Ier3 (immediate early response 3) - Rat Genome Database

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Gene: Ier3 (immediate early response 3) Rattus norvegicus
Analyze
Symbol: Ier3
Name: immediate early response 3
RGD ID: 1303321
Description: Predicted to act upstream of or within several processes, including intracellular signal transduction; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; and regulation of nucleobase-containing compound metabolic process. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in T-cell non-Hodgkin lymphoma. Orthologous to human IER3 (immediate early response 3); INTERACTS WITH 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 1,3-dinitrobenzene; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Dif2; Iex1; Ler3; MGC124532; Prg1; radiation-inducible immediate-early gene IEX-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2202,928,378 - 2,929,582 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl202,928,378 - 2,929,583 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx202,979,772 - 2,980,976 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0202,984,757 - 2,985,961 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0203,011,134 - 3,012,338 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0203,438,798 - 3,440,002 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl203,438,798 - 3,440,769 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0205,535,616 - 5,536,820 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4203,076,568 - 3,077,772 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1203,076,800 - 3,077,971 (-)NCBI
Celera20354,289 - 355,493 (-)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (ISO)
2,4-dinitrotoluene  (EXP)
2,5-hexanedione  (EXP)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
3',5'-cyclic AMP  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
8-Br-cAMP  (ISO)
acetamide  (EXP)
acrolein  (ISO)
acrylamide  (ISO)
actinomycin D  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-pinene  (ISO)
amitrole  (EXP)
antimycin A  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atazanavir sulfate  (ISO)
atrazine  (EXP)
azathioprine  (ISO)
azoxystrobin  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[ghi]perylene  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-naphthoflavone  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
butan-1-ol  (ISO)
butanal  (ISO)
butyric acid  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
calciol  (ISO)
calcitriol  (ISO)
camostat  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
cefaloridine  (EXP)
chenodeoxycholic acid  (ISO)
chlordecone  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (EXP,ISO)
choline  (ISO)
chromium(6+)  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corticosterone  (EXP)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
deoxycholic acid  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (ISO)
dieldrin  (ISO)
diethylstilbestrol  (ISO)
dinophysistoxin 1  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
ethanol  (ISO)
fenamidone  (ISO)
fluoranthene  (ISO)
flusilazole  (EXP,ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
gamma-hexachlorocyclohexane  (ISO)
gastrin-17  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glyphosate  (EXP)
griseofulvin  (ISO)
hexaconazole  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
hydroxyurea  (ISO)
imidacloprid  (EXP)
Indeno[1,2,3-cd]pyrene  (ISO)
indometacin  (ISO)
irinotecan  (ISO)
isoprenaline  (ISO)
isotretinoin  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
maneb  (ISO)
melphalan  (ISO)
mercury dibromide  (ISO)
methimazole  (EXP)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (ISO)
N-Nitrosopyrrolidine  (ISO)
naphthalene  (EXP,ISO)
nefazodone  (EXP,ISO)
nickel atom  (ISO)
nickel dichloride  (EXP,ISO)
nickel subsulfide  (ISO)
nickel sulfate  (ISO)
o-anisidine  (ISO)
O-methyleugenol  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
omeprazole  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
p-anisidine  (ISO)
p-chloromercuribenzoic acid  (ISO)
paclitaxel  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenanthrene  (ISO)
phenobarbital  (ISO)
phenylephrine  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phorone  (EXP)
picene  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
propanal  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
reactive oxygen species  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sodium hydroxide  (ISO)
Soman  (EXP)
succimer  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
superoxide  (ISO)
T-2 toxin  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (ISO)
tetraphene  (ISO)
thiabendazole  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
triadimefon  (ISO)
tributylstannane  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valnoctamide  (ISO)
valproic acid  (ISO)
valpromide  (ISO)
valsartan  (ISO)
vincristine  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleus  (IBA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
3. Development of T-cell lymphomas in Emu-IEX-1 mice. Zhang Y, etal., Oncogene 2003 Oct 9;22(44):6845-51.
Additional References at PubMed
PMID:8653710   PMID:11753682   PMID:12477932   PMID:16166241   PMID:19096392   PMID:19923449   PMID:20467439   PMID:27890615  


