Sgpl1 (sphingosine-1-phosphate lyase 1)

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Gene: Sgpl1 (sphingosine-1-phosphate lyase 1) Rattus norvegicus

Analyze

Symbol:

Sgpl1

Name:

sphingosine-1-phosphate lyase 1

RGD ID:

628599

Description:

Predicted to enable sphinganine-1-phosphate aldolase activity. Predicted to be involved in apoptotic signaling pathway; fatty acid metabolic process; and sphingolipid metabolic process. Predicted to act upstream of or within several processes, including face morphogenesis; gonad development; and vasculogenesis. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in nephrotic syndrome type 14. Orthologous to human SGPL1 (sphingosine-1-phosphate lyase 1); PARTICIPATES IN Fabry disease pathway; Gaucher's disease pathway; Krabbe disease pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

S1PL; SP-lyase 1; Spgl1; sphingosine phosphate lyase 1; sphingosine-1-phosphate aldolase; spl; SPL 1

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SGPL1 (sphingosine-1-phosphate lyase 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Sgpl1 (sphingosine phosphate lyase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Sgpl1 (sphingosine-1-phosphate lyase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SGPL1 (sphingosine-1-phosphate lyase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SGPL1 (sphingosine-1-phosphate lyase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Sgpl1 (sphingosine-1-phosphate lyase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SGPL1 (sphingosine-1-phosphate lyase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SGPL1 (sphingosine-1-phosphate lyase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Sgpl1 (sphingosine-1-phosphate lyase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	SGPL1 (sphingosine-1-phosphate lyase 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Sgpl1 (sphingosine phosphate lyase 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	sgpl1 (sphingosine-1-phosphate lyase 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	DPL1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Sply	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	spl-1	Alliance	DIOPT (InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	spl-2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	spl-3	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	20	29,047,793 - 29,094,209 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	29,047,796 - 29,094,084 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	20	30,065,894 - 30,110,041 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	20	29,452,195 - 29,496,346 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	20	30,194,650 - 30,238,806 (-)	NCBI	Rnor_WKY
Rnor_6.0	20	30,699,936 - 30,769,178 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	30,699,872 - 30,749,940 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	20	32,497,280 - 32,543,188 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	20	28,459,734 - 28,505,017 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	20	28,473,533 - 28,518,817 (-)	NCBI
Celera	20	30,483,317 - 30,527,561 (-)	NCBI		Celera
Cytogenetic Map	20	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

nephrotic syndrome (ISO)

nephrotic syndrome type 14 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (EXP)

2,3',4,4',5-Pentachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

3-chloropropane-1,2-diol (EXP)

4,4'-diaminodiphenylmethane (ISO)

4-hydroxynon-2-enal (ISO)

aflatoxin B1 (ISO)

ammonium chloride (EXP)

aristolochic acid A (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

carbon nanotube (ISO)

chromium(3+) trichloride (ISO)

cyproconazole (ISO)

diazinon (EXP)

dieldrin (EXP)

dioxygen (ISO)

divanadium pentaoxide (ISO)

dorsomorphin (ISO)

epoxiconazole (ISO)

ethanol (ISO)

fipronil (EXP)

gentamycin (EXP)

graphite (EXP)

ivermectin (ISO)

oxaliplatin (EXP)

paracetamol (EXP,ISO)

perfluorohexanesulfonic acid (ISO)

perfluorononanoic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

phenobarbital (ISO)

propiconazole (ISO)

resveratrol (ISO)

rotenone (ISO)

SB 431542 (ISO)

sodium dichromate (ISO)

sunitinib (ISO)

thimerosal (ISO)

thioacetamide (EXP)

topotecan (EXP)

triphenyl phosphate (EXP)

triptonide (ISO)

troglitazone (ISO)

valdecoxib (EXP)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

androgen metabolic process (ISO)

apoptotic signaling pathway (ISO,ISS)

carboxylic acid metabolic process (IEA)

ceramide metabolic process (ISO,ISS)

estrogen metabolic process (ISO)

face morphogenesis (ISO)

fatty acid metabolic process (ISO,ISS)

female gonad development (ISO)

fibroblast migration (ISO)

hemopoiesis (ISO)

kidney development (ISO)

Leydig cell differentiation (ISO)

luteinization (ISO)

nitrogen compound metabolic process (ISO)

platelet-derived growth factor receptor signaling pathway (ISO)

post-embryonic development (ISO)

regulation of multicellular organism growth (ISO)

roof of mouth development (ISO)

skeletal system morphogenesis (ISO)

spermatogenesis (ISO)

sphingolipid catabolic process (IBA,ISO,ISS)

vasculogenesis (ISO)

Cellular Component

endoplasmic reticulum (IBA,ISO,ISS)

endoplasmic reticulum membrane (IEA)

Molecular Function

carbon-carbon lyase activity (IEA)

protein binding (ISO)

pyridoxal phosphate binding (IEA)

sphinganine-1-phosphate aldolase activity (IBA,ISO,ISS)

Molecular Pathway Annotations Click to see Annotation Detail View

Fabry disease pathway (ISO)

Gaucher's disease pathway (ISO)

Krabbe disease pathway (ISO)

metachromatic leukodystrophy pathway (ISO)

sphingolipid metabolic pathway (IEA,ISO)

sphingosine 1-phosphate signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
4.	PID Annotation Import Pipeline	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
5.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
6.	GOA pipeline	RGD automated data pipeline
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
8.	Subcellular localization and membrane topology of sphingosine-1-phosphate lyase in rat liver.	Van Veldhoven PP and Mannaerts GP, J Biol Chem 1991 Jul 5;266(19):12502-7.

