Hsd17b8 (hydroxysteroid (17-beta) dehydrogenase 8) - Rat Genome Database

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Gene: Hsd17b8 (hydroxysteroid (17-beta) dehydrogenase 8) Rattus norvegicus
Analyze
Symbol: Hsd17b8
Name: hydroxysteroid (17-beta) dehydrogenase 8
RGD ID: 1303158
Description: Predicted to enable several functions, including (3R)-hydroxyacyl-CoA dehydrogenase (NAD+) activity; NADH binding activity; and steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Predicted to be involved in estrogen biosynthetic process; fatty acid biosynthetic process; and protein heterotetramerization. Predicted to act upstream of or within androgen metabolic process and estrogen metabolic process. Predicted to be located in mitochondrial envelope; mitochondrial matrix; and plasma membrane. Predicted to be part of oxidoreductase complex. Orthologous to human HSD17B8 (hydroxysteroid 17-beta dehydrogenase 8); PARTICIPATES IN steroid hormone biosynthetic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; androgen antagonist; bis(2-ethylhexyl) phthalate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: (3R)-3-hydroxyacyl-CoA dehydrogenase; 17-beta-HSD 8; 17-beta-hydroxysteroid dehydrogenase 8; 3-ketoacyl-[acyl-carrier-protein] reductase alpha subunit; 3-oxoacyl-[acyl-carrier-protein] reductase; estradiol 17-beta-dehydrogenase 8; Fabgl; KAR alpha subunit; Ke6; MGC109594; RING2; testosterone 17-beta-dehydrogenase 8
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8204,828,571 - 4,830,635 (+)NCBIGRCr8
mRatBN7.2204,826,725 - 4,828,742 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl204,822,026 - 4,828,742 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx205,578,527 - 5,580,523 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0204,940,281 - 4,942,277 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0205,421,165 - 5,423,160 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0203,817,212 - 3,819,316 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl203,817,179 - 3,819,235 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0205,896,543 - 5,898,654 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4204,964,860 - 4,966,855 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1204,965,086 - 4,967,082 (+)NCBI
Celera206,426,931 - 6,428,926 (+)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
androgen antagonist  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP)
Butylbenzyl phthalate  (EXP)
Butylparaben  (EXP)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
deguelin  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
diethyl phthalate  (EXP)
diethylstilbestrol  (EXP)
dipentyl phthalate  (EXP)
dorsomorphin  (ISO)
elemental selenium  (ISO)
entinostat  (ISO)
enzacamene  (EXP)
folic acid  (ISO)
genistein  (ISO)
gentamycin  (EXP)
gossypol  (ISO)
isobutanol  (ISO)
ivermectin  (ISO)
lead(0)  (ISO)
mercury dibromide  (ISO)
methylmercury chloride  (ISO)
mifepristone  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
NAD zwitterion  (ISO)
NAD(+)  (ISO)
NADP zwitterion  (ISO)
NADP(+)  (ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP,ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
rac-lactic acid  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
thifluzamide  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)
XL147  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Physical mapping of the Ring1, Ring2, Ke6, Ke4, Rxrb, Col11a2, and RT1.Hb genes in the rat major histocompatibility complex. Walter L, etal., Immunogenetics 1996;44(3):218-21.
