Adarb1 (adenosine deaminase, RNA-specific, B1) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Adarb1 (adenosine deaminase, RNA-specific, B1) Rattus norvegicus
Analyze
Symbol: Adarb1
Name: adenosine deaminase, RNA-specific, B1
RGD ID: 2033
Description: Enables double-stranded RNA adenosine deaminase activity; double-stranded RNA binding activity; and identical protein binding activity. Involved in adenosine to inosine editing; mRNA modification; and positive regulation of mRNA processing. Located in nucleoplasm. Used to study obesity and transient cerebral ischemia. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis. Orthologous to human ADARB1 (adenosine deaminase RNA specific B1); PARTICIPATES IN microRNA pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,3,4,7,8-Pentachlorodibenzofuran; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: Adar2; double stranded RNA specific deaminase RED1; double-stranded RNA-specific editase 1; dsRNA adenosine deaminase; RED1; RNA editing deaminase of glutamate receptors; RNA-editing deaminase 1; RNA-editing enzyme 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82011,222,171 - 11,350,416 (+)NCBIGRCr8
mRatBN7.22011,222,569 - 11,350,854 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2011,222,583 - 11,350,852 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2011,919,732 - 12,047,120 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02011,280,701 - 11,408,103 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02011,752,435 - 11,879,837 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02011,972,352 - 12,101,022 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2011,972,381 - 12,101,047 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02014,137,226 - 14,264,945 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42011,616,718 - 11,747,294 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12011,678,671 - 11,744,168 (+)NCBI
Celera2012,725,154 - 12,852,814 (+)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,4,7,8-Pentachlorodibenzofuran  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-Dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline  (EXP)
2,4-dinitrobenzenesulfonic acid  (ISO)
2,6-dinitrotoluene  (EXP)
2-methylcholine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
alachlor  (EXP)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arachidonic acid  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
C60 fullerene  (EXP)
caffeine  (EXP)
calciol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlormequat chloride  (EXP)
chloroprene  (EXP)
chromium(6+)  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
decabromodiphenyl ether  (EXP)
dexamethasone  (ISO)
dibutyl phthalate  (ISO)
disulfiram  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
fenvalerate  (EXP)
fluoxetine  (ISO)
folic acid  (ISO)
FR900359  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glyphosate  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methapyrilene  (ISO)
methimazole  (EXP)
methoxyacetic acid  (EXP)
methylmercury chloride  (EXP)
mitoxantrone  (ISO)
Monobutylphthalate  (EXP)
N,N-diethyl-m-toluamide  (EXP)
nitrofen  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP)
permethrin  (EXP)
pirinixic acid  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
pyrogallol  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tetrachloromethane  (ISO)
topotecan  (EXP)
triacsin C  (ISO)
triadimefon  (EXP)
tributylstannane  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA)
cytosol  (IEA,ISO)
nucleolus  (IBA,IEA,ISO)
nucleoplasm  (IDA,IEA,ISO)
nucleus  (IEA,ISO)
synapse  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. TDP-43 pathology in sporadic ALS occurs in motor neurons lacking the RNA editing enzyme ADAR2. Aizawa H, etal., Acta Neuropathol. 2010 Jul;120(1):75-84. doi: 10.1007/s00401-010-0678-x. Epub 2010 Apr 7.
2. Acute spinal cord injury persistently reduces R/G RNA editing of AMPA receptors. Barbon A, etal., J Neurochem. 2010 Jul;114(2):397-407. doi: 10.1111/j.1471-4159.2010.06767.x. Epub 2010 Apr 23.
3. Structure and sequence determinants required for the RNA editing of ADAR2 substrates. Dawson TR, etal., J Biol Chem 2004 Feb 6;279(6):4941-51. Epub 2003 Nov 30.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. A-to-I editing of microRNAs: regulating the regulators? Gommans WM Semin Cell Dev Biol. 2012 May;23(3):251-7. doi: 10.1016/j.semcdb.2011.09.018. Epub 2011 Oct 5.
6. Developmental changes in expression and self-editing of adenosine deaminase type 2 pre-mRNA and mRNA in rat brain and cultured cortical neurons. Hang PN, etal., Neurosci Res. 2008 Aug;61(4):398-403. doi: 10.1016/j.neures.2008.04.007. Epub 2008 Apr 26.
7. Profound downregulation of the RNA editing enzyme ADAR2 in ALS spinal motor neurons. Hideyama T, etal., Neurobiol Dis. 2012 Mar;45(3):1121-8. doi: 10.1016/j.nbd.2011.12.033. Epub 2011 Dec 28.
