Brd2 (bromodomain containing 2) - Rat Genome Database

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Gene: Brd2 (bromodomain containing 2) Rattus norvegicus
Analyze
Symbol: Brd2
Name: bromodomain containing 2
RGD ID: 1303324
Description: Predicted to enable chromatin binding activity; lysine-acetylated histone binding activity; and protein serine/threonine kinase activity. Predicted to be involved in nucleosome assembly; protein phosphorylation; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within neural tube closure. Predicted to be located in cytoplasm and nuclear speck. Predicted to be active in chromatin and nucleus. Human ortholog(s) of this gene implicated in B-cell lymphoma; B-lymphoblastic leukemia/lymphoma; juvenile myoclonic epilepsy; and photosensitivity disease. Orthologous to human BRD2 (bromodomain containing 2); PARTICIPATES IN histone modification pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: bromodomain-containing 2; bromodomain-containing protein 2; LOC108348112; Ring3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Is Marker For: QTLs:   Tcs1  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2204,727,078 - 4,735,389 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl204,728,151 - 4,735,388 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx205,480,415 - 5,487,612 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0204,842,158 - 4,849,355 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0205,323,436 - 5,330,635 (+)NCBIRnor_WKY
Rnor_6.0203,910,555 - 3,921,074 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl205,262,120 - 5,269,337 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl203,910,555 - 3,917,426 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0207,323,184 - 7,330,398 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4204,864,606 - 4,871,813 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1204,864,832 - 4,872,040 (+)NCBI
Celera206,328,831 - 6,336,038 (+)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(S)-nicotine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
3,3'-diindolylmethane  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
acrylamide  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
alpha-pinene  (ISO)
amphetamine  (EXP)
aristolochic acid A  (ISO)
azoxystrobin  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[k]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
CGP 52608  (ISO)
chloroacetaldehyde  (ISO)
chloropicrin  (ISO)
cidofovir anhydrous  (ISO)
cisplatin  (ISO)
clodronic acid  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
Cuprizon  (ISO)
cyclosporin A  (ISO)
deguelin  (ISO)
diazinon  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
fenofibrate  (EXP)
fenthion  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
furan  (ISO)
gentamycin  (EXP)
ifosfamide  (ISO)
ivermectin  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
metformin  (EXP)
methamphetamine  (ISO)
methapyrilene  (EXP)
methimazole  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
N-(6-acetamidohexyl)acetamide  (ISO)
N-methylformamide  (ISO)
nickel sulfate  (ISO)
nicotine  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
pentachlorophenol  (ISO)
phenobarbital  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
pyrimidines  (ISO)
quercetin  (ISO)
quinazolines  (ISO)
rac-lactic acid  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sodium fluoride  (ISO)
temozolomide  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triptonide  (ISO)
trovafloxacin  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromatin  (IBA)
cytoplasm  (ISO)
nuclear speck  (IEA,ISO)
nucleoplasm  (ISO)
nucleus  (IBA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Change in nuclear-cytoplasmic localization of a double-bromodomain protein during proliferation and differentiation of mouse spinal cord and dorsal root ganglia. Crowley T, etal., Brain Res Dev Brain Res 2004 Apr 19;149(2):93-101.
2. Reproductive cycle regulation of nuclear import, euchromatic localization, and association with components of Pol II mediator of a mammalian double-bromodomain protein. Crowley TE, etal., Mol Endocrinol 2002 Aug;16(8):1727-37.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. E mu-BRD2 transgenic mice develop B-cell lymphoma and leukemia. Greenwald RJ, etal., Blood. 2004 Feb 15;103(4):1475-84. Epub 2003 Oct 16.
5. Association of BRD2 polymorphisms with photoparoxysmal response. Lorenz S, etal., Neurosci Lett. 2006 May 29;400(1-2):135-9. Epub 2006 Mar 3.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. BRD2 (RING3) is a probable major susceptibility gene for common juvenile myoclonic epilepsy. Pal DK, etal., Am J Hum Genet 2003 Aug;73(2):261-70. Epub 2003 Jun 25.
8. GOA pipeline RGD automated data pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. The bromodomain: From epigenome reader to druggable target. Sanchez R, etal., Biochim Biophys Acta. 2014 Aug;1839(8):676-685. doi: 10.1016/j.bbagrm.2014.03.011. Epub 2014 Mar 28.
11. BRD4 sustains melanoma proliferation and represents a new target for epigenetic therapy. Segura MF, etal., Cancer Res. 2013 Oct 15;73(20):6264-76. doi: 10.1158/0008-5472.CAN-13-0122-T. Epub 2013 Aug 15.
12. Brd2 disruption in mice causes severe obesity without Type 2 diabetes. Wang F, etal., Biochem J. 2009 Dec 14;425(1):71-83. doi: 10.1042/BJ20090928.
Additional References at PubMed
PMID:12477932   PMID:15060004   PMID:18406326  


