Aire (autoimmune regulator) - Rat Genome Database

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Gene: Aire (autoimmune regulator) Rattus norvegicus
Analyze
Symbol: Aire
Name: autoimmune regulator
RGD ID: 1311139
Description: Predicted to enable several functions, including histone binding activity; identical protein binding activity; and zinc ion binding activity. Predicted to be involved in several processes, including immune system development; negative thymic T cell selection; and positive regulation of macromolecule biosynthetic process. Predicted to be located in cytoplasm; germ cell nucleus; and nuclear body. Predicted to be active in nucleus. Used to study autoimmune polyendocrine syndrome. Human ortholog(s) of this gene implicated in autoimmune polyendocrine syndrome and autoimmune polyendocrine syndrome type 1. Orthologous to human AIRE (autoimmune regulator); PARTICIPATES IN primary immunodeficiency pathway; ubiquitin/proteasome degradation pathway; INTERACTS WITH acrylamide; bisphenol A; cadmium dichloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy); LOC294328
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Aireem1Ang  
Genetic Models: BN-Aireem1Ang-/- SD.BN-Aireem1Ang-/-
Candidate Gene For: Iddm23
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82010,635,775 - 10,650,709 (+)NCBIGRCr8
mRatBN7.22010,636,058 - 10,651,060 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2010,636,123 - 10,651,060 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2011,335,440 - 11,350,201 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02010,696,343 - 10,711,104 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02011,168,390 - 11,183,326 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02011,365,630 - 11,380,636 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2011,365,697 - 11,380,631 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02013,535,776 - 13,550,486 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42010,980,031 - 10,996,102 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12010,980,315 - 10,996,140 (+)NCBI
Celera2012,141,888 - 12,156,863 (+)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Aire deficiency causes increased susceptibility to streptozotocin-induced murine type 1 diabetes. Hassler S, etal., Scand J Immunol. 2008 Jun;67(6):569-80. Epub 2008 Apr 8.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. Breakdown of Immune Tolerance in AIRE-Deficient Rats Induces a Severe Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy-like Autoimmune Disease. Ossart J, etal., J Immunol. 2018 Aug 1;201(3):874-887. doi: 10.4049/jimmunol.1701318. Epub 2018 Jun 29.
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Comprehensive gene review and curation RGD comprehensive gene curation
11. Characterization of mutations in patients with autoimmune polyglandular syndrome type 1 (APS1). Wang CY, etal., Hum Genet. 1998 Dec;103(6):681-5.
Additional References at PubMed
PMID:11156688   PMID:11274163   PMID:11533054   PMID:11854172   PMID:15712268   PMID:17599412   PMID:18292755   PMID:19015306   PMID:19446523   PMID:19923453   PMID:20185822   PMID:23382543  
PMID:23993652   PMID:26084028   PMID:28540407  


