Bcr (BCR activator of RhoGEF and GTPase)

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Gene: Bcr (BCR activator of RhoGEF and GTPase) Rattus norvegicus

Analyze

Symbol:

Bcr

Name:

BCR activator of RhoGEF and GTPase

RGD ID:

1307993

Description:

Enables enzyme binding activity. Involved in platelet-derived growth factor receptor signaling pathway and protein autophosphorylation. Located in cytoplasm. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; chronic myeloid leukemia; and leukemia. Orthologous to human BCR (BCR activator of RhoGEF and GTPase); PARTICIPATES IN chronic myeloid leukemia pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; atrazine.

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

BCR, RhoGEF and GTPase activating protein; breakpoint cluster region; breakpoint cluster region homolog; LOC309696

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	BCR (BCR activator of RhoGEF and GTPase)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Bcr (BCR activator of RhoGEF and GTPase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Bcr (BCR activator of RhoGEF and GTPase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	BCR (BCR activator of RhoGEF and GTPase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	BCR (BCR activator of RhoGEF and GTPase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Bcr (BCR activator of RhoGEF and GTPase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	BCR (BCR activator of RhoGEF and GTPase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	BCR (BCR activator of RhoGEF and GTPase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Bcr (BCR activator of RhoGEF and GTPase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	BCR (BCR activator of RhoGEF and GTPase)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Bcr (BCR activator of RhoGEF and GTPase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	bcr (BCR activator of RhoGEF and GTPase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	si:dkey-91m11.5	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	RhoGAP1A	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	20	13,471,679 - 13,596,497 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	13,471,668 - 13,597,016 (-)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	20	14,421,250 - 14,546,406 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	14,421,141 - 14,545,772 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	20	16,604,476 - 16,729,388 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	20	13,972,773 - 14,097,816 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	20	13,973,364 - 14,098,043 (-)	NCBI
Celera	20	14,955,473 - 15,079,934 (-)	NCBI		Celera
Cytogenetic Map	20	p12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acute lymphoblastic leukemia (ISO)

B-lymphoblastic leukemia/lymphoma (ISO)

Blast Crisis (ISO)

chronic myelogenous leukemia, BCR-ABL1 positive (ISO)

chronic myeloid leukemia (ISO)

DiGeorge syndrome (ISO)

Experimental Liver Cirrhosis (ISO)

Experimental Neoplasms (ISO)

leukemia (ISO)

myeloid leukemia (ISO)

Myeloid Leukemia, Chronic-Phase (ISO)

myeloid neoplasm (ISO)

Necrosis (ISO)

schizophrenia (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-butoxyethanol (ISO)

4,4'-sulfonyldiphenol (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

antirheumatic drug (ISO)

arsenite(3-) (ISO)

arsenous acid (ISO)

ATP (ISO)

atrazine (EXP)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

beta-hexachlorocyclohexane (ISO)

bisphenol A (EXP)

bortezomib (ISO)

caffeine (ISO)

CGP 52608 (ISO)

chlorpyrifos (EXP,ISO)

clobetasol (ISO)

clothianidin (ISO)

cobalt dichloride (ISO)

copper(II) sulfate (ISO)

coumarin (ISO)

cyfluthrin (ISO)

dexamethasone (EXP)

diarsenic trioxide (ISO)

dibutyl phthalate (EXP)

dicrotophos (ISO)

ethanol (ISO)

fenofibrate (EXP)

flavonoids (ISO)

folic acid (ISO)

gallic acid (ISO)

histamine (ISO)

hydrogen cyanide (ISO)

irinotecan (ISO)

LY294002 (ISO)

N-nitrosodiethylamine (EXP)

nilotinib (ISO)