Genomics

Comparative Map Data
Brd2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2204,727,078 - 4,735,389 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl204,728,151 - 4,735,388 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx205,480,415 - 5,487,612 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0204,842,158 - 4,849,355 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0205,323,436 - 5,330,635 (+)NCBIRnor_WKY
Rnor_6.0203,910,555 - 3,921,074 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl205,262,120 - 5,269,337 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl203,910,555 - 3,917,426 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0207,323,184 - 7,330,398 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4204,864,606 - 4,871,813 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1204,864,832 - 4,872,040 (+)NCBI
Celera206,328,831 - 6,336,038 (+)NCBICelera
Cytogenetic Map20p12NCBI
BRD2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38632,968,594 - 32,981,505 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl632,968,594 - 32,981,505 (+)EnsemblGRCh38hg38GRCh38
GRCh37632,936,371 - 32,949,282 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36633,044,415 - 33,057,059 (+)NCBINCBI36Build 36hg18NCBI36
Build 34633,044,414 - 33,057,059NCBI
Celera634,485,349 - 34,498,195 (+)NCBICelera
Cytogenetic Map6p21.32NCBI
HuRef632,678,978 - 32,691,818 (+)NCBIHuRef
CHM1_1632,937,242 - 32,950,091 (+)NCBICHM1_1
T2T-CHM13v2.0632,789,953 - 32,802,871 (+)NCBIT2T-CHM13v2.0
Brd2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391734,330,993 - 34,341,581 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1734,330,997 - 34,341,608 (-)EnsemblGRCm39 Ensembl
GRCm381734,112,019 - 34,122,814 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1734,112,023 - 34,122,634 (-)EnsemblGRCm38mm10GRCm38
MGSCv371734,248,964 - 34,258,692 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361733,722,473 - 33,730,354 (-)NCBIMGSCv36mm8
Celera1736,864,043 - 36,873,770 (-)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1717.98NCBI
Brd2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554371,584,479 - 1,592,826 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554371,584,890 - 1,592,486 (+)NCBIChiLan1.0ChiLan1.0
BRD2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1633,657,488 - 33,666,054 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl633,657,648 - 33,666,031 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0632,538,130 - 32,550,823 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
BRD2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1122,534,034 - 2,546,029 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl122,534,034 - 2,546,029 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha122,615,604 - 2,627,599 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0122,864,982 - 2,876,982 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl122,864,927 - 2,876,950 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1122,533,065 - 2,545,060 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0122,614,613 - 2,626,605 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0122,689,162 - 2,701,159 (+)NCBIUU_Cfam_GSD_1.0
Brd2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494638,145,455 - 38,153,085 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647625,807,163 - 25,818,899 (-)EnsemblSpeTri2.0
SpeTri2.0NW_00493647625,807,179 - 25,818,914 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BRD2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl725,152,043 - 25,162,578 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1725,096,579 - 25,162,591 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2729,463,191 - 29,529,204 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BRD2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11739,113,519 - 39,126,267 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604432,757,658 - 32,770,463 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Brd2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475423,742,509 - 23,750,062 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475423,742,506 - 23,750,668 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Brd2
44 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:129
Count of miRNA genes:92
Interacting mature miRNAs:98
Transcripts:ENSRNOT00000000535, ENSRNOT00000060194
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125159026Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
2306850Pia40Pristane induced arthritis QTL 400.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2015279595304575Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20289259726381954Rat
1300152Bp195Blood pressure QTL 1953.46arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2036216499243559Rat
1331772Cdexp2CD45RC expression in CD8 T cells QTL 25.7CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)20362164910078919Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20362165614101050Rat
61474Eae1Experimental allergic encephalomyelitis QTL 13nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)2046066076691706Rat
4889857Pur27Proteinuria QTL 2712.20.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20460660717617956Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20460660717617956Rat
7175096Tcs1T cell selection QTL 1T cell selectionexpression2047270785024580Rat

