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Gene: Sgpl1 (sphingosine-1-phosphate lyase 1) Rattus norvegicus
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Symbol: Sgpl1
Name: sphingosine-1-phosphate lyase 1
Description: Predicted to have sphinganine-1-phosphate aldolase activity. Predicted to be involved in several processes, including animal organ development; cellular hormone metabolic process; and sphingolipid metabolic process. Predicted to localize to the endoplasmic reticulum. Human ortholog(s) of this gene implicated in nephrotic syndrome type 14. Orthologous to human SGPL1 (sphingosine-1-phosphate lyase 1); PARTICIPATES IN Fabry disease pathway; Gaucher's disease pathway; Krabbe disease pathway; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: S1PL; SP-lyase 1; Spgl1; sphingosine phosphate lyase 1; sphingosine-1-phosphate aldolase; spl; SPL 1
Orthologs:
Homo sapiens (human) : SGPL1 (sphingosine-1-phosphate lyase 1)  HGNC  Alliance
Mus musculus (house mouse) : Sgpl1 (sphingosine phosphate lyase 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sgpl1 (sphingosine-1-phosphate lyase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SGPL1 (sphingosine-1-phosphate lyase 1)
Canis lupus familiaris (dog) : SGPL1 (sphingosine-1-phosphate lyase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sgpl1 (sphingosine-1-phosphate lyase 1)
Sus scrofa (pig) : SGPL1 (sphingosine-1-phosphate lyase 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.02030,699,936 - 30,769,178 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2030,699,872 - 30,749,940 (-)Ensembl
Rnor_5.02032,497,280 - 32,543,188 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42028,459,734 - 28,505,017 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12028,473,533 - 28,518,817 (-)NCBI
Celera2030,483,317 - 30,527,561 (-)NCBICelera
Cytogenetic Map20q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Sgpl1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 628599
Created: 2003-02-27
Species: Rattus norvegicus
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.