip2	Rat	paraquat	multiple interactions	ISO	RGD:1312404	6480464	[Maneb co-treated with Paraquat] results in increased expression of ACT1 protein	CTD	PMID:23562983
Traf3ip2	Rat	pirinixic acid	multiple interactions	ISO	RGD:1312403	6480464	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in more ...	CTD	PMID:19710929
Traf3ip2	Rat	pirinixic acid	decreases expression	EXP		6480464	pirinixic acid results in decreased expression of TRAF3IP2 mRNA	CTD	PMID:19162173
Traf3ip2	Rat	pirinixic acid	decreases expression	ISO	RGD:1312404	6480464	pirinixic acid results in decreased expression of TRAF3IP2 mRNA	CTD	PMID:17426115
Traf3ip2	Rat	piroxicam	multiple interactions	ISO	RGD:1312403	6480464	[Piroxicam co-treated with Cisplatin] results in decreased expression of TRAF3IP2 mRNA	CTD	PMID:21858171
Traf3ip2	Rat	poly(I:C)	multiple interactions	ISO	RGD:1312403	6480464	[TL8-506 co-treated with Poly I-C] results in increased expression of TRAF3IP2 mRNA	CTD	PMID:35688559
Traf3ip2	Rat	potassium chromate	decreases expression	ISO	RGD:1312403	6480464	potassium chromate(VI) results in decreased expression of TRAF3IP2 mRNA	CTD	PMID:22079256
Traf3ip2	Rat	potassium chromate	multiple interactions	ISO	RGD:1312403	6480464	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of TRAF3IP2 mRNA	CTD	PMID:22079256
Traf3ip2	Rat	raloxifene	multiple interactions	ISO	RGD:1312403	6480464	[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of TRAF3IP2 mRNA	CTD	PMID:19059307
Traf3ip2	Rat	S-(1,2-dichlorovinyl)-L-cysteine	multiple interactions	ISO	RGD:1312403	6480464	[S-(1,2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of TRAF3IP2 mRNA	CTD	PMID:35811015
Traf3ip2	Rat	SB 431542	multiple interactions	ISO	RGD:1312403	6480464	[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ...	CTD	PMID:27188386
Traf3ip2	Rat	silicon dioxide	increases expression	ISO	RGD:1312403	6480464	Silicon Dioxide analog results in increased expression of TRAF3IP2 mRNA	CTD	PMID:23806026
Traf3ip2	Rat	sodium arsenite	decreases expression	ISO	RGD:1312403	6480464	sodium arsenite results in decreased expression of TRAF3IP2 mRNA	CTD	PMID:38568856
Traf3ip2	Rat	sodium arsenite	multiple interactions	ISO	RGD:1312403	6480464	[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of TRAF3IP2 more ...	CTD	PMID:39836092
Traf3ip2	Rat	sodium fluoride	increases expression	ISO	RGD:1312404	6480464	Sodium Fluoride results in increased expression of TRAF3IP2 mRNA; Sodium Fluoride results in increased expression more ...	CTD	PMID:30225638
Traf3ip2	Rat	sunitinib	decreases expression	ISO	RGD:1312403	6480464	Sunitinib results in decreased expression of TRAF3IP2 mRNA	CTD	PMID:31533062
Traf3ip2	Rat	tamoxifen	multiple interactions	ISO	RGD:1312403	6480464	[Tamoxifen co-treated with ESR2 protein] results in decreased expression of TRAF3IP2 mRNA	CTD	PMID:19059307
Traf3ip2	Rat	thiabendazole	multiple interactions	EXP		6480464	[azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with more ...	CTD	PMID:33854195
Traf3ip2	Rat	thioacetamide	decreases expression	EXP		6480464	Thioacetamide results in decreased expression of TRAF3IP2 mRNA	CTD	PMID:34492290
Traf3ip2	Rat	topotecan	multiple interactions	EXP		6480464	[oxaliplatin co-treated with Topotecan] results in increased expression of TRAF3IP2 mRNA	CTD	PMID:25729387
Traf3ip2	Rat	trichloroethene	increases expression	EXP		6480464	Trichloroethylene results in increased expression of TRAF3IP2 mRNA	CTD	PMID:33387578
Traf3ip2	Rat	triphenyl phosphate	affects expression	ISO	RGD:1312403	6480464	triphenyl phosphate affects the expression of TRAF3IP2 mRNA	CTD	PMID:37042841
Traf3ip2	Rat	valproic acid	increases methylation	ISO	RGD:1312403	6480464	Valproic Acid results in increased methylation of TRAF3IP2 gene	CTD	PMID:29154799
Traf3ip2	Rat	valproic acid	increases expression	ISO	RGD:1312403	6480464	Valproic Acid results in increased expression of TRAF3IP2 mRNA	CTD	PMID:23179753\|PMID:24383497\|PMID:26272509\|PMID:29154799
Traf3ip2	Rat	valproic acid	multiple interactions	ISO	RGD:1312403	6480464	[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ...	CTD	PMID:27188386

