Gprc6a (G protein-coupled receptor, class C, group 6, member A) - Rat Genome Database

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Gene: Gprc6a (G protein-coupled receptor, class C, group 6, member A) Rattus norvegicus
Analyze
Symbol: Gprc6a
Name: G protein-coupled receptor, class C, group 6, member A
RGD ID: 735077
Description: Predicted to enable G protein-coupled receptor activity. Predicted to be involved in regulation of testosterone biosynthetic process and response to amino acid. Located in plasma membrane. Orthologous to human GPRC6A (G protein-coupled receptor class C group 6 member A); INTERACTS WITH bisphenol A; streptozocin; warfarin.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: G protein-coupled receptor, family C, group 6, member A; G-protein coupled receptor family C group 6 member A
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82031,464,818 - 31,486,121 (-)NCBIGRCr8
mRatBN7.22030,922,106 - 30,943,412 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2030,922,106 - 30,943,412 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2031,933,050 - 31,954,357 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02031,323,970 - 31,345,277 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02032,056,871 - 32,078,866 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02032,607,653 - 32,628,953 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2032,607,653 - 32,628,953 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02034,391,559 - 34,412,859 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42030,235,065 - 30,256,951 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12030,248,864 - 30,270,751 (-)NCBI
Celera2032,337,968 - 32,359,241 (-)NCBICelera
Cytogenetic Map20q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cell surface  (IEA)
plasma membrane  (IBA,IDA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Molecular cloning, expression, and sequence analysis of GPRC6A, a novel family C G-protein-coupled receptor. Wellendorph P and Brauner-Osborne H, Gene 2004 Jun 23;335:37-46.
7. The rat GPRC6A: cloning and characterization. Wellendorph P, etal., Gene. 2007 Jul 15;396(2):257-67. Epub 2007 Mar 24.
Additional References at PubMed
PMID:16199532   PMID:28280242  


Genomics

Comparative Map Data
Gprc6a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82031,464,818 - 31,486,121 (-)NCBIGRCr8
mRatBN7.22030,922,106 - 30,943,412 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2030,922,106 - 30,943,412 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2031,933,050 - 31,954,357 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02031,323,970 - 31,345,277 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02032,056,871 - 32,078,866 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02032,607,653 - 32,628,953 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2032,607,653 - 32,628,953 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02034,391,559 - 34,412,859 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42030,235,065 - 30,256,951 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12030,248,864 - 30,270,751 (-)NCBI
Celera2032,337,968 - 32,359,241 (-)NCBICelera
Cytogenetic Map20q11NCBI
GPRC6A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386116,792,085 - 116,829,240 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6116,792,085 - 116,829,083 (-)EnsemblGRCh38hg38GRCh38
GRCh376117,113,248 - 117,150,246 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366117,219,941 - 117,256,891 (-)NCBINCBI36Build 36hg18NCBI36
Build 346117,219,940 - 117,256,891NCBI
Celera6117,856,343 - 117,893,293 (-)NCBICelera
Cytogenetic Map6q22.1NCBI
HuRef6114,692,894 - 114,729,847 (-)NCBIHuRef
CHM1_16117,377,275 - 117,414,231 (-)NCBICHM1_1
T2T-CHM13v2.06117,975,811 - 118,012,987 (-)NCBIT2T-CHM13v2.0
Gprc6a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391051,490,919 - 51,507,554 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1051,490,919 - 51,507,557 (-)EnsemblGRCm39 Ensembl
GRCm381051,614,823 - 51,631,458 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1051,614,823 - 51,631,461 (-)EnsemblGRCm38mm10GRCm38
MGSCv371051,334,629 - 51,351,264 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361051,303,238 - 51,319,873 (-)NCBIMGSCv36mm8
Celera1052,458,235 - 52,474,872 (-)NCBICelera
Cytogenetic Map10B3NCBI
cM Map1025.66NCBI
Gprc6a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955436137,809 - 159,481 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955436137,809 - 159,481 (-)NCBIChiLan1.0ChiLan1.0
GPRC6A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25136,806,917 - 136,843,842 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16134,699,926 - 134,736,844 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06114,601,360 - 114,638,286 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16118,744,929 - 118,781,099 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6118,744,929 - 118,781,099 (-)Ensemblpanpan1.1panPan2
GPRC6A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1157,191,210 - 57,212,008 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl157,191,325 - 57,212,027 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha157,982,884 - 58,007,086 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0157,369,654 - 57,393,866 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl157,373,198 - 57,393,895 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1157,264,046 - 57,288,251 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0157,112,172 - 57,136,372 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0157,740,939 - 57,765,164 (-)NCBIUU_Cfam_GSD_1.0
Gprc6a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946107,932,060 - 107,951,693 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493665838,931 - 58,534 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493665838,931 - 58,534 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPRC6A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl144,854,512 - 44,874,777 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1144,852,731 - 44,875,518 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2150,131,381 - 50,153,730 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GPRC6A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11356,994,267 - 57,028,736 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1356,995,346 - 57,028,305 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604029,330,675 - 29,363,823 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gprc6a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479812,865,731 - 12,888,685 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479812,865,834 - 12,888,598 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gprc6a
282 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:24
Count of miRNA genes:22
Interacting mature miRNAs:23
Transcripts:ENSRNOT00000000451
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)201761783247606836Rat
2303587Bw93Body weight QTL 9313body mass (VT:0001259)body weight (CMO:0000012)202510672254435887Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
2303626Vencon10Ventilatory control QTL 100.001respiration trait (VT:0001943)respiration rate (CMO:0000289)201919072154435887Rat
1598869Memor6Memory QTL 63.1exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)202924438854435887Rat
7411652Foco24Food consumption QTL 240.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)201175751554435887Rat
1331747Hrtrt16Heart rate QTL 163.163heart pumping trait (VT:2000009)heart rate (CMO:0000002)202520973454435887Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
2303578Gluco50Glucose level QTL 502blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)202510672254435887Rat
2317880Alcrsp25Alcohol response QTL 252.3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)201769755054435887Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat
9590092Insglur9Insulin/glucose ratio QTL 918.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)201175751554435887Rat
2300188Bmd68Bone mineral density QTL 686.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)202510672254435887Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
3 1 1 4 14 1 2 1 9 3 1 2 9 13

