Fkbpl (FKBP prolyl isomerase like) - Rat Genome Database

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Gene: Fkbpl (FKBP prolyl isomerase like) Rattus norvegicus
Analyze
Symbol: Fkbpl
Name: FKBP prolyl isomerase like
RGD ID: 1303227
Description: Predicted to act upstream of or within regulation of blood vessel branching. Predicted to be located in extracellular region. Orthologous to human FKBPL (FKBP prolyl isomerase like); INTERACTS WITH 17beta-estradiol; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: FK506 binding protein-like; FK506-binding protein-like; WAF-1/CIP1 stabilizing protein 39; WISp39
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8204,104,457 - 4,105,927 (-)NCBIGRCr8
mRatBN7.2204,099,845 - 4,101,315 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl204,099,806 - 4,101,368 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx204,800,132 - 4,801,601 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0204,161,885 - 4,163,354 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0204,698,962 - 4,700,431 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0204,411,890 - 4,413,360 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl204,411,876 - 4,413,366 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0206,491,246 - 6,492,716 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4204,201,108 - 4,202,576 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1204,201,335 - 4,202,803 (-)NCBI
Celera203,928,889 - 3,930,356 (+)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GOA pipeline RGD automated data pipeline
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:25767277  


Genomics

Comparative Map Data
Fkbpl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8204,104,457 - 4,105,927 (-)NCBIGRCr8
mRatBN7.2204,099,845 - 4,101,315 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl204,099,806 - 4,101,368 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx204,800,132 - 4,801,601 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0204,161,885 - 4,163,354 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0204,698,962 - 4,700,431 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0204,411,890 - 4,413,360 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl204,411,876 - 4,413,366 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0206,491,246 - 6,492,716 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4204,201,108 - 4,202,576 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1204,201,335 - 4,202,803 (-)NCBI
Celera203,928,889 - 3,930,356 (+)NCBICelera
Cytogenetic Map20p12NCBI
FKBPL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38632,128,707 - 32,130,288 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl632,128,707 - 32,130,288 (-)EnsemblGRCh38hg38GRCh38
GRCh37632,096,484 - 32,098,065 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36632,204,462 - 32,206,045 (-)NCBINCBI36Build 36hg18NCBI36
Build 34632,204,462 - 32,206,045NCBI
Celera633,663,523 - 33,665,106 (-)NCBICelera
Cytogenetic Map6p21.32NCBI
HuRef631,850,605 - 31,852,188 (-)NCBIHuRef
CHM1_1632,098,694 - 32,100,277 (-)NCBICHM1_1
T2T-CHM13v2.0631,981,899 - 31,983,480 (-)NCBIT2T-CHM13v2.0
Fkbpl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391734,863,788 - 34,865,791 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1734,863,738 - 34,865,298 (+)EnsemblGRCm39 Ensembl
GRCm381734,644,814 - 34,646,817 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1734,644,764 - 34,646,324 (+)EnsemblGRCm38mm10GRCm38
MGSCv371734,781,828 - 34,783,272 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361734,252,939 - 34,254,383 (+)NCBIMGSCv36mm8
Celera1737,740,054 - 37,741,498 (+)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1718.22NCBI
Fkbpl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955437592,098 - 594,244 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955437592,098 - 594,244 (-)NCBIChiLan1.0ChiLan1.0
FKBPL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2546,591,277 - 46,593,789 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1642,552,747 - 42,555,261 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0631,775,596 - 31,777,862 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1632,656,077 - 32,657,714 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl632,656,101 - 32,657,150 (-)Ensemblpanpan1.1panPan2
FKBPL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1121,525,638 - 1,527,309 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl121,525,662 - 1,526,711 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha121,659,989 - 1,661,604 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0121,664,473 - 1,666,087 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl121,664,497 - 1,665,546 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1121,527,499 - 1,529,115 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0121,592,966 - 1,594,581 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0121,659,400 - 1,661,015 (-)NCBIUU_Cfam_GSD_1.0
Fkbpl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494636,085,732 - 36,087,296 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367271,474,533 - 1,475,582 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367271,474,052 - 1,475,602 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FKBPL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl724,172,238 - 24,173,405 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1724,172,227 - 24,174,553 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2727,993,041 - 27,994,660 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FKBPL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11739,898,926 - 39,900,760 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1739,899,687 - 39,900,733 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604432,030,895 - 32,032,520 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fkbpl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475424,181,330 - 24,184,748 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fkbpl
11 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:211
Count of miRNA genes:160
Interacting mature miRNAs:177
Transcripts:ENSRNOT00000000494
Prediction methods:Microtar, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125159026Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
2306850Pia40Pristane induced arthritis QTL 400.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2015279595304575Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
61448Ciaa1CIA Autoantibody QTL 1300.001blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)2026463954597031Rat
61472Aia1Adjuvant induced arthritis QTL 1180.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2026463954597031Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20289259726381954Rat
1300152Bp195Blood pressure QTL 1953.46arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2036216499243559Rat
1331772Cdexp2CD45RC expression in CD8 T cells QTL 25.7CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)20362164910078919Rat
737973Pia21Pristane induced arthritis QTL 214.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2036216564606812Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20362165614101050Rat

Markers in Region
D20Yum61  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2204,099,411 - 4,099,577 (-)MAPPERmRatBN7.2
Rnor_6.0204,413,628 - 4,413,793NCBIRnor6.0
Rnor_5.0206,492,984 - 6,493,149UniSTSRnor5.0
RGSC_v3.4204,200,675 - 4,200,840UniSTSRGSC3.4
Celera203,930,624 - 3,930,789UniSTS
Cytogenetic Map20p12UniSTS
RH138792  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2204,099,916 - 4,100,062 (-)MAPPERmRatBN7.2
Rnor_6.0204,413,143 - 4,413,288NCBIRnor6.0
Rnor_5.0206,492,499 - 6,492,644UniSTSRnor5.0
RGSC_v3.4204,201,180 - 4,201,325UniSTSRGSC3.4
Celera203,930,139 - 3,930,284UniSTS
RH 3.4 Map2053.23UniSTS
Cytogenetic Map20p12UniSTS
UniSTS:237630  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2204,099,920 - 4,100,134 (-)MAPPERmRatBN7.2
Rnor_6.0204,413,071 - 4,413,284NCBIRnor6.0
Rnor_5.0206,492,427 - 6,492,640UniSTSRnor5.0
RGSC_v3.