8. Point mutation in an AMPA receptor gene rescues lethality in mice deficient in the RNA-editing enzyme ADAR2. Higuchi M, etal., Nature 2000 Jul 6;406(6791):78-81.
9. Adenosine deaminases acting on RNA (ADARs): RNA-editing enzymes. Keegan LP, etal., Genome Biol. 2004;5(2):209. Epub 2004 Feb 2.
10. A mammalian RNA editing enzyme. Melcher T, etal., Nature 1996 Feb 1;379(6564):460-4.
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. In vitro analysis of the binding of ADAR2 to the pre-mRNA encoding the GluR-B R/G site. Ohman M, etal., RNA. 2000 May;6(5):687-97.
13. ADAR2-dependent RNA editing of AMPA receptor subunit GluR2 determines vulnerability of neurons in forebrain ischemia. Peng PL, etal., Neuron. 2006 Mar 2;49(5):719-33.
14. Dimerization of ADAR2 is mediated by the double-stranded RNA binding domain. Poulsen H, etal., RNA. 2006 Jul;12(7):1350-60. Epub 2006 May 8.
15. GOA pipeline RGD automated data pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Regulation of alternative splicing by RNA editing. Rueter SM, etal., Nature. 1999 May 6;399(6731):75-80.
19. Modulation of RNA editing by functional nucleolar sequestration of ADAR2. Sansam CL, etal., Proc Natl Acad Sci U S A 2003 Nov 25;100(24):14018-23. Epub 2003 Nov 11.
20. Hyperphagia-mediated obesity in transgenic mice misexpressing the RNA-editing enzyme ADAR2. Singh M, etal., J Biol Chem. 2007 Aug 3;282(31):22448-59. Epub 2007 Jun 12.
21. Structure and specific RNA binding of ADAR2 double-stranded RNA binding motifs. Stefl R, etal., Structure. 2006 Feb;14(2):345-55.
22. RNA-interacting proteins act as site-specific repressors of ADAR2-mediated RNA editing and fluctuate upon neuronal stimulation. Tariq A, etal., Nucleic Acids Res. 2013 Feb 1;41(4):2581-93. doi: 10.1093/nar/gks1353. Epub 2012 Dec 28.
23. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:8889548   PMID:8995285   PMID:9111310   PMID:9149227   PMID:9450685   PMID:12810917   PMID:16440002   PMID:16956888   PMID:17369310   PMID:18178553   PMID:20826656   PMID:21289159  
PMID:21620933   PMID:22681889   PMID:23139803   PMID:28082424   PMID:30559217  


Genomics

Comparative Map Data
Adarb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82011,222,171 - 11,350,416 (+)NCBIGRCr8
mRatBN7.22011,222,569 - 11,350,854 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2011,222,583 - 11,350,852 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2011,919,732 - 12,047,120 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02011,280,701 - 11,408,103 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02011,752,435 - 11,879,837 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02011,972,352 - 12,101,022 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2011,972,381 - 12,101,047 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02014,137,226 - 14,264,945 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42011,616,718 - 11,747,294 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12011,678,671 - 11,744,168 (+)NCBI
Celera2012,725,154 - 12,852,814 (+)NCBICelera
Cytogenetic Map20p12NCBI
ADARB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382145,074,578 - 45,226,563 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2145,073,853 - 45,226,560 (+)EnsemblGRCh38hg38GRCh38
GRCh372146,494,493 - 46,646,478 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362145,318,943 - 45,470,902 (+)NCBINCBI36Build 36hg18NCBI36
Build 342145,318,942 - 45,470,902NCBI
Celera2131,601,137 - 31,754,043 (+)NCBICelera
Cytogenetic Map21q22.3NCBI
HuRef2131,920,569 - 32,018,419 (+)NCBIHuRef
CHM1_12146,055,410 - 46,207,429 (+)NCBICHM1_1
T2T-CHM13v2.02143,436,861 - 43,590,594 (+)NCBIT2T-CHM13v2.0
Adarb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391077,126,561 - 77,254,125 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1077,126,560 - 77,254,104 (-)EnsemblGRCm39 Ensembl
GRCm381077,290,727 - 77,418,292 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1077,290,726 - 77,418,270 (-)EnsemblGRCm38mm10GRCm38
MGSCv371076,753,472 - 76,881,018 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361076,734,449 - 76,861,989 (-)NCBIMGSCv36mm8
Celera1078,334,514 - 78,460,578 (-)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Adarb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540741,886,286 - 41,962,897 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540741,886,286 - 41,962,846 (+)NCBIChiLan1.0ChiLan1.0