Genomics

Comparative Map Data
Ier3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2202,928,378 - 2,929,582 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl202,928,378 - 2,929,583 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx202,979,772 - 2,980,976 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0202,984,757 - 2,985,961 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0203,011,134 - 3,012,338 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0203,438,798 - 3,440,002 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl203,438,798 - 3,440,769 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0205,535,616 - 5,536,820 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4203,076,568 - 3,077,772 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1203,076,800 - 3,077,971 (-)NCBI
Celera20354,289 - 355,493 (-)NCBICelera
Cytogenetic Map20p12NCBI
IER3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38630,743,199 - 30,744,547 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl630,743,199 - 30,744,548 (-)EnsemblGRCh38hg38GRCh38
GRCh37630,710,976 - 30,712,324 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36630,818,955 - 30,820,306 (-)NCBINCBI36Build 36hg18NCBI36
Build 34630,818,955 - 30,820,303NCBI
Celera632,309,116 - 32,310,467 (-)NCBICelera
Cytogenetic Map6p21.33NCBI
HuRef630,510,790 - 30,512,141 (-)NCBIHuRef
CHM1_1630,713,084 - 30,714,431 (-)NCBICHM1_1
T2T-CHM13v2.0630,607,402 - 30,608,750 (-)NCBIT2T-CHM13v2.0
Ier3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391736,132,605 - 36,133,803 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1736,132,576 - 36,133,815 (+)EnsemblGRCm39 Ensembl
GRCm381735,821,713 - 35,822,911 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1735,821,684 - 35,822,923 (+)EnsemblGRCm38mm10GRCm38
MGSCv371735,958,658 - 35,959,856 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361735,429,766 - 35,430,964 (+)NCBIMGSCv36mm8
Celera1739,331,780 - 39,332,978 (+)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1718.7NCBI
Ier3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955583730,289 - 731,260 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955583730,353 - 731,301 (-)NCBIChiLan1.0ChiLan1.0
IER3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1641,266,813 - 41,268,643 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0630,488,162 - 30,489,784 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1631,357,853 - 31,359,205 (-)NCBIpanpan1.1PanPan1.1panPan2
IER3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.112529,002 - 530,328 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl12529,339 - 530,232 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha12666,269 - 667,557 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.012672,140 - 673,428 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl12672,477 - 673,370 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.112530,032 - 531,319 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.012598,936 - 600,223 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.012667,496 - 668,784 (-)NCBIUU_Cfam_GSD_1.0
Ier3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494634,036,216 - 34,037,522 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936837401,524 - 402,741 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936837401,475 - 402,769 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IER3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl723,265,564 - 23,266,827 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1723,265,560 - 23,266,905 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2726,987,529 - 26,988,875 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IER3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11741,712,539 - 41,713,895 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1741,712,528 - 41,714,126 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604430,437,411 - 30,438,758 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ier3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475424,991,690 - 24,992,643 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475424,991,650 - 24,992,645 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ier3
3 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:56
Count of miRNA genes:54
Interacting mature miRNAs:55
Transcripts:ENSRNOT00000001099
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724519Bp144Blood pressure QTL 1440.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2013624629Rat
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125159026Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
2306850Pia40Pristane induced arthritis QTL 400.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2015279595304575Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
61448Ciaa1CIA Autoantibody QTL 1300.001blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)2026463954597031Rat
61472Aia1Adjuvant induced arthritis QTL 1180.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2026463954597031Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20289259726381954Rat