Additional References at PubMed
PMID:8940387   PMID:9712896   PMID:12477932   PMID:14651853   PMID:17978863   PMID:18614015   PMID:19571038   PMID:25203508   PMID:34800366  


Genomics

Comparative Map Data
Hsd17b8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8204,828,571 - 4,830,635 (+)NCBIGRCr8
mRatBN7.2204,826,725 - 4,828,742 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl204,822,026 - 4,828,742 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx205,578,527 - 5,580,523 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0204,940,281 - 4,942,277 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0205,421,165 - 5,423,160 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0203,817,212 - 3,819,316 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl203,817,179 - 3,819,235 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0205,896,543 - 5,898,654 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4204,964,860 - 4,966,855 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1204,965,086 - 4,967,082 (+)NCBI
Celera206,426,931 - 6,428,926 (+)NCBICelera
Cytogenetic Map20p12NCBI
HSD17B8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38633,204,655 - 33,206,831 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl633,204,655 - 33,206,831 (+)EnsemblGRCh38hg38GRCh38
GRCh37633,172,432 - 33,174,608 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36633,280,397 - 33,282,585 (+)NCBINCBI36Build 36hg18NCBI36
Build 34633,280,396 - 33,282,585NCBI
Celera634,726,785 - 34,728,973 (+)NCBICelera
Cytogenetic Map6p21.32NCBI
HuRef632,914,459 - 32,916,653 (+)NCBIHuRef
CHM1_1633,174,288 - 33,176,486 (+)NCBICHM1_1
T2T-CHM13v2.0633,026,008 - 33,028,184 (+)NCBIT2T-CHM13v2.0
Hsd17b8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391734,245,007 - 34,247,029 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1734,245,007 - 34,247,034 (-)EnsemblGRCm39 Ensembl
GRCm381734,026,033 - 34,028,055 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1734,026,033 - 34,028,060 (-)EnsemblGRCm38mm10GRCm38
MGSCv371734,162,978 - 34,165,000 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361733,636,489 - 33,638,511 (-)NCBIMGSCv36mm8
Celera1736,772,162 - 36,774,185 (-)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1717.98NCBI
Hsd17b8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554371,778,276 - 1,780,397 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554371,778,276 - 1,780,397 (+)NCBIChiLan1.0ChiLan1.0
HSD17B8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2547,682,351 - 47,684,652 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1643,554,020 - 43,556,322 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0632,776,837 - 32,779,042 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1633,891,753 - 33,893,950 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl633,891,753 - 33,893,950 (+)Ensemblpanpan1.1panPan2
HSD17B8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1122,667,674 - 2,669,918 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl122,663,515 - 2,669,917 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha122,748,819 - 2,751,058 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0122,998,414 - 3,000,653 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl122,998,475 - 3,000,551 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1122,666,602 - 2,668,840 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0122,747,969 - 2,750,208 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0122,822,541 - 2,824,780 (+)NCBIUU_Cfam_GSD_1.0
Hsd17b8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494638,309,422 - 38,311,663 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647625,648,604 - 25,650,757 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647625,648,604 - 25,650,757 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HSD17B8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl725,247,608 - 25,249,785 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1725,247,577 - 25,249,786 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2729,753,837 - 29,756,042 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HSD17B8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11738,868,307 - 38,870,564 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1738,868,685 - 38,870,459 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604433,038,755 - 33,041,527 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hsd17b8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475423,600,706 - 23,602,751 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475423,600,706 - 23,602,786 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hsd17b8