ADARB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22241,127,906 - 41,286,535 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12135,998,325 - 36,156,517 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02131,374,841 - 31,532,721 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12144,663,136 - 44,816,756 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2144,715,931 - 44,815,748 (+)Ensemblpanpan1.1panPan2
ADARB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13138,715,529 - 38,799,353 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3138,678,184 - 38,796,521 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3137,859,697 - 37,997,419 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03138,267,094 - 38,405,109 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3138,321,094 - 38,405,109 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13138,129,384 - 38,267,671 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03138,090,539 - 38,229,180 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03138,604,578 - 38,742,906 (+)NCBIUU_Cfam_GSD_1.0
Adarb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497137,992,436 - 38,073,951 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367781,053,871 - 1,137,828 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367781,056,259 - 1,137,772 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADARB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13207,691,174 - 207,791,802 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113207,746,915 - 207,791,809 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213217,610,539 - 217,651,965 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ADARB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1288,780,954 - 88,915,672 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl288,833,707 - 88,918,066 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605416,962,483 - 17,101,687 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adarb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474530,549,257 - 30,635,269 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474530,549,195 - 30,635,081 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Adarb1
882 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:490
Count of miRNA genes:252
Interacting mature miRNAs:300
Transcripts:ENSRNOT00000001642
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20289259726381954Rat
7387283Uae44Urinary albumin excretion QTL 440.1712urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)20126123605Rat
4889870Pur30Proteinuria QTL 30190.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20804241029322208Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125159026Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20460660717617956Rat
631265Iresp1Immunoglobin response QTL18.3blood anti-double stranded DNA antibody amount (VT:0004762)serum anti-DNA antibody level (CMO:0001533)20903971913461775Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
4889857Pur27Proteinuria QTL 2712.20.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20460660717617956Rat
70154Insul2Insulin level QTL 23.75blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20669170617489458Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
1581577Pur15Proteinuria QTL 154.380.0002urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)20804241017617956Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20362165614101050Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat

Markers in Region
D20Got9  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.02011,992,792 - 11,993,391NCBIRnor6.0
Rnor_6.02011,993,184 - 11,993,391NCBIRnor6.0
Rnor_5.02014,157,066 - 14,157,488UniSTSRnor5.0
RH 3.4 Map20149.5RGD
RH 3.4 Map20149.5UniSTS
RH 2.0 Map20154.6RGD
Cytogenetic Map20p12UniSTS
RH131354  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22011,350,599 - 11,350,804 (+)MAPPERmRatBN7.2
Rnor_6.02012,100,769 - 12,100,973NCBIRnor6.0
Rnor_5.02014,264,692 - 14,264,896UniSTSRnor5.0
RGSC_v3.42011,747,041 - 11,747,245UniSTSRGSC3.4
Celera2012,852,561 - 12,852,765UniSTS
RH 3.4 Map20154.14UniSTS
Cytogenetic Map20p12UniSTS
MDB0447  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22011,350,665 - 11,350,767 (+)MAPPERmRatBN7.2
Rnor_6.02012,100,835 - 12,100,936NCBIRnor6.0
Rnor_5.02014,264,758 - 14,264,859UniSTSRnor5.0
RGSC_v3.42011,747,107 - 11,747,208UniSTSRGSC3.4
Celera2012,852,627 - 12,852,728UniSTS
Cytogenetic Map20p12UniSTS
BF388249  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22011,347,468 - 11,347,636 (+)MAPPERmRatBN7.2
Rnor_6.02012,097,638 - 12,097,805NCBIRnor6.0
Rnor_5.02014,261,561 - 14,261,728UniSTSRnor5.0
RGSC_v3.42011,743,910 - 11,744,077UniSTSRGSC3.4
Celera2012,849,431 - 12,849,598UniSTS
RH 3.4 Map20154.84UniSTS