Additional References at PubMed

PMID:14570870	PMID:17143286	PMID:19056881	PMID:24809814	PMID:25630683	PMID:28165339	PMID:29070677	PMID:33450132

Genomics

Comparative Map Data

Sgpl1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	20	29,047,793 - 29,094,209 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	29,047,796 - 29,094,084 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	20	30,065,894 - 30,110,041 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	20	29,452,195 - 29,496,346 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	20	30,194,650 - 30,238,806 (-)	NCBI	Rnor_WKY
Rnor_6.0	20	30,699,936 - 30,769,178 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	30,699,872 - 30,749,940 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	20	32,497,280 - 32,543,188 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	20	28,459,734 - 28,505,017 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	20	28,473,533 - 28,518,817 (-)	NCBI
Celera	20	30,483,317 - 30,527,561 (-)	NCBI		Celera
Cytogenetic Map	20	q11	NCBI

SGPL1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	10	70,815,948 - 70,881,184 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	10	70,815,905 - 70,895,816 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	10	72,575,704 - 72,640,941 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	10	72,245,722 - 72,309,873 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	10	72,245,721 - 72,309,871	NCBI
Celera	10	65,857,672 - 65,923,231 (+)	NCBI		Celera
Cytogenetic Map	10	q22.1	NCBI
HuRef	10	66,569,390 - 66,634,948 (+)	NCBI		HuRef
CHM1_1	10	72,858,499 - 72,923,730 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	10	71,685,760 - 71,750,988 (+)	NCBI		T2T-CHM13v2.0

Sgpl1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	60,934,421 - 60,983,463 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	60,934,421 - 60,983,482 (-)	Ensembl		GRCm39 Ensembl
GRCm38	10	61,098,642 - 61,147,684 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	61,098,642 - 61,147,703 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	60,561,390 - 60,610,413 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	10	60,493,999 - 60,542,956 (-)	NCBI		MGSCv36	mm8
Celera	10	62,199,269 - 62,248,215 (-)	NCBI		Celera
Cytogenetic Map	10	B4	NCBI
cM Map	10	32.14	NCBI

Sgpl1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955437	20,488,330 - 20,547,171 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955437	20,489,641 - 20,547,105 (-)	NCBI	ChiLan1.0	ChiLan1.0

SGPL1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	10	69,812,082 - 69,876,444 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	10	69,812,092 - 69,876,438 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	10	67,286,349 - 67,351,574 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

SGPL1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	4	21,666,264 - 21,717,476 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	4	21,660,939 - 21,715,155 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	4	21,795,341 - 21,851,669 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	4	21,939,185 - 21,995,525 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	4	21,944,334 - 21,995,521 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	4	21,834,799 - 21,891,148 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	4	22,040,063 - 22,096,345 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	4	22,392,266 - 22,448,632 (+)	NCBI		UU_Cfam_GSD_1.0

Sgpl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	59,357,640 - 59,407,321 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936521	7,848,972 - 7,900,041 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936521	7,850,370 - 7,899,998 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SGPL1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	73,724,100 - 73,781,800 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	73,696,902 - 73,781,830 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	79,572,301 - 79,628,480 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SGPL1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	9	60,425,703 - 60,487,196 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	9	60,424,305 - 60,487,146 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666048	21,148,927 - 21,211,740 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Sgpl1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624754	4,844,552 - 4,886,709 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624754	4,844,472 - 4,889,006 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Sgpl1
56 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	34
Count of miRNA genes:	32
Interacting mature miRNAs:	34
Transcripts:	ENSRNOT00000065127
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
8694189	Bw153	Body weight QTL 153	3.13	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	20	1	29191651	Rat
9590275	Scort15	Serum corticosterone level QTL 15	3.48	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	20	1	29191651	Rat
7411650	Foco23	Food consumption QTL 23	20.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	20	1	29191651	Rat
9590109	Sffal8	Serum free fatty acids level QTL 8	5.32	0.01	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	20	1	29191651	Rat
9589155	Insul32	Insulin level QTL 32	6.38	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	20	1	29191651	Rat
6893685	Bw111	Body weight QTL 111	2.7	0.004	body mass (VT:0001259)	body weight (CMO:0000012)	20	1	32578807	Rat
7411668	Foco32	Food consumption QTL 32	8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	20	1	36600972	Rat
9590252	Scort12	Serum corticosterone level QTL 12	20.46	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	20	1	36600972	Rat
2305926	Iddm37	Insulin dependent diabetes mellitus QTL 37	6		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	20	1527842	46527842	Rat
1641915	Colcr9	Colorectal carcinoma resistance QTL 9	2.97	0.0024	intestine integrity trait (VT:0010554)	benign colorectal tumor number (CMO:0001795)	20	1530655	46530655	Rat
1598816	Memor12	Memory QTL 12	2.4		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	20	2606836	47606836	Rat
4889870	Pur30	Proteinuria QTL 30	19	0.005	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	20	8042410	29322208	Rat
7411652	Foco24	Food consumption QTL 24		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	20	11757515	54435887	Rat
9590092	Insglur9	Insulin/glucose ratio QTL 9	18.38	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	20	11757515	54435887	Rat
4889610	Pancm3	Pancreatic morphology QTL 3	3.75	0.001	pancreas mass (VT:0010144)	pancreas wet weight (CMO:0000626)	20	17617832	47606836	Rat
2317880	Alcrsp25	Alcohol response QTL 25	2.3		response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	20	17697550	54435887	Rat
2303626	Vencon10	Ventilatory control QTL 10		0.001	respiration trait (VT:0001943)	respiration rate (CMO:0000289)	20	19190721	54435887	Rat
2303578	Gluco50	Glucose level QTL 50	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	20	25106722	54435887	Rat
2303587	Bw93	Body weight QTL 93	13		body mass (VT:0001259)	body weight (CMO:0000012)	20	25106722	54435887	Rat
2300188	Bmd68	Bone mineral density QTL 68	6.4	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	20	25106722	54435887	Rat
1331747	Hrtrt16	Heart rate QTL 16	3.163		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	20	25209734	54435887	Rat

