Bcr (BCR activator of RhoGEF and GTPase) - Rat Genome Database

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Gene: Bcr (BCR activator of RhoGEF and GTPase) Rattus norvegicus
Symbol: Bcr
Name: BCR activator of RhoGEF and GTPase
RGD ID: 1307993
Description: Enables enzyme binding activity. Involved in platelet-derived growth factor receptor signaling pathway. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; chronic myeloid leukemia; and leukemia. Orthologous to human BCR (BCR activator of RhoGEF and GTPase); PARTICIPATES IN chronic myeloid leukemia pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: BCR, RhoGEF and GTPase activating protein; breakpoint cluster region; breakpoint cluster region homolog; LOC309696
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.22013,469,325 - 13,596,942 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2013,471,668 - 13,597,016 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.02014,421,250 - 14,546,406 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2014,421,141 - 14,545,772 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02016,604,476 - 16,729,388 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42013,972,773 - 14,097,816 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12013,973,364 - 14,098,043 (-)NCBI
Celera2014,955,473 - 15,079,934 (-)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-butoxyethanol  (ISO)
2-palmitoylglycerol  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
antirheumatic drug  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-hexachlorocyclohexane  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
caffeine  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (EXP,ISO)
clobetasol  (ISO)
clothianidin  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
cyfluthrin  (ISO)
dexamethasone  (EXP)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
ethanol  (ISO)
fenofibrate  (EXP)
flavonoids  (ISO)
folic acid  (ISO)
gallic acid  (ISO)
histamine  (ISO)
hydrogen cyanide  (ISO)
irinotecan  (ISO)
LY294002  (ISO)
methimazole  (EXP)
methoxychlor  (EXP)
N-nitrosodiethylamine  (EXP)
nilotinib  (ISO)
Nor-9-carboxy-delta9-THC  (ISO)
paracetamol  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
ponatinib  (ISO)
potassium cyanide  (ISO)
purmorphamine  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
serpentine asbestos  (ISO)
sorafenib  (ISO)
sulfadimethoxine  (EXP)
testosterone  (EXP)
theophylline  (ISO)
trichostatin A  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. BCR/ABL p210, p190 and p230 fusion genes in 250 Mexican patients with chronic myeloid leukaemia (CML). Arana-Trejo RM, etal., Clin Lab Haematol. 2002 Jun;24(3):145-50.
2. Transferred BCR/ABL DNA from K562 extracellular vesicles causes chronic myeloid leukemia in immunodeficient mice. Cai J, etal., PLoS One. 2014 Aug 18;9(8):e105200. doi: 10.1371/journal.pone.0105200. eCollection 2014.
3. A BCR-ABL(p190) fusion gene made by homologous recombination causes B-cell acute lymphoblastic leukemias in chimeric mice with independence of the endogenous bcr product. Castellanos A, etal., Blood. 1997 Sep 15;90(6):2168-74.
4. p160 Bcr mediates platelet-derived growth factor activation of extracellular signal-regulated kinase in vascular smooth muscle cells. Che W, etal., Circulation. 2001 Sep 18;104(12):1399-406.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Fine mapping of chromosome 22 breakpoints within the breakpoint cluster region (bcr) implies a role for bcr exon 3 in determining disease duration in chronic myeloid leukemia. Grossman A, etal., Am J Hum Genet. 1989 Nov;45(5):729-38.
8. Minor BCR (m-bcr) rearrangements may appear in major BCR (M-bcr)-positive CML cases. Karlic H, etal., Hematol Pathol. 1992;6(4):203-7.
9. BCR gene expression blocks Bcr-Abl induced pathogenicity in a mouse model. Lin F, etal., Oncogene. 2001 Apr 5;20(15):1873-81.
10. Does a rise in the BCR-ABL1 transcript level identify chronic phase CML patients responding to imatinib who have a high risk of cytogenetic relapse? Marin D, etal., Br J Haematol. 2009 May;145(3):373-5. doi: 10.1111/j.1365-2141.2009.07646.x. Epub 2009 Mar 12.