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Traf3ip2	Rat	B cell affinity maturation	involved_in	ISO	RGD:1312404	1624291	MGI:3510784 PMID:20543113	RGD	PMID:20543113
Traf3ip2	Rat	B cell apoptotic process	acts_upstream_of_or_within	ISO	RGD:1312404	1624291	MGI:3510784 PMID:15485634	RGD	PMID:15485634
Traf3ip2	Rat	B cell homeostasis	involved_in	ISO	RGD:1312404	1624291	MGI:3510784 PMID:20543113	RGD	PMID:20543113
Traf3ip2	Rat	B cell mediated immunity	involved_in	ISO	RGD:1312404	1624291	MGI:2143599\|MGI:88336 PMID:18624351	RGD	PMID:18624351
Traf3ip2	Rat	CD40 signaling pathway	involved_in	ISO	RGD:1312404	1624291	MGI:88336 PMID:18624351	RGD	PMID:18624351
Traf3ip2	Rat	cellular response to cytokine stimulus	involved_in	ISO	RGD:1312404	1624291	MGI:3510784 PMID:21856933	RGD	PMID:21856933
Traf3ip2	Rat	cellular response to interleukin-17	involved_in	ISO	RGD:1312404	1624291	PMID:29563620	RGD	PMID:29563620
Traf3ip2	Rat	cytokine-mediated signaling pathway	involved_in	ISO	RGD:1312404	1624291	MGI:3831153 PMID:19155511	RGD	PMID:19155511
Traf3ip2	Rat	eosinophil homeostasis	involved_in	ISO	RGD:1312404	1624291	MGI:3510784 PMID:19155512	RGD	PMID:19155512
Traf3ip2	Rat	eosinophil mediated immunity	involved_in	ISO	RGD:1312404	1624291	MGI:3831153 PMID:19155511	RGD	PMID:19155511
Traf3ip2	Rat	establishment of T cell polarity	involved_in	ISO	RGD:1312404	1624291	MGI:3510784 PMID:21856933	RGD	PMID:21856933
Traf3ip2	Rat	gene expression	involved_in	ISO	RGD:1312404	1624291	MGI:3510784\|MGI:3707541\|MGI:3831153 PMID:19155511, PMID:19155512, PMID:19825828, PMID:21822257, PMID:21856933, PMID:28561022	RGD	PMID:19155511\|PMID:19155512\|PMID:19825828\|PMID:21822257\|PMID:21856933\|PMID:28561022
Traf3ip2	Rat	heart development	involved_in	ISO	RGD:1312404	1624291	PMID:27466370	RGD	PMID:27466370
Traf3ip2	Rat	humoral immune response	involved_in	IBA	MGI:2143599\|PANTHER:PTN002152027	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Traf3ip2	Rat	humoral immune response	acts_upstream_of_or_within	ISO	RGD:1312404	1624291	MGI:3510784 PMID:15485634	RGD	PMID:15485634
Traf3ip2	Rat	immune response	involved_in	ISO	RGD:1312404	1624291	MGI:3510784\|MGI:3707541\|MGI:4820827 PMID:20660351, PMID:21822257, PMID:23995070	RGD	PMID:20660351\|PMID:21822257\|PMID:23995070
Traf3ip2	Rat	inflammatory response	involved_in	ISO	RGD:1312403	1624291	PMID:17277779	RGD	PMID:17277779
Traf3ip2	Rat	inflammatory response	involved_in	ISO	RGD:1312404	1624291	MGI:3510784 PMID:17277779, PMID:18624351, PMID:19155512, PMID:20303295, PMID:21856933	RGD	PMID:17277779\|PMID:18624351\|PMID:19155512\|PMID:20303295\|PMID:21856933
Traf3ip2	Rat	inflammatory response	involved_in	IEA	UniProtKB:O43734\|ensembl:ENSP00000357750	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Traf3ip2	Rat	interleukin-17-mediated signaling pathway	involved_in	ISO	RGD:1312403	1624291	PMID:19825828, PMID:24120361	RGD	PMID:19825828\|PMID:24120361
Traf3ip2	Rat	interleukin-17-mediated signaling pathway	involved_in	IEA	UniProtKB:O43734\|ensembl:ENSP00000357750	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Traf3ip2	Rat	interleukin-17-mediated signaling pathway	involved_in	ISO	RGD:1312404	1624291	MGI:3510784\|MGI:4820827 PMID:19155512, PMID:19825828, PMID:20303295, PMID:20660351, PMID:21822257, PMID:21822258, PMID:23995070, PMID:28561022	RGD	PMID:19155512\|PMID:19825828\|PMID:20303295\|PMID:20660351\|PMID:21822257\|PMID:21822258\|PMID:23995070\|PMID:28561022
Traf3ip2	Rat	interleukin-17A-mediated signaling pathway	involved_in	ISO	RGD:1312403	1624291	PMID:17277779, PMID:19825828	RGD	PMID:17277779\|PMID:19825828
Traf3ip2	Rat	interleukin-17A-mediated signaling pathway	involved_in	IEA	UniProtKB:O43734\|ensembl:ENSP00000357750	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Traf3ip2	Rat	interleukin-17A-mediated signaling pathway	involved_in	ISO	RGD:1312404	1624291	MGI:3510784\|MGI:3831153 PMID:17277779, PMID:19155511	RGD	PMID:17277779\|PMID:19155511
Traf3ip2	Rat	kidney development	involved_in	ISO	RGD:1312404	1624291	MGI:3510784 PMID:22585710	RGD	PMID:22585710
Traf3ip2	Rat	leukocyte activation involved in inflammatory response	involved_in	ISO	RGD:1312404	1624291	MGI:3510784 PMID:20303295	RGD	PMID:20303295
Traf3ip2	Rat	lymph node development	involved_in	ISO	RGD:1312404	1624291	MGI:3510784 PMID:22585710	RGD	PMID:22585710
Traf3ip2	Rat	mRNA stabilization	involved_in	ISO	RGD:1312404	1624291	PMID:17785852, PMID:21822258	RGD	PMID:17785852\|PMID:21822258
Traf3ip2	Rat	mucus secretion	involved_in	ISO	RGD:1312404	1624291	MGI:3831153 PMID:19155511	RGD	PMID:19155511
Traf3ip2	Rat	neutrophil activation	involved_in	ISO	RGD:1312404	1624291	MGI:3510784 PMID:19155512	RGD	PMID:19155512
Traf3ip2	Rat	positive regulation of canonical NF-kappaB signal transduction	involved_in	ISO	RGD:1312403	1624291	PMID:12761501	RGD	PMID:12761501
Traf3ip2	Rat	positive regulation of canonical NF-kappaB signal transduction	involved_in	IBA	PANTHER:PTN002152027\|UniProtKB:O43734	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Traf3ip2	Rat	positive regulation of canonical NF-kappaB signal transduction	involved_in	IEA	UniProtKB:O43734\|ensembl:ENSP00000357750	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Traf3ip2	Rat	positive regulation of defense response to virus by host	involved_in	ISO	RGD:1312403	1624291	PMID:23066157	RGD	PMID:23066157
Traf3ip2	Rat	positive regulation of defense response to virus by host	involved_in	IEA	UniProtKB:O43734\|ensembl:ENSP00000357750	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Traf3ip2	Rat	protein import into nucleus	involved_in	ISO	RGD:1312404	1624291	PMID:28561022	RGD	PMID:28561022
Traf3ip2	Rat	protein K63-linked ubiquitination	involved_in	ISO	RGD:1312403	1624291	PMID:19825828	RGD	PMID:19825828
Traf3ip2	Rat	protein K63-linked ubiquitination	involved_in	IEA	UniProtKB:O43734\|ensembl:ENSP00000357750	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Traf3ip2	Rat	protein localization to nucleus	involved_in	ISO	RGD:1312404	1624291	PMID:29563620	RGD	PMID:29563620
Traf3ip2	Rat	protein localization to P-body	involved_in	ISO	RGD:1312404	1624291	PMID:29563620	RGD	PMID:29563620
Traf3ip2	Rat	protein polyubiquitination	involved_in	ISO	RGD:1312404	1624291	PMID:19825828	RGD	PMID:19825828
Traf3ip2	Rat	protein ubiquitination	involved_in	ISO	RGD:1312404	1624291	MGI:4011845 PMID:23042150	RGD	PMID:23042150
Traf3ip2	Rat	response to cytokine	involved_in	ISO	RGD:1312404	1624291	MGI:3510784 PMID:19155512	RGD	PMID:19155512
Traf3ip2	Rat	response to xenobiotic stimulus	involved_in	ISO	RGD:1312404	1624291	MGI:3831153 PMID:19155511	RGD	PMID:19155511
Traf3ip2	Rat	signal transduction involved in regulation of gene expression	involved_in	ISO	RGD:1312404	1624291	PMID:21822258	RGD	PMID:21822258
Traf3ip2	Rat	skin development	involved_in	ISO	RGD:1312404	1624291	MGI:4820827 PMID:20660351	RGD	PMID:20660351
Traf3ip2	Rat	spleen development	involved_in	ISO	RGD:1312404	1624291	MGI:3510784 PMID:22585710	RGD	PMID:22585710
Traf3ip2	Rat	T cell activation	involved_in	ISO	RGD:1312404	1624291	MGI:3510784 PMID:20303295	RGD	PMID:20303295
Traf3ip2	Rat	T cell differentiation	involved_in	ISO	RGD:1312404	1624291	MGI:3510784 PMID:22585710	RGD	PMID:22585710
Traf3ip2	Rat	T-helper 17 type immune response	involved_in	ISO	RGD:1312404	1624291	PMID:28561022	RGD	PMID:28561022
Traf3ip2	Rat	transitional two stage B cell differentiation	involved_in	ISO	RGD:1312404	1624291	MGI:3510784 PMID:20543113	RGD	PMID:20543113
Traf3ip2	Rat	tumor necrosis factor-mediated signaling pathway	involved_in	ISO	RGD:1312404	1624291	MGI:1344376 PMID:18624351	RGD	PMID:18624351
Traf3ip2	Rat	type 2 immune response	involved_in	ISO	RGD:1312404	1624291	MGI:3510784 PMID:21856933	RGD	PMID:21856933