Sequence


Ensembl Acc Id: ENSRNOT00000000451   ⟹   ENSRNOP00000000451
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2030,922,106 - 30,943,412 (-)Ensembl
Rnor_6.0 Ensembl2032,607,653 - 32,628,953 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000112868   ⟹   ENSRNOP00000080341
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2030,922,106 - 30,943,412 (-)Ensembl
RefSeq Acc Id: NM_001271106   ⟹   NP_001258035
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82031,464,818 - 31,486,121 (-)NCBI
mRatBN7.22030,922,106 - 30,943,412 (-)NCBI
Rnor_6.02032,607,653 - 32,628,953 (-)NCBI
Rnor_5.02034,391,559 - 34,412,859 (-)NCBI
Celera2032,337,968 - 32,359,241 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001258035 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAD59483 (Get FASTA)   NCBI Sequence Viewer  
  EDL92950 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000000451.3
  ENSRNOP00000080341.1
  ENSRNOP00055020984
  ENSRNOP00060009806
  ENSRNOP00065003261
GenBank Protein Q70VB1 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001258035   ⟸   NM_001271106
- Peptide Label: precursor
- UniProtKB: Q70VB1 (UniProtKB/Swiss-Prot),   A6K472 (UniProtKB/TrEMBL),   A0A8I6G4E9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000000451   ⟸   ENSRNOT00000000451
Ensembl Acc Id: ENSRNOP00000080341   ⟸   ENSRNOT00000112868
Protein Domains
G-protein coupled receptors family 3 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q70VB1-F1-model_v2 AlphaFold Q70VB1 1-928 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:735077 AgrOrtholog
BioCyc Gene G2FUF-3661 BioCyc
Ensembl Genes ENSRNOG00000000401 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055015033 UniProtKB/Swiss-Prot
  ENSRNOG00060007836 UniProtKB/Swiss-Prot
  ENSRNOG00065003223 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000000451.6 UniProtKB/Swiss-Prot
  ENSRNOT00000112868.1 UniProtKB/TrEMBL
  ENSRNOT00055025717 UniProtKB/Swiss-Prot
  ENSRNOT00060012928 UniProtKB/Swiss-Prot
  ENSRNOT00065004560 UniProtKB/Swiss-Prot
Gene3D-CATH 2.10.50.30 UniProtKB/Swiss-Prot
  3.40.50.2300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR, family 3, nine cysteines domain UniProtKB/TrEMBL
InterPro ANF_lig-bd_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_3_9-Cys_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_3_9-Cys_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_3_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_3_Ca_sens_rcpt-rel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_3_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peripla_BP_I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:294394 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 294394 ENTREZGENE
PANTHER G-PROTEIN COUPLED RECEPTOR FAMILY C GROUP 6 MEMBER A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR24061 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANF_receptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NCD3G UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gprc6a PhenoGen
PRINTS CASENSINGR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRMGR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F3_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F3_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000000401 RatGTEx
  ENSRNOG00055015033 RatGTEx
  ENSRNOG00060007836 RatGTEx
  ENSRNOG00065003223 RatGTEx
Superfamily-SCOP SSF53822 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6G4E9 ENTREZGENE, UniProtKB/TrEMBL
  A6K472 ENTREZGENE, UniProtKB/TrEMBL
  GPC6A_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-02-06 Gprc6a  G protein-coupled receptor, class C, group 6, member A  Gprc6a  G protein-coupled receptor, family C, group 6, member A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Gprc6a  G protein-coupled receptor, family C, group 6, member A      Symbol and Name status set to approved 1299863 APPROVED