11. BCR binds to the xeroderma pigmentosum group B protein. Maru Y, etal., Biochem Biophys Res Commun. 1999 Jul 5;260(2):309-12.
12. Methylation of the major breakpoint cluster region (M-bcr) in Philadelphia-positive CML. Mills KI, etal., Leukemia. 1993 May;7(5):707-11.
13. Regulation of synaptic Rac1 activity, long-term potentiation maintenance, and learning and memory by BCR and ABR Rac GTPase-activating proteins. Oh D, etal., J Neurosci. 2010 Oct 20;30(42):14134-44. doi: 10.1523/JNEUROSCI.1711-10.2010.
14. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Outcomes of children with BCR-ABL1-like acute lymphoblastic leukemia treated with risk-directed therapy based on the levels of minimal residual disease. Roberts KG, etal., J Clin Oncol. 2014 Sep 20;32(27):3012-20.
20. bcr-abl RNA in patients with chronic myelogenous leukemia. Shtivelman E, etal., Blood. 1987 Mar;69(3):971-3.
21. Quantitative monitoring of BCR/ABL transcript during STI-571 therapy. Wu CJ, etal., Leuk Lymphoma. 2002 Dec;43(12):2281-9. doi: 10.1080/1042819021000039992.
Additional References at PubMed
PMID:1903516   PMID:7479768   PMID:7889565   PMID:11684658   PMID:11809706   PMID:11921339   PMID:15001553   PMID:17116687   PMID:19056867   PMID:19703997   PMID:19946888   PMID:22446327  
PMID:22767509   PMID:23152932   PMID:23382219   PMID:23940119   PMID:25331951   PMID:25763846   PMID:29046349  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.22013,469,325 - 13,596,942 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2013,471,668 - 13,597,016 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.02014,421,250 - 14,546,406 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2014,421,141 - 14,545,772 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02016,604,476 - 16,729,388 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42013,972,773 - 14,097,816 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12013,973,364 - 14,098,043 (-)NCBI
Celera2014,955,473 - 15,079,934 (-)NCBICelera
Cytogenetic Map20p12NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh382223,180,509 - 23,318,037 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2223,179,704 - 23,318,037 (+)EnsemblGRCh38hg38GRCh38
GRCh372223,522,696 - 23,660,224 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362221,852,552 - 21,990,224 (+)NCBINCBI36Build 36hg18NCBI36
Build 342221,847,105 - 21,982,690NCBI
Celera227,337,083 - 7,474,738 (+)NCBICelera
Cytogenetic Map22q11.23ENTREZGENE
HuRef226,461,675 - 6,627,574 (+)NCBIHuRef
CHM1_12223,534,806 - 23,672,427 (+)NCBICHM1_1
T2T-CHM13v2.02223,603,367 - 23,740,899 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391074,896,384 - 75,020,753 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1074,896,424 - 75,020,753 (+)EnsemblGRCm39 Ensembl
GRCm381075,060,560 - 75,184,923 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1075,060,592 - 75,184,921 (+)EnsemblGRCm38mm10GRCm38
MGSCv371074,523,641 - 74,647,668 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361074,504,612 - 74,628,764 (+)NCBIMGSCv36mm8
MGSCv361075,455,937 - 75,580,316 (+)NCBIMGSCv36mm8
Celera1076,108,779 - 76,233,250 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1038.49NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554557,598,794 - 7,727,386 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554557,598,794 - 7,727,386 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan12234,933,439 - 35,070,914 (-)NCBINHGRI_mPanPan1
PanPan1.12221,803,806 - 21,922,123 (+)NCBIpanpan1.1PanPan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.12627,856,280 - 27,980,923 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2627,856,082 - 27,978,318 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2626,931,961 - 27,056,311 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02629,260,365 - 29,385,328 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12627,343,693 - 27,468,548 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02626,961,155 - 27,085,857 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02627,950,465 - 28,075,113 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024405118142,324,235 - 142,465,697 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936619288,340 - 432,315 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936619288,377 - 432,297 