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Traf3ip2	Rat	cytoplasmic vesicle	is_active_in	ISO	RGD:1312404	1624291	UniProtKB:P70372 PMID:29563620	RGD	PMID:29563620
Traf3ip2	Rat	nucleus	is_active_in	ISO	RGD:1312404	1624291	UniProtKB:Q6PDM2 PMID:29563620	RGD	PMID:29563620

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Traf3ip2	Rat	protein binding	enables	ISO	RGD:1312404	1624291	UniProtKB:P70191\|UniProtKB:P70196\|UniProtKB:P70372\|UniProtKB:Q01705\|UniProtKB:Q3U564\|UniProtKB:Q60943\|UniProtKB:Q6PDM2\|UniProtKB:Q8BH06\|UniProtKB:Q9JIP3\|UniProtKB:Q9R0T8 PMID:15102471, PMID:19155511, PMID:19155512, PMID:21822257, PMID:21822258, PMID:28561022, PMID:29563620, PMID:33723527	RGD	PMID:15102471\|PMID:19155511\|PMID:19155512\|PMID:21822257\|PMID:21822258\|PMID:28561022\|PMID:29563620\|PMID:33723527
Traf3ip2	Rat	protein binding	enables	ISO	RGD:1312403	1624291	UniProtKB:O75716\|UniProtKB:Q13084\|UniProtKB:Q15654\|UniProtKB:Q8NAC3\|UniProtKB:Q96C98\|UniProtKB:Q96F46\|UniProtKB:Q9NRM6\|UniProtKB:Q9UFD9\|UniProtKB:Q9Y4K3 PMID:12459498, PMID:21516116, PMID:24120361, PMID:25416956	RGD	PMID:12459498\|PMID:21516116\|PMID:24120361\|PMID:25416956
Traf3ip2	Rat	signaling receptor binding	enables	ISO	RGD:1312404	1624291	UniProtKB:Q8K4C2 PMID:20554964	RGD	PMID:20554964
Traf3ip2	Rat	ubiquitin protein ligase activity	enables	ISO	RGD:1312403	1624291	PMID:19825828	RGD	PMID:19825828
Traf3ip2	Rat	ubiquitin protein ligase activity	enables	ISO	RGD:1312404	1624291	PMID:19825828	RGD	PMID:19825828
Traf3ip2	Rat	ubiquitin protein ligase activity	enables	IEA	UniProtKB:O43734\|ensembl:ENSP00000357750	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107

Disease Annotations Click to see Annotation Detail View

atopic dermatitis (ISS)

Candidiasis, Familial, 8 (ISO)

Discoid Lupus Erythematosus (ISO)

psoriasis (ISO)

psoriasis 13 (ISO)

psoriatic arthritis (ISO)

Sjogren's syndrome (ISS)

systemic lupus erythematosus (ISS)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2-butoxyethanol (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxynon-2-enal (ISO)

4-hydroxyphenyl retinamide (ISO)

5-aza-2'-deoxycytidine (ISO)

6-propyl-2-thiouracil (EXP,ISO)

acrolein (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

alpha-pinene (ISO)

amphetamine (EXP)

antirheumatic drug (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenous acid (ISO)

azoxystrobin (EXP)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

bleomycin A2 (ISO)

cadmium dichloride (ISO)

calcitriol (ISO)

CGP 52608 (ISO)

chlorpyrifos (EXP,ISO)

ciglitazone (ISO)

cisplatin (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

diarsenic trioxide (ISO)

diiodine (ISO)

dorsomorphin (ISO)

ethanol (ISO)

glyphosate (EXP)

imidacloprid (EXP)

indole-3-methanol (EXP)

lead(0) (ISO)

lipopolysaccharide (ISO)

maneb (ISO)

menadione (ISO)

monosodium L-glutamate (ISO)

oxaliplatin (EXP)

ozone (ISO)

paracetamol (EXP,ISO)

paraquat (ISO)

pirinixic acid (EXP,ISO)

piroxicam (ISO)

poly(I:C) (ISO)

potassium chromate (ISO)

raloxifene (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

sodium fluoride (ISO)

sunitinib (ISO)

tamoxifen (ISO)

thiabendazole (EXP)

thioacetamide (EXP)

topotecan (EXP)

trichloroethene (EXP)

triphenyl phosphate (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

B cell affinity maturation (ISO)

B cell apoptotic process (ISO)

B cell homeostasis (ISO)

B cell mediated immunity (ISO)