Nor-9-carboxy-delta9-THC (ISO)

paracetamol (EXP)

phenobarbital (ISO)

ponatinib (ISO)

potassium cyanide (ISO)

purmorphamine (ISO)

quercetin (ISO)

resveratrol (ISO)

serpentine asbestos (ISO)

sorafenib (ISO)

testosterone (EXP)

theophylline (ISO)

trichostatin A (ISO)

tungsten (ISO)

valproic acid (ISO)

vinclozolin (EXP)

vorinostat (ISO)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

actin cytoskeleton organization (ISO)

activation of GTPase activity (ISO)

brain development (ISO)

cell migration (ISO)

cellular response to lipopolysaccharide (ISO)

definitive hemopoiesis (ISO)

establishment of localization in cell (ISO)

focal adhesion assembly (ISO)

homeostasis of number of cells (ISO)

inner ear morphogenesis (ISO)

intracellular protein transmembrane transport (ISO)

keratinocyte differentiation (ISO)

macrophage migration (ISO)

modulation of chemical synaptic transmission (ISO,ISS)

negative regulation of blood vessel remodeling (ISO)

negative regulation of cell migration (ISO)

negative regulation of cellular extravasation (ISO)

negative regulation of inflammatory response (ISO)

negative regulation of macrophage migration (ISO)

negative regulation of neutrophil degranulation (ISO)

negative regulation of reactive oxygen species metabolic process (ISO)

negative regulation of respiratory burst (ISO)

neuromuscular process controlling balance (ISO)

neutrophil degranulation (ISO)

phagocytosis (ISO)

platelet-derived growth factor receptor signaling pathway (IDA)

positive regulation of GTPase activity (IEA)

positive regulation of phagocytosis (ISO)

protein autophosphorylation (IDA)

regulation of cell cycle (ISO)

regulation of nitrogen compound metabolic process (ISO)

regulation of Rho protein signal transduction (ISO)

regulation of vascular permeability (ISO)

renal system process (ISO)

response to lipopolysaccharide (ISO)

signal transduction (IEA)

small GTPase mediated signal transduction (ISO)

Cellular Component

axon (IEA)

cytoplasm (IDA)

cytosol (ISO)

dendritic spine (IEA)

glutamatergic synapse (IDA,IEP,ISO,ISS)

membrane (IBA)

plasma membrane (ISO)

postsynaptic density (ISO)

postsynaptic density, intracellular component (IDA,IEP)

protein-containing complex (ISO)

Schaffer collateral - CA1 synapse (ISO,ISS)

Molecular Function

ATP binding (IEA)

enzyme binding (IPI)

GTPase activator activity (IEA,ISO)

guanyl-nucleotide exchange factor activity (ISO)

protein binding (IPI,ISO)

protein serine kinase activity (IEA)

protein serine/threonine kinase activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

