Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dimethylhydrazine | multiple interactions | ISO | Hsd17b8 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of HSD17B8 mRNA | CTD | PMID:22206623 | 1,2-dimethylhydrazine | increases expression | ISO | Hsd17b8 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in increased expression of HSD17B8 mRNA | CTD | PMID:22206623 | 17beta-estradiol | multiple interactions | ISO | HSD17B8 (Homo sapiens) | 6480464 | [Estradiol co-treated with TGFB1 protein] results in decreased expression of HSD17B8 mRNA | CTD | PMID:30165855 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of HSD17B8 mRNA | CTD | PMID:21215274 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Hsd17b8 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of HSD17B8 mRNA | CTD | PMID:21570461 and PMID:24680724 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of HSD17B8 mRNA | CTD | PMID:33387578 | 2-hydroxypropanoic acid | decreases expression | ISO | HSD17B8 (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of HSD17B8 mRNA | CTD | PMID:30851411 | 4-hydroxyphenyl retinamide | increases expression | ISO | Hsd17b8 (Mus musculus) | 6480464 | Fenretinide results in increased expression of HSD17B8 mRNA | CTD | PMID:28973697 | androgen antagonist | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of HSD17B8 mRNA | CTD | PMID:25607892 | aristolochic acid A | decreases expression | ISO | HSD17B8 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of HSD17B8 mRNA | CTD | PMID:33212167 | arsane | multiple interactions | ISO | HSD17B8 (Homo sapiens) | 6480464 | [sodium arsenate results in increased abundance of Arsenic] which results in decreased expression of HSD17B8 mRNA | CTD | PMID:32525701 | arsenic atom | multiple interactions | ISO | HSD17B8 (Homo sapiens) | 6480464 | [sodium arsenate results in increased abundance of Arsenic] which results in decreased expression of HSD17B8 mRNA | CTD | PMID:32525701 | arsenous acid | decreases expression | ISO | HSD17B8 (Homo sapiens) | 6480464 | Arsenic Trioxide results in decreased expression of HSD17B8 mRNA | CTD | PMID:27829220 | atrazine | increases expression | ISO | HSD17B8 (Homo sapiens) | 6480464 | Atrazine results in increased expression of HSD17B8 mRNA | CTD | PMID:22378314 | benzo[a]pyrene | decreases expression | ISO | HSD17B8 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of HSD17B8 mRNA | CTD | PMID:32234424 | bis(2-chloroethyl) sulfide | increases expression | ISO | Hsd17b8 (Mus musculus) | 6480464 | Mustard Gas results in increased expression of HSD17B8 mRNA | CTD | PMID:15674844 | bis(2-ethylhexyl) phthalate | decreases expression | ISO | HSD17B8 (Homo sapiens) | 6480464 | Diethylhexyl Phthalate results in decreased expression of HSD17B8 mRNA | CTD | PMID:28412506 | bis(2-ethylhexyl) phthalate | increases expression | EXP | | 6480464 | Diethylhexyl Phthalate results in increased expression of HSD17B8 mRNA | CTD | PMID:19560483 and PMID:26472102 | bisphenol A | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of HSD17B8 mRNA | CTD | PMID:25607892 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of HSD17B8 mRNA | CTD | PMID:25181051 | Butylbenzyl phthalate | increases expression | EXP | | 6480464 | butylbenzyl phthalate results in increased expression of HSD17B8 mRNA | CTD | PMID:19560483 and PMID:26472102 | Butylparaben | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of HSD17B8 mRNA | CTD | PMID:25607892 | cadmium dichloride | decreases expression | ISO | HSD17B8 (Homo sapiens) | 6480464 | Cadmium Chloride results in decreased expression of HSD17B8 mRNA | CTD | PMID:21457566 | cadmium dichloride | decreases methylation | EXP | | 6480464 | Cadmium Chloride results in decreased methylation of HSD17B8 promoter | CTD | PMID:22457795 | carbon nanotube | decreases expression | ISO | Hsd17b8 (Mus musculus) | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | CGP 52608 | multiple interactions | ISO | HSD17B8 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to HSD17B8 gene] | CTD | PMID:28238834 | cisplatin | affects response to substance | ISO | HSD17B8 (Homo sapiens) | 6480464 | HSD17B8 protein affects the susceptibility to Cisplatin | CTD | PMID:16217747 | cisplatin | increases expression | ISO | HSD17B8 (Homo sapiens) | 6480464 | Cisplatin results in increased expression of HSD17B8 mRNA | CTD | PMID:27392435 | cisplatin | multiple interactions | ISO | HSD17B8 (Homo sapiens) | 6480464 | [Cisplatin co-treated with jinfukang] results in increased expression of HSD17B8 mRNA | CTD | PMID:27392435 | cobalt dichloride | decreases expression | ISO | HSD17B8 (Homo sapiens) | 6480464 | cobaltous chloride