CD40 signaling pathway (ISO)

cellular response to cytokine stimulus (ISO)

cellular response to interleukin-17 (ISO)

cytokine-mediated signaling pathway (ISO)

eosinophil homeostasis (ISO)

eosinophil mediated immunity (ISO)

establishment of T cell polarity (ISO)

gene expression (ISO)

heart development (ISO)

humoral immune response (IBA,ISO)

immune response (ISO)

inflammatory response (IEA,ISO)

interleukin-17-mediated signaling pathway (IEA,ISO)

interleukin-17A-mediated signaling pathway (IEA,ISO)

kidney development (ISO)

leukocyte activation involved in inflammatory response (ISO)

lymph node development (ISO)

mRNA stabilization (ISO)

mucus secretion (ISO)

neutrophil activation (ISO)

positive regulation of canonical NF-kappaB signal transduction (IBA,IEA,ISO)

positive regulation of defense response to virus by host (IEA,ISO)

protein import into nucleus (ISO)

protein K63-linked ubiquitination (IEA,ISO)

protein localization to nucleus (ISO)

protein localization to P-body (ISO)

protein polyubiquitination (ISO)

protein ubiquitination (ISO)

response to cytokine (ISO)

response to xenobiotic stimulus (ISO)

signal transduction involved in regulation of gene expression (ISO)

skin development (ISO)

spleen development (ISO)

T cell activation (ISO)

T cell differentiation (ISO)

T-helper 17 type immune response (ISO)

transitional two stage B cell differentiation (ISO)

tumor necrosis factor-mediated signaling pathway (ISO)

type 2 immune response (ISO)

Cellular Component

cytoplasmic vesicle (ISO)

nucleus (ISO)

Molecular Function

protein binding (ISO)

signaling receptor binding (ISO)

ubiquitin protein ligase activity (IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
3.	GOA pipeline	RGD automated data pipeline
4.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:12761501	PMID:15485634	PMID:20554964	PMID:23066157

Genomics

Comparative Map Data

Traf3ip2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	20	44,565,992 - 44,609,240 (+)	NCBI		GRCr8
mRatBN7.2	20	43,011,405 - 43,054,654 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	43,011,450 - 43,054,667 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	20	44,760,488 - 44,803,525 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	44,419,713 - 44,462,750 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	45,161,986 - 45,205,098 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	20	44,679,861 - 44,722,874 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	44,680,449 - 44,722,872 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	20	46,401,898 - 46,445,446 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	20	43,747,622 - 43,792,255 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	20	43,727,541 - 43,769,944 (+)	NCBI		Celera
Cytogenetic Map	20	q12	NCBI

TRAF3IP2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	111,555,381 - 111,605,878 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	111,555,381 - 111,606,906 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	111,876,584 - 111,927,081 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	111,986,836 - 112,034,014 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	6	111,986,835 - 112,034,014	NCBI
Celera	6	112,626,739 - 112,674,049 (-)	NCBI		Celera
Cytogenetic Map	6	q21	NCBI
HuRef	6	109,448,986 - 109,500,061 (-)	NCBI		HuRef
CHM1_1	6	112,139,458 - 112,190,300 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	6	112,738,381 - 112,788,887 (-)	NCBI		T2T-CHM13v2.0

Traf3ip2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	39,488,930 - 39,531,303 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	39,488,930 - 39,531,303 (+)	Ensembl		GRCm39 Ensembl
GRCm38	10	39,612,934 - 39,655,307 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	39,612,934 - 39,655,307 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	39,332,740 - 39,375,113 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	10	39,302,350 - 39,344,723 (+)	NCBI		MGSCv36	mm8
Celera	10	40,498,927 - 40,541,335 (+)	NCBI		Celera
Cytogenetic Map	10	B1	NCBI
cM Map	10	20.86	NCBI

Traf3ip2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955411	36,326,926 - 36,363,288 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955411	36,328,152 - 36,363,614 (-)	NCBI	ChiLan1.0	ChiLan1.0

TRAF3IP2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	131,572,937 - 131,620,512 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	129,458,898 - 129,506,170 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	109,367,333 - 109,414,601 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	113,443,540 - 113,490,402 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	113,444,005 - 113,485,533 (-)	Ensembl	panpan1.1		panPan2

TRAF3IP2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	12	68,029,861 - 68,070,901 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	12	68,030,197 - 68,058,518 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	12	67,849,673 - 67,891,354 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	12	68,911,754 - 68,953,406 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	12	68,911,760 - 68,952,954 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	12	68,263,251 - 68,304,918 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	12	68,109,790 - 68,151,470 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	12	68,435,643 - 68,477,316 (-)	NCBI		UU_Cfam_GSD_1.0

Traf3ip2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	103,076,436 - 103,116,386 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936679	316,277 - 336,557 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936679	308,508 - 348,561 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TRAF3IP2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	77,487,577 - 77,541,198 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	77,483,997 - 77,541,557 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	87,044,462 - 87,102,274 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TRAF3IP2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	13	62,272,893 - 62,320,096 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	13	62,285,589 - 62,324,312 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666040	34,579,431 - 34,626,946 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Traf3ip2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624933	506,254 - 554,015 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624933	507,879 - 558,357 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Traf3ip2
196 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	42
Count of miRNA genes:	37
Interacting mature miRNAs:	39
Transcripts:	ENSRNOT00000000728
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
4889610	Pancm3	Pancreatic morphology QTL 3	3.75	0.001	pancreas mass (VT:0010144)	pancreas wet weight (CMO:0000626)	20	17617832	47606836	Rat
2303587	Bw93	Body weight QTL 93	13		body mass (VT:0001259)	body weight (CMO:0000012)	20	25106722	54435887	Rat
1641915	Colcr9	Colorectal carcinoma resistance QTL 9	2.97	0.0024	intestine integrity trait (VT:0010554)	benign colorectal tumor number (CMO:0001795)	20	1530655	46530655	Rat
2305926	Iddm37	Insulin dependent diabetes mellitus QTL 37	6		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	20	1527842	46527842	Rat
2303626	Vencon10	Ventilatory control QTL 10		0.001	respiration trait (VT:0001943)	respiration rate (CMO:0000289)	20	19190721	54435887	Rat
1598869	Memor6	Memory QTL 6	3.1		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	20	29244388	54435887	Rat
70158	Bp60	Blood pressure QTL 60	3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	20	31614284	44396023	Rat
7411652	Foco24	Food consumption QTL 24		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	20	11757515	54435887	Rat
1331747	Hrtrt16	Heart rate QTL 16	3.163		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	20	25209734	54435887	Rat
1598816	Memor12	Memory QTL 12	2.4		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	20	2606836	47606836	Rat
2303578	Gluco50	Glucose level QTL 50	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	20	25106722	54435887	Rat
2317880	Alcrsp25	Alcohol response QTL 25	2.3		response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	20	17697550	54435887	Rat
9590092	Insglur9	Insulin/glucose ratio QTL 9	18.38	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	20	11757515	54435887	Rat
2300188	Bmd68	Bone mineral density QTL 68	6.4	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	20	25106722	54435887	Rat