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1449,208,762 - 49,322,103 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11449,208,662 - 49,322,109 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21452,727,404 - 52,771,825 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1192,569,841 - 2,703,703 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl192,566,190 - 2,702,920 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660854,423,712 - 4,553,443 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046247479,528,996 - 9,662,131 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247479,528,968 - 9,664,055 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Bcr
918 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:109
Count of miRNA genes:88
Interacting mature miRNAs:98
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125159026Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20289259726381954Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20362165614101050Rat
4889857Pur27Proteinuria QTL 2712.20.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20460660717617956Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20460660717617956Rat
70154Insul2Insulin level QTL 23.75blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20669170617489458Rat
1581577Pur15Proteinuria QTL 154.380.0002urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)20804241017617956Rat
4889870Pur30Proteinuria QTL 30190.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20804241029322208Rat
7411652Foco24Food consumption QTL 240.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)201175751554435887Rat
9590092Insglur9Insulin/glucose ratio QTL 918.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)201175751554435887Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22013,552,036 - 13,552,235 (+)MAPPERmRatBN7.2
Rnor_6.02014,502,172 - 14,502,370NCBIRnor6.0
Rnor_5.02016,684,863 - 16,685,061UniSTSRnor5.0
RGSC_v3.42014,052,569 - 14,052,767UniSTSRGSC3.4
RGSC_v3.42014,052,568 - 14,052,768RGDRGSC3.4
RGSC_v3.12014,052,795 - 14,052,995RGD
Celera2015,035,358 - 15,035,556UniSTS
RH 2.0 Map20215.8RGD
SHRSP x BN Map2013.6199RGD
FHH x ACI Map206.9698RGD
Cytogenetic Map20p12UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22013,538,581 - 13,538,760 (+)MAPPERmRatBN7.2
Rnor_6.02014,488,416 - 14,488,594NCBIRnor6.0
Rnor_5.02016,671,252 - 16,671,430UniSTSRnor5.0
RGSC_v3.42014,039,361 - 14,039,539UniSTSRGSC3.4
Celera2015,021,980 - 15,022,158UniSTS
RH 3.4 Map20179.42UniSTS
Cytogenetic Map20p12UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22013,506,208 - 13,506,364 (+)MAPPERmRatBN7.2
Rnor_6.02014,455,776 - 14,455,931NCBIRnor6.0
Rnor_5.02016,638,980 - 16,639,135UniSTSRnor5.0
RGSC_v3.42014,006,960 - 14,007,115UniSTSRGSC3.4
Celera2014,989,861 - 14,990,016UniSTS
RH 3.4 Map20177.91UniSTS
Cytogenetic Map20p12UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22013,594,092 - 13,594,276 (+)MAPPERmRatBN7.2
Rnor_6.02014,543,799 - 14,543,982NCBIRnor6.0
Rnor_5.02016,726,547 - 16,726,730UniSTSRnor5.0
RGSC_v3.42014,095,322 - 14,095,505UniSTSRGSC3.4
Celera2015,077,384 - 15,077,567UniSTS
Cytogenetic Map20p12UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22013,595,397 - 13,595,485 (+)MAPPERmRatBN7.2
Rnor_6.02014,545,104 - 14,545,191NCBIRnor6.0
Rnor_5.02016,727,852 - 16,727,939UniSTSRnor5.0
RGSC_v3.42014,096,627 - 14,096,714UniSTSRGSC3.4
Celera2015,078,689 - 15,078,776UniSTS
Cytogenetic Map20p12UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 2 26 12 6 7 6 71 32 33 11
Low 1 17 45 35 12 35 8 11 3 3 8 8
Below cutoff


RefSeq Acc Id: ENSRNOT00000001766   ⟹   ENSRNOP00000001766
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2013,471,668 - 13,597,016 (-)Ensembl
Rnor_6.0 Ensembl2014,421,141 - 14,545,772 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000102298   ⟹   ENSRNOP00000091048
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2013,471,668 - 13,480,701 (-)Ensembl
RefSeq Acc Id: NM_001419609   ⟹   NP_001406538
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
mRatBN7.22013,469,325 - 13,596,942 (-)NCBI
RefSeq Acc Id: XM_039099172   ⟹   XP_038955100
Rat AssemblyChrPosition (strand)Source
mRatBN7.22013,472,136 - 13,519,398 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001406538 (Get FASTA)   NCBI Sequence Viewer  