results in decreased expression of HSD17B8 mRNA | CTD | PMID:19376846 | copper(II) sulfate | decreases expression | ISO | HSD17B8 (Homo sapiens) | 6480464 | Copper Sulfate results in decreased expression of HSD17B8 mRNA | CTD | PMID:19549813 | coumestrol | increases expression | ISO | HSD17B8 (Homo sapiens) | 6480464 | Coumestrol results in increased expression of HSD17B8 mRNA | CTD | PMID:19167446 | cyclosporin A | increases expression | ISO | HSD17B8 (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of HSD17B8 mRNA | CTD | PMID:27989131 | deguelin | decreases expression | ISO | HSD17B8 (Homo sapiens) | 6480464 | deguelin results in decreased expression of HSD17B8 mRNA | CTD | PMID:33512557 | diarsenic trioxide | decreases expression | ISO | HSD17B8 (Homo sapiens) | 6480464 | Arsenic Trioxide results in decreased expression of HSD17B8 mRNA | CTD | PMID:27829220 | dibutyl phthalate | increases expression | EXP | | 6480464 | Dibutyl Phthalate results in increased expression of HSD17B8 mRNA | CTD | PMID:19560483 and PMID:26472102 | diethyl phthalate | increases expression | EXP | | 6480464 | diethyl phthalate results in increased expression of HSD17B8 mRNA | CTD | PMID:26472102 | diethylstilbestrol | decreases expression | EXP | | 6480464 | Diethylstilbestrol results in decreased expression of HSD17B8 mRNA | CTD | PMID:36653537 | dipentyl phthalate | increases expression | EXP | | 6480464 | di-n-pentyl phthalate results in increased expression of HSD17B8 mRNA | CTD | PMID:19560483 and PMID:26472102 | dorsomorphin | multiple interactions | ISO | HSD17B8 (Homo sapiens) | 6480464 | [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | elemental selenium | increases expression | ISO | HSD17B8 (Homo sapiens) | 6480464 | Selenium results in increased expression of HSD17B8 mRNA | CTD | PMID:19244175 | entinostat | increases expression | ISO | HSD17B8 (Homo sapiens) | 6480464 | entinostat results in increased expression of HSD17B8 mRNA | CTD | PMID:27188386 | enzacamene | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of HSD17B8 mRNA | CTD | PMID:25607892 | folic acid | multiple interactions | ISO | Hsd17b8 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of HSD17B8 mRNA | CTD | PMID:22206623 | genistein | increases expression | ISO | HSD17B8 (Homo sapiens) | 6480464 | Genistein results in increased expression of HSD17B8 protein | CTD | PMID:20884965 | genistein | multiple interactions | ISO | HSD17B8 (Homo sapiens) | 6480464 | ESR2 promotes the reaction [Genistein results in increased expression of HSD17B8 protein] | CTD | PMID:20884965 | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of HSD17B8 mRNA | CTD | PMID:33387578 | gossypol | multiple interactions | ISO | HSD17B8 (Homo sapiens) | 6480464 | [Gossypol co-treated with NAD] binds to HSD17B8 protein | CTD | PMID:25526675 | isobutanol | multiple interactions | ISO | HSD17B8 (Homo sapiens) | 6480464 | [[Gasoline co-treated with isobutyl alcohol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in decreased expression of HSD17B8 mRNA | CTD | PMID:29432896 | ivermectin | decreases expression | ISO | HSD17B8 (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of HSD17B8 protein | CTD | PMID:32959892 | lead(0) | affects methylation | ISO | HSD17B8 (Homo sapiens) | 6480464 | Lead affects the methylation of HSD17B8 gene | CTD | PMID:31636367 | mercury dibromide | decreases expression | ISO | HSD17B8 (Homo sapiens) | 6480464 | mercuric bromide results in decreased expression of HSD17B8 mRNA | CTD | PMID:26272509 | mercury dibromide | multiple interactions | ISO | HSD17B8 (Homo sapiens) | 6480464 | [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HSD17B8 mRNA | CTD | PMID:27188386 | methylmercury chloride | decreases expression | ISO | HSD17B8 (Homo sapiens) | 6480464 | methylmercuric chloride results in decreased expression of HSD17B8 mRNA | CTD | PMID:28001369 | mifepristone | decreases expression | ISO | HSD17B8 (Homo sapiens) | 6480464 | Mifepristone results in decreased expression of HSD17B8 mRNA | CTD | PMID:17584828 | N-acetyl-L-cysteine | multiple interactions | ISO | HSD17B8 (Homo sapiens) | 6480464 | Acetylcysteine inhibits the reaction [SOD2 protein affects the expression of HSD17B8 mRNA] | CTD | PMID:18829485 | N-methyl-4-phenylpyridinium | increases expression | ISO | Hsd17b8 (Mus musculus) | 6480464 | 1-Methyl-4-phenylpyridinium results in increased expression of HSD17B8 mRNA | CTD | PMID:22776087 | NAD zwitterion | multiple interactions | ISO | HSD17B8 (Homo sapiens) | 6480464 | [Gossypol co-treated with NAD] binds to HSD17B8 protein | CTD | PMID:25526675 | NAD(+) | multiple interactions | ISO | HSD17B8 (Homo