chronic myeloid leukemia pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	BCR/ABL p210, p190 and p230 fusion genes in 250 Mexican patients with chronic myeloid leukaemia (CML).	Arana-Trejo RM, etal., Clin Lab Haematol. 2002 Jun;24(3):145-50.
2.	Transferred BCR/ABL DNA from K562 extracellular vesicles causes chronic myeloid leukemia in immunodeficient mice.	Cai J, etal., PLoS One. 2014 Aug 18;9(8):e105200. doi: 10.1371/journal.pone.0105200. eCollection 2014.
3.	A BCR-ABL(p190) fusion gene made by homologous recombination causes B-cell acute lymphoblastic leukemias in chimeric mice with independence of the endogenous bcr product.	Castellanos A, etal., Blood. 1997 Sep 15;90(6):2168-74.
4.	p160 Bcr mediates platelet-derived growth factor activation of extracellular signal-regulated kinase in vascular smooth muscle cells.	Che W, etal., Circulation. 2001 Sep 18;104(12):1399-406.
5.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
7.	Fine mapping of chromosome 22 breakpoints within the breakpoint cluster region (bcr) implies a role for bcr exon 3 in determining disease duration in chronic myeloid leukemia.	Grossman A, etal., Am J Hum Genet. 1989 Nov;45(5):729-38.
8.	Minor BCR (m-bcr) rearrangements may appear in major BCR (M-bcr)-positive CML cases.	Karlic H, etal., Hematol Pathol. 1992;6(4):203-7.
9.	BCR gene expression blocks Bcr-Abl induced pathogenicity in a mouse model.	Lin F, etal., Oncogene. 2001 Apr 5;20(15):1873-81.
10.	Does a rise in the BCR-ABL1 transcript level identify chronic phase CML patients responding to imatinib who have a high risk of cytogenetic relapse?	Marin D, etal., Br J Haematol. 2009 May;145(3):373-5. doi: 10.1111/j.1365-2141.2009.07646.x. Epub 2009 Mar 12.
11.	BCR binds to the xeroderma pigmentosum group B protein.	Maru Y, etal., Biochem Biophys Res Commun. 1999 Jul 5;260(2):309-12.
12.	Methylation of the major breakpoint cluster region (M-bcr) in Philadelphia-positive CML.	Mills KI, etal., Leukemia. 1993 May;7(5):707-11.
13.	Regulation of synaptic Rac1 activity, long-term potentiation maintenance, and learning and memory by BCR and ABR Rac GTPase-activating proteins.	Oh D, etal., J Neurosci. 2010 Oct 20;30(42):14134-44. doi: 10.1523/JNEUROSCI.1711-10.2010.
14.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
15.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
16.	GOA pipeline	RGD automated data pipeline
17.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
19.	Outcomes of children with BCR-ABL1-like acute lymphoblastic leukemia treated with risk-directed therapy based on the levels of minimal residual disease.	Roberts KG, etal., J Clin Oncol. 2014 Sep 20;32(27):3012-20.
20.	bcr-abl RNA in patients with chronic myelogenous leukemia.	Shtivelman E, etal., Blood. 1987 Mar;69(3):971-3.
21.	Quantitative monitoring of BCR/ABL transcript during STI-571 therapy.	Wu CJ, etal., Leuk Lymphoma. 2002 Dec;43(12):2281-9. doi: 10.1080/1042819021000039992.

Additional References at PubMed

PMID:1903516	PMID:7479768	PMID:7889565	PMID:11684658	PMID:11809706	PMID:11921339	PMID:15001553	PMID:17116687	PMID:19056867	PMID:19703997	PMID:19946888	PMID:22446327
PMID:22767509	PMID:23152932	PMID:23382219	PMID:23940119	PMID:25331951	PMID:25763846	PMID:29046349

Genomics

Comparative Map Data

Bcr
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	20	13,471,679 - 13,596,497 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	13,471,668 - 13,597,016 (-)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	20	14,421,250 - 14,546,406 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	14,421,141 - 14,545,772 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	20	16,604,476 - 16,729,388 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	20	13,972,773 - 14,097,816 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	20	13,973,364 - 14,098,043 (-)	NCBI
Celera	20	14,955,473 - 15,079,934 (-)	NCBI		Celera
Cytogenetic Map	20	p12	NCBI

BCR
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	22	23,180,509 - 23,318,037 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	22	23,179,704 - 23,318,037 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	22	23,522,696 - 23,660,224 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	22	21,852,552 - 21,990,224 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	22	21,847,105 - 21,982,690	NCBI
Celera	22	7,337,083 - 7,474,738 (+)	NCBI		Celera
Cytogenetic Map	22	q11.23	ENTREZGENE
HuRef	22	6,461,675 - 6,627,574 (+)	NCBI		HuRef
CHM1_1	22	23,534,806 - 23,672,427 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	22	23,603,367 - 23,740,899 (+)	NCBI		T2T-CHM13v2.0

Bcr
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	74,896,384 - 75,020,755 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	74,896,424 - 75,020,753 (+)	Ensembl		GRCm39 Ensembl
GRCm38	10	75,060,560 - 75,184,923 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	75,060,592 - 75,184,921 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	74,523,641 - 74,647,668 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	10	74,504,612 - 74,628,764 (+)	NCBI		MGSCv36	mm8
MGSCv36	10	75,455,937 - 75,580,316 (+)	NCBI		MGSCv36	mm8
Celera	10	76,108,779 - 76,233,250 (+)	NCBI		Celera
Cytogenetic Map	10	C1	NCBI
cM Map	10	38.49	NCBI

