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Gene: RT1-S3 (RT1 class Ib, locus S3) Rattus norvegicus
Symbol: RT1-S3
Name: RT1 class Ib, locus S3
Description: Predicted to have beta-2-microglobulin binding activity; peptide antigen binding activity; and signaling receptor binding activity. Predicted to be involved in several processes, including positive regulation of cytokine production; positive regulation of immune effector process; and positive regulation of lymphocyte proliferation. Predicted to localize to the MHC protein complex; external side of plasma membrane; and extracellular space. Orthologous to human HLA-E (major histocompatibility complex, class I, E); PARTICIPATES IN allograft rejection pathway; antigen processing and presentation pathway; autoimmune thyroiditis pathway; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 1,3-dinitrobenzene; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: BM1; BM1av1; H2-T23; histocompatibility 2, T region locus 23; MHC class Ib RT1.S3; RT-BM1; RT1 class Ib gene(BM!); RT1 class Ib, locus BM1; RT1-BM1; RT1.S3; RTBM1
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0203,176,124 - 3,180,825 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0205,274,209 - 5,278,991 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4202,815,943 - 2,820,644 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1202,816,244 - 2,820,867 (+)NCBI
Celera20101,124 - 105,825 (+)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on RT1-S3
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 735037
Created: 2004-02-05
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.