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Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dichloroethane | affects expression | ISO | RGD:1551969 | 6480464 | ethylene dichloride affects the expression of GRM4 mRNA | CTD | PMID:28960355 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of GRM4 mRNA | CTD | PMID:33387578 | 4,4'-sulfonyldiphenol | decreases expression | ISO | RGD:1551969 | 6480464 | bis(4-hydroxyphenyl)sulfone results in decreased expression of GRM4 mRNA | CTD | PMID:30951980 | 4,4'-sulfonyldiphenol | decreases methylation | ISO | RGD:1551969 | 6480464 | bis(4-hydroxyphenyl)sulfone results in decreased methylation of GRM4 exon | CTD | PMID:33297965 | 6-propyl-2-thiouracil | decreases expression | EXP | | 6480464 | Propylthiouracil results in decreased expression of GRM4 mRNA | CTD | PMID:24780913 | afimoxifene | increases expression | ISO | RGD:731311 | 6480464 | afimoxifene results in increased expression of GRM4 mRNA | CTD | PMID:23373633 | Aflatoxin B2 alpha | increases methylation | ISO | RGD:731311 | 6480464 | aflatoxin B2 results in increased methylation of GRM4 intron | CTD | PMID:30157460 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of GRM4 mRNA | CTD | PMID:16483693 | antimycin A | decreases expression | ISO | RGD:731311 | 6480464 | Antimycin A results in decreased expression of GRM4 mRNA | CTD | PMID:33512557 | arsenite(3-) | decreases expression | ISO | RGD:1551969 | 6480464 | arsenite results in decreased expression of GRM4 mRNA | CTD | PMID:33053406 | atrazine | increases expression | ISO | RGD:731311 | 6480464 | Atrazine results in increased expression of GRM4 mRNA | CTD | PMID:22378314 | atropine | multiple interactions | ISO | RGD:731311 | 6480464 | Atropine inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium] | CTD | PMID:18171729 | benzo[a]pyrene | decreases expression | EXP | | 6480464 | Benzo(a)pyrene results in decreased expression of GRM4 mRNA | CTD | PMID:21839799 | benzo[a]pyrene | affects methylation | ISO | RGD:731311 | 6480464 | Benzo(a)pyrene affects the methylation of GRM4 intron, Benzo(a)pyrene affects the methylation of GRM4 promoter | CTD | PMID:27901495, PMID:30157460 | benzo[a]pyrene | decreases methylation | ISO | RGD:1551969 | 6480464 | Benzo(a)pyrene results in decreased methylation of GRM4 exon | CTD | PMID:27901495 | benzo[a]pyrene | decreases methylation | ISO | RGD:731311 | 6480464 | Benzo(a)pyrene results in decreased methylation of GRM4 exon | CTD | PMID:27901495 | benzo[a]pyrene | increases methylation | ISO | RGD:731311 | 6480464 | Benzo(a)pyrene results in increased methylation of GRM4 3' UTR | CTD | PMID:27901495 | benzo[e]pyrene | increases methylation | ISO | RGD:731311 | 6480464 | benzo(e)pyrene results in increased methylation of GRM4 intron | CTD | PMID:30157460 | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of GRM4 mRNA | CTD | PMID:25181051 | bisphenol A | affects methylation | ISO | RGD:731311 | 6480464 | bisphenol A affects the methylation of GRM4 gene | CTD | PMID:31601247 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of GRM4 mRNA | CTD | PMID:30816183, PMID:33441873 | bisphenol A | decreases expression | ISO | RGD:1551969 | 6480464 | bisphenol A results in decreased expression of GRM4 mRNA | CTD | PMID:30951980 | bisphenol F | decreases expression | ISO | RGD:1551969 | 6480464 | bisphenol F results in decreased expression of GRM4 mRNA | CTD | PMID:30951980 | Brodifacoum | decreases expression | EXP | | 6480464 | bromfenacoum results in decreased expression of GRM4 protein | CTD | PMID:28903499 | butanal | increases expression | ISO | RGD:731311 | 6480464 | butyraldehyde results in increased expression of GRM4 mRNA | CTD | PMID:26079696 | carbachol | multiple interactions | ISO | RGD:731311 | 6480464 | [Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium more ... | CTD | PMID:18171729 | CGP 52608 | multiple interactions | ISO | RGD:731311 | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to GRM4 gene] | CTD | PMID:28238834 | chlorpyrifos | increases expression | EXP | | 6480464 | Chlorpyrifos results in increased expression of GRM4 mRNA | CTD | PMID:19440498 | choline | multiple interactions | ISO | RGD:1551969 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of GRM4 gene | CTD | PMID:20938992 | copper atom | increases expression | EXP | | 6480464 | Copper deficiency results in increased expression of GRM4 mRNA | CTD | PMID:26033743 | copper(0) | increases expression | EXP | | 6480464 | Copper deficiency results in increased expression of GRM4 mRNA | CTD | PMID:26033743 | deguelin | decreases expression | ISO | RGD:731311 | 6480464 | deguelin results in decreased expression of GRM4 mRNA | CTD | PMID:33512557 | dextran sulfate | multiple interactions | ISO | RGD:1551969 | 6480464 | [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of GRM4 mRNA | CTD | PMID:29950665 | diazinon | affects expression | EXP | | 6480464 | Diazinon affects the expression of GRM4 mRNA | CTD | PMID:19440498 | ethanol | decreases expression | EXP | | 6480464 | Ethanol results in decreased expression of GRM4 mRNA | CTD | PMID:20655511 | ethanol | multiple interactions | ISO | RGD:1551969 | 6480464 | Ethanol affects the expression of and affects the splicing of GRM4 mRNA | CTD | PMID:30319688 | ethanol | increases expression | ISO | RGD:1551969 | 6480464 | Ethanol results in increased expression of GRM4 mRNA | CTD | PMID:30319688 | fenpyroximate | decreases expression | ISO | RGD:731311 | 6480464 | fenpyroximate results in decreased expression of GRM4 mRNA | CTD | PMID:33512557 | folic acid | multiple interactions | ISO | RGD:1551969 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of GRM4 gene | CTD | PMID:20938992 | folic acid | decreases expression | ISO | RGD:1551969 | 6480464 | Folic Acid results in decreased expression of GRM4 mRNA | CTD | PMID:25629700 | furan | increases expression | EXP | | 6480464 | furan results in increased expression of GRM4 mRNA | CTD | PMID:25539665 | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of GRM4 mRNA | CTD | PMID:33387578 | glycidol | decreases expression | EXP | | 6480464 | glycidol results in decreased expression of GRM4 mRNA | CTD | PMID:24915197 | L-methionine | multiple interactions | ISO | RGD:1551969 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of GRM4 gene | CTD | PMID:20938992 | lead diacetate | affects expression | EXP | | 6480464 | lead acetate affects the expression of GRM4 mRNA | CTD | PMID:22160880 | lead diacetate | increases expression | ISO | RGD:1551969 | 6480464 | lead acetate results in increased expression of GRM4 mRNA | CTD | PMID:24260418 | lipopolysaccharide | multiple interactions | ISO | RGD:731311 | 6480464 | [S-(1, 2-dichlorovinyl)cysteine co-treated with Lipopolysaccharides] results in decreased expression of GRM4 mRNA | CTD | PMID:35811015 | methapyrilene | increases methylation | ISO | RGD:731311 | 6480464 | Methapyrilene results in increased methylation of GRM4 intron | CTD | PMID:30157460 | methoxyacetic acid | affects expression | EXP | | 6480464 | methoxyacetic acid affects the expression of GRM4 mRNA | CTD | PMID:20864626 | Nor-9-carboxy-delta9-THC | multiple interactions | ISO | RGD:731311 | 6480464 | [Cannabinoids results in increased abundance of 11-nor-delta(9)-tetrahydrocannabinol-9-carboxylic acid] which affects the methylation of GRM4 gene | CTD | PMID:30521419 | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of GRM4 mRNA | CTD | PMID:33387578 | pentanal | increases expression | ISO | RGD:731311 | 6480464 | pentanal results in