sapiens) | 6480464 | [Gossypol co-treated with NAD] binds to HSD17B8 protein | CTD | PMID:25526675 | NADP zwitterion | multiple interactions | ISO | HSD17B8 (Homo sapiens) | 6480464 | NADP binds to and results in increased activity of HSD17B8 protein | CTD | PMID:25526675 | NADP(+) | multiple interactions | ISO | HSD17B8 (Homo sapiens) | 6480464 | NADP binds to and results in increased activity of HSD17B8 protein | CTD | PMID:25526675 | ozone | multiple interactions | ISO | Hsd17b8 (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of Ozone] which results in decreased expression of HSD17B8 mRNA | CTD | PMID:34911549 | p-chloromercuribenzoic acid | decreases expression | ISO | HSD17B8 (Homo sapiens) | 6480464 | p-Chloromercuribenzoic Acid results in decreased expression of HSD17B8 mRNA | CTD | PMID:26272509 | p-chloromercuribenzoic acid | multiple interactions | ISO | HSD17B8 (Homo sapiens) | 6480464 | [NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HSD17B8 mRNA | CTD | PMID:27188386 | paracetamol | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of HSD17B8 mRNA | CTD | PMID:25607892 | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of HSD17B8 mRNA | CTD | PMID:33387578 | paracetamol | decreases expression | ISO | HSD17B8 (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of HSD17B8 mRNA | CTD | PMID:29067470 | phenylmercury acetate | decreases expression | ISO | HSD17B8 (Homo sapiens) | 6480464 | Phenylmercuric Acetate results in decreased expression of HSD17B8 mRNA | CTD | PMID:26272509 | phenylmercury acetate | multiple interactions | ISO | HSD17B8 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HSD17B8 mRNA | CTD | PMID:27188386 | pirinixic acid | increases expression | ISO | Hsd17b8 (Mus musculus) | 6480464 | pirinixic acid results in increased expression of HSD17B8 mRNA | CTD | PMID:17426115 | rac-lactic acid | decreases expression | ISO | HSD17B8 (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of HSD17B8 mRNA | CTD | PMID:30851411 | SB 431542 | multiple interactions | ISO | HSD17B8 (Homo sapiens) | 6480464 | [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | selenium atom | increases expression | ISO | HSD17B8 (Homo sapiens) | 6480464 | Selenium results in increased expression of HSD17B8 mRNA | CTD | PMID:19244175 | sodium arsenate | multiple interactions | ISO | HSD17B8 (Homo sapiens) | 6480464 | [sodium arsenate results in increased abundance of Arsenic] which results in decreased expression of HSD17B8 mRNA | CTD | PMID:32525701 | sunitinib | decreases expression | ISO | HSD17B8 (Homo sapiens) | 6480464 | Sunitinib results in decreased expression of HSD17B8 mRNA | CTD | PMID:31533062 | tetrachloroethene | decreases expression | ISO | Hsd17b8 (Mus musculus) | 6480464 | Tetrachloroethylene results in decreased expression of HSD17B8 mRNA | CTD | PMID:28973375 | tetrachloromethane | decreases expression | ISO | Hsd17b8 (Mus musculus) | 6480464 | Carbon Tetrachloride results in decreased expression of HSD17B8 mRNA | CTD | PMID:31919559 | thifluzamide | decreases expression | ISO | HSD17B8 (Homo sapiens) | 6480464 | thifluzamide results in decreased expression of HSD17B8 mRNA | CTD | PMID:33512557 | thioacetamide | decreases expression | EXP | | 6480464 | Thioacetamide results in decreased expression of HSD17B8 mRNA | CTD | PMID:34492290 | tris(2-butoxyethyl) phosphate | increases expression | ISO | HSD17B8 (Homo sapiens) | 6480464 | tris(2-butoxyethyl) phosphate results in increased expression of HSD17B8 mRNA | CTD | PMID:29024780 | tunicamycin | increases expression | ISO | HSD17B8 (Homo sapiens) | 6480464 | Tunicamycin results in increased expression of HSD17B8 mRNA | CTD | PMID:29453283 | urethane | decreases expression | ISO | HSD17B8 (Homo sapiens) | 6480464 | Urethane results in decreased expression of HSD17B8 mRNA | CTD | PMID:28818685 | valproic acid | affects expression | ISO | HSD17B8 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of HSD17B8 mRNA | CTD | PMID:25979313 | valproic acid | increases expression | ISO | Hsd17b8 (Mus musculus) | 6480464 | Valproic Acid results in increased expression of HSD17B8 mRNA | CTD | PMID:21427059 | valproic acid | increases expression | ISO | HSD17B8 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of HSD17B8 mRNA | CTD | PMID:19101580 more ... | vitamin E | increases expression | ISO | HSD17B8 (Homo sapiens) | 6480464 | Vitamin E results in increased expression of HSD17B8 mRNA | CTD | PMID:19244175 | XL147 | multiple interactions | ISO | Hsd17b8 (Mus musculus) | 6480464 | XL147 inhibits the reaction [N-nitroso-tris-chloroethylurea results in increased expression of HSD17B8 mRNA] | CTD | PMID:29891994 | |