Markers in Region

RH131445

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	20	43,010,570 - 43,010,776 (+)	MAPPER	mRatBN7.2
Rnor_6.0	20	44,679,570 - 44,679,775	NCBI	Rnor6.0
Rnor_5.0	20	46,401,019 - 46,401,224	UniSTS	Rnor5.0
RGSC_v3.4	20	43,746,743 - 43,746,948	UniSTS	RGSC3.4
Celera	20	43,726,662 - 43,726,867	UniSTS
Cytogenetic Map	20	q12	UniSTS

BF410372

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	20	43,016,682 - 43,016,884 (+)	MAPPER	mRatBN7.2
Rnor_6.0	20	44,685,702 - 44,685,903	NCBI	Rnor6.0
Rnor_5.0	20	46,407,176 - 46,407,377	UniSTS	Rnor5.0
RGSC_v3.4	20	43,752,900 - 43,753,101	UniSTS	RGSC3.4
Celera	20	43,732,755 - 43,732,956	UniSTS
RH 3.4 Map	20	465.01	UniSTS
Cytogenetic Map	20	q12	UniSTS

RH137093

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	20	43,054,463 - 43,054,625 (+)	MAPPER	mRatBN7.2
Rnor_6.0	20	44,722,684 - 44,722,845	NCBI	Rnor6.0
Rnor_5.0	20	46,445,256 - 46,445,417	UniSTS	Rnor5.0
RGSC_v3.4	20	43,792,065 - 43,792,226	UniSTS	RGSC3.4
Celera	20	43,769,754 - 43,769,915	UniSTS
RH 3.4 Map	20	460.5	UniSTS
Cytogenetic Map	20	q12	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001044248	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006256532	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039098886	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039098887	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063279316	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063279317	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063279318	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_597419	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC100099	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474051	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000020	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000000728 ⟹ ENSRNOP00000000728

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	20	43,011,450 - 43,051,794 (+)	Ensembl
Rnor_6.0 Ensembl	20	44,680,449 - 44,722,872 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000103797 ⟹ ENSRNOP00000081231

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	20	43,011,450 - 43,054,667 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000119731 ⟹ ENSRNOP00000095663

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	20	43,011,450 - 43,054,657 (+)	Ensembl

RefSeq Acc Id:

NM_001044248 ⟹ NP_001037713

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	44,566,037 - 44,609,240 (+)	NCBI
mRatBN7.2	20	43,011,450 - 43,054,654 (+)	NCBI
Rnor_6.0	20	44,680,449 - 44,722,874 (+)	NCBI
Rnor_5.0	20	46,401,898 - 46,445,446 (+)	NCBI
RGSC_v3.4	20	43,747,622 - 43,792,255 (+)	RGD
Celera	20	43,727,541 - 43,769,944 (+)	RGD

Sequence:

show sequence

GGAGAGGGCGAGGGAGGTCTGAGCGGCCCGAGGTGGATCCCGGAGAGCAGAGCCCGCGACCACC
CCCTGGGCCCGTCTGTCGGTGGCGATCTTAGAAACTAGAATGAATCGAAGCATTCCCGTGGAGG
TTGACGAATCGGAGCCCTTCCCGAGTCAGTTGCTGAATCCGATCCCAGAATCTTCTCCAGAAGA
GGAATTGGAACCACCTGCCCCAAATACAAGGAACACGGCACCCAGCAGCTTGTCTGTACTCCAA
CGCCCTCCCCTGAAACTTGCAAATCACCAGCCTGTGTCGCAACAGGTCACCTGCTTGCGAGCTA
AAGTCCTGGAGGAGAGTGAAGCCAGTTTCCTTAGAAGGCACCCTGATCTCGGCAAAGATGTTTC
CTCCTGCTCCTCTGAAGCCAGTGAGCCTGGGTCTGAGCTTGGAGCCCTCTCTCTAGAGCATCGC
TTTACACATATGGAAAAACGCGATAGATGGCTGGGACCTCAGCTTTCAGCAGCTTCTCCCGACA
CTGGCCATGACTCAGACAAATCAGACCCAAGTTTGCCTATGGCTTTGGCAGACTCCTCCAGTAG
TGACCAAGAGATGAGGCCCAGGCCCGGGTCCCGGCCCCGGCCCTGGCCCCGGCACCACAGGAAC
AGGGCAGCCCCAGATGTGCCCACGATAGACACTGGGTATGATTCCCAGCCCCAAGATGTCCTGG
GCATCAGGCAGCTGGAAAAGCCCTTGCCCCTCACCTCCTCATGTTACCTGCAGGACCTCCCTGG
GCCTCTCAGGTCCAAGGAATTTCCCCAGTTTGAACTCCAGAGGTATCCGGCGAATGCGCCGATG
CTGCCTCTCGATCCTTCCCCACAGGTTCCATGGAGTTATCAGTACTGTCGTCCCGGAGGGCCCT
ATCACCACCAGGCGCCATATGGTCATGGCTACCCTCCAGCAGCAGCCTACCAGCAAGTCATCCA
GCCTGCTCTGCCTGAGCAGGCCCTTCTCGGGGCAAGGGTGAGAGGCCTGCACCCTATGCAGAAG
GTCGTCCTGAATGACTCCAGCCCCCAGGACCAAGAAGAGAGGCCTGCACAGCGAGACTTCTCTT
TCTCAAGGCTCCCAAGGGACCGGCTCTGCCGCCCACCATCTAATGGAGCTGGAGCTCCCGAGGA
GTCCTTGGACCGTCCTGCAGAGCTGAGACCACATGGTCCCCAGGCTCTGTCCCCAGCTGCCGTG
CCTAGACCCCCTAGCAACCCCTTAGCCCGAGGAACTCTGAAAACCAGCAATTTGCCAGAGGAAT
TACGGAAGGTCTTTATCACTTATTCTATGGACACAGCCATGGAGGTGGTGAAGTGTGTGAACTT
CCTGCTGGTGAATGGCTTCCAAACCGCCATTGACATATTTGAGGACAGAATCCGGGGTATTGAT
ATCATTAAATGGATGGAGCGCTACCTTCGAGATAAGACAGTGATGATAATCGTAGCAATCAGCC
CCAAATACAAACAGGATGTGGAAGGCACTGGGTCGCAGCTGGACGAGGATGAGCATGGCTTACA
TACTAAGTACATTCATCGGATGATGCAGATCGAGTTTATAAATCAGGGAAGCATGAATTTCAGG
TTCATCCCTGTGCTCTTCCCAAATGCCAAGAAGGAGCATGTGCCGACCTGGCTGCAGAACACTC
ACGTGTACAGCTGGCCCAAGAATAAGAAAAACATCCTTCTGCGGCTGCTCCGAGAGGAGGAGTA
CGTAGCTCCTCCCCGAGGCCCTCTGCCCACCCTTCAGGTGGTACCTTTGTGATGCCAGCCTGTT
CTCACAGCATTCGTCCAGCCAAGCTGGTTGGTGGCACTCAGGCCTGGAACACCTGTTCTACAGA
GTTCCCGGCCTCCTGAGTCTGAGGTGTCCTCGCCCGGCCTCCAGTGCTTCTGGGAGTGGATGTT
GCAGGTGATGGCTGCCCGGACCTATGGCCACAAAAACTCTCATCACTTCAGCTACTCTTATGAG
TTGGCCGGATGCTTTGTGTCCTTAGACCAGTCTGAATCGTGCTCAATTAATAAAGTGATTATTC
TTTGTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_006256532 ⟹ XP_006256594

