Grm4 (glutamate metabotropic receptor 4) - Rat Genome Database
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Gene: Grm4 (glutamate metabotropic receptor 4) Rattus norvegicus
Analyze
Symbol: Grm4
Name: glutamate metabotropic receptor 4
RGD ID: 2745
Description: Exhibits calcium-dependent protein binding activity and calmodulin binding activity. Predicted to be involved in several processes, including activation of MAPK activity; adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway; and modulation of chemical synaptic transmission. Localizes to dendritic shaft; presynaptic active zone membrane; and terminal bouton. Orthologous to human GRM4 (glutamate metabotropic receptor 4); PARTICIPATES IN glutamate signaling pathway; INTERACTS WITH 6-propyl-2-thiouracil; ammonium chloride; benzo[a]pyrene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: glutamate receptor, metabotropic 4; metabotropic glutamate receptor 4; mGluR4
Orthologs:
Homo sapiens (human) : GRM4 (glutamate metabotropic receptor 4)  HGNC  Alliance
Mus musculus (house mouse) : Grm4 (glutamate receptor, metabotropic 4)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Grm4 (glutamate metabotropic receptor 4)
Pan paniscus (bonobo/pygmy chimpanzee) : GRM4 (glutamate metabotropic receptor 4)
Canis lupus familiaris (dog) : GRM4 (glutamate metabotropic receptor 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Grm4 (glutamate metabotropic receptor 4)
Sus scrofa (pig) : GRM4 (glutamate metabotropic receptor 4)
Heterocephalus glaber (naked mole-rat) : Grm4 (glutamate metabotropic receptor 4)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Note: There is an assembly problem in the Rnor_6.0 reference genome assembly, and therefore, the 5' end of this gene was annotated on NW_007906049.1 and the 3' end was annotated on NW_007906047.1 in NCBI's Rattus norvegicus Annotation Release 105. [17 Jun 2015]; Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0206,745,682 - 6,791,521 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl206,745,682 - 6,791,519 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0208,986,551 - 9,064,972 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4205,627,733 - 5,727,274 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1205,627,959 - 5,727,501 (-)NCBI
Celera207,048,565 - 7,156,973 (-)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:8738157   PMID:8815915   PMID:9473604   PMID:11122333   PMID:11891216   PMID:14592619   PMID:14593202   PMID:15047615   PMID:15102938   PMID:15494036   PMID:15730868   PMID:17177262  
PMID:17401670   PMID:18593581   PMID:20824730   PMID:21288202   PMID:21358553   PMID:21795692   PMID:22528491   PMID:22570379   PMID:22653971   PMID:23374450   PMID:26176363   PMID:28487067  
PMID:28661401   PMID:28829739  


Genomics

Comparative Map Data
Grm4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0206,745,682 - 6,791,521 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl206,745,682 - 6,791,519 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0208,986,551 - 9,064,972 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4205,627,733 - 5,727,274 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1205,627,959 - 5,727,501 (-)NCBI
Celera207,048,565 - 7,156,973 (-)NCBICelera
Cytogenetic Map20p12NCBI
GRM4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl634,018,645 - 34,155,622 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl634,018,643 - 34,155,622 (-)EnsemblGRCh38hg38GRCh38
GRCh38634,018,643 - 34,155,622 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37633,989,623 - 34,123,399 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36634,097,606 - 34,209,421 (-)NCBINCBI36hg18NCBI36
Build 34634,097,606 - 34,209,421NCBI
Celera635,543,989 - 35,655,835 (-)NCBI
Cytogenetic Map6p21.31NCBI
HuRef633,731,329 - 33,846,092 (-)NCBIHuRef
CHM1_1633,988,493 - 34,125,948 (-)NCBICHM1_1
Grm4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391727,641,361 - 27,732,800 (-)NCBI
GRCm381727,422,387 - 27,513,826 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1727,422,387 - 27,521,403 (-)EnsemblGRCm38mm10GRCm38
MGSCv371727,559,332 - 27,640,249 (-)NCBIGRCm37mm9NCBIm37
MGSCv361727,149,976 - 27,230,893 (-)NCBImm8
Celera1727,978,671 - 28,055,379 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
Grm4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554372,358,795 - 2,430,260 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554372,358,839 - 2,449,145 (-)NCBIChiLan1.0ChiLan1.0
GRM4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1634,696,058 - 34,822,328 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl634,696,058 - 34,830,868 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0633,592,030 - 33,718,712 (-)NCBIMhudiblu_PPA_v0panPan3
GRM4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl123,346,395 - 3,459,878 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1123,346,395 - 3,459,722 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Grm4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493647624,866,356 - 24,968,362 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GRM4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl730,179,305 - 30,279,121 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1730,179,723 - 30,278,579 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2734,838,381 - 34,928,232 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Grm4
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475422,931,964 - 23,000,003 (+)NCBI