Cytogenetic Map20p12UniSTS
D10Bwg0447e  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22011,350,677 - 11,350,850 (+)MAPPERmRatBN7.2
Rnor_6.02012,100,847 - 12,101,019NCBIRnor6.0
Rnor_5.02014,264,770 - 14,264,942UniSTSRnor5.0
RGSC_v3.42011,747,119 - 11,747,291UniSTSRGSC3.4
Celera2012,852,639 - 12,852,811UniSTS
Cytogenetic Map20p12UniSTS
UniSTS:259034  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22011,324,035 - 11,325,235 (+)MAPPERmRatBN7.2
Rnor_6.02012,074,053 - 12,075,254NCBIRnor6.0
Rnor_5.02014,238,150 - 14,239,351UniSTSRnor5.0
RGSC_v3.42011,718,455 - 11,719,656UniSTSRGSC3.4
Celera2012,826,024 - 12,827,225UniSTS
Cytogenetic Map20p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001111055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001111056 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001111057 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_012894 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006256275 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006256276 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008772864 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601551 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039098451 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039098454 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063278976 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063278977 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BF388249 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB556744 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB576423 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB720085 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB801553 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK840559 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U43534 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U90444 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000001642   ⟹   ENSRNOP00000001642
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2011,222,583 - 11,350,852 (+)Ensembl
Rnor_6.0 Ensembl2011,972,381 - 12,101,021 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000083851   ⟹   ENSRNOP00000069261
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2011,297,437 - 11,350,852 (+)Ensembl
Rnor_6.0 Ensembl2012,052,693 - 12,101,047 (+)Ensembl
RefSeq Acc Id: NM_001111055   ⟹   NP_001104525
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82011,222,171 - 11,350,416 (+)NCBI
mRatBN7.22011,222,595 - 11,350,853 (+)NCBI
Rnor_6.02011,972,381 - 12,101,022 (+)NCBI
Rnor_5.02014,137,226 - 14,264,945 (+)NCBI
RGSC_v3.42011,616,718 - 11,747,294 (+)RGD
Celera2012,725,154 - 12,852,814 (+)RGD
Sequence:
RefSeq Acc Id: NM_001111056   ⟹   NP_001104526
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82011,222,171 - 11,350,416 (+)NCBI
mRatBN7.22011,222,595 - 11,350,853 (+)NCBI
Rnor_6.02011,972,381 - 12,101,022 (+)NCBI
Rnor_5.02014,137,226 - 14,264,945 (+)NCBI
RGSC_v3.42011,616,718 - 11,747,294 (+)RGD
Celera2012,725,154 - 12,852,814 (+)RGD
Sequence:
RefSeq Acc Id: NM_001111057   ⟹   NP_001104527
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82011,222,171 - 11,350,416 (+)NCBI
mRatBN7.22011,222,595 - 11,350,853 (+)NCBI
Rnor_6.02011,972,381 - 12,101,022 (+)NCBI
Rnor_5.02014,137,226 - 14,264,945 (+)NCBI
RGSC_v3.42011,616,718 - 11,747,294 (+)RGD
Celera2012,725,154 - 12,852,814 (+)RGD
Sequence:
RefSeq Acc Id: NM_012894   ⟹   NP_037026
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82011,222,171 - 11,350,416 (+)NCBI
mRatBN7.22011,222,595 - 11,350,853 (+)NCBI
Rnor_6.02011,972,381 - 12,101,022 (+)NCBI
Rnor_5.02014,137,226 - 14,264,945 (+)NCBI
RGSC_v3.42011,616,718 - 11,747,294 (+)RGD
Celera2012,725,154 - 12,852,814 (+)RGD
Sequence:
RefSeq Acc Id: XM_006256275   ⟹   XP_006256337
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82011,295,575 - 11,350,416 (+)NCBI
mRatBN7.22011,296,724 - 11,350,854 (+)NCBI
Rnor_6.02012,046,730 - 12,101,022 (+)NCBI
Rnor_5.02014,137,226 - 14,264,945 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006256276   ⟹   XP_006256338
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82011,295,963 - 11,350,416 (+)NCBI
mRatBN7.22011,296,725 - 11,350,854 (+)NCBI
Rnor_6.02012,046,730 - 12,101,022 (+)NCBI
Rnor_5.02014,137,226 - 14,264,945 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039098451   ⟹   XP_038954379
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82011,311,213 - 11,350,416 (+)NCBI
mRatBN7.22011,311,643 - 11,350,854 (+)NCBI
RefSeq Acc Id: XM_039098454   ⟹   XP_038954382
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82011,297,316 - 11,350,416 (+)NCBI
