C4b (complement C4B) - Rat Genome Database

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Gene: C4b (complement C4B) Rattus norvegicus
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Symbol: C4b
Name: complement C4B (Ensembl:complement C4B (Chido blood group))
RGD ID: 1591983
Description: Predicted to enable carbohydrate binding activity and complement component C1q complex binding activity. Predicted to be involved in complement activation and positive regulation of apoptotic cell clearance. Predicted to act upstream of or within immunoglobulin mediated immune response. Located in extracellular space. Human ortholog(s) of this gene implicated in autistic disorder; autoimmune disease (multiple); complement component 4b deficiency; and renal cell carcinoma. Orthologous to several human genes including C4B (complement C4B (Chido/Rodgers blood group)); PARTICIPATES IN coagulation cascade pathway; complement system pathway; Staphylococcus aureus infection pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: C4-2; C4l; complement C4-like protein; complement C4B (Chido blood group); complement component 4, gene 2; complement component 4B (Chido blood group)
RGD Orthologs
Human
Mouse
Dog
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8204,201,979 - 4,216,292 (+)NCBIGRCr8
mRatBN7.2204,197,371 - 4,211,684 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl204,197,366 - 4,211,681 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx204,903,172 - 4,917,487 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0204,264,923 - 4,279,238 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0204,799,242 - 4,813,541 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0204,302,344 - 4,316,752 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl204,302,344 - 4,316,715 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0206,381,700 - 6,396,108 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4204,300,687 - 4,315,882 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera203,819,383 - 3,833,684 (-)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(R)-lipoic acid  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2-aminothiophenol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxy-TEMPO  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrolein  (ISO)
aldehydo-D-glucose  (ISO)
alpha-pinene  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[ghi]perylene  (ISO)
bisphenol A  (ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
carbon nanotube  (ISO)
carbonyl sulfide  (EXP)
carnosic acid  (ISO)
choline  (ISO)
clofibrate  (ISO)
clopidogrel  (ISO)
coenzyme Q10  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyclosporin A  (EXP)
cylindrospermopsin  (ISO)
cyproconazole  (ISO)
D-glucose  (ISO)
D-penicillamine  (ISO)
deoxynivalenol  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
diuron  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
fenthion  (ISO)
finasteride  (EXP)
flutamide  (EXP)
folic acid  (ISO)
fructose  (ISO)
furan  (EXP)
gentamycin  (EXP)
glucose  (ISO)
glyphosate  (ISO)
inulin  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
kainic acid  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
levofloxacin  (EXP)
lipoic acid  (ISO)
lipopolysaccharide  (ISO)
lycopene  (ISO)
methidathion  (ISO)
methimazole  (EXP)
methylmercury chloride  (EXP)
N-nitrosodiethylamine  (ISO)
nefazodone  (EXP)
nickel atom  (ISO)
O-acetyl-L-carnitine  (ISO)
olanzapine  (ISO)
ozone  (ISO)
paracetamol  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (EXP,ISO)
propiconazole  (ISO)
resveratrol  (ISO)
senecionine  (ISO)
sodium arsenite  (ISO)
streptozocin  (EXP)
sulindac  (EXP)
tacrolimus hydrate  (EXP)
tauroursodeoxycholic acid  (EXP)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tolcapone  (EXP)
triptonide  (ISO)
vanadyl sulfate  (EXP)
vancomycin  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Complement C4 protein expression by rat hepatic stellate cells. Fimmel CJ, etal., J Immunol. 1996 Sep 15;157(6):2601-9.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. [Enzyme immunoassay of masked complement component C4 deficiency in patients with urogenital Chlamydia infection]. Gora NV, etal., Zh Mikrobiol Epidemiol Immunobiol. 2011 May-Jun;(3):76-80.
4. [Masked deficiency of C4 component of complement in patients with chronic gastrointestinal tract diseases of different etiology]. Kozlov LV, etal., Zh Mikrobiol Epidemiol Immunobiol. 2011 Jul-Aug;(4):61-5.
5. Differential expression of complement proteins in cerebrospinal fluid from active multiple sclerosis patients. Li Y, etal., J Cell Biochem. 2011 Jul;112(7):1930-7. doi: 10.1002/jcb.23113.
6. Association between copy number variation of complement component C4 and Graves' disease. Liu YH, etal., J Biomed Sci. 2011 Sep 26;18:71.
7. The link of C4B null allele to autism and to a family history of autoimmunity in Egyptian autistic children. Mostafa GA and Shehab AA, J Neuroimmunol. 2010 Jun;223(1-2):115-9. Epub 2010 May 10.
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Comprehensive gene review and curation RGD comprehensive gene curation
13. Increased frequency of complement C4B deficiency in rheumatoid arthritis. Rigby WF, etal., Arthritis Rheum. 2011 Nov 10. doi: 10.1002/art.33472.
14. The rat expresses two complement factor C4 proteins, but only one isotype is expressed in the liver. Roos C, etal., J Immunol. 2005 Jan 15;174(2):970-5.
15. Gene copy-number variation and associated polymorphisms of complement component C4 in human systemic lupus erythematosus (SLE): low copy number is a risk factor for and high copy number is a protective factor against SLE susceptibility in European Americans. Yang Y, etal., Am J Hum Genet. 2007 Jun;80(6):1037-54. Epub 2007 Apr 26.
16. Genetic deficiency of complement isoforms C4A or C4B predicts improved survival of metastatic renal cell carcinoma. Zafar GI, etal., J Urol. 2009 Mar;181(3):1028-34; discussion 1034. Epub 2009 Jan 16.
Additional References at PubMed
PMID:2395880   PMID:3023818   PMID:12136338   PMID:12421924   PMID:15060004   PMID:16502470   PMID:19302245   PMID:22333221   PMID:22516433   PMID:23376485   PMID:23533145   PMID:25645918  
PMID:26814963  


