Ado (2-aminoethanethiol dioxygenase) - Rat Genome Database

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Gene: Ado (2-aminoethanethiol dioxygenase) Rattus norvegicus
Analyze
Symbol: Ado
Name: 2-aminoethanethiol dioxygenase
RGD ID: 1308233
Description: Predicted to enable cysteamine dioxygenase activity and iron ion binding activity. Predicted to be involved in cellular response to hypoxia. Orthologous to human ADO (2-aminoethanethiol dioxygenase); PARTICIPATES IN taurine and hypotaurine metabolic pathway; INTERACTS WITH 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2-aminoethanethiol (cysteamine) dioxygenase; LOC309732; RGD1308233; similar to hypothetical protein FLJ14547
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82021,043,694 - 21,044,862 (+)NCBIGRCr8
mRatBN7.22021,044,815 - 21,045,983 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2021,044,555 - 21,049,235 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2021,768,994 - 21,770,162 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02021,122,055 - 21,123,223 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02021,599,535 - 21,600,703 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02022,447,996 - 22,449,176 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2022,447,994 - 22,449,176 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02024,545,375 - 24,546,303 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42021,877,141 - 21,878,612 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12021,835,054 - 21,892,516 (+)NCBI
Celera2022,406,218 - 22,407,386 (+)NCBICelera
Cytogenetic Map20p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
2. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:18614015  


Genomics

Comparative Map Data
Ado
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82021,043,694 - 21,044,862 (+)NCBIGRCr8
mRatBN7.22021,044,815 - 21,045,983 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2021,044,555 - 21,049,235 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2021,768,994 - 21,770,162 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02021,122,055 - 21,123,223 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02021,599,535 - 21,600,703 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02022,447,996 - 22,449,176 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2022,447,994 - 22,449,176 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02024,545,375 - 24,546,303 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42021,877,141 - 21,878,612 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12021,835,054 - 21,892,516 (+)NCBI
Celera2022,406,218 - 22,407,386 (+)NCBICelera
Cytogenetic Map20p11NCBI
ADO
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381062,804,720 - 62,808,479 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1062,804,720 - 62,808,479 (+)EnsemblGRCh38hg38GRCh38
GRCh371064,564,480 - 64,568,239 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361064,234,522 - 64,238,245 (+)NCBINCBI36Build 36hg18NCBI36
Build 341064,234,651 - 64,238,244NCBI
Celera1057,831,785 - 57,835,508 (+)NCBICelera
Cytogenetic Map10q21.3NCBI
HuRef1058,556,298 - 58,560,021 (+)NCBIHuRef
CHM1_11064,846,508 - 64,850,231 (+)NCBICHM1_1
T2T-CHM13v2.01063,662,863 - 63,666,622 (+)NCBIT2T-CHM13v2.0
Ado
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391067,380,341 - 67,384,785 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1067,380,341 - 67,384,898 (-)EnsemblGRCm39 Ensembl
GRCm381067,544,511 - 67,548,955 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1067,544,511 - 67,549,068 (-)EnsemblGRCm38mm10GRCm38
MGSCv371067,007,259 - 67,011,703 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361066,940,488 - 66,944,299 (-)NCBIMGSCv36mm8
Celera1068,635,994 - 68,640,438 (-)NCBICelera
Cytogenetic Map10B5.1NCBI
cM Map1034.96NCBI
Ado
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542516,049,284 - 16,050,096 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542516,049,194 - 16,052,275 (+)NCBIChiLan1.0ChiLan1.0
ADO
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2874,987,624 - 74,994,534 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11074,996,097 - 74,999,868 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01059,312,788 - 59,316,554 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11061,641,371 - 61,644,848 (+)NCBIpanpan1.1PanPan1.1panPan2
ADO
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1414,698,582 - 14,702,635 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl414,698,616 - 14,699,428 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha414,915,996 - 14,920,120 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0414,962,585 - 14,966,710 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl414,962,691 - 14,963,503 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1414,945,248 - 14,949,371 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0415,070,279 - 15,074,404 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0415,425,875 - 15,430,000 (+)NCBIUU_Cfam_GSD_1.0
Ado
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721366,391,222 - 66,394,926 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049367531,965,840 - 1,969,554 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADO
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1466,277,947 - 66,278,759 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11466,277,224 - 66,281,964 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21471,509,996 - 71,514,349 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ADO
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1968,483,110 - 68,486,866 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl968,485,720 - 68,486,532 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604829,367,071 - 29,371,016 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ado
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624791965,433 - 966,245 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624791962,840 - 966,603 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ado
4 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:221
Count of miRNA genes:156
Interacting mature miRNAs:181
Transcripts:ENSRNOT00000000791
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125159026Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20289259726381954Rat
4889870Pur30Proteinuria QTL 30190.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20804241029322208Rat
7411652Foco24Food consumption QTL 240.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)201175751554435887Rat
9590092Insglur9Insulin/glucose ratio QTL 918.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)201175751554435887Rat
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)201761783247606836Rat
2317880Alcrsp25Alcohol response QTL 252.3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)201769755054435887Rat
2303626Vencon10Ventilatory control QTL 100.001respiration trait (VT:0001943)respiration rate (CMO:0000289)201919072154435887Rat