Genomics

Comparative Map Data
Aire
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82010,635,775 - 10,650,709 (+)NCBIGRCr8
mRatBN7.22010,636,058 - 10,651,060 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2010,636,123 - 10,651,060 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2011,335,440 - 11,350,201 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02010,696,343 - 10,711,104 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02011,168,390 - 11,183,326 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02011,365,630 - 11,380,636 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2011,365,697 - 11,380,631 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02013,535,776 - 13,550,486 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42010,980,031 - 10,996,102 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12010,980,315 - 10,996,140 (+)NCBI
Celera2012,141,888 - 12,156,863 (+)NCBICelera
Cytogenetic Map20p12NCBI
AIRE
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382144,285,876 - 44,298,648 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2144,285,838 - 44,298,648 (+)EnsemblGRCh38hg38GRCh38
GRCh372145,705,759 - 45,718,531 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362144,530,191 - 44,542,530 (+)NCBINCBI36Build 36hg18NCBI36
Build 342144,534,575 - 44,542,300NCBI
Celera2130,811,017 - 30,823,364 (+)NCBICelera
Cytogenetic Map21q22.3NCBI
HuRef2131,076,211 - 31,088,675 (+)NCBIHuRef
CHM1_12145,266,544 - 45,278,925 (+)NCBICHM1_1
T2T-CHM13v2.02142,639,932 - 42,652,704 (+)NCBIT2T-CHM13v2.0
Aire
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391077,865,856 - 77,879,444 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1077,865,856 - 77,879,444 (-)EnsemblGRCm39 Ensembl
GRCm381078,030,022 - 78,043,610 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1078,030,022 - 78,043,610 (-)EnsemblGRCm38mm10GRCm38
MGSCv371077,492,776 - 77,506,325 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361077,433,160 - 77,446,709 (-)NCBIMGSCv36mm8
Celera1079,069,034 - 79,082,580 (-)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Aire
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540741,157,484 - 41,165,014 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540741,157,503 - 41,165,032 (-)NCBIChiLan1.0ChiLan1.0
AIRE
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22240,293,363 - 40,306,567 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12135,143,474 - 35,157,937 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02130,543,018 - 30,556,225 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12143,837,170 - 43,849,830 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2143,837,340 - 43,848,974 (+)Ensemblpanpan1.1panPan2
AIRE
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13138,139,513 - 38,149,294 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3138,139,099 - 38,149,296 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3137,296,701 - 37,307,469 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03137,686,832 - 37,697,601 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3137,686,636 - 37,696,584 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13137,553,994 - 37,564,750 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03137,534,760 - 37,545,522 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03138,032,729 - 38,043,507 (+)NCBIUU_Cfam_GSD_1.0
Aire
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497137,330,752 - 37,342,258 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936500125,795 - 137,056 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936500125,589 - 137,071 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AIRE
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13207,148,401 - 207,158,346 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113207,148,401 - 207,158,355 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213217,028,220 - 217,038,176 (+)NCBISscrofa10.2Sscrofa10.2susScr3
AIRE
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1288,019,122 - 88,031,998 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl288,019,522 - 88,031,801 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605416,133,673 - 16,147,350 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Aire
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474529,850,560 - 29,857,029 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474529,850,410 - 29,857,351 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Aire
202 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:42
Count of miRNA genes:39
Interacting mature miRNAs:41
Transcripts:ENSRNOT00000001611
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20289259726381954Rat
7387283Uae44Urinary albumin excretion QTL 440.1712urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)20126123605Rat
4889870Pur30Proteinuria QTL 30190.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20804241029322208Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125159026Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20460660717617956Rat
631265Iresp1Immunoglobin response QTL18.3blood anti-double stranded DNA antibody amount (VT:0004762)serum anti-DNA antibody level (CMO:0001533)20903971913461775Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
4889857Pur27Proteinuria QTL 2712.20.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20460660717617956Rat
70154Insul2Insulin level QTL 23.75blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20669170617489458Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
1581577Pur15Proteinuria QTL 154.380.0002urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)20804241017617956Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20362165614101050Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat

Markers in Region
D20Rat67  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr82010,650,045 - 10,650,277 (+)Marker Load Pipeline
mRatBN7.22010,650,396 - 10,650,628 (+)MAPPERmRatBN7.2
Rnor_6.02011,379,968 - 11,380,199NCBIRnor6.0
Rnor_5.02013,549,818 - 13,550,049UniSTSRnor5.0
RGSC_v3.42010,995,438 - 10,995,671RGDRGSC3.4
RGSC_v3.42010,995,439 - 10,995,670UniSTSRGSC3.4
RGSC_v3.12010,995,412 - 10,995,904RGD
Celera2012,156,219 - 12,156,431UniSTS
RH 3.4 Map20150.8UniSTS
RH 3.4 Map20150.8RGD
RH 2.0 Map20154.8RGD
SHRSP x BN Map2011.54RGD
Cytogenetic Map20p12UniSTS
D20Got10  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22010,650,144 - 10,650,325 (+)MAPPERmRatBN7.2
mRatBN7.21393,930,095 - 93,931,328 (+)MAPPERmRatBN7.2
Rnor_6.02011,379,716 - 11,379,896NCBIRnor6.0
Rnor_6.013100,649,193 - 100,650,424NCBIRnor6.0
Rnor_5.013105,583,034 - 105,584,265UniSTSRnor5.0
Rnor_5.02013,549,566 - 13,549,746UniSTSRnor5.0
RGSC_v3.42010,995,189 - 10,995,367RGDRGSC3.4
RGSC_v3.42010,995,190 - 10,995,367UniSTSRGSC3.4
RGSC_v3.41398,225,241 - 98,226,472UniSTSRGSC3.4
RGSC_v3.12010,995,417 - 10,995,594RGD
Celera2012,155,967 - 12,156,147UniSTS
Celera1393,463,578 - 93,464,809UniSTS
RH 3.4 Map20144.9RGD
RH 3.4 Map20144.9UniSTS
RH 2.0 Map20155.9RGD
Cytogenetic Map20p12UniSTS
D20Ztm3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22010,952,740 - 10,953,040 (+)MAPPERmRatBN7.2
Rnor_6.02011,669,099 - 11,669,398NCBIRnor6.0
Rnor_5.02013,834,856 - 13,835,155UniSTSRnor5.0
RGSC_v3.42011,336,555 - 11,336,854UniSTSRGSC3.4
Celera2012,456,436 - 12,456,748UniSTS
Cytogenetic Map20p12UniSTS


