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Gene: Bcr (BCR activator of RhoGEF and GTPase) Rattus norvegicus
Symbol: Bcr
Name: BCR activator of RhoGEF and GTPase
Description: Exhibits enzyme binding activity. Involved in platelet-derived growth factor receptor signaling pathway and protein autophosphorylation. Localizes to the cytoplasm; glutamatergic synapse; and postsynaptic density, intracellular component. Human ortholog(s) of this gene implicated in chronic myeloid leukemia; leukemia; and precursor lymphoblastic lymphoma/leukemia. Orthologous to human BCR (BCR activator of RhoGEF and GTPase); PARTICIPATES IN chronic myeloid leukemia pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; atrazine; bisphenol A.
Type: protein-coding
RefSeq Status: MODEL
Also known as: BCR, RhoGEF and GTPase activating protein; breakpoint cluster region; breakpoint cluster region homolog; LOC309696
Homo sapiens (human) : BCR (BCR activator of RhoGEF and GTPase)  HGNC  Alliance
Mus musculus (house mouse) : Bcr (breakpoint cluster region)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Bcr (BCR activator of RhoGEF and GTPase)
Pan paniscus (bonobo/pygmy chimpanzee) : BCR (BCR activator of RhoGEF and GTPase)
Canis lupus familiaris (dog) : BCR (BCR activator of RhoGEF and GTPase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Bcr (BCR activator of RhoGEF and GTPase)
Sus scrofa (pig) : BCR (BCR activator of RhoGEF and GTPase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.02014,421,250 - 14,546,406 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02016,604,476 - 16,729,388 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42013,972,773 - 14,097,816 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12013,973,364 - 14,098,043 (-)NCBI
Celera2014,955,473 - 15,079,934 (-)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
More on Bcr
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1307993
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-07-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.