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Adenosine deaminases acting on RNA (ADARs): RNA-editing enzymes.

Authors: Keegan, LP  Leroy, A  Sproul, D  O'Connell, MA 
Citation: Keegan LP, etal., Genome Biol. 2004;5(2):209. Epub 2004 Feb 2.
Pubmed: (View Article at PubMed) PMID:14759252
DOI: Full-text: DOI:10.1186/gb-2004-5-2-209

Adenosine deaminases acting on RNA (ADARs) were discovered as a result of their ability extensively to deaminate adenosines in any long double-stranded RNA, converting them to inosines. Subsequently, ADARs were found to deaminate adenosines site-specifically within the coding sequences of transcripts encoding ion-channel subunits, increasing the diversity of these proteins in the central nervous system. ADARI is now known to be involved in defending the genome against viruses, and it may affect RNA interference. ADARs are found in animals but are not known in other organisms. It appears that ADARs evolved from a member of another family, adenosine deaminases acting on tRNAs (ADATs), by steps including fusion of two or more double-stranded-RNA binding domains to a common type of zinc-containing adenosine-deaminase domain.


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RGD Object Information
RGD ID: 8553748
Created: 2014-05-08
Species: All species
Last Modified: 2014-05-08
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.