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	30	45	29	19	29	1	1	74	35	36	11	1
Low		13	12	12		12	7	10			5		7
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_173116	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008772870	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008772871	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008772872	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008772873	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039098466	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AJ512838	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474016	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000324	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000065127 ⟹ ENSRNOP00000059089

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	20	30,702,005 - 30,749,940 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000084391 ⟹ ENSRNOP00000070983

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	20	29,047,796 - 29,094,084 (-)	Ensembl
Rnor_6.0 Ensembl	20	30,699,872 - 30,748,784 (-)	Ensembl

RefSeq Acc Id:

NM_173116 ⟹ NP_775139

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	20	29,049,862 - 29,094,023 (-)	NCBI
Rnor_6.0	20	30,702,005 - 30,749,940 (-)	NCBI
Rnor_5.0	20	32,497,280 - 32,543,188 (-)	NCBI
RGSC_v3.4	20	28,459,734 - 28,505,017 (-)	RGD
Celera	20	30,483,317 - 30,527,561 (-)	RGD

Sequence:

show sequence

TCGCTTGCAGAACCGAGGCGCGTGAGGTGGGCGGCGGCCAGCTGAGCCCCTGCGAGGAAGAAGG
CGCGGGTCCACGGCTTGTGGAGACGCAGTAGCAGAGGAGCCCTGAGGAGCCATCTGCAGAGGAA
GATGCCGAGTACCGACCTTCTCAAGTTGAAGGACTTCGAGCCTTATTTGGAGATTTTGGAAGCA
TATTCCACAAAAGCCAAGAATTACGTGAATGGGTACTGCACCAAATACGAGCCCTGGCAGCTCA
TTGCGGGGAGTGTCCTGTGTACTCTGCTGGTAGTCTGGGTATATGAGCTTATCTTCCAGCCAGA
GAGTTTATGGTCTCGGTTTAAAAATAAATTATTTAGGCTTATAAGGAAGATGCCATTTATTGGA
CGTAAGATACAACAGCAGCTTACCAAAGCCAAGAAGGATCTTGTCAAGAACATGCCATTCCTGA
AGTTGGACAAAGATTATGTGAAAACCCTGCCTGCTCAGGGTCTGAGCACAGCTGAGGTTCTGGA
GAGACTCAAGGAGTACAGCTCCATGGATGTCTTCTGGCAAGAAGGGAAAGCCTCAGGAGCTGTG
TACAGTGGGGAGCCGAAGCTCACCGAGCTGCTGGTGCAGGCTTACGGAGAATTCACGTGGAGCA
ATCCACTGCACCCAGATATCTTCCCCGGACTACGGAAGTTAGAGGCAGAAATCGTGAGGATGAC
TTGCTCCCTCTTCAATGGGGGGCCAGACTCCTGTGGATGTGTGACTTCTGGGGGAACAGAAAGC
ATCCTAATGGCCTGCAAAGCATATCGGGACTTGGCCTTAGAGAAGGGGATCAAAACTCCAGAAA
TTGTGGCTCCTGAGAGTGCCCACGCCGCATTCGACAAAGCAGCTCATTATTTCGGAATGAAGAT
TGTACGCGTTGCGCAGAAAAAGAACATGGAGGTGGATGTGCGGGCAATGAAAAGAGCCATCTCC
AGGAACACAGCCATGCTGGTCTGTTCTGCCCCACAGTTTCCTCATGGTGTGATAGATCCTATCC
CCGAAGTGGCCAAGCTGGCTGTCAAATATAAAATCCCATTCCATGTGGATGCTTGTCTTGGGGG
CTTCCTCATTGTCTTCATGGAGAAAGCAGGGTACCCACTGGAGAAACCATTTGATTTCCGGGTG
AAAGGTGTGACCAGCATTTCAGCAGATACTCATAAGTACGGCTATGCTCCCAAAGGTTCATCAG
TGGTGATGTACTCTAACGAGAAGTACAGGAAGTACCAGTTCTTTGTTGATGCAGATTGGCAAGG
TGGCATCTACGCATCTCCAAGCATAGCTGGCTCACGGCCTGGTGGCATCATTGCAGCCTGTTGG
GCCGCCTTGATGCACTTTGGTGAGAACGGCTATGTTGAAGCTACCAAACAGATCATCAAAACTG
CTCGCTTCCTCAAGTCAGAACTGGAAAACATCAAAAACATCTTCATTTTGGGGGATCCTCAATT
GTCAGTTATTGCTCTGGGCTCCAACGATTTTGACATCTACCGACTATCTAATATGATGTCTGCT
AAGGGGTGGAATTTTAACTACTTGCAGTTCCCAAGAAGCATTCATTTCTGCATTACGTTAGTAC
ATACTCGGAAGCGAGTGGCAATCCAGTTCCTAAAGGATATCCGGGAATCGGTCACACAAATCAT
GAAGAATCCTAAAGCTAAGACCACAGGAATGGGTGCCATCTATGGCATGGCCCAGGCAACCATT
GACAGGAAGATGGTTGCAGAAATATCCTCCGTCTTCTTGGACAGCCTTTATAGTACAGACCCTG
TGACTCAGGGTAACCAGATGAACGGTTCTCCAAAGCCCCGCTGAACTTTGACCCTTGATAGATC
CATGGAACTTCAGGCCTTCAGAAGGTTCTTGGCATTTAGAACCCACCACACACAACTTGACATC
TGGACTGGCTCCTTAGAGCACAAATAGGATAAACCGTAAGATAGCTTCAGCCTCAGGACTCCTT
TGTCTCCTTTTGGGGCTTTTAGTTTGAAGACCCTGAAGGATCCCACTGC