Genetic Models
This gene Aire is modified in the following models/strains:


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
6 11 28 28 32 17 19 17 2 66 30 26 13 27 15

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001106379 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001434617 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006256247 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601597 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601598 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601599 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601600 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601601 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601602 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279042 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279043 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279044 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279046 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279047 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279048 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279049 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC109383 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000001611   ⟹   ENSRNOP00000001611
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2010,636,123 - 10,651,060 (+)Ensembl
Rnor_6.0 Ensembl2011,365,697 - 11,380,631 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000106293   ⟹   ENSRNOP00000082176
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2010,636,123 - 10,651,060 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000113259   ⟹   ENSRNOP00000094625
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2010,636,123 - 10,651,060 (+)Ensembl
RefSeq Acc Id: NM_001106379   ⟹   NP_001099849
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82010,635,775 - 10,650,709 (+)NCBI
mRatBN7.22010,636,123 - 10,651,060 (+)NCBI
Rnor_6.02011,365,697 - 11,380,631 (+)NCBI
Rnor_5.02013,535,776 - 13,550,486 (+)NCBI
RGSC_v3.42010,980,031 - 10,996,102 (+)RGD
Celera2012,141,888 - 12,156,863 (+)RGD
Sequence:
RefSeq Acc Id: XM_006256247   ⟹   XP_006256309
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82010,635,781 - 10,650,709 (+)NCBI
mRatBN7.22010,636,058 - 10,651,051 (+)NCBI
Rnor_6.02011,365,630 - 11,380,636 (+)NCBI
Rnor_5.02013,535,776 - 13,550,486 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017601599   ⟹   XP_017457088
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82010,635,833 - 10,648,631 (+)NCBI
mRatBN7.22010,636,058 - 10,649,758 (+)NCBI
Rnor_6.02011,365,630 - 11,378,553 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017601601   ⟹   XP_017457090
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82010,635,833 - 10,648,631 (+)NCBI
mRatBN7.22010,636,058 - 10,649,758 (+)NCBI
Rnor_6.02011,365,630 - 11,378,553 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063279042   ⟹   XP_063135112
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82010,635,833 - 10,650,614 (+)NCBI
RefSeq Acc Id: XM_063279043   ⟹   XP_063135113
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82010,635,833 - 10,650,614 (+)NCBI
RefSeq Acc Id: XM_063279044   ⟹   XP_063135114
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82010,635,833 - 10,650,614 (+)NCBI
RefSeq Acc Id: XM_063279045   ⟹   XP_063135115
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82010,635,833 - 10,650,614 (+)NCBI
RefSeq Acc Id: XM_063279046   ⟹   XP_063135116
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82010,635,833 - 10,650,614 (+)NCBI
RefSeq Acc Id: XM_063279047   ⟹   XP_063135117
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82010,635,833 - 10,650,614 (+)NCBI
RefSeq Acc Id: XM_063279048   ⟹   XP_063135118
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82010,635,833 - 10,648,631 (+)NCBI
RefSeq Acc Id: XM_063279049   ⟹   XP_063135119
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82010,635,833 - 10,648,631 (+)NCBI
RefSeq Acc Id: NP_001099849   ⟸   NM_001106379
- UniProtKB: A6JK47 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256309   ⟸   XM_006256247
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017457088   ⟸   XM_017601599
- Peptide Label: isoform X8
- UniProtKB: A0A8I6AL71 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017457090   ⟸   XM_017601601
- Peptide Label: isoform X10
- UniProtKB: A6JK49 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000001611   ⟸   ENSRNOT00000001611
Ensembl Acc Id: ENSRNOP00000082176   ⟸   ENSRNOT00000106293
Ensembl Acc Id: ENSRNOP00000094625   ⟸   ENSRNOT00000113259
RefSeq Acc Id: XP_063135114   ⟸   XM_063279044
- Peptide Label: isoform X4
- UniProtKB: A0A8I5ZTP2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063135112   ⟸   XM_063279042
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063135115   ⟸   XM_063279045
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063135116   ⟸   XM_063279046
- Peptide Label: isoform X6
- UniProtKB: A6JK48 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063135113   ⟸   XM_063279043
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063135117   ⟸   XM_063279047
- Peptide Label: isoform X7
RefSeq Acc Id: XP_063135118   ⟸   XM_063279048
- Peptide Label: isoform X9
RefSeq Acc Id: XP_063135119   ⟸   XM_063279049
- Peptide Label: isoform X11
Protein Domains
HSR   PHD-type   SAND