7 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:105
Count of miRNA genes:82
Interacting mature miRNAs:92
Transcripts:ENSRNOT00000000542
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2306850Pia40Pristane induced arthritis QTL 400.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2015279595304575Rat
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
4889857Pur27Proteinuria QTL 2712.20.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20460660717617956Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
7175096Tcs1T cell selection QTL 1T cell selection trait (VT:0004917)expression2047270785024580Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20289259726381954Rat
61474Eae1Experimental allergic encephalomyelitis QTL 13nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)2046066076691706Rat
7387283Uae44Urinary albumin excretion QTL 440.1712urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)20126123605Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125159026Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20460660717617956Rat
1331772Cdexp2CD45RC expression in CD8 T cells QTL 25.7CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)20362164910078919Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
1300152Bp195Blood pressure QTL 1953.46arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2036216499243559Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20362165614101050Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat

Markers in Region
RH129332  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2204,826,327 - 4,826,514 (-)MAPPERmRatBN7.2
Rnor_6.0203,819,440 - 3,819,626NCBIRnor6.0
Rnor_5.0205,898,771 - 5,898,957UniSTSRnor5.0
RGSC_v3.4204,964,442 - 4,964,628UniSTSRGSC3.4
Celera206,426,513 - 6,426,699UniSTS
RH 3.4 Map9391.29UniSTS
Cytogenetic Map20p12UniSTS
RH133333  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2204,828,458 - 4,828,652 (-)MAPPERmRatBN7.2
Rnor_6.0203,817,302 - 3,817,495NCBIRnor6.0
Rnor_5.0205,896,633 - 5,896,826UniSTSRnor5.0
RGSC_v3.4204,966,573 - 4,966,766UniSTSRGSC3.4
Celera206,428,644 - 6,428,837UniSTS
RH 3.4 Map2059.7UniSTS
Cytogenetic Map20p12UniSTS
H2-Ke6  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2204,827,329 - 4,828,356 (-)MAPPERmRatBN7.2
Rnor_6.0203,817,598 - 3,818,624NCBIRnor6.0
Rnor_5.0205,896,929 - 5,897,955UniSTSRnor5.0
RGSC_v3.4204,965,444 - 4,966,470UniSTSRGSC3.4
Celera206,427,515 - 6,428,541UniSTS
Cytogenetic Map20p12UniSTS
Slc39a7  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2204,825,108 - 4,826,342 (-)MAPPERmRatBN7.2
Rnor_6.0203,819,612 - 3,820,845NCBIRnor6.0
Rnor_5.0205,898,943 - 5,900,176UniSTSRnor5.0
RGSC_v3.4204,963,223 - 4,964,456UniSTSRGSC3.4
Celera206,425,294 - 6,426,527UniSTS
Cytogenetic Map20p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000000542   ⟹   ENSRNOP00000000542
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl203,817,212 - 3,819,200 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000077357   ⟹   ENSRNOP00000071707
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl204,822,026 - 4,828,742 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000081163   ⟹   ENSRNOP00000073184
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl203,817,212 - 3,818,058 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000081486   ⟹   ENSRNOP00000073887
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl204,826,759 - 4,828,742 (+)Ensembl
Rnor_6.0 Ensembl203,817,179 - 3,819,235 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000083728
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl203,817,215 - 3,819,191 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000091369
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl203,818,470 - 3,818,862 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000091622   ⟹   ENSRNOP00000069385
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl203,817,212 - 3,818,045 (-)Ensembl
RefSeq Acc Id: NM_212529   ⟹   NP_997694
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8204,828,639 - 4,830,634 (+)NCBI
mRatBN7.2204,826,746 - 4,828,741 (+)NCBI
Rnor_6.0203,817,213 - 3,819,208 (-)NCBI
Rnor_5.0205,896,543 - 5,898,654 (-)NCBI
RGSC_v3.4204,964,860 - 4,966,855 (+)RGD
Celera206,426,931 - 6,428,926 (+)RGD
Sequence:
RefSeq Acc Id: XM_006255964   ⟹   XP_006256026
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8204,828,572 - 4,830,635 (+)NCBI