Bcr
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955455	7,598,794 - 7,727,386 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955455	7,598,794 - 7,727,386 (+)	NCBI	ChiLan1.0	ChiLan1.0

BCR
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	22	21,803,806 - 21,922,123 (+)	NCBI	panpan1.1	PanPan1.1	panPan2

BCR
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	26	27,856,280 - 27,980,923 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	26	27,856,082 - 27,978,318 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	26	26,931,961 - 27,056,311 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	26	29,260,365 - 29,385,328 (+)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	26	27,343,693 - 27,468,548 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	26	26,961,155 - 27,085,857 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	26	27,950,465 - 28,075,113 (+)	NCBI		UU_Cfam_GSD_1.0

Bcr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	142,324,235 - 142,465,697 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936619	288,340 - 432,315 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936619	288,377 - 432,297 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

BCR
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	49,208,762 - 49,322,103 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	49,208,662 - 49,322,109 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	52,727,404 - 52,771,825 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

BCR
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	19	2,569,841 - 2,703,703 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	19	2,566,190 - 2,702,920 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666085	4,423,712 - 4,553,443 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Bcr
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624747	9,528,996 - 9,662,131 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624747	9,528,968 - 9,664,055 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Bcr
896 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	109
Count of miRNA genes:	88
Interacting mature miRNAs:	98
Transcripts:	ENSRNOT00000001766
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1354642	Despr15	Despair related QTL 15		0.0027	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	20	1	24159021	Rat
1600382	Edcs3	Endometrial carcinoma susceptibility QTL3	3.5	0.003	uterus morphology trait (VT:0001120)	percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)	20	1	25159026	Rat
2317851	Alcrsp22	Alcohol response QTL 22	3.2	0.05	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	20	1	27339237	Rat
1641893	Alcrsp7	Alcohol response QTL 7			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	20	1	27339237	Rat
8694189	Bw153	Body weight QTL 153	3.13	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	20	1	29191651	Rat
9590275	Scort15	Serum corticosterone level QTL 15	3.48	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	20	1	29191651	Rat
7411650	Foco23	Food consumption QTL 23	20.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	20	1	29191651	Rat
9590109	Sffal8	Serum free fatty acids level QTL 8	5.32	0.01	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	20	1	29191651	Rat
9589155	Insul32	Insulin level QTL 32	6.38	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	20	1	29191651	Rat
6893685	Bw111	Body weight QTL 111	2.7	0.004	body mass (VT:0001259)	body weight (CMO:0000012)	20	1	32578807	Rat
7411668	Foco32	Food consumption QTL 32	8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	20	1	36600972	Rat
9590252	Scort12	Serum corticosterone level QTL 12	20.46	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	20	1	36600972	Rat
2305926	Iddm37	Insulin dependent diabetes mellitus QTL 37	6		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	20	1527842	46527842	Rat
1641915	Colcr9	Colorectal carcinoma resistance QTL 9	2.97	0.0024	intestine integrity trait (VT:0010554)	benign colorectal tumor number (CMO:0001795)	20	1530655	46530655	Rat
1598816	Memor12	Memory QTL 12	2.4		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	20	2606836	47606836	Rat
2317057	Aia27	Adjuvant induced arthritis QTL 27	2.83		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	20	2892597	26381954	Rat
61432	Cia1	Collagen induced arthritis QTL 1			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	20	3621656	14101050	Rat
4889857	Pur27	Proteinuria QTL 27	12.2	0.001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	20	4606607	17617956	Rat
1558640	Prcs2	Prostate cancer susceptibility QTL 2	3.3		prostate integrity trait (VT:0010571)	percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)	20	4606607	17617956	Rat
70154	Insul2	Insulin level QTL 2	3.75		blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	20	6691706	17489458	Rat
1581577	Pur15	Proteinuria QTL 15	4.38	0.0002	urine total protein amount (VT:0000032)	urine protein excretion rate (CMO:0000759)	20	8042410	17617956	Rat
4889870	Pur30	Proteinuria QTL 30	19	0.005	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	20	8042410	29322208	Rat
7411652	Foco24	Food consumption QTL 24		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	20	11757515	54435887	Rat
9590092	Insglur9	Insulin/glucose ratio QTL 9	18.38	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	20	11757515	54435887	Rat