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	44,569,341 - 44,609,240 (+)	NCBI
mRatBN7.2	20	43,013,075 - 43,054,379 (+)	NCBI
Rnor_6.0	20	44,681,874 - 44,722,874 (+)	NCBI
Rnor_5.0	20	46,401,898 - 46,445,446 (+)	NCBI

Sequence:

show sequence

TGGCTTTAACCACATAGGGGGAAATGGGATTTCTTGAATTTAGCTCATGTCCCATGTGTTTGCT
GAGAGGCAAGGCAGGCTCCAGAGCTGGCAGATAATCCCGTGGCAGAGGCCAGGAGCTGGATCAG
AAGGCACTCCAGGCCACAAACAGTCCGTGTGTGGGCCTTTAATGGGAGGGGAAAGGGAACAGAA
ACCCATCAGCCCCATGTAAGGCTGACGACTGATTGGAGTCATTACTGGCTGGCAGACGCACTGG
ATCCTTAACCTCTTCCAAACCACTGCTTTAAGGAACATTATTATTGTTTCTTTTGAGCAATTCC
TGACAGTCAGTACAGTTCCAGCAGGTTCTGGCTGAGGGGACTGGTTTGGAACTTTGGGTATTGT
TAAACTCTCTGTAGGGTGTCCATGAGGTCTGTACCAGACACCACTATGTATTCCGGAATAAGGG
CACCAGACTCCCAACACATTTGCTTGTGGCGACTTCTTGCTTCTTATTTCAAATCCCAGAGTGT
TACCATCTGAAACCGGGGTAGCAGCTGTATTTCTGTCAGACCCTCTTTGATGGTAGACGGTCCA
CTACAGCCACTCTTAATCTGGTGTTCTTCCAAGTCATTCCACACAGGACAAGTGTGAGGAGGTG
GGTGATGCAGCCATTCTGACGTGTTCACTTCGTGGGGCCGCCTTGAGCAGGGCGAGGGGCCAGA
CAACGTGGCAGGACCCAGGGGGGTGGGGTGGGGTATGTTCCTAGCCTAGCGATTCTCAGAGAGC
CCAAAGACACACAGTGTTCAAGCCTGTACCTCCCTGGATGAAGGGTTAGTGACTTTCAGACACA
CTGAAAATTAAAGAGGAGAAAGTCCTAGGTAGATTACGGTGGCGGAGTTTGTCTAAAGGAAATC
AATGTCTTACACATTGCAGAGTGGAAATCTCAGATAGATCCTGAATTCAAATCATTTTCTGCAG
CAGGCGATTTTAGATTAGTTCACGTCCATATGAACTACAGGCAGCTGCTGTAGGAATGAGCACA
GGTGGAGGTGTGGCCAACTTCCAGGTCCTTCCATAGCCAATTAAATGGCCCTTAAACCTGGATC
CTATTTCTTTATCAAAGTAATCCAACTGGCCTTCCCCAAGAAGCATCTGATGGCTGGAATCTAG
AAGCTGTCCTCCAGGCTTCTCCTGTTTTAGTTCCGGAAACACAGCTCCCTCCCTCCCATCCCAC
ATTCCTTGTCTCCGGCCCAGCATGCCTCCTAGAGCCCACTTGGCTCCTCCAAACTTGGCGCTCT
GCTCTGCTCACTCTTCTTGTATACAGGTGTGCACACAGGCCTTCTCAGGGACCATCGGCTTTAA
AGCAGCCATGGAAGGGTGGCCTTTCGTCCATGTGTCAGTCCTTAGCTTGCTGCCACTTTGGCTC
GGTTCCCTGATGGCACTGCTGAAAGCAAGATGTTTGGGTAGGTGGGAGACCCTCACGCAGCCTG
TTCCCCTTTAACACCCAGCAGACCCAGTCCGAATGGGGTCTTGGCAACTCCCTGAGCGATGAAG
GAAACCTGGCTCCTTTGCCGCATTGGAATCCTGTGCCCAGCCCTCTCTGCCACTCCTCTCCGCT
CTCATGCTCATCTCTGAACTTTTTCTATCCTGAGTCATCTGCCTAGTCATCCTGGCCCCTGGCC
CACTCTGCGCATGCGTGCCTCGCCCCAGACCCTTCCTGTACCTGTAACCCGCCTAGATTACAAG
GTCTTCTTCCCTCTCATAGCCCTACGGATTCCCAGGCCTTTTCCTCTCCTCCATACCCTTCCTG
TCCCTTCCACTTCACTCTGTGGCCTGAGCTGAATTAGGTACACTAGAAAGAGCGCCTTATGTGA
AGCAAGCACACAGACAGACAGACAGACAGACAGACAGACAGACAGACAGACAGTGGCAACAAAA
ACTCCTGACCCAGCTTGAGGTTGTTTCTCTAAATGTTTTTATTACCAGCTCTCAGTGTGGTAGG
CGGTCTGATCCCAGAAGTCTCCCTTCCCCCTTTCAAGTTCAGCACGAAGTCCCAAGTCCACTTT
ACAGAGCAGAGCACTATGACCGCCCTGGGCTTGTTGTGAGTCTTCCTCGTAAGGTGCAGCAAAT
GTCCCCGTGTCAACACGGCTCACGCCGCCTCAGAGACTCTGGCAAATCGTACTTGAACAGCTTC
TCTCTCAGGGAAATTCTGCAAAAACTAGAATGAATCGAAGCATTCCCGTGGAGGTTGACGAATC
GGAGCCCTTCCCGAGTCAGTTGCTGAATCCGATCCCAGAATCTTCTCCAGAAGAGGAATTGGAA
CCACCTGCCCCAAATACAAGGAACACGGCACCCAGCAGCTTGTCTGTACTCCAACGCCCTCCCC
TGAAACTTGCAAATCACCAGCCTGTGTCGCAACAGGTCACCTGCTTGCGAGCTAAAGTCCTGGA
GGAGAGTGAAGCCAGTTTCCTTAGAAGGCACCCTGATCTCGGCAAAGATGTTTCCTCCTGCTCC
TCTGAAGCCAGTGAGCCTGGGTCTGAGCTTGGAGCCCTCTCTCTAGAGCATCGCTTTACACATA
TGGAAAAACGCGATAGATGGCTGGGACCTCAGCTTTCAGCAGCTTCTCCCGACACTGGCCATGA
CTCAGACAAATCAGACCCAAGTTTGCCTATGGCTTTGGCAGACTCCTCCAGTAGTGACCAAGAG
ATGAGGCCCAGGCCCGGGTCCCGGCCCCGGCCCTGGCCCCGGCACCACAGGAACAGGGCAGCCC
CAGATGTGCCCACGATAGACACTGGGTATGATTCCCAGCCCCAAGATGTCCTGGGCATCAGGCA
GCTGGAAAAGCCCTTGCCCCTCACCTCCTCATGTTACCTGCAGGACCTCCCTGGGCCTCTCAGG
TCCAAGGAATTTCCCCAGTTTGAACTCCAGAGGTATCCGGCGAATGCGCCGATGCTGCCTCTCG
ATCCTTCCCCACAGGTTCCATGGAGTTATCAGTACTGTCGTCCCGGAGGGCCCTATCACCACCA
GGCGCCATATGGTCATGGCTACCCTCCAGCAGCAGCCTACCAGCAAGTCATCCAGCCTGCTCTG
CCTGAGCAGGCCCTTCTCGGGGCAAGGGTGAGAGGCCTGCACCCTATGCAGAAGGTCGTCCTGA
ATGACTCCAGCCCCCAGGACCAAGAAGAGAGGCCTGCACAGCGAGACTTCTCTTTCTCAAGGCT
CCCAAGGGACCGGCTCTGCCGCCCACCATCTAATGGAGCTGGAGCTCCCGAGGAGTCCTTGGAC
CGTCCTGCAGAGCTGAGACCACATGGTCCCCAGGCTCTGTCCCCAGCTGCCGTGCCTAGACCCC
CTAGCAACCCCTTAGCCCGAGGAACTCTGAAAACCAGCAATTTGCCAGAGGAATTACGGAAGGT
CTTTATCACTTATTCTATGGACACAGCCATGGAGGTGGTGAAGTGTGTGAACTTCCTGCTGGTG
AATGGCTTCCAAACCGCCATTGACATATTTGAGGACAGAATCCGGGGTATTGATATCATTAAAT
GGATGGAGCGCTACCTTCGAGATAAGACAGTGATGATAATCGTAGCAATCAGCCCCAAATACAA
ACAGGATGTGGAAGGCACTGGGTCGCAGCTGGACGAGGATGAGCATGGCTTACATACTAAGTAC
ATTCATCGGATGATGCAGATCGAGTTTATAAATCAGGGAAGCATGAATTTCAGGTTCATCCCTG
TGCTCTTCCCAAATGCCAAGAAGGAGCATGTGCCGACCTGGCTGCAGAACACTCACGTGTACAG
CTGGCCCAAGAATAAGAAAAACATCCTTCTGCGGCTGCTCCGAGAGGAGGAGTACGTAGCTCCT
CCCCGAGGCCCTCTGCCCACCCTTCAGGTGGTACCTTTGTGATGCCAGCCTGTTCTCACAGCAT
TCGTCCAGCCAAGCTGGTTGGTGGCACTCAGGCCTGGAACACCTGTTCTACAGAGTTCCCGGCC
TCCTGAGTCTGAGGTGTCCTCGCCCGGCCTCCAGTGCTTCTGGGAGTGGATGTTGCAGGTGATG
GCTGCCCGGACCTATGGCCACAAAAACTCTCATCACTTCAGCTACTCTTATGAGTTGGCCGGAT
GCTTTGTGTCCTTAGACCAGTCTGAATCGTGCTCAATTAATAAAGTGATTATTCTTTGTAA