Position Markers
D20Got103  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0207,109,783 - 7,109,926NCBIRnor6.0
Rnor_6.0206,846,191 - 6,846,334NCBIRnor6.0
Rnor_5.0209,085,931 - 9,086,074UniSTSRnor5.0
Celera207,151,743 - 7,151,886UniSTS
Cytogenetic Map20p12UniSTS
RH138230  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0206,748,835 - 6,748,955NCBIRnor6.0
Rnor_5.0208,989,704 - 8,989,824UniSTSRnor5.0
RGSC_v3.4205,630,889 - 5,631,009UniSTSRGSC3.4
Celera207,051,718 - 7,051,838UniSTS
Cytogenetic Map20p12UniSTS
RH 3.4 Map2055.53UniSTS
BF401962  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera207,127,654 - 7,127,777UniSTS
Cytogenetic Map20p12UniSTS
RH 3.4 Map2055.43UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124652101Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125653396Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20126305996Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20126305996Rat
7387283Uae44Urinary albumin excretion QTL 440.1712urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)20127357423Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20128375393Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20128375393Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20128375393Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20128375393Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20128375393Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20133300419Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20137550487Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20137550487Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20201865447018654Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20299970747999707Rat
61472Aia1Adjuvant induced arthritis QTL 1180.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2031518156896013Rat
61448Ciaa1CIA Autoantibody QTL 1300.001blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)2031518156896013Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20340211127968216Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20403911318872273Rat
4889857Pur27Proteinuria QTL 2712.20.001total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20403911318872273Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance in proximity to the target during voluntary locomotion in an experimental apparatus (CMO:0002674)20410895649108956Rat
1300152Bp195Blood pressure QTL 1953.46arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2048554689899946Rat
1331772Cdexp2CD45RC expression in CD8 T cells QTL 25.7CD8-positive T cell quantity (VT:0008077)blood CD45RChigh CD8 T cell count to CD45RClow CD8 T cell count ratio (CMO:0001990)20485546810800530Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20485547515050565Rat
70154Insul2Insulin level QTL 23.75blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20587544818739210Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:144
Count of miRNA genes:99
Interacting mature miRNAs:121
Transcripts:ENSRNOT00000066115
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 37
Low 16 4 4 1 4 37 13 19
Below cutoff 3 17 5 4 7 4 2 2 22 16 3 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_022666 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AABR07044462 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AABR07044463 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AABR07044464 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01099715 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01099716 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01099717 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01099718 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01099719 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01099720 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01099721 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01099722 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01099723 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01099724 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01099725 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01099726 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC095263 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M90518 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M92077 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U47331 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000066115
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl206,746,577 - 6,791,519 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000083426
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl206,745,744 - 6,791,519 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000093374
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl206,791,320 - 6,791,516 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000093633
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl206,745,682 - 6,772,903 (-)Ensembl
RefSeq Acc Id: NM_022666   ⟹   NP_073157
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0206,745,682 - 6,791,521 (-)NCBI
Rnor_5.0208,986,551 - 9,064,972 (-)NCBI
RGSC_v3.4205,627,733 - 5,727,274 (-)RGD
Celera207,048,565 - 7,156,973 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_073157 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA88788 (Get FASTA)   NCBI Sequence Viewer  
  AAA93190 (Get FASTA)   NCBI Sequence Viewer  
  EDL96884 (Get FASTA)   NCBI Sequence Viewer  
  EDL96885 (Get FASTA)   NCBI Sequence Viewer  
  P31423 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_073157   ⟸   NM_022666
- Peptide Label: precursor
- UniProtKB: P31423 (UniProtKB/Swiss-Prot)
- Sequence:

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2745 AgrOrtholog
Ensembl Genes ENSRNOG00000000487 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000093633 ENTREZGENE
Gene3D-CATH 2.10.50.30 UniProtKB/Swiss-Prot
InterPro ANF_lig-bd_rcpt UniProtKB/Swiss-Prot
  GPCR_3 UniProtKB/Swiss-Prot
  GPCR_3_9-Cys_dom UniProtKB/Swiss-Prot
  GPCR_3_9-Cys_sf UniProtKB/Swiss-Prot
  GPCR_3_C UniProtKB/Swiss-Prot
  GPCR_3_CS UniProtKB/Swiss-Prot
  GPCR_3_mtglu_rcpt UniProtKB/Swiss-Prot
  GPCR_3_mtglu_rcpt_4 UniProtKB/Swiss-Prot
  Peripla_BP_I UniProtKB/Swiss-Prot
KEGG Report rno:24417 UniProtKB/Swiss-Prot
NCBI Gene 24417 ENTREZGENE
Pfam 7tm_3 UniProtKB/Swiss-Prot
  ANF_receptor UniProtKB/Swiss-Prot
  NCD3G UniProtKB/Swiss-Prot
PhenoGen Grm4 PhenoGen
PRINTS GPCRMGR UniProtKB/Swiss-Prot
  MTABOTROPC4R UniProtKB/Swiss-Prot
  MTABOTROPICR UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F3_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F3_2 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F3_3 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F3_4 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF53822 UniProtKB/Swiss-Prot
UniGene Rn.89046 ENTREZGENE
UniProt GRM4_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-11 Grm4  glutamate metabotropic receptor 4  Grm4  glutamate receptor, metabotropic 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Grm4  glutamate receptor, metabotropic 4    Glutamate receptor, metabotropic 4  Name updated 625702 APPROVED
2002-06-10 Grm4  Glutamate receptor, metabotropic 4      Symbol and Name status set to approved 70586 APPROVED