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Gene: Ank3 (ankyrin 3) Rattus norvegicus
Symbol: Ank3
Name: ankyrin 3
Description: Exhibits several functions, including ion channel binding activity; protein binding activity, bridging; and spectrin binding activity. Involved in several processes, including clustering of voltage-gated sodium channels; positive regulation of membrane depolarization during cardiac muscle cell action potential; and positive regulation of transport. Localizes to several cellular components, including the cytoplasm; neuron projection; and spectrin-associated cytoskeleton. Predicted to colocalize with the bicellular tight junction. Biomarker of status epilepticus. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human ANK3 (ankyrin 3); INTERACTS WITH (+)-pilocarpine; 2,2',5,5'-tetrachlorobiphenyl; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: ANK-3; ankyrin 3 (G); ankyrin 3, epithelial; ankyrin 3, epithelial isoform g; ankyrin 3, node of Ranvier; ankyrin 3, node of Ranvier (ankyrin G); ankyrin-3; ankyrin-G
Homo sapiens (human) : ANK3 (ankyrin 3)  HGNC  Alliance
Mus musculus (house mouse) : Ank3 (ankyrin 3, epithelial)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ank3 (ankyrin 3)
Pan paniscus (bonobo/pygmy chimpanzee) : ANK3 (ankyrin 3)
Canis lupus familiaris (dog) : ANK3 (ankyrin 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ank3 (ankyrin 3)
Sus scrofa (pig) : ANK3 (ankyrin 3)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.02019,948,767 - 20,480,628 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02022,087,201 - 22,609,939 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42019,328,684 - 19,828,196 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12019,342,749 - 19,991,423 (-)NCBI
Celera2019,989,307 - 20,463,938 (-)NCBICelera
Cytogenetic Map20p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Ank3
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620157
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.