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Gene: Ier3 (immediate early response 3) Rattus norvegicus
Symbol: Ier3
Name: immediate early response 3
Description: Predicted to be involved in several processes, including intrinsic apoptotic signaling pathway in response to DNA damage; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; and regulation of nucleobase-containing compound metabolic process. Predicted to localize to the nucleus. Orthologous to human IER3 (immediate early response 3); INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 1,3-dinitrobenzene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Dif2; Iex1; Ler3; MGC124532; Prg1; radiation-inducible immediate-early gene IEX-1
Homo sapiens (human) : IER3 (immediate early response 3)  HGNC  Alliance
Mus musculus (house mouse) : Ier3 (immediate early response 3)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ier3 (immediate early response 3)
Pan paniscus (bonobo/pygmy chimpanzee) : IER3 (immediate early response 3)
Canis lupus familiaris (dog) : IER3 (immediate early response 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ier3 (immediate early response 3)
Sus scrofa (pig) : IER3 (immediate early response 3)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0203,438,798 - 3,440,002 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0205,535,616 - 5,536,820 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4203,076,568 - 3,077,772 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1203,076,800 - 3,077,971 (-)NCBI
Celera20354,289 - 355,493 (-)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
More on Ier3
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1303321
Created: 2004-12-03
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.