hide sequence

RefSeq Acc Id:

XM_008772871 ⟹ XP_008771093

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	20	29,047,793 - 29,094,209 (-)	NCBI
Rnor_6.0	20	30,699,936 - 30,749,948 (-)	NCBI

Sequence:

show sequence

CGAGTGAGTCGCTTGGCAGAACCGAGGCGCGTGAGACGCAGTAGCAGAGGAGCCCTGAGGAGCC
ATCTGCAGAGGAAGATGCCGAGTACCGACCTTCTCAAGTTGAAGGACTTCGAGCCTTATTTGGA
GATTTTGGAAGCATATTCCACAAAAGCCAAGAATTACGTGAATGGGTACTGCACCAAATACGAG
CCCTGGCAGCTCATTGCGGGGAGTGTCCTGTGTACTCTGCTGGTAGTCTGGGTATATGAGCTTA
TCTTCCAGCCAGAGAGTTTATGGTCTCGGTTTAAAAATAAATTATTTAGGCTTATAAGGAAGAT
GCCATTTATTGGACGTAAGATACAACAGCAGCTTACCAAAGCCAAGAAGGATCTTGTCAAGAAC
ATGCCATTCCTGAAGTTGGACAAAGATTATGTGAAAACCCTGCCTGCTCAGGGTCTGAGCACAG
CTGAGGTTCTGGAGAGACTCAAGGAGTACAGCTCCATGGATGTCTTCTGGCAAGAAGGGAAAGC
CTCAGGAGCTGTGTACAGTGGGGAGCCGAAGCTCACCGAGCTGCTGGTGCAGGCTTACGGAGAA
TTCACGTGGAGCAATCCACTGCACCCAGATATCTTCCCCGGACTACGGAAGTTAGAGGCAGAAA
TCGTGAGGATGACTTGCTCCCTCTTCAATGGGGGGCCAGACTCCTGTGGATGTGTGACTTCTGG
GGGAACAGAAAGCATCCTAATGGCCTGCAAAGCATATCGGGACTTGGCCTTAGAGAAGGGGATC
AAAACTCCAGAAATTGTGGCTCCTGAGAGTGCCCACGCCGCATTCGACAAAGCAGCTCATTATT
TCGGAATGAAGATTGTACGCGTTGCGCAGAAAAAGAACATGGAGGTGGATGTGCGGGCAATGAA
AAGAGCCATCTCCAGGAACACAGCCATGCTGGTCTGTTCTGCCCCACAGTTTCCTCATGGTGTG
ATAGATCCTATCCCCGAAGTGGCCAAGCTGGCTGTCAAATATAAAATCCCATTCCATGTGGATG
CTTGTCTTGGGGGCTTCCTCATTGTCTTCATGGAGAAAGCAGGGTACCCACTGGAGAAACCATT
TGATTTCCGGGTGAAAGGTGTGACCAGCATTTCAGCAGATACTCATAAGTACGGCTATGCTCCC
AAAGGTTCATCAGTGGTGATGTACTCTAACGAGAAGTACAGGAAGTACCAGTTCTTTGTTGATG
CAGATTGGCAAGGTGGCATCTACGCATCTCCAAGCATAGCTGGCTCACGGCCTGGTGGCATCAT
TGCAGCCTGTTGGGCCGCCTTGATGCACTTTGGTGAGAACGGCTATGTTGAAGCTACCAAACAG
ATCATCAAAACTGCTCGCTTCCTCAAGTCAGAACTGGAAAACATCAAAAACATCTTCATTTTGG
GGGATCCTCAATTGTCAGTTATTGCTCTGGGCTCCAACGATTTTGACATCTACCGACTATCTAA
TATGATGTCTGCTAAGGGGTGGAATTTTAACTACTTGCAGTTCCCAAGAAGCATTCATTTCTGC
ATTACGTTAGTACATACTCGGAAGCGAGTGGCAATCCAGTTCCTAAAGGATATCCGGGAATCGG
TCACACAAATCATGAAGAATCCTAAAGCTAAGACCACAGGAATGGGTGCCATCTATGGCATGGC
CCAGGCAACCATTGACAGGAAGATGGTTGCAGAAATATCCTCCGTCTTCTTGGACAGCCTTTAT
AGTACAGACCCTGTGACTCAGGGTAACCAGATGAACGGTTCTCCAAAGCCCCGCTGAACTTTGA
CCCTTGATAGATCCATGGAACTTCAGGCCTTCAGAAGGTTCTTGGCATTTAGAACCCACCACAC
ACAACTTGACATCTGGACTGGCTCCTTAGAGCACAAATAGGATAAACCGTAAGATAGCTTCAGC
CTCAGGACTCCTTTGTCTCCTTTTGGGGCTTTTAGTTTGAAGACCCTGAAGGATCCCACTGCAT
AATGAGTCTGCCCTGGTTATTAATGTTGCCCTAGGAATTGTTTTAACCATATTTTCCTCTAACA
TCTTTAGCATCATCTTCACTTATGCGGCGGCCCTGACCTGTCCTGATTGCTTAGGGAAAATGTG
AGATAGCAAGAGGGTGTCTCAACGTTCTGGCTGTCAGGCAGGGGGCATTTATGTACTGTGTTCC
CTGGGTGGGTGCTAATCTGTCCCACTCGGGGAGATTTCAGCCTCTGCGTCAGGAGATGCTGCTT
GTCTCTCAGGATCGCTCTCATTACAACTTGCTTTACTTTTCCAAGCACAAGTTGGCCAGGTTAC
TGGCCTCTCTTTTTTTTTAATTACTGGAGTGTGTTCCCTTGACGGGGTTTGAAGTGCTCCTTTG
TCTTGTGCACGACCATGGCTGCTGCCACCTTTGGAGATGCCTGTTGGCCGTGATGCTCACACTT
GTGTGTTCTTATTACTGTAGGGTAGGAAATGAACGTGTTTTTCAGAGAAGCTTGGGCTTTCTGG
CTATTGGCGCTGCCTCGAGTCTGGAGTAGGTGTAGATCACACCTGAGCCCTCTCCTGGGCCAGA
GAAGCCAAAGCCAGCCCCTTCCCCATATTTTCTTGAACAGCAGCATAGTAAGCACCTAGGTCAT
GCACATGTGGGCGGTGGTCTTCCCCTTCAACTTTGCCTTAAGCCTTCGTGTAATGAGAATCCAG
TTTTATTGAAGAAAACACTCCACAAGTGTCCTTGACTTCCCTCAGTGGGTGTGAAGACGTTTGG
AGGACACTTGCTCCATCAGTGTGTTCTCTGCCCCTTCCCCCCTTTTTTAAGCTTCCAAAGGTAC
GACGGCATTTTAGCTCCAGGTACTGGACGTTCCTCAGGCCCTGCTAAAGGAAGCAGCATAGGAC
AAGAGGCATTTTGGAGTAGAAAGGAATGGCTGTAGCCATTACACTTGGGGCCTGGGATTCTTTC
GTGAGACTGATCGCCCAGGGTTATACAGGGACACAAGCGATCCCTGGCCAACTTCCCACTTGCT
TTTCCCTTTTAGGGATTGGGGGCTCTGAGGAAGACCGAGCCCTGTCCTGCTCTGATGACCATAC
CGTGTGCCTTTCTACCTAGCAGCAAGTAATAAATTTAGTCCTCACCCAGGCCCTGGCAGAAATG
GACCCCTATTTGTGGGGTGTCTGTTTTGTAGGAAAGGACTTGGGACAAATCACCAGAAGCCATG
CTCTGTTCCTTCCCCTTCTCAGGGATTCCTGAGTATTTGCCTGAGTATGGCTGGCTGGGAGAGC
CAAGCTGTCAGACTCTTCCTCACCTTCCTTGGGAAGTGGTCTTCAGCACTGTTCTGACTCCAAA
GCTGTGACCAGCTGGCTCATTGCAGGGCAAGCACATATGTCCACTTCCCTCCTGTGTGCTCTAC
AGTGCATTCTGAGGCTCAGGGATGGTTGGTGTGACCCATGTCAGAGGGAGGCTGAGTTCCTGAG
CTCACACACTTTCCAGTGGTTAGAGCTATGCAGGACTCATCTCTGGGCCTACAGTGCATCATGC
TGGAGAAGTCCAGGAACCACCTAGCAGGCACCACTGGCTTGCCAGTGGCTAAAATGGAGACCCA
TCCTTTATAGTCTCAGCAGAGCCGGGGACCAAGCCGTTCCCTTCCTTGTGGTAGCACTGGCATG
GGGTGCTGGTGTTTTTCAGAGGGACCTGCTGCAGCCATTTTAATTCATGATTAGGAACCTTAGT
GCAACTTAAGACTTTCATTGTGTGTTTATGTGTGCATGCCATACCTAGCCGGTGACAGGGTGGG
TAGGGTGTCTAGTATCATGGTATCATGTGGCTTAGTAGGTGCCACAGTAACTTCTGCAAACATT
GTACTGTCTTGTTTCTGTATTAGAGGTAGCTAGTCATGTGGATATACTGACGTGTTCCTTTTAA
TATTACCAGTTTTATACTTGGAAAATGGTACTTGCCTCTTTGAAATCTGTTTTGTCTCCTCTAA
TGTCCCCATCGTCTCCAAGTCCTTTCCTAACTGCGGCAATAACTCTTCAGAAGCAATTGAATAA
TAAATGTCCCAAATCGTAA

hide sequence

RefSeq Acc Id:

XM_008772872 ⟹ XP_008771094

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	20	29,047,793 - 29,094,022 (-)	NCBI
Rnor_6.0	20	30,699,936 - 30,749,839 (-)	NCBI

Sequence:

show sequence

GCCGCGACGCAGTAGCAGAGGAGCCCTGAGGAGCCATCTGCAGAGGAAGATGCCGAGTACCGAC
CTTCTCAAGTTGAAGGACTTCGAGCCTTATTTGGAGATTTTGGAAGCATATTCCACAAAAGCCA
AGAATTACGTGAATGGGTACTGCACCAAATACGAGCCCTGGCAGCTCATTGCGGGGAGTGTCCT
GTGTACTCTGCTGGTAGTCTGGGTATATGAGCTTATCTTCCAGCCAGAGAGTTTATGGTCTCGG
TTTAAAAATAAATTATTTAGGCTTATAAGGAAGATGCCATTTATTGGACGTAAGATACAACAGC
AGCTTACCAAAGCCAAGAAGGATCTTGTCAAGAACATGCCATTCCTGAAGTTGGACAAAGATTA
TGTGAAAACCCTGCCTGCTCAGGGTCTGAGCACAGCTGAGGTTCTGGAGAGACTCAAGGAGTAC
AGCTCCATGGATGTCTTCTGGCAAGAAGGGAAAGCCTCAGGAGCTGTGTACAGTGGGGAGCCGA
AGCTCACCGAGCTGCTGGTGCAGGCTTACGGAGAATTCACGTGGAGCAATCCACTGCACCCAGA
TATCTTCCCCGGACTACGGAAGTTAGAGGCAGAAATCGTGAGGATGACTTGCTCCCTCTTCAAT
GGGGGGCCAGACTCCTGTGGATGTGTGACTTCTGGGGGAACAGAAAGCATCCTAATGGCCTGCA
AAGCATATCGGGACTTGGCCTTAGAGAAGGGGATCAAAACTCCAGAAATTGTGGCTCCTGAGAG
TGCCCACGCCGCATTCGACAAAGCAGCTCATTATTTCGGAATGAAGATTGTACGCGTTGCGCAG
AAAAAGAACATGGAGGTGGATGTGCGGGCAATGAAAAGAGCCATCTCCAGGAACACAGCCATGC
TGGTCTGTTCTGCCCCACAGTTTCCTCATGGTGTGATAGATCCTATCCCCGAAGTGGCCAAGCT
GGCTGTCAAATATAAAATCCCATTCCATGTGGATGCTTGTCTTGGGGGCTTCCTCATTGTCTTC
ATGGAGAAAGCAGGGTACCCACTGGAGAAACCATTTGATTTCCGGGTGAAAGGTGTGACCAGCA
TTTCAGCAGATACTCATAAGTACGGCTATGCTCCCAAAGGTTCATCAGTGGTGATGTACTCTAA
CGAGAAGTACAGGAAGTACCAGTTCTTTGTTGATGCAGATTGGCAAGGTGGCATCTACGCATCT
CCAAGCATAGCTGGCTCACGGCCTGGTGGCATCATTGCAGCCTGTTGGGCCGCCTTGATGCACT
TTGGTGAGAACGGCTATGTTGAAGCTACCAAACAGATCATCAAAACTGCTCGCTTCCTCAAGTC
AGAACTGGAAAACATCAAAAACATCTTCATTTTGGGGGATCCTCAATTGTCAGTTATTGCTCTG
GGCTCCAACGATTTTGACATCTACCGACTATCTAATATGATGTCTGCTAAGGGGTGGAATTTTA
ACTACTTGCAGTTCCCAAGAAGCATTCATTTCTGCATTACGTTAGTACATACTCGGAAGCGAGT
GGCAATCCAGTTCCTAAAGGATATCCGGGAATCGGTCACACAAATCATGAAGAATCCTAAAGCT
AAGACCACAGGAATGGGTGCCATCTATGGCATGGCCCAGGCAACCATTGACAGGAAGATGGTTG
CAGAAATATCCTCCGTCTTCTTGGACAGCCTTTATAGTACAGACCCTGTGACTCAGGGTAACCA
GATGAACGGTTCTCCAAAGCCCCGCTGAACTTTGACCCTTGATAGATCCATGGAACTTCAGGCC
TTCAGAAGGTTCTTGGCATTTAGAACCCACCACACACAACTTGACATCTGGACTGGCTCCTTAG
AGCACAAATAGGATAAACCGTAAGATAGCTTCAGCCTCAGGACTCCTTTGTCTCCTTTTGGGGC
TTTTAGTTTGAAGACCCTGAAGGATCCCACTGCATAATGAGTCTGCCCTGGTTATTAATGTTGC
CCTAGGAATTGTTTTAACCATATTTTCCTCTAACATCTTTAGCATCATCTTCACTTATGCGGCG
GCCCTGACCTGTCCTGATTGCTTAGGGAAAATGTGAGATAGCAAGAGGGTGTCTCAACGTTCTG
GCTGTCAGGCAGGGGGCATTTATGTACTGTGTTCCCTGGGTGGGTGCTAATCTGTCCCACTCGG
GGAGATTTCAGCCTCTGCGTCAGGAGATGCTGCTTGTCTCTCAGGATCGCTCTCATTACAACTT
GCTTTACTTTTCCAAGCACAAGTTGGCCAGGTTACTGGCCTCTCTTTTTTTTTAATTACTGGAG
TGTGTTCCCTTGACGGGGTTTGAAGTGCTCCTTTGTCTTGTGCACGACCATGGCTGCTGCCACC
TTTGGAGATGCCTGTTGGCCGTGATGCTCACACTTGTGTGTTCTTATTACTGTAGGGTAGGAAA
TGAACGTGTTTTTCAGAGAAGCTTGGGCTTTCTGGCTATTGGCGCTGCCTCGAGTCTGGAGTAG
GTGTAGATCACACCTGAGCCCTCTCCTGGGCCAGAGAAGCCAAAGCCAGCCCCTTCCCCATATT
TTCTTGAACAGCAGCATAGTAAGCACCTAGGTCATGCACATGTGGGCGGTGGTCTTCCCCTTCA
ACTTTGCCTTAAGCCTTCGTGTAATGAGAATCCAGTTTTATTGAAGAAAACACTCCACAAGTGT
CCTTGACTTCCCTCAGTGGGTGTGAAGACGTTTGGAGGACACTTGCTCCATCAGTGTGTTCTCT
GCCCCTTCCCCCCTTTTTTAAGCTTCCAAAGGTACGACGGCATTTTAGCTCCAGGTACTGGACG
TTCCTCAGGCCCTGCTAAAGGAAGCAGCATAGGACAAGAGGCATTTTGGAGTAGAAAGGAATGG
CTGTAGCCATTACACTTGGGGCCTGGGATTCTTTCGTGAGACTGATCGCCCAGGGTTATACAGG
GACACAAGCGATCCCTGGCCAACTTCCCACTTGCTTTTCCCTTTTAGGGATTGGGGGCTCTGAG
GAAGACCGAGCCCTGTCCTGCTCTGATGACCATACCGTGTGCCTTTCTACCTAGCAGCAAGTAA
TAAATTTAGTCCTCACCCAGGCCCTGGCAGAAATGGACCCCTATTTGTGGGGTGTCTGTTTTGT
AGGAAAGGACTTGGGACAAATCACCAGAAGCCATGCTCTGTTCCTTCCCCTTCTCAGGGATTCC
TGAGTATTTGCCTGAGTATGGCTGGCTGGGAGAGCCAAGCTGTCAGACTCTTCCTCACCTTCCT
TGGGAAGTGGTCTTCAGCACTGTTCTGACTCCAAAGCTGTGACCAGCTGGCTCATTGCAGGGCA
AGCACATATGTCCACTTCCCTCCTGTGTGCTCTACAGTGCATTCTGAGGCTCAGGGATGGTTGG
TGTGACCCATGTCAGAGGGAGGCTGAGTTCCTGAGCTCACACACTTTCCAGTGGTTAGAGCTAT
GCAGGACTCATCTCTGGGCCTACAGTGCATCATGCTGGAGAAGTCCAGGAACCACCTAGCAGGC
ACCACTGGCTTGCCAGTGGCTAAAATGGAGACCCATCCTTTATAGTCTCAGCAGAGCCGGGGAC
CAAGCCGTTCCCTTCCTTGTGGTAGCACTGGCATGGGGTGCTGGTGTTTTTCAGAGGGACCTGC
TGCAGCCATTTTAATTCATGATTAGGAACCTTAGTGCAACTTAAGACTTTCATTGTGTGTTTAT
GTGTGCATGCCATACCTAGCCGGTGACAGGGTGGGTAGGGTGTCTAGTATCATGGTATCATGTG
GCTTAGTAGGTGCCACAGTAACTTCTGCAAACATTGTACTGTCTTGTTTCTGTATTAGAGGTAG
CTAGTCATGTGGATATACTGACGTGTTCCTTTTAATATTACCAGTTTTATACTTGGAAAATGGT
ACTTGCCTCTTTGAAATCTGTTTTGTCTCCTCTAATGTCCCCATCGTCTCCAAGTCCTTTCCTA
ACTGCGGCAATAACTCTTCAGAAGCAATTGAATAATAAATGTCCCAAATCGTAA

hide sequence

RefSeq Acc Id:

XM_039098466 ⟹ XP_038954394

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	20	29,047,793 - 29,094,119 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_775139	(Get FASTA)	NCBI Sequence Viewer
	XP_008771093	(Get FASTA)	NCBI Sequence Viewer
	XP_008771094	(Get FASTA)	NCBI Sequence Viewer
	XP_038954394	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	CAD55407	(Get FASTA)	NCBI Sequence Viewer
	EDL93035	(Get FASTA)	NCBI Sequence Viewer
	EDL93036	(Get FASTA)	NCBI Sequence Viewer
	Q8CHN6	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_775139 ⟸ NM_173116

- UniProtKB:

Q8CHN6 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MPSTDLLKLKDFEPYLEILEAYSTKAKNYVNGYCTKYEPWQLIAGSVLCTLLVVWVYELIFQPE
SLWSRFKNKLFRLIRKMPFIGRKIQQQLTKAKKDLVKNMPFLKLDKDYVKTLPAQGLSTAEVLE
RLKEYSSMDVFWQEGKASGAVYSGEPKLTELLVQAYGEFTWSNPLHPDIFPGLRKLEAEIVRMT
CSLFNGGPDSCGCVTSGGTESILMACKAYRDLALEKGIKTPEIVAPESAHAAFDKAAHYFGMKI
VRVAQKKNMEVDVRAMKRAISRNTAMLVCSAPQFPHGVIDPIPEVAKLAVKYKIPFHVDACLGG
FLIVFMEKAGYPLEKPFDFRVKGVTSISADTHKYGYAPKGSSVVMYSNEKYRKYQFFVDADWQG
GIYASPSIAGSRPGGIIAACWAALMHFGENGYVEATKQIIKTARFLKSELENIKNIFILGDPQL
SVIALGSNDFDIYRLSNMMSAKGWNFNYLQFPRSIHFCITLVHTRKRVAIQFLKDIRESVTQIM
KNPKAKTTGMGAIYGMAQATIDRKMVAEISSVFLDSLYSTDPVTQGNQMNGSPKPR

hide sequence

RefSeq Acc Id:

XP_008771093 ⟸ XM_008772871

- Peptide Label:

isoform X1

- Sequence:

show sequence

MPSTDLLKLKDFEPYLEILEAYSTKAKNYVNGYCTKYEPWQLIAGSVLCTLLVVWVYELIFQPE
SLWSRFKNKLFRLIRKMPFIGRKIQQQLTKAKKDLVKNMPFLKLDKDYVKTLPAQGLSTAEVLE
RLKEYSSMDVFWQEGKASGAVYSGEPKLTELLVQAYGEFTWSNPLHPDIFPGLRKLEAEIVRMT
CSLFNGGPDSCGCVTSGGTESILMACKAYRDLALEKGIKTPEIVAPESAHAAFDKAAHYFGMKI
VRVAQKKNMEVDVRAMKRAISRNTAMLVCSAPQFPHGVIDPIPEVAKLAVKYKIPFHVDACLGG
FLIVFMEKAGYPLEKPFDFRVKGVTSISADTHKYGYAPKGSSVVMYSNEKYRKYQFFVDADWQG
GIYASPSIAGSRPGGIIAACWAALMHFGENGYVEATKQIIKTARFLKSELENIKNIFILGDPQL
SVIALGSNDFDIYRLSNMMSAKGWNFNYLQFPRSIHFCITLVHTRKRVAIQFLKDIRESVTQIM
KNPKAKTTGMGAIYGMAQATIDRKMVAEISSVFLDSLYSTDPVTQGNQMNGSPKPR

hide sequence

RefSeq Acc Id:	XP_008771094 ⟸ XM_008772872
- Peptide Label:	isoform X2
- UniProtKB:	Q8CHN6 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MPSTDLLKLKDFEPYLEILEAYSTKAKNYVNGYCTKYEPWQLIAGSVLCTLLVVWVYELIFQPE SLWSRFKNKLFRLIRKMPFIGRKIQQQLTKAKKDLVKNMPFLKLDKDYVKTLPAQGLSTAEVLE RLKEYSSMDVFWQEGKASGAVYSGEPKLTELLVQAYGEFTWSNPLHPDIFPGLRKLEAEIVRMT CSLFNGGPDSCGCVTSGGTESILMACKAYRDLALEKGIKTPEIVAPESAHAAFDKAAHYFGMKI VRVAQKKNMEVDVRAMKRAISRNTAMLVCSAPQFPHGVIDPIPEVAKLAVKYKIPFHVDACLGG FLIVFMEKAGYPLEKPFDFRVKGVTSISADTHKYGYAPKGSSVVMYSNEKYRKYQFFVDADWQG GIYASPSIAGSRPGGIIAACWAALMHFGENGYVEATKQIIKTARFLKSELENIKNIFILGDPQL SVIALGSNDFDIYRLSNMMSAKGWNFNYLQFPRSIHFCITLVHTRKRVAIQFLKDIRESVTQIM KNPKAKTTGMGAIYGMAQATIDRKMVAEISSVFLDSLYSTDPVTQGNQMNGSPKPR hide sequence

RefSeq Acc Id:

ENSRNOP00000059089 ⟸ ENSRNOT00000065127

RefSeq Acc Id:

ENSRNOP00000070983 ⟸ ENSRNOT00000084391

RefSeq Acc Id:	XP_038954394 ⟸ XM_039098466
- Peptide Label:	isoform X2
- UniProtKB:	Q8CHN6 (UniProtKB/Swiss-Prot)

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q8CHN6-F1-model_v2	AlphaFold	Q8CHN6	1-568	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13701600

Promoter ID:

EPDNEW_R12123

Type:

multiple initiation site

Name:

Sgpl1_1

Description:

sphingosine-1-phosphate lyase 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	20	30,749,961 - 30,750,021	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:628599	AgrOrtholog
BioCyc Gene	G2FUF-3729	BioCyc
Ensembl Genes	ENSRNOG00000000565	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000070983	ENTREZGENE
	ENSRNOP00000070983.2	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000084391	ENTREZGENE
	ENSRNOT00000084391.2	UniProtKB/TrEMBL
Gene3D-CATH	3.40.640.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.90.1150.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	PyrdxlP-dep_de-COase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PyrdxlP-dep_Trfase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PyrdxlP-dep_Trfase_dom1	UniProtKB/Swiss-Prot
	PyrdxlP-dep_Trfase_major	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PyrdxlP-dep_Trfase_small	UniProtKB/TrEMBL
KEGG Report	rno:286896	UniProtKB/Swiss-Prot
NCBI Gene	286896	ENTREZGENE
Pfam	Pyridoxal_deC	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Sgpl1	PhenoGen
Superfamily-SCOP	SSF53383	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8L2R514_RAT	UniProtKB/TrEMBL
	Q8CHN6	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-11-17	Sgpl1	sphingosine-1-phosphate lyase 1	Sgpl1	sphingosine phosphate lyase 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-12-17	Sgpl1	sphingosine phosphate lyase 1	Spgl1	sphingosine-1-phosphate lyase 1	Symbol and Name updated	1303942	APPROVED
2003-02-27	Spgl1	sphingosine-1-phosphate lyase 1			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_cellular_localization	localized to the microsomal fraction	727205

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)