HSD17B8 (hydroxysteroid 17-beta dehydrogenase 8)

Gene: HSD17B8 (hydroxysteroid 17-beta dehydrogenase 8) Chlorocebus sabaeus

Analyze

Symbol:

HSD17B8

Name:

hydroxysteroid 17-beta dehydrogenase 8

RGD ID:

18564908

Description:

ENCODES a protein that exhibits (3R)-hydroxyacyl-CoA dehydrogenase (NAD+) activity (inferred); estradiol 17-beta-dehydrogenase [NAD(P)] activity (inferred); NADH binding (inferred); INVOLVED IN androgen metabolic process (ortholog); estrogen metabolic process (ortholog); ASSOCIATED WITH autosomal dominant intellectual developmental disorder 5 (ortholog); genetic disease (ortholog); proteasome-associated autoinflammatory syndrome 1 (ortholog); FOUND IN membrane (inferred); mitochondrial envelope (inferred); mitochondrial matrix (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

estradiol 17-beta-dehydrogenase 8

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	17	38,868,307 - 38,870,564 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	17	38,868,685 - 38,870,459 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666044	33,038,755 - 33,041,527 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autosomal dominant intellectual developmental disorder 5 (ISO)

genetic disease (ISO)

proteasome-associated autoinflammatory syndrome 1 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

androgen metabolic process (IEA,ISO)

estrogen biosynthetic process (IEA)

estrogen metabolic process (IEA,ISO)

fatty acid biosynthetic process (IEA)

fatty acid metabolic process (IEA)

protein heterotetramerization (IEA)

Cellular Component

membrane (IEA)

mitochondrial envelope (IEA)

mitochondrial matrix (IEA)

oxidoreductase complex (IEA)

plasma membrane (IEA)

Molecular Function

(3R)-hydroxyacyl-CoA dehydrogenase (NAD+) activity (IEA)

estradiol 17-beta-dehydrogenase [NAD(P)] activity (IEA)

NADH binding (IEA)

oxidoreductase activity (IEA)

protein binding (ISO)

testosterone dehydrogenase (NAD+) activity (IEA)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

HSD17B8
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	17	38,868,307 - 38,870,564 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	17	38,868,685 - 38,870,459 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666044	33,038,755 - 33,041,527 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

HSD17B8
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	33,204,655 - 33,206,831 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	33,204,655 - 33,206,831 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	33,172,432 - 33,174,608 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	33,280,397 - 33,282,585 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	6	33,280,396 - 33,282,585	NCBI
Celera	6	34,726,785 - 34,728,973 (+)	NCBI		Celera
Cytogenetic Map	6	p21.32	NCBI
HuRef	6	32,914,459 - 32,916,653 (+)	NCBI		HuRef
CHM1_1	6	33,174,288 - 33,176,486 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	6	33,026,008 - 33,028,184 (+)	NCBI		T2T-CHM13v2.0

Hsd17b8
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	34,245,007 - 34,247,029 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	34,245,007 - 34,247,034 (-)	Ensembl		GRCm39 Ensembl
GRCm38	17	34,026,033 - 34,028,055 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	34,026,033 - 34,028,060 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	34,162,978 - 34,165,000 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	33,636,489 - 33,638,511 (-)	NCBI		MGSCv36	mm8
Celera	17	36,772,162 - 36,774,185 (-)	NCBI		Celera
Cytogenetic Map	17	B1	NCBI
cM Map	17	17.98	NCBI

Hsd17b8
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	20	4,828,571 - 4,830,635 (+)	NCBI		GRCr8
mRatBN7.2	20	4,826,725 - 4,828,742 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	4,822,026 - 4,828,742 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	20	5,578,527 - 5,580,523 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	4,940,281 - 4,942,277 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	5,421,165 - 5,423,160 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	20	3,817,212 - 3,819,316 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	3,817,179 - 3,819,235 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	20	5,896,543 - 5,898,654 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	20	4,964,860 - 4,966,855 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	20	4,965,086 - 4,967,082 (+)	NCBI
Celera	20	6,426,931 - 6,428,926 (+)	NCBI		Celera
Cytogenetic Map	20	p12	NCBI

Hsd17b8
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955437	1,778,276 - 1,780,397 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955437	1,778,276 - 1,780,397 (+)	NCBI	ChiLan1.0	ChiLan1.0

HSD17B8
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	47,682,351 - 47,684,652 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	43,554,020 - 43,556,322 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	32,776,837 - 32,779,042 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	33,891,753 - 33,893,950 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	33,891,753 - 33,893,950 (+)	Ensembl	panpan1.1		panPan2

HSD17B8
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	12	2,667,674 - 2,669,918 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	12	2,663,515 - 2,669,917 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	12	2,748,819 - 2,751,058 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	12	2,998,414 - 3,000,653 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	12	2,998,475 - 3,000,551 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	12	2,666,602 - 2,668,840 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	12	2,747,969 - 2,750,208 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	12	2,822,541 - 2,824,780 (+)	NCBI		UU_Cfam_GSD_1.0

Hsd17b8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	38,309,422 - 38,311,663 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936476	25,648,604 - 25,650,757 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936476	25,648,604 - 25,650,757 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