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZV49-F1-model_v2 AlphaFold D3ZV49 1-547 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311139 AgrOrtholog
BioCyc Gene G2FUF-4274 BioCyc
Ensembl Genes ENSRNOG00000001213 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000001611.5 UniProtKB/TrEMBL
  ENSRNOT00000106293.1 UniProtKB/TrEMBL
  ENSRNOT00000113259.1 UniProtKB/TrEMBL
Gene3D-CATH 3.10.390.10 UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/TrEMBL
InterPro AIRE UniProtKB/TrEMBL
  AIRE_PHD2 UniProtKB/TrEMBL
  SAND_dom UniProtKB/TrEMBL
  SAND_dom-like UniProtKB/TrEMBL
  Sp100 UniProtKB/TrEMBL
  Sp110/Sp140/Sp140L-like UniProtKB/TrEMBL
  Zinc_finger_PHD-type_CS UniProtKB/TrEMBL
  Znf_FYVE_PHD UniProtKB/TrEMBL
  Znf_PHD UniProtKB/TrEMBL
  Znf_PHD-finger UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
KEGG Report rno:294328 UniProtKB/TrEMBL
NCBI Gene 294328 ENTREZGENE
PANTHER NUCLEAR BODY PROTEIN SP140 UniProtKB/TrEMBL
  RIKEN CDNA A630001G21 GENE UniProtKB/TrEMBL
Pfam PHD UniProtKB/TrEMBL
  SAND UniProtKB/TrEMBL
  Sp100 UniProtKB/TrEMBL
PhenoGen Aire PhenoGen
PRINTS AIREGULATOR UniProtKB/TrEMBL
PROSITE HSR UniProtKB/TrEMBL
  SAND UniProtKB/TrEMBL
  ZF_PHD_1 UniProtKB/TrEMBL
  ZF_PHD_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000001213 RatGTEx
SMART PHD UniProtKB/TrEMBL
  SAND UniProtKB/TrEMBL
Superfamily-SCOP FYVE_PHD_ZnF UniProtKB/TrEMBL
  SAND_like UniProtKB/TrEMBL
UniProt A0A8I5ZTP2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AL71 ENTREZGENE, UniProtKB/TrEMBL
  A6JK47 ENTREZGENE, UniProtKB/TrEMBL
  A6JK48 ENTREZGENE, UniProtKB/TrEMBL
  A6JK49 ENTREZGENE, UniProtKB/TrEMBL
  D3ZV49 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-26 Aire  autoimmune regulator  Aire  autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Aire  autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)   Aire_predicted  autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Aire_predicted  autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy) (predicted)      Symbol and Name status set to approved 70820 APPROVED