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Gene: RT1-DMb (RT1 class II, locus DMb) Rattus norvegicus
Symbol: RT1-DMb
Name: RT1 class II, locus DMb
Description: Predicted to have MHC class II protein complex binding activity. Predicted to be involved in several processes, including antigen processing and presentation of exogenous peptide antigen via MHC class II; chaperone cofactor-dependent protein refolding; and positive regulation of T cell activation. Predicted to localize to several cellular components, including MHC class II protein complex; endosome; and lysosomal membrane. Orthologous to human HLA-DMB (major histocompatibility complex, class II, DM beta); PARTICIPATES IN allograft rejection pathway; antigen processing and presentation pathway; asthma pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 3,3',5,5'-tetrabromobisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: DMb; Hla-dmb; major histocompatibility complex, class II, DM beta; MHC class II-like beta chain; RT1 class II, DM beta; RT1.DMb; RT1.Mb
Is Marker For: Strains:   DA.AS2-(Tesb-RT1-DMb)   DA.KHW-(RT1-Db1-RT1-DMb)   DA.E3-(Btnl2-RT1-DMb)  
QTLs:   Tcs2  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0203,945,383 - 3,952,838 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl205,227,045 - 5,234,290 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0207,288,114 - 7,295,355 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4204,829,535 - 4,836,772 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1204,829,762 - 4,836,902 (-)NCBI
Celera206,293,763 - 6,301,000 (-)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (Rnor_6.0)
Related Rat Strains
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on RT1-DMb
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 735096
Created: 2004-02-05
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.