Genomics

Comparative Map Data
C4b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8204,201,979 - 4,216,292 (+)NCBIGRCr8
mRatBN7.2204,197,371 - 4,211,684 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl204,197,366 - 4,211,681 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx204,903,172 - 4,917,487 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0204,264,923 - 4,279,238 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0204,799,242 - 4,813,541 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0204,302,344 - 4,316,752 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl204,302,344 - 4,316,715 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0206,381,700 - 6,396,108 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4204,300,687 - 4,315,882 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera203,819,383 - 3,833,684 (-)NCBICelera
Cytogenetic Map20p12NCBI
C4B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38632,014,795 - 32,035,418 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl632,014,795 - 32,035,418 (+)EnsemblGRCh38hg38GRCh38
GRCh37631,982,572 - 32,003,195 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36632,057,813 - 32,078,435 (+)NCBINCBI36Build 36hg18NCBI36
Celera633,549,596 - 33,570,219 (+)NCBICelera
Cytogenetic Map6p21.33NCBI
CHM1_1631,984,848 - 32,005,386 (+)NCBICHM1_1
T2T-CHM13v2.0631,868,001 - 31,888,625 (+)NCBIT2T-CHM13v2.0
C4b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391734,947,249 - 34,962,876 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1734,947,354 - 34,962,856 (-)EnsemblGRCm39 Ensembl
GRCm381734,728,139 - 34,743,902 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1734,728,380 - 34,743,882 (-)EnsemblGRCm38mm10GRCm38
MGSCv371734,865,325 - 34,880,842 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361734,336,443 - 34,351,939 (-)NCBIMGSCv36mm8
Celera1737,826,575 - 37,840,058 (-)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1718.29NCBI
LOC481722
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1121,433,185 - 1,448,056 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha121,568,269 - 1,582,800 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0121,575,361 - 1,589,884 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1121,433,082 - 1,447,359 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0121,501,274 - 1,515,547 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0121,567,611 - 1,582,146 (+)NCBIUU_Cfam_GSD_1.0
C4A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl724,068,019 - 24,083,061 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1724,068,019 - 24,083,060 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2727,729,081 - 27,744,181 (-)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

.
Variants in C4b
196 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:96
Count of miRNA genes:79
Interacting mature miRNAs:86
Transcripts:ENSRNOT00000031704
Prediction methods:Microtar, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.