hide sequence

RefSeq Acc Id:

XM_039098886 ⟹ XP_038954814

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	44,565,992 - 44,596,004 (+)	NCBI
mRatBN7.2	20	43,011,405 - 43,040,121 (+)	NCBI

RefSeq Acc Id:

XM_039098887 ⟹ XP_038954815

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	44,600,611 - 44,609,240 (+)	NCBI
mRatBN7.2	20	43,045,707 - 43,054,654 (+)	NCBI

RefSeq Acc Id:

XM_063279316 ⟹ XP_063135386

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	44,565,992 - 44,603,613 (+)	NCBI

RefSeq Acc Id:

XM_063279317 ⟹ XP_063135387

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	44,584,547 - 44,609,240 (+)	NCBI

RefSeq Acc Id:

XM_063279318 ⟹ XP_063135388

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	44,595,493 - 44,609,240 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001037713	(Get FASTA)	NCBI Sequence Viewer
	XP_006256594	(Get FASTA)	NCBI Sequence Viewer
	XP_038954814	(Get FASTA)	NCBI Sequence Viewer
	XP_038954815	(Get FASTA)	NCBI Sequence Viewer
	XP_063135386	(Get FASTA)	NCBI Sequence Viewer
	XP_063135387	(Get FASTA)	NCBI Sequence Viewer
	XP_063135388	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI00100	(Get FASTA)	NCBI Sequence Viewer
	EDL87824	(Get FASTA)	NCBI Sequence Viewer
	EDL87825	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000000728
	ENSRNOP00000000728.6
	ENSRNOP00000081231.1
	ENSRNOP00000095663
	ENSRNOP00000095663.1

RefSeq Acc Id:

NP_001037713 ⟸ NM_001044248

- UniProtKB:

Q498R8 (UniProtKB/TrEMBL), F7ENK0 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MNRSIPVEVDESEPFPSQLLNPIPESSPEEELEPPAPNTRNTAPSSLSVLQRPPLKLANHQPVS
QQVTCLRAKVLEESEASFLRRHPDLGKDVSSCSSEASEPGSELGALSLEHRFTHMEKRDRWLGP
QLSAASPDTGHDSDKSDPSLPMALADSSSSDQEMRPRPGSRPRPWPRHHRNRAAPDVPTIDTGY
DSQPQDVLGIRQLEKPLPLTSSCYLQDLPGPLRSKEFPQFELQRYPANAPMLPLDPSPQVPWSY
QYCRPGGPYHHQAPYGHGYPPAAAYQQVIQPALPEQALLGARVRGLHPMQKVVLNDSSPQDQEE
RPAQRDFSFSRLPRDRLCRPPSNGAGAPEESLDRPAELRPHGPQALSPAAVPRPPSNPLARGTL
KTSNLPEELRKVFITYSMDTAMEVVKCVNFLLVNGFQTAIDIFEDRIRGIDIIKWMERYLRDKT
VMIIVAISPKYKQDVEGTGSQLDEDEHGLHTKYIHRMMQIEFINQGSMNFRFIPVLFPNAKKEH
VPTWLQNTHVYSWPKNKKNILLRLLREEEYVAPPRGPLPTLQVVPL

hide sequence

RefSeq Acc Id:	XP_006256594 ⟸ XM_006256532
- Peptide Label:	isoform X1
- UniProtKB:	Q498R8 (UniProtKB/TrEMBL), F7ENK0 (UniProtKB/TrEMBL)
- Sequence:	show sequence MNRSIPVEVDESEPFPSQLLNPIPESSPEEELEPPAPNTRNTAPSSLSVLQRPPLKLANHQPVS QQVTCLRAKVLEESEASFLRRHPDLGKDVSSCSSEASEPGSELGALSLEHRFTHMEKRDRWLGP QLSAASPDTGHDSDKSDPSLPMALADSSSSDQEMRPRPGSRPRPWPRHHRNRAAPDVPTIDTGY DSQPQDVLGIRQLEKPLPLTSSCYLQDLPGPLRSKEFPQFELQRYPANAPMLPLDPSPQVPWSY QYCRPGGPYHHQAPYGHGYPPAAAYQQVIQPALPEQALLGARVRGLHPMQKVVLNDSSPQDQEE RPAQRDFSFSRLPRDRLCRPPSNGAGAPEESLDRPAELRPHGPQALSPAAVPRPPSNPLARGTL KTSNLPEELRKVFITYSMDTAMEVVKCVNFLLVNGFQTAIDIFEDRIRGIDIIKWMERYLRDKT VMIIVAISPKYKQDVEGTGSQLDEDEHGLHTKYIHRMMQIEFINQGSMNFRFIPVLFPNAKKEH VPTWLQNTHVYSWPKNKKNILLRLLREEEYVAPPRGPLPTLQVVPL hide sequence

Ensembl Acc Id:

ENSRNOP00000000728 ⟸ ENSRNOT00000000728

RefSeq Acc Id:	XP_038954814 ⟸ XM_039098886
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_038954815 ⟸ XM_039098887
- Peptide Label:	isoform X6

Ensembl Acc Id:

ENSRNOP00000081231 ⟸ ENSRNOT00000103797

Ensembl Acc Id:

ENSRNOP00000095663 ⟸ ENSRNOT00000119731

RefSeq Acc Id:	XP_063135386 ⟸ XM_063279316
- Peptide Label:	isoform X2
- UniProtKB:	A0A8I5ZS21 (UniProtKB/TrEMBL), A0A8I6GLR0 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063135387 ⟸ XM_063279317
- Peptide Label:	isoform X4

RefSeq Acc Id:	XP_063135388 ⟸ XM_063279318
- Peptide Label:	isoform X5
- UniProtKB:	A6KIH0 (UniProtKB/TrEMBL)

Protein Domains

SEFIR

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q498R8-F1-model_v2	AlphaFold	Q498R8	1-558	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13701651

Promoter ID:

EPDNEW_R12175

Type:

initiation region

Name:

Traf3ip2_1

Description:

Traf3 interacting protein 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	20	44,680,439 - 44,680,499	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1593240	AgrOrtholog
BioCyc Gene	G2FUF-3470	BioCyc
Ensembl Genes	ENSRNOG00000000595	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000000728	ENTREZGENE
	ENSRNOT00000000728.6	UniProtKB/TrEMBL
	ENSRNOT00000103797.1	UniProtKB/TrEMBL
	ENSRNOT00000119731	ENTREZGENE
	ENSRNOT00000119731.1	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7376204	IMAGE-MGC_LOAD
InterPro	E3_ubiq_ligase_TRAF3IP2	UniProtKB/TrEMBL
	SEFIR	UniProtKB/TrEMBL
KEGG Report	rno:361857	UniProtKB/TrEMBL
MGC_CLONE	MGC:112844	IMAGE-MGC_LOAD
NCBI Gene	361857	ENTREZGENE
PANTHER	ADAPTER PROTEIN CIKS	UniProtKB/TrEMBL
	E3 UBIQUITIN LIGASE TRAF3IP2	UniProtKB/TrEMBL
Pfam	SEFIR	UniProtKB/TrEMBL
PhenoGen	Traf3ip2	PhenoGen
PROSITE	SEFIR	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000000595	RatGTEx
UniProt	A0A8I5ZS21	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6GLR0	ENTREZGENE, UniProtKB/TrEMBL
	A6KIH0	ENTREZGENE, UniProtKB/TrEMBL
	F7ENK0	ENTREZGENE, UniProtKB/TrEMBL
	Q498R8	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2009-06-15	Traf3ip2	Traf3 interacting protein 2	RGD1304768	similar to Adapter protein CIKS (Connection to IKK and SAPK/JNK) (Nuclear factor NF-kappa-B activator 1) (ACT1)	Data merged from RGD:1304768	1643240	APPROVED
2008-04-30	RGD1304768	similar to Adapter protein CIKS (Connection to IKK and SAPK/JNK) (Nuclear factor NF-kappa-B activator 1) (ACT1)	RGD1304768_predicted	similar to Adapter protein CIKS (Connection to IKK and SAPK/JNK) (Nuclear factor NF-kappa-B activator 1) (ACT1) (predicted)	'predicted' is removed	2292626	APPROVED
2008-03-06	Traf3ip2	Traf3 interacting protein 2	MGC112844	chromosome 6 open reading frame 4	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-11-20	MGC112844	chromosome 6 open reading frame 4			Symbol and Name status set to provisional	70820	PROVISIONAL
2005-01-20	RGD1304768_predicted	similar to Adapter protein CIKS (Connection to IKK and SAPK/JNK) (Nuclear factor NF-kappa-B activator 1) (ACT1) (predicted)	LOC294437_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC294437_predicted	similar to Adapter protein CIKS (Connection to IKK and SAPK/JNK) (Nuclear factor NF-kappa-B activator 1) (ACT1) (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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