Markers in Region
RH138042  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22021,043,642 - 21,043,780 (+)MAPPERmRatBN7.2
Rnor_6.02022,446,820 - 22,446,957NCBIRnor6.0
Rnor_5.02024,544,199 - 24,544,336UniSTSRnor5.0
RGSC_v3.42021,876,230 - 21,876,367UniSTSRGSC3.4
Celera2022,404,986 - 22,405,123UniSTS
Cytogenetic Map20p11UniSTS
RH139021  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22021,045,380 - 21,045,657 (+)MAPPERmRatBN7.2
Rnor_6.02022,448,574 - 22,448,850NCBIRnor6.0
Rnor_5.02024,545,701 - 24,545,977UniSTSRnor5.0
RGSC_v3.42021,878,012 - 21,878,288UniSTSRGSC3.4
Celera2022,406,784 - 22,407,060UniSTS
RH 3.4 Map4701.2UniSTS
Cytogenetic Map20p11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 20 2 2 2 64 16 32
Low 3 23 55 39 19 39 8 11 10 19 9 11 8
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000000791
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2022,447,994 - 22,449,176 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000097613   ⟹   ENSRNOP00000083299
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2021,044,555 - 21,049,235 (+)Ensembl
RefSeq Acc Id: NM_001107626   ⟹   NP_001101096
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82021,043,694 - 21,044,862 (+)NCBI
mRatBN7.22021,044,815 - 21,045,983 (+)NCBI
Rnor_6.02022,447,996 - 22,449,176 (+)NCBI
Rnor_5.02024,545,375 - 24,546,303 (+)NCBI
RGSC_v3.42021,877,141 - 21,878,612 (+)RGD
Celera2022,406,218 - 22,407,386 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001101096 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL97324 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000083299
  ENSRNOP00000083299.1
RefSeq Acc Id: NP_001101096   ⟸   NM_001107626
- UniProtKB: A0A8I5ZWY4 (UniProtKB/TrEMBL),   A6JKV8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000083299   ⟸   ENSRNOT00000097613

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308233 AgrOrtholog
BioCyc Gene G2FUF-3871 BioCyc
BioCyc Pathway PWY-7850 [taurine biosynthesis II] BioCyc
BioCyc Pathway Image PWY-7850 BioCyc
Ensembl Genes ENSRNOG00000000639 Ensembl
  ENSRNOG00000070733 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000097613 ENTREZGENE
  ENSRNOT00000097613.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.10 UniProtKB/TrEMBL
InterPro PCO/ADO UniProtKB/TrEMBL
  RmlC-like_jellyroll UniProtKB/TrEMBL
  RmlC_Cupin_sf UniProtKB/TrEMBL
KEGG Report rno:309732 UniProtKB/TrEMBL
NCBI Gene 309732 ENTREZGENE
PANTHER 2-AMINOETHANETHIOL DIOXYGENASE UniProtKB/TrEMBL
  PTHR22966 UniProtKB/TrEMBL
Pfam PCO_ADO UniProtKB/TrEMBL
PhenoGen Ado PhenoGen
RatGTEx ENSRNOG00000000639 RatGTEx
  ENSRNOG00000070733 RatGTEx
Superfamily-SCOP SSF51182 UniProtKB/TrEMBL
UniProt A0A8I5ZWY4 ENTREZGENE, UniProtKB/TrEMBL
  A6JKV8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-08 Ado  2-aminoethanethiol dioxygenase  Ado  2-aminoethanethiol (cysteamine) dioxygenase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-26 Ado  2-aminoethanethiol (cysteamine) dioxygenase  RGD1308233_predicted  similar to hypothetical protein FLJ14547 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 RGD1308233_predicted  similar to hypothetical protein FLJ14547 (predicted)  LOC309732_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC309732_predicted  similar to hypothetical protein FLJ14547 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL