RGD Reference Report - Acute spinal cord injury persistently reduces R/G RNA editing of AMPA receptors. - Rat Genome Database

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Acute spinal cord injury persistently reduces R/G RNA editing of AMPA receptors.

Authors: Barbon, A  Fumagalli, F  Caracciolo, L  Madaschi, L  Lesma, E  Mora, C  Carelli, S  Slotkin, TA  Racagni, G  Di Giulio, AM  Gorio, A  Barlati, S 
Citation: Barbon A, etal., J Neurochem. 2010 Jul;114(2):397-407. doi: 10.1111/j.1471-4159.2010.06767.x. Epub 2010 Apr 23.
RGD ID: 10755338
Pubmed: PMID:20456005   (View Abstract at PubMed)
DOI: DOI:10.1111/j.1471-4159.2010.06767.x   (Journal Full-text)

Spinal cord injury (SCI) triggers a complex ischemic and inflammatory reaction, involving activation of neurotransmitter systems, in particular glutamate, culminating in cell death. We hypothesized that SCI might lead to alteration in the RNA editing of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptors that govern critical determinants of neuronal survival. To this end, we examined the molecular changes set in motion by SCI that affect the channel properties of AMPA receptors. SCI strongly reduced the level of AMPA receptor R/G editing, involving not only the site of the lesion but also adjacent areas of the cord spared by the lesion. The effects, with changes for some subunits and loci, were observed as long as 30 days after lesioning and may correlate with a partial decrease in enzymatic activity of adenosine deaminase acting on RNA 2 (ADAR2), as deduced from the analysis of ADAR2 self-editing. The reduced editing at the R/G site of glutamate receptor subunits (GluRs) is likely to reduce post-synaptic excitatory responses to glutamate, thus limiting the progression of cell death; however, prolonged suppression of GluR function in later stages may hinder synaptic plasticity. These observations provide the first direct evidence of the potential contribution of RNA editing to excitatory neural injury and recovery after SCI.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Spinal Cord Injuries  ISOAdarb1 (Rattus norvegicus)10755338; 10755338 RGD 
Spinal Cord Injuries  IDA 10755338 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Adarb1  (adenosine deaminase, RNA-specific, B1)

Genes (Mus musculus)
Adarb1  (adenosine deaminase, RNA-specific, B1)

Genes (Homo sapiens)
ADARB1  (adenosine deaminase RNA specific B1)


Additional Information