mRatBN7.22011,297,752 - 11,350,854 (+)NCBI
RefSeq Acc Id: XM_063278976   ⟹   XP_063135046
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82011,311,215 - 11,350,416 (+)NCBI
RefSeq Acc Id: XM_063278977   ⟹   XP_063135047
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82011,311,216 - 11,350,416 (+)NCBI
RefSeq Acc Id: NP_037026   ⟸   NM_012894
- Peptide Label: isoform 1
- UniProtKB: P51400 (UniProtKB/Swiss-Prot),   A6JK92 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001104525   ⟸   NM_001111055
- Peptide Label: isoform 2
- UniProtKB: P51400 (UniProtKB/Swiss-Prot),   A6JK91 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001104526   ⟸   NM_001111056
- Peptide Label: isoform 3
- UniProtKB: P51400 (UniProtKB/Swiss-Prot),   A6JK94 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001104527   ⟸   NM_001111057
- Peptide Label: isoform 4
- UniProtKB: A6JK95 (UniProtKB/TrEMBL),   A6JK93 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256337   ⟸   XM_006256275
- Peptide Label: isoform X1
- UniProtKB: P51400 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006256338   ⟸   XM_006256276
- Peptide Label: isoform X2
- UniProtKB: P51400 (UniProtKB/Swiss-Prot),   A0A0G2JUX0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000069261   ⟸   ENSRNOT00000083851
Ensembl Acc Id: ENSRNOP00000001642   ⟸   ENSRNOT00000001642
RefSeq Acc Id: XP_038954382   ⟸   XM_039098454
- Peptide Label: isoform X6
- UniProtKB: P51400 (UniProtKB/Swiss-Prot),   A6JK92 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038954379   ⟸   XM_039098451
- Peptide Label: isoform X5
- UniProtKB: G3V649 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063135046   ⟸   XM_063278976
- Peptide Label: isoform X3
- UniProtKB: P51400 (UniProtKB/Swiss-Prot),   A6JK94 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063135047   ⟸   XM_063278977
- Peptide Label: isoform X4
- UniProtKB: A6JK93 (UniProtKB/TrEMBL),   A6JK95 (UniProtKB/TrEMBL)
Protein Domains
A to I editase   DRBM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P51400-F1-model_v2 AlphaFold P51400 1-711 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701507
Promoter ID:EPDNEW_R12031
Type:initiation region
Name:Adarb1_1
Description:adenosine deaminase, RNA-specific, B1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02011,972,389 - 11,972,449EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2033 AgrOrtholog
BioCyc Gene G2FUF-4229 BioCyc
Ensembl Genes ENSRNOG00000001227 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000001642 ENTREZGENE
  ENSRNOT00000001642.7 UniProtKB/TrEMBL
  ENSRNOT00000083851 ENTREZGENE
  ENSRNOT00000083851.2 UniProtKB/TrEMBL
  ENSRNOT00000145951 ENTREZGENE
Gene3D-CATH 3.30.160.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro A_deamin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADAR2_DSRM_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADAR2_DSRM_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  dsRBD_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25367 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 25367 ENTREZGENE
PANTHER DOUBLE-STRANDED RNA-SPECIFIC EDITASE 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EUKARYOTE SPECIFIC DSRNA BINDING PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam A_deamin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  dsrm UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Adarb1 PhenoGen
PROSITE A_DEAMIN_EDITASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DS_RBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000001227 RatGTEx
SMART ADEAMc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DSRM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP dsRNA-binding domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC208996
UniProt A0A0G2JUX0 ENTREZGENE, UniProtKB/TrEMBL
  A6JK91 ENTREZGENE, UniProtKB/TrEMBL
  A6JK92 ENTREZGENE, UniProtKB/TrEMBL
  A6JK93 ENTREZGENE, UniProtKB/TrEMBL
  A6JK94 ENTREZGENE, UniProtKB/TrEMBL
  A6JK95 ENTREZGENE, UniProtKB/TrEMBL
  G3V649 ENTREZGENE, UniProtKB/TrEMBL
  P51400 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2001-06-26 Adarb1  adenosine deaminase, RNA-specific, B1      Name updated to reflect Human and Mouse nomenclature 67952 APPROVED
2001-06-26 Adarb1  RNA editing deaminase of glutamate receptors      Name withdrawn 67952 WITHDRAWN

RGD Curation Notes
Note Type Note Reference
gene_function catalyzes the deamination of adenosine in double stranded mRNA 631737
gene_process required for the site specific pre-mRNA editing of brain glutamate receptor RNAs 631737