Markers in Region
AW228947  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.0205,990,258 - 5,990,366NCBIRnor5.0
Rnor_5.0207,330,134 - 7,330,242NCBIRnor5.0
Rnor_5.01061,374,939 - 61,375,047NCBIRnor5.0
RGSC_v3.41062,114,541 - 62,114,648UniSTSRGSC3.4
RGSC_v3.4204,871,557 - 4,871,664UniSTSRGSC3.4
Celera206,335,782 - 6,335,889UniSTS
Cytogenetic Map10q24UniSTS
Cytogenetic Map20p12UniSTS
CGCb741  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2204,731,699 - 4,731,873 (-)MAPPERmRatBN7.2
mRatBN7.2204,731,699 - 4,731,873 (+)MAPPERmRatBN7.2
Rnor_6.0203,914,071 - 3,914,244NCBIRnor6.0
Rnor_6.0205,265,648 - 5,265,821NCBIRnor6.0
Rnor_5.0207,326,709 - 7,326,882UniSTSRnor5.0
Rnor_5.0205,993,619 - 5,993,792UniSTSRnor5.0
RGSC_v3.4204,868,131 - 4,868,304UniSTSRGSC3.4
Celera206,332,356 - 6,332,529UniSTS
Cytogenetic Map20p12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 20 8
Low 3 43 57 41 19 41 8 11 54 35 33 11 8
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_212495 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008772772 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008772773 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601578 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601579 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039098497 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039098498 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC098547 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC100654 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX883042 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225945 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226688 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226877 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232599 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000000535   ⟹   ENSRNOP00000000535
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl204,728,151 - 4,735,382 (+)Ensembl
Rnor_6.0 Ensembl205,262,120 - 5,269,328 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000060194
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl204,730,185 - 4,735,382 (+)Ensembl
Rnor_6.0 Ensembl203,910,583 - 3,917,224 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000077454
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl203,910,555 - 3,917,426 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000080585   ⟹   ENSRNOP00000072049
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl204,728,518 - 4,735,388 (+)Ensembl
Rnor_6.0 Ensembl205,262,466 - 5,269,337 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000082900   ⟹   ENSRNOP00000070430
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl205,262,946 - 5,265,935 (+)Ensembl
RefSeq Acc Id: NM_212495   ⟹   NP_997660
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2204,728,175 - 4,735,382 (+)NCBI
Rnor_6.0203,910,562 - 3,917,769 (-)NCBI
Rnor_5.0207,323,184 - 7,330,398 (+)NCBI
RGSC_v3.4204,864,606 - 4,871,813 (+)RGD
Celera206,328,831 - 6,336,038 (+)RGD
Sequence:
RefSeq Acc Id: XM_008772772   ⟹   XP_008770994
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2204,729,003 - 4,735,389 (+)NCBI
Rnor_6.0203,910,555 - 3,916,979 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017601578   ⟹   XP_017457067
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2204,727,078 - 4,735,374 (+)NCBI
Rnor_6.0203,910,555 - 3,918,918 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039098497   ⟹   XP_038954425
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2204,728,518 - 4,735,389 (+)NCBI
RefSeq Acc Id: XM_039098498   ⟹   XP_038954426
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2204,728,743 - 4,732,948 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_997660   ⟸   NM_212495
- UniProtKB: Q6MGA9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017457067   ⟸   XM_017601578
- Peptide Label: isoform X1
- UniProtKB: Q6MGA9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008770994   ⟸   XM_008772772
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000070430   ⟸   ENSRNOT00000082900
RefSeq Acc Id: ENSRNOP00000072049   ⟸   ENSRNOT00000080585
RefSeq Acc Id: ENSRNOP00000000535   ⟸   ENSRNOT00000000535
RefSeq Acc Id: XP_038954425   ⟸   XM_039098497
- Peptide Label: isoform X3
- UniProtKB: A0A0G2K1Z8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038954426   ⟸   XM_039098498
- Peptide Label: isoform X4
Protein Domains
Bromo   NET

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6MGA9-F1-model_v2 AlphaFold Q6MGA9 1-798 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1303324 AgrOrtholog
BioCyc Gene G2FUF-4548 BioCyc
Ensembl Genes ENSRNOG00000000461 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00000045877 Ensembl
Ensembl Protein ENSRNOP00000000535 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000072049 ENTREZGENE
  ENSRNOP00000072049.2 UniProtKB/TrEMBL
  ENSRNOP00000082798 ENTREZGENE
  ENSRNOP00000082798.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000000535 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000060194 ENTREZGENE
  ENSRNOT00000060194.5 UniProtKB/TrEMBL
  ENSRNOT00000080585 ENTREZGENE
  ENSRNOT00000080585.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1270.220 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.920.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Bromo_Brdt_I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Bromo_Brdt_II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Bromodomain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Bromodomain-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Bromodomain_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NET_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NET_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:294276 UniProtKB/Swiss-Prot
NCBI Gene 294276 ENTREZGENE
Pfam BET UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Bromodomain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Brd2 PhenoGen
PRINTS BROMODOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE BROMODOMAIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BROMODOMAIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NET UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART BROMO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47370 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K1Z8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZYL9_RAT UniProtKB/TrEMBL
  BRD2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Brd2  bromodomain containing 2  LOC108348112  bromodomain-containing protein 2  Data Merged 737654 PROVISIONAL
2016-08-02 LOC108348112  bromodomain-containing protein 2      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-03-30 Brd2  bromodomain containing 2    bromodomain-containing 2  Name updated 1299863 APPROVED
2005-02-14 Brd2  bromodomain-containing 2      Symbol and Name status set to provisional 70820 PROVISIONAL