HSD17B8
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	25,247,608 - 25,249,785 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	25,247,577 - 25,249,786 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	29,753,837 - 29,756,042 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Hsd17b8
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624754	23,600,706 - 23,602,751 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624754	23,600,706 - 23,602,786 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	endocrine system	hemolymphoid system	nervous system
High
Medium	36	12	49
Low		8	11
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007972969	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038005953	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005242995	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005242996	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC241459	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACDXN010000012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCSAT00000007608 ⟹ ENSCSAP00000005782

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	17	38,868,685 - 38,870,459 (-)	Ensembl

RefSeq Acc Id:

XM_007972969 ⟹ XP_007971160

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	17	38,868,307 - 38,870,564 (-)	NCBI
Vero_WHO_p1.0	NW_023666044	33,038,755 - 33,041,129 (+)	NCBI

Sequence:

show sequence

CTAAGGCTGGCGGGTCTTTGATTGGCCCCGGCTTTGCCCTGGCCACACCCCCCTCTGCGCTGGG
ATTGGCTTAGTGCTGGGGTTCCCACCCACCCACAGGCCGCAATGGCGTCTCAGCTCCAGAACCG
GCTCCGCTCCGCACTGGCCTTGGTCACAGGTGCGGGGAGCGGCATCGGCCGAGCAGTCAGTGTA
CGCCTGGCCGGAGAGGGGGCCACCGTAGCTGCCTGCGACCTGGACGGGGCAGCGGCACAGGAGA
CGGTGCGGCTGCTGGGCGGGCCAGGGAACAAGGAGGGGCCGCCCCGAGGGAACCACGCTGCCTT
CCAGGCTGACGTGTCTGAGGCCAGAGCCGCCAGGCGCCTGCTGGAACAAGTGCAGGCCTGCTTT
TCTCGCCCACCATCTGTCGTTGTGTCCTGTGCGGGCATCACCCAGGATGAGTTTCTGCTGCACA
TGTCTGAGGATGACTGGGACAAAGTCATAGCTGTCAACCTCAAGGGTACCTTCCTAGTCACTCA
GGCTGCAGCACAAGCCCTGGTGTCCAGTGGTTGTCGTGGTTCCATCATCAACATCAGTAGCATC
ACAGGAAAGGTGGGGAACATGGGGCAGACAAACTATGTAGCATCCAAGGCTGGAGTGATTGGGC
TGACCCAGACTGCAGCCCGGGAGCTTGGACGACATGGGATCCGCTGTAACTCTGTCCTCCCAGG
GTTCATTGCAACACCCATGACACAGAAAGTGCCACAGAAAGTGGTGGACAAGATTACTGAAATG
ATCCCGATGGGATACTTGGGGGACCCTGAGGATGTGGCAGATGTGGTCGCATTCTTGGCATCTG
AAGACAGTGGATACATCACAGGGGCCTCAGTGGAAGTCACTGGAGGTCTTTTCATGTAACTGCC
TCAAGCACCCTGGACTCTGCTCACCCCCCATCACTCTGCCTGGCCTCCTGCTGATGAGGACTCT
AAGTTCCCAGGCTACAAAAGGGGTGGCAGTGTATGGCTCAGGAATGCTGAATATGGGAAGCAGG
GGTGCTTGTGACCCTAATAAATTCCAAATCCTCTTCCCTGCCA

hide sequence

RefSeq Acc Id:

XM_038005953 ⟹ XP_037861881

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
Vero_WHO_p1.0	NW_023666044	33,040,477 - 33,041,527 (+)	NCBI

RefSeq Acc Id:

XR_005242995

Type:

NON-CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
Vero_WHO_p1.0	NW_023666044	33,038,755 - 33,041,129 (+)	NCBI

RefSeq Acc Id:

XR_005242996

Type:

NON-CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
Vero_WHO_p1.0	NW_023666044	33,038,755 - 33,041,129 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_007971160	(Get FASTA)	NCBI Sequence Viewer
	XP_037861881	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000005782
	ENSCSAP00000005782.1

RefSeq Acc Id:	XP_007971160 ⟸ XM_007972969
- Peptide Label:	isoform X1
- UniProtKB:	A0A0D9RAZ3 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSCSAP00000005782 ⟸ ENSCSAT00000007608

RefSeq Acc Id:	XP_037861881 ⟸ XM_038005953
- Peptide Label:	isoform X2

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000009530	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000007608.1	UniProtKB/TrEMBL
Gene3D-CATH	NAD(P)-binding Rossmann-like Domain	UniProtKB/TrEMBL
InterPro	NAD(P)-bd_dom_sf	UniProtKB/TrEMBL
	Sc_DH/Rdtase_CS	UniProtKB/TrEMBL
	SDR_fam	UniProtKB/TrEMBL
NCBI Gene	HSD17B8	ENTREZGENE
PANTHER	(3R)-3-HYDROXYACYL-COA DEHYDROGENASE	UniProtKB/TrEMBL
	SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER	UniProtKB/TrEMBL
Pfam	adh_short_C2	UniProtKB/TrEMBL
PRINTS	GDHRDH	UniProtKB/TrEMBL
	SDRFAMILY	UniProtKB/TrEMBL
PROSITE	ADH_SHORT	UniProtKB/TrEMBL
SMART	PKS_KR	UniProtKB/TrEMBL
Superfamily-SCOP	SSF51735	UniProtKB/TrEMBL
UniProt	A0A0D9RAZ3	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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