Markers in Region

D20Rat33

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	20	13,552,036 - 13,552,235 (+)	MAPPER	mRatBN7.2
Rnor_6.0	20	14,502,172 - 14,502,370	NCBI	Rnor6.0
Rnor_5.0	20	16,684,863 - 16,685,061	UniSTS	Rnor5.0
RGSC_v3.4	20	14,052,569 - 14,052,767	UniSTS	RGSC3.4
RGSC_v3.4	20	14,052,568 - 14,052,768	RGD	RGSC3.4
RGSC_v3.1	20	14,052,795 - 14,052,995	RGD
Celera	20	15,035,358 - 15,035,556	UniSTS
RH 2.0 Map	20	215.8	RGD
SHRSP x BN Map	20	13.6199	RGD
FHH x ACI Map	20	6.9698	RGD
Cytogenetic Map	20	p12	UniSTS

BE102216

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	20	13,538,581 - 13,538,760 (+)	MAPPER	mRatBN7.2
Rnor_6.0	20	14,488,416 - 14,488,594	NCBI	Rnor6.0
Rnor_5.0	20	16,671,252 - 16,671,430	UniSTS	Rnor5.0
RGSC_v3.4	20	14,039,361 - 14,039,539	UniSTS	RGSC3.4
Celera	20	15,021,980 - 15,022,158	UniSTS
RH 3.4 Map	20	179.42	UniSTS
Cytogenetic Map	20	p12	UniSTS

BE102779

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	20	13,506,208 - 13,506,364 (+)	MAPPER	mRatBN7.2
Rnor_6.0	20	14,455,776 - 14,455,931	NCBI	Rnor6.0
Rnor_5.0	20	16,638,980 - 16,639,135	UniSTS	Rnor5.0
RGSC_v3.4	20	14,006,960 - 14,007,115	UniSTS	RGSC3.4
Celera	20	14,989,861 - 14,990,016	UniSTS
RH 3.4 Map	20	177.91	UniSTS
Cytogenetic Map	20	p12	UniSTS

BE106868

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	20	13,594,092 - 13,594,276 (+)	MAPPER	mRatBN7.2
Rnor_6.0	20	14,543,799 - 14,543,982	NCBI	Rnor6.0
Rnor_5.0	20	16,726,547 - 16,726,730	UniSTS	Rnor5.0
RGSC_v3.4	20	14,095,322 - 14,095,505	UniSTS	RGSC3.4
Celera	20	15,077,384 - 15,077,567	UniSTS
Cytogenetic Map	20	p12	UniSTS

BCR

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	20	13,595,397 - 13,595,485 (+)	MAPPER	mRatBN7.2
Rnor_6.0	20	14,545,104 - 14,545,191	NCBI	Rnor6.0
Rnor_5.0	20	16,727,852 - 16,727,939	UniSTS	Rnor5.0
RGSC_v3.4	20	14,096,627 - 14,096,714	UniSTS	RGSC3.4
Celera	20	15,078,689 - 15,078,776	UniSTS
Cytogenetic Map	20	p12	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	2	26	12	6	7	6			71	32	33	11
Low	1	17	45	35	12	35	8	11	3	3	8		8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_006223884	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017601885	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039099171	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039099172	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473988	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000324	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000001766 ⟹ ENSRNOP00000001766

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	20	13,471,668 - 13,597,016 (-)	Ensembl
Rnor_6.0 Ensembl	20	14,421,141 - 14,545,772 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000102298 ⟹ ENSRNOP00000091048

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	20	13,471,668 - 13,480,701 (-)	Ensembl

RefSeq Acc Id:

XM_039099171 ⟹ XP_038955099

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	20	13,471,679 - 13,596,497 (-)	NCBI

RefSeq Acc Id:

XM_039099172 ⟹ XP_038955100

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	20	13,472,136 - 13,519,398 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_038955099	(Get FASTA)	NCBI Sequence Viewer
	XP_038955100	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL97233	(Get FASTA)	NCBI Sequence Viewer
	F1LXF1	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

ENSRNOP00000001766 ⟸ ENSRNOT00000001766

RefSeq Acc Id:	XP_038955099 ⟸ XM_039099171
- Peptide Label:	isoform X1
- UniProtKB:	F1LXF1 (UniProtKB/Swiss-Prot)

RefSeq Acc Id:	XP_038955100 ⟸ XM_039099172
- Peptide Label:	isoform X2

RefSeq Acc Id:

ENSRNOP00000091048 ⟸ ENSRNOT00000102298

Protein Domains

C2 DH PH Rho-GAP

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-F1LXF1-F1-model_v2	AlphaFold	F1LXF1	1-1270	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1307993	AgrOrtholog
BioCyc Gene	G2FUF-4103	BioCyc
Ensembl Genes	ENSRNOG00000001304	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000001766	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOP00000091048.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000001766	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOT00000102298.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.555.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	1.20.900.10	UniProtKB/Swiss-Prot
	2.30.29.30	UniProtKB/Swiss-Prot
	2.60.40.150	UniProtKB/Swiss-Prot
	4.10.280.30	UniProtKB/Swiss-Prot
InterPro	Abr/Bcr	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Bcr-Abl_oncoprot_oligo	UniProtKB/Swiss-Prot
	Bcr-Abl_oncoprot_oligo_sf	UniProtKB/Swiss-Prot
	C2_dom	UniProtKB/Swiss-Prot
	C2_domain_sf	UniProtKB/Swiss-Prot
	DBL_dom_sf	UniProtKB/Swiss-Prot
	DH-domain	UniProtKB/Swiss-Prot
	GDS_CDC24_CS	UniProtKB/Swiss-Prot
	PH-like_dom_sf	UniProtKB/Swiss-Prot
	PH_domain	UniProtKB/Swiss-Prot
	Rho_GTPase_activation_prot	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	RhoGAP_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene	309696	ENTREZGENE
PANTHER	PTHR23182	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Bcr-Abl_Oligo	UniProtKB/Swiss-Prot
	PF00168	UniProtKB/Swiss-Prot
	RhoGAP	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	RhoGEF	UniProtKB/Swiss-Prot
PhenoGen	Bcr	PhenoGen
PROSITE	DH_1	UniProtKB/Swiss-Prot
	DH_2	UniProtKB/Swiss-Prot
	PH_DOMAIN	UniProtKB/Swiss-Prot
	PS50004	UniProtKB/Swiss-Prot
	RHOGAP	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	RhoGAP	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	RhoGEF	UniProtKB/Swiss-Prot
	SM00233	UniProtKB/Swiss-Prot
	SM00239	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF48065	UniProtKB/Swiss-Prot
	SSF48350	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF49562	UniProtKB/Swiss-Prot
	SSF69036	UniProtKB/Swiss-Prot
UniProt	A0A8I6GJB7_RAT	UniProtKB/TrEMBL
	BCR_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2019-05-06	Bcr	BCR activator of RhoGEF and GTPase	Bcr	BCR activator of RhoGEF and GTPase	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2019-04-10	Bcr	BCR activator of RhoGEF and GTPase	Bcr	BCR, RhoGEF and GTPase activating protein	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2016-05-18	Bcr	BCR, RhoGEF and GTPase activating protein	Bcr	breakpoint cluster region	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-09-25	Bcr	breakpoint cluster region	Bcr	breakpoint cluster region homolog	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Bcr	breakpoint cluster region homolog	Bcr_predicted	breakpoint cluster region homolog (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Bcr_predicted	breakpoint cluster region (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - OMIM

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