increased expression of GRM4 mRNA | CTD | PMID:26079696 | phenobarbital | decreases expression | EXP | | 6480464 | Phenobarbital results in decreased expression of GRM4 mRNA | CTD | PMID:19162173 | PhIP | increases expression | ISO | RGD:731311 | 6480464 | 2-amino-1-methyl-6-phenylimidazo(4, 5-b)pyridine results in increased expression of GRM4 mRNA | CTD | PMID:20816883 | picoxystrobin | decreases expression | ISO | RGD:731311 | 6480464 | picoxystrobin results in decreased expression of GRM4 mRNA | CTD | PMID:33512557 | pioglitazone | multiple interactions | ISO | RGD:1551969 | 6480464 | [N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in increased expression of GRM4 mRNA | CTD | PMID:27935865 | propanal | increases expression | ISO | RGD:731311 | 6480464 | propionaldehyde results in increased expression of GRM4 mRNA | CTD | PMID:26079696 | pyrimidifen | decreases expression | ISO | RGD:731311 | 6480464 | pyrimidifen results in decreased expression of GRM4 mRNA | CTD | PMID:33512557 | resveratrol | multiple interactions | ISO | RGD:731311 | 6480464 | [Plant Extracts co-treated with Resveratrol] results in decreased expression of GRM4 mRNA | CTD | PMID:23557933 | rotenone | decreases response to substance | EXP | | 6480464 | GRM4 protein results in decreased susceptibility to Rotenone | CTD | PMID:16624952 | rotenone | decreases expression | ISO | RGD:731311 | 6480464 | Rotenone results in decreased expression of GRM4 mRNA | CTD | PMID:33512557 | S-(1,2-dichlorovinyl)-L-cysteine | multiple interactions | ISO | RGD:731311 | 6480464 | [S-(1, 2-dichlorovinyl)cysteine co-treated with Lipopolysaccharides] results in decreased expression of GRM4 mRNA | CTD | PMID:35811015 | scopolamine | multiple interactions | ISO | RGD:731311 | 6480464 | Scopolamine inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium] | CTD | PMID:18171729 | T-2 toxin | decreases expression | EXP | | 6480464 | T-2 Toxin results in decreased expression of GRM4 mRNA | CTD | PMID:26141394 | tebufenpyrad | decreases expression | ISO | RGD:731311 | 6480464 | 4-chloro-N-((4-(1, 1-dimethylethyl)phenyl)methyl)-3-ethyl-1-methyl-1H-pyrazole-5-carboxamide results in decreased expression of GRM4 mRNA | CTD | PMID:33512557 | thallium | multiple interactions | ISO | RGD:731311 | 6480464 | [Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium more ... | CTD | PMID:18171729 | thifluzamide | decreases expression | ISO | RGD:731311 | 6480464 | thifluzamide results in decreased expression of GRM4 mRNA | CTD | PMID:33512557 | titanium dioxide | multiple interactions | ISO | RGD:1551969 | 6480464 | [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of GRM4 mRNA | CTD | PMID:29950665 | trichloroethene | increases expression | EXP | | 6480464 | Trichloroethylene results in increased expression of GRM4 mRNA | CTD | PMID:33387578 | triptonide | increases expression | ISO | RGD:1551969 | 6480464 | triptonide results in increased expression of GRM4 mRNA | CTD | PMID:33045310 | tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate | multiple interactions | ISO | RGD:731311 | 6480464 | Atropine inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium] | CTD | PMID:18171729 | Tropicamide | multiple interactions | ISO | RGD:731311 | 6480464 | Tropicamide inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium] | CTD | PMID:18171729 | valproic acid | increases methylation | ISO | RGD:731311 | 6480464 | Valproic Acid results in increased methylation of GRM4 gene | CTD | PMID:29154799 | valproic acid | increases expression | EXP | | 6480464 | Valproic Acid results in increased expression of GRM4 mRNA | CTD | PMID:32428529 | valproic acid | decreases expression | EXP | | 6480464 | Valproic Acid results in decreased expression of GRM4 mRNA | CTD | PMID:32428529 | |