Hsd17b8 (hydroxysteroid (17-beta) dehydrogenase 8) - Rat Genome Database

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Gene: Hsd17b8 (hydroxysteroid (17-beta) dehydrogenase 8) Rattus norvegicus
Analyze
Symbol: Hsd17b8
Name: hydroxysteroid (17-beta) dehydrogenase 8
RGD ID: 1303158
Description: Predicted to enable NADH binding activity; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; and quinone binding activity. Predicted to be involved in estrogen biosynthetic process; fatty acid biosynthetic process; and protein heterotetramerization. Predicted to act upstream of or within androgen metabolic process and estrogen metabolic process. Predicted to be located in mitochondrial envelope; mitochondrial matrix; and plasma membrane. Predicted to be part of oxidoreductase complex. Orthologous to human HSD17B8 (hydroxysteroid 17-beta dehydrogenase 8); PARTICIPATES IN steroid hormone biosynthetic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; androgen antagonist; bis(2-ethylhexyl) phthalate.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: (3R)-3-hydroxyacyl-CoA dehydrogenase; 17-beta-HSD 8; 17-beta-hydroxysteroid dehydrogenase 8; 3-ketoacyl-[acyl-carrier-protein] reductase alpha subunit; 3-oxoacyl-[acyl-carrier-protein] reductase; estradiol 17-beta-dehydrogenase 8; Fabgl; KAR alpha subunit; Ke6; MGC109594; RING2; testosterone 17-beta-dehydrogenase 8
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2204,826,725 - 4,828,742 (+)NCBI
Rnor_6.0 Ensembl203,817,179 - 3,819,235 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0203,817,212 - 3,819,316 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0205,896,543 - 5,898,654 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4204,964,860 - 4,966,855 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1204,965,086 - 4,967,082 (+)NCBI
Celera206,426,931 - 6,428,926 (+)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:8940387   PMID:9712896   PMID:12477932   PMID:14651853   PMID:17978863   PMID:18614015   PMID:19571038   PMID:25203508  


Genomics

Comparative Map Data
Hsd17b8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2204,826,725 - 4,828,742 (+)NCBI
Rnor_6.0 Ensembl203,817,179 - 3,819,235 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0203,817,212 - 3,819,316 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0205,896,543 - 5,898,654 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4204,964,860 - 4,966,855 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1204,965,086 - 4,967,082 (+)NCBI
Celera206,426,931 - 6,428,926 (+)NCBICelera
Cytogenetic Map20p12NCBI
HSD17B8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl633,204,655 - 33,206,831 (+)EnsemblGRCh38hg38GRCh38
GRCh38633,204,655 - 33,206,831 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37633,172,432 - 33,174,608 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36633,280,397 - 33,282,585 (+)NCBINCBI36hg18NCBI36
Build 34633,280,396 - 33,282,585NCBI
Celera634,726,785 - 34,728,973 (+)NCBI
Cytogenetic Map6p21.32NCBI
HuRef632,914,459 - 32,916,653 (+)NCBIHuRef
CHM1_1633,174,288 - 33,176,486 (+)NCBICHM1_1
H2-Ke6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391734,245,007 - 34,247,029 (-)NCBIGRCm39mm39
GRCm39 Ensembl1734,245,007 - 34,247,034 (-)Ensembl
GRCm381734,026,033 - 34,028,055 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1734,026,033 - 34,028,060 (-)EnsemblGRCm38mm10GRCm38
MGSCv371734,162,978 - 34,165,000 (-)NCBIGRCm37mm9NCBIm37
MGSCv361733,636,489 - 33,638,511 (-)NCBImm8
Celera1736,772,162 - 36,774,185 (-)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1717.98NCBI
Hsd17b8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554371,778,276 - 1,780,397 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554371,778,276 - 1,780,397 (+)NCBIChiLan1.0ChiLan1.0
HSD17B8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1633,891,753 - 33,893,950 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl633,891,753 - 33,893,950 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0632,776,837 - 32,779,042 (+)NCBIMhudiblu_PPA_v0panPan3
HSD17B8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1122,667,674 - 2,669,918 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl122,663,515 - 2,669,917 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha122,748,819 - 2,751,058 (+)NCBI
ROS_Cfam_1.0122,998,414 - 3,000,653 (+)NCBI
UMICH_Zoey_3.1122,666,602 - 2,668,840 (+)NCBI
UNSW_CanFamBas_1.0122,747,969 - 2,750,208 (+)NCBI
UU_Cfam_GSD_1.0122,822,541 - 2,824,780 (+)NCBI
Hsd17b8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494638,309,422 - 38,311,663 (+)NCBI
SpeTri2.0NW_00493647625,648,604 - 25,650,757 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HSD17B8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl725,247,608 - 25,249,785 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1725,247,577 - 25,249,786 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2729,753,837 - 29,756,042 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HSD17B8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11738,868,307 - 38,870,564 (-)NCBI
ChlSab1.1 Ensembl1738,868,685 - 38,870,459 (-)Ensembl
Vero_WHO_p1.0NW_02366604433,038,755 - 33,041,527 (+)NCBI
Hsd17b8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475423,600,706 - 23,602,786 (-)NCBI

Position Markers
RH129332  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2204,826,327 - 4,826,514 (-)MAPPER
Rnor_6.0203,819,440 - 3,819,626NCBIRnor6.0
Rnor_5.0205,898,771 - 5,898,957UniSTSRnor5.0
RGSC_v3.4204,964,442 - 4,964,628UniSTSRGSC3.4
Celera206,426,513 - 6,426,699UniSTS
RH 3.4 Map9391.29UniSTS
Cytogenetic Map20p12UniSTS
RH133333  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2204,828,458 - 4,828,652 (-)MAPPER
Rnor_6.0203,817,302 - 3,817,495NCBIRnor6.0
Rnor_5.0205,896,633 - 5,896,826UniSTSRnor5.0
RGSC_v3.4204,966,573 - 4,966,766UniSTSRGSC3.4
Celera206,428,644 - 6,428,837UniSTS
RH 3.4 Map2059.7UniSTS
Cytogenetic Map20p12UniSTS
H2-Ke6  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2204,827,329 - 4,828,356 (-)MAPPER
Rnor_6.0203,817,598 - 3,818,624NCBIRnor6.0
Rnor_5.0205,896,929 - 5,897,955UniSTSRnor5.0
RGSC_v3.4204,965,444 - 4,966,470UniSTSRGSC3.4
Celera206,427,515 - 6,428,541UniSTS
Cytogenetic Map20p12UniSTS
Slc39a7  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2204,825,108 - 4,826,342 (-)MAPPER
Rnor_6.0203,819,612 - 3,820,845NCBIRnor6.0
Rnor_5.0205,898,943 - 5,900,176UniSTSRnor5.0
RGSC_v3.4204,963,223 - 4,964,456UniSTSRGSC3.4
Celera206,425,294 - 6,426,527UniSTS
Cytogenetic Map20p12UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724519Bp144Blood pressure QTL 1440.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2015192000Rat
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124652101Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125653396Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20126305996Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20126305996Rat
7387283Uae44Urinary albumin excretion QTL 440.1712urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)20127357423Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20128375393Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20128375393Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20128375393Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20128375393Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20128375393Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20133300419Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20137550487Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20137550487Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20201865447018654Rat
2306850Pia40Pristane induced arthritis QTL 400.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2020187706567419Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20299970747999707Rat
61472Aia1Adjuvant induced arthritis QTL 1180.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2031518156896013Rat
61448Ciaa1CIA Autoantibody QTL 1300.001blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)2031518156896013Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20340211127968216Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:105
Count of miRNA genes:82
Interacting mature miRNAs:92
Transcripts:ENSRNOT00000000542
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 7 10 73 35 41 11 7
Low 1 1 1 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000000542   ⟹   ENSRNOP00000000542
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl203,817,212 - 3,819,200 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000081163   ⟹   ENSRNOP00000073184
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl203,817,212 - 3,818,058 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000081486   ⟹   ENSRNOP00000073887
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl203,817,179 - 3,819,235 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000083728
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl203,817,215 - 3,819,191 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000091369
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl203,818,470 - 3,818,862 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000091622   ⟹   ENSRNOP00000069385
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl203,817,212 - 3,818,045 (-)Ensembl
RefSeq Acc Id: NM_212529   ⟹   NP_997694
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2204,826,746 - 4,828,741 (+)NCBI
Rnor_6.0203,817,213 - 3,819,208 (-)NCBI
Rnor_5.0205,896,543 - 5,898,654 (-)NCBI
RGSC_v3.4204,964,860 - 4,966,855 (+)RGD
Celera206,426,931 - 6,428,926 (+)RGD
Sequence:
RefSeq Acc Id: XM_006255964   ⟹   XP_006256026
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2204,826,878 - 4,828,742 (+)NCBI
Rnor_6.0203,817,212 - 3,819,316 (-)NCBI
Rnor_5.0205,896,543 - 5,898,654 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006255965   ⟹   XP_006256027
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2204,826,725 - 4,828,742 (+)NCBI
Rnor_6.0203,817,212 - 3,819,316 (-)NCBI
Rnor_5.0205,896,543 - 5,898,654 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006255966   ⟹   XP_006256028
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2204,826,878 - 4,828,742 (+)NCBI
Rnor_6.0203,817,212 - 3,819,316 (-)NCBI
Rnor_5.0205,896,543 - 5,898,654 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039098810   ⟹   XP_038954738
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2204,826,878 - 4,828,742 (+)NCBI
RefSeq Acc Id: XR_362002
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2204,826,878 - 4,828,742 (+)NCBI
Rnor_6.0203,817,212 - 3,819,316 (-)NCBI
Rnor_5.0205,896,543 - 5,898,654 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_997694   ⟸   NM_212529
- UniProtKB: Q6MGB5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006256027   ⟸   XM_006255965
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006256028   ⟸   XM_006255966
- Peptide Label: isoform X3
- UniProtKB: A0A0G2K6P1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256026   ⟸   XM_006255964
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000000542   ⟸   ENSRNOT00000000542
RefSeq Acc Id: ENSRNOP00000073887   ⟸   ENSRNOT00000081486
RefSeq Acc Id: ENSRNOP00000073184   ⟸   ENSRNOT00000081163
RefSeq Acc Id: ENSRNOP00000069385   ⟸   ENSRNOT00000091622
RefSeq Acc Id: XP_038954738   ⟸   XM_039098810
- Peptide Label: isoform X4