  XP_038955100 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL97233 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000001766
GenBank Protein F1LXF1 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: ENSRNOP00000001766   ⟸   ENSRNOT00000001766
RefSeq Acc Id: XP_038955100   ⟸   XM_039099172
- Peptide Label: isoform X2
RefSeq Acc Id: ENSRNOP00000091048   ⟸   ENSRNOT00000102298
RefSeq Acc Id: NP_001406538   ⟸   NM_001419609
- UniProtKB: F1LXF1 (UniProtKB/Swiss-Prot),   A6JKL7 (UniProtKB/TrEMBL)
Protein Domains
C2   DH   PH   Rho-GAP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LXF1-F1-model_v2 AlphaFold F1LXF1 1-1270 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307993 AgrOrtholog
BioCyc Gene G2FUF-4103 BioCyc
Ensembl Genes ENSRNOG00000001304 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055021982 UniProtKB/Swiss-Prot
  ENSRNOG00060026163 UniProtKB/Swiss-Prot
  ENSRNOG00065023404 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000001766 ENTREZGENE
  ENSRNOT00000001766.8 UniProtKB/Swiss-Prot
  ENSRNOT00000102298.1 UniProtKB/TrEMBL
  ENSRNOT00055037757 UniProtKB/Swiss-Prot
  ENSRNOT00060045492 UniProtKB/Swiss-Prot
  ENSRNOT00065040068 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.555.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.900.10 UniProtKB/Swiss-Prot UniProtKB/Swiss-Prot UniProtKB/Swiss-Prot UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C2 domain UniProtKB/TrEMBL
  Dbl homology (DH) domain UniProtKB/TrEMBL
  Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) UniProtKB/TrEMBL
InterPro Abr/Bcr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Bcr-Abl_oncoprot_oligo UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Bcr-Abl_oncoprot_oligo_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C2_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DBL_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DH-domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GDS_CDC24_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rho_GTPase_activation_prot UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RhoGAP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR23182 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Bcr-Abl_Oligo UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00168 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_19 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RhoGAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RhoGEF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Bcr PhenoGen
PROSITE DH_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DH_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS50004 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RHOGAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000001304 RatGTEx
  ENSRNOG00055021982 RatGTEx
  ENSRNOG00060026163 RatGTEx
  ENSRNOG00065023404 RatGTEx
SMART RhoGAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RhoGEF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00233 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00239 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Bcr-Abl oncoprotein oligomerization domain UniProtKB/TrEMBL
  C2 domain (Calcium/lipid-binding domain, CaLB) UniProtKB/TrEMBL
  DBL homology domain (DH-domain) UniProtKB/TrEMBL
  PH domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48065 UniProtKB/Swiss-Prot
  SSF48350 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49562 UniProtKB/Swiss-Prot
  SSF69036 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-05-06 Bcr  BCR activator of RhoGEF and GTPase  Bcr  BCR activator of RhoGEF and GTPase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2019-04-10 Bcr  BCR activator of RhoGEF and GTPase  Bcr  BCR, RhoGEF and GTPase activating protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-05-18 Bcr  BCR, RhoGEF and GTPase activating protein  Bcr  breakpoint cluster region  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Bcr  breakpoint cluster region  Bcr  breakpoint cluster region homolog   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Bcr  breakpoint cluster region homolog   Bcr_predicted  breakpoint cluster region homolog (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Bcr_predicted  breakpoint cluster region (predicted)      Symbol and Name status set to approved 70820 APPROVED