Markers in Region
RH131920  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2202,928,448 - 2,928,631 (+)MAPPERmRatBN7.2
Rnor_6.0203,438,869 - 3,439,051NCBIRnor6.0
Rnor_5.0205,535,687 - 5,535,869UniSTSRnor5.0
RGSC_v3.4203,076,639 - 3,076,821UniSTSRGSC3.4
Celera20354,360 - 354,542UniSTS
RH 3.4 Map2052.72UniSTS
Cytogenetic Map20p12UniSTS
UniSTS:496739  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2202,928,940 - 2,929,042 (+)MAPPERmRatBN7.2
Rnor_6.0203,439,361 - 3,439,462NCBIRnor6.0
Rnor_5.0205,536,179 - 5,536,280UniSTSRnor5.0
RGSC_v3.4203,077,131 - 3,077,232UniSTSRGSC3.4
Celera20354,852 - 354,953UniSTS
Cytogenetic Map20p12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 35 35 29 3 29 3 8 31 29 11
Low 8 22 12 16 12 8 8 66 4 12 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000001099   ⟹   ENSRNOP00000001099
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl202,928,378 - 2,929,583 (-)Ensembl
Rnor_6.0 Ensembl203,438,798 - 3,440,002 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000080822   ⟹   ENSRNOP00000070335
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl203,438,968 - 3,439,983 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000084981   ⟹   ENSRNOP00000069087
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl203,439,512 - 3,440,769 (-)Ensembl
RefSeq Acc Id: NM_212505   ⟹   NP_997670
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2202,928,378 - 2,929,582 (-)NCBI
Rnor_6.0203,438,798 - 3,440,002 (-)NCBI
Rnor_5.0205,535,616 - 5,536,820 (-)NCBI
RGSC_v3.4203,076,568 - 3,077,772 (-)RGD
Celera20354,289 - 355,493 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_997670 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH99831 (Get FASTA)   NCBI Sequence Viewer  
  CAE84029 (Get FASTA)   NCBI Sequence Viewer  
  EDL86742 (Get FASTA)   NCBI Sequence Viewer  
  EDL86743 (Get FASTA)   NCBI Sequence Viewer  
  EDL86744 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000001099
  ENSRNOP00000001099.3
Reference Protein Sequences
RefSeq Acc Id: NP_997670   ⟸   NM_212505
- UniProtKB: Q499N0 (UniProtKB/TrEMBL),   Q6MG18 (UniProtKB/TrEMBL),   A6KT88 (UniProtKB/TrEMBL),   F6PRN7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000070335   ⟸   ENSRNOT00000080822
RefSeq Acc Id: ENSRNOP00000069087   ⟸   ENSRNOT00000084981
RefSeq Acc Id: ENSRNOP00000001099   ⟸   ENSRNOT00000001099

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6MG18-F1-model_v2 AlphaFold Q6MG18 1-160 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701302
Promoter ID:EPDNEW_R11826
Type:single initiation site
Name:Ier3_1
Description:immediate early response 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0203,440,003 - 3,440,063EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1303321 AgrOrtholog
BioCyc Gene G2FUF-4775 BioCyc
Ensembl Genes ENSRNOG00000000827 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000001099 ENTREZGENE
  ENSRNOT00000001099.7 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7933804 IMAGE-MGC_LOAD
InterPro IEX-1 UniProtKB/TrEMBL
KEGG Report rno:294235 UniProtKB/TrEMBL
MGC_CLONE MGC:124532 IMAGE-MGC_LOAD
NCBI Gene 294235 ENTREZGENE
PANTHER PTHR16915 UniProtKB/TrEMBL
  RADIATION-INDUCIBLE IMMEDIATE-EARLY GENE IEX-1 UniProtKB/TrEMBL
PhenoGen Ier3 PhenoGen
PRINTS GENEIEX1 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000000827 RatGTEx
UniProt A6KT88 ENTREZGENE, UniProtKB/TrEMBL
  A6KT90_RAT UniProtKB/TrEMBL
  F6PRN7 ENTREZGENE, UniProtKB/TrEMBL
  Q499N0 ENTREZGENE, UniProtKB/TrEMBL
  Q6MG18 ENTREZGENE
UniProt Secondary Q6MG18 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Ier3  immediate early response 3  Ler3    Symbol updated 1299863 APPROVED
2005-02-14 Ler3  immediate early response 3      Symbol and Name status set to provisional 70820 PROVISIONAL