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701315
Promoter ID:EPDNEW_R11839
Type:single initiation site
Name:Hsd17b8_1
Description:hydroxysteroid (17-beta) dehydrogenase 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0203,819,205 - 3,819,265EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1303158 AgrOrtholog
Ensembl Genes ENSRNOG00000000466 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000000542 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000069385 UniProtKB/TrEMBL
  ENSRNOP00000073184 UniProtKB/TrEMBL
  ENSRNOP00000073887 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000000542 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000081163 UniProtKB/TrEMBL
  ENSRNOT00000081486 UniProtKB/TrEMBL
  ENSRNOT00000091622 UniProtKB/TrEMBL
InterPro NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sc_DH/Rdtase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SDR_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:361802 UniProtKB/Swiss-Prot
NCBI Gene 361802 ENTREZGENE
Pfam adh_short UniProtKB/TrEMBL
PhenoGen Hsd17b8 PhenoGen
PRINTS GDHRDH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SDRFAMILY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ADH_SHORT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF51735 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JV82_RAT UniProtKB/TrEMBL
  A0A0G2K4V1_RAT UniProtKB/TrEMBL
  A0A0G2K6P1 ENTREZGENE, UniProtKB/TrEMBL
  DHB8_RAT UniProtKB/Swiss-Prot
  Q5BJM1_RAT UniProtKB/TrEMBL
  Q6MGB5 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Hsd17b8  hydroxysteroid (17-beta) dehydrogenase 8      Symbol and Name status set to approved 1299863 APPROVED
2005-07-14 Hsd17b8  hydroxysteroid (17-beta) dehydrogenase 8      Symbol and Name status set to provisional 70820 PROVISIONAL