mRatBN7.2204,826,878 - 4,828,742 (+)NCBI
Rnor_6.0203,817,212 - 3,819,316 (-)NCBI
Rnor_5.0205,896,543 - 5,898,654 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006255965   ⟹   XP_006256027
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8204,828,576 - 4,830,635 (+)NCBI
mRatBN7.2204,826,725 - 4,828,742 (+)NCBI
Rnor_6.0203,817,212 - 3,819,316 (-)NCBI
Rnor_5.0205,896,543 - 5,898,654 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006255966   ⟹   XP_006256028
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8204,828,575 - 4,830,635 (+)NCBI
mRatBN7.2204,826,878 - 4,828,742 (+)NCBI
Rnor_6.0203,817,212 - 3,819,316 (-)NCBI
Rnor_5.0205,896,543 - 5,898,654 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039098810   ⟹   XP_038954738
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8204,828,571 - 4,830,635 (+)NCBI
mRatBN7.2204,826,878 - 4,828,742 (+)NCBI
RefSeq Acc Id: XM_063279212   ⟹   XP_063135282
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8204,828,598 - 4,830,635 (+)NCBI
RefSeq Acc Id: XR_362002
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8204,828,571 - 4,830,635 (+)NCBI
mRatBN7.2204,826,878 - 4,828,742 (+)NCBI
Rnor_6.0203,817,212 - 3,819,316 (-)NCBI
Rnor_5.0205,896,543 - 5,898,654 (-)NCBI
Sequence:
RefSeq Acc Id: NP_997694   ⟸   NM_212529
- UniProtKB: Q6MGB5 (UniProtKB/Swiss-Prot),   A6JJG1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256027   ⟸   XM_006255965
- Peptide Label: isoform X2
- UniProtKB: A6JJG3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256028   ⟸   XM_006255966
- Peptide Label: isoform X3
- UniProtKB: A0A0G2K156 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256026   ⟸   XM_006255964
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K6P1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000000542   ⟸   ENSRNOT00000000542
Ensembl Acc Id: ENSRNOP00000073887   ⟸   ENSRNOT00000081486
Ensembl Acc Id: ENSRNOP00000073184   ⟸   ENSRNOT00000081163
Ensembl Acc Id: ENSRNOP00000069385   ⟸   ENSRNOT00000091622
RefSeq Acc Id: XP_038954738   ⟸   XM_039098810
- Peptide Label: isoform X4
Ensembl Acc Id: ENSRNOP00000071707   ⟸   ENSRNOT00000077357
RefSeq Acc Id: XP_063135282   ⟸   XM_063279212
- Peptide Label: isoform X5

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6MGB5-F1-model_v2 AlphaFold Q6MGB5 1-259 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701315
Promoter ID:EPDNEW_R11839
Type:single initiation site
Name:Hsd17b8_1
Description:hydroxysteroid (17-beta) dehydrogenase 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0203,819,205 - 3,819,265EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1303158 AgrOrtholog
BioCyc Gene G2FUF-4541 BioCyc
Ensembl Genes ENSRNOG00000000466 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000077357.2 UniProtKB/TrEMBL
  ENSRNOT00000081486 ENTREZGENE
  ENSRNOT00000081486.2 UniProtKB/TrEMBL
  ENSRNOT00000120559 ENTREZGENE
  ENSRNOT00000131886 ENTREZGENE
Gene3D-CATH NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sc_DH/Rdtase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SDR_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:361802 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 361802 ENTREZGENE
PANTHER (3R)-3-HYDROXYACYL-COA DEHYDROGENASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DEHYDROGENASES, SHORT CHAIN UniProtKB/TrEMBL
  DEHYDROGENASES, SHORT CHAIN UniProtKB/TrEMBL
  SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam adh_short UniProtKB/TrEMBL
  adh_short_C2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hsd17b8 PhenoGen
PRINTS GDHRDH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SDRFAMILY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ADH_SHORT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000000466 RatGTEx
SMART PKS_KR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF51735 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K156 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2K6P1 ENTREZGENE, UniProtKB/TrEMBL
  A6JJG1 ENTREZGENE, UniProtKB/TrEMBL
  A6JJG2_RAT UniProtKB/TrEMBL
  A6JJG3 ENTREZGENE, UniProtKB/TrEMBL
  A6JJG4_RAT UniProtKB/TrEMBL
  A6JJG5_RAT UniProtKB/TrEMBL
  DHB8_RAT UniProtKB/Swiss-Prot
  Q5BJM1_RAT UniProtKB/TrEMBL
  Q6MGB5 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Hsd17b8  hydroxysteroid (17-beta) dehydrogenase 8      Symbol and Name status set to approved 1299863 APPROVED
2005-07-14 Hsd17b8  hydroxysteroid (17-beta) dehydrogenase 8      Symbol and Name status set to provisional 70820 PROVISIONAL