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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1303158
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hsd17b8
Name: hydroxysteroid (17-beta) dehydrogenase 8
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hsd17b8affects expressionISOHSD17B8 (Homo sapiens)6480464CTDValproic Acid affects the expression of HSD17B8 mRNAPMID:25979313
Hsd17b8increases expressionISOHSD17B8 (Homo sapiens)6480464CTDValproic Acid results in increased expression of HSD17B8 mRNAPMID:19101580 PMID:23179753 PMID:27188386 PMID:29154799
Hsd17b8increases expressionISOHsd17b8 (Mus musculus)6480464CTDValproic Acid results in increased expression of HSD17B8 mRNAPMID:21427059
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