Gene: Sgpl1 (sphingosine-1-phosphate lyase 1) Rattus norvegicus
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Symbol: Sgpl1
Name: sphingosine-1-phosphate lyase 1
Description: ENCODES a protein that exhibits sphinganine-1-phosphate aldolase activity (ortholog); INVOLVED IN androgen metabolic process (ortholog); apoptotic signaling pathway (ortholog); ceramide metabolic process (ortholog); PARTICIPATES IN Fabry disease pathway; Gaucher's disease pathway; Krabbe disease pathway; ASSOCIATED WITH nephrotic syndrome type 14 (ortholog); FOUND IN endoplasmic reticulum (ortholog); INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene
AGR Description: Predicted to have pyridoxal phosphate binding activity and sphinganine-1-phosphate aldolase activity; predicted to be involved in several processes, including animal organ development, cellular hormone metabolic process, and membrane lipid metabolic process; predicted to localize to the endoplasmic reticulum; orthologous to human SGPL1 (sphingosine-1-phosphate lyase 1).
Merged Description: Predicted to have pyridoxal phosphate binding activity and sphinganine-1-phosphate aldolase activity; predicted to be involved in several processes, including animal organ development, cellular hormone metabolic process, and membrane lipid metabolic process; predicted to localize to the endoplasmic reticulum; orthologous to human SGPL1 (sphingosine-1-phosphate lyase 1); PARTICIPATES IN Fabry disease pathway; Gaucher's disease pathway; Krabbe disease pathway; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: S1PL; SP-lyase 1; Spgl1; sphingosine phosphate lyase 1; sphingosine-1-phosphate aldolase; spl; SPL 1
Orthologs:
Homo sapiens (human) : SGPL1 (sphingosine-1-phosphate lyase 1)  HGNC  Alliance
Mus musculus (house mouse) : Sgpl1 (sphingosine phosphate lyase 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sgpl1 (sphingosine-1-phosphate lyase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SGPL1 (sphingosine-1-phosphate lyase 1)
Canis lupus familiaris (dog) : SGPL1 (sphingosine-1-phosphate lyase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sgpl1 (sphingosine-1-phosphate lyase 1)
Sus scrofa (pig) : SGPL1 (sphingosine-1-phosphate lyase 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.02030,699,936 - 30,769,178 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02032,497,280 - 32,543,188 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42028,459,734 - 28,505,017 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12028,473,533 - 28,518,817 (-)NCBI
Celera2030,483,317 - 30,527,561 (-)NCBICelera
Cytogenetic Map20q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model

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Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
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Transcriptome
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Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

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Nomenclature History
RGD Curation Notes
  
More on Sgpl1
Alliance Gene
NCBI Gene
Ensembl Gene
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NCBI Genome Data Viewer

RGD Object Information
RGD ID: 628599
Created: 2003-02-27
Species: Rattus norvegicus
Last Modified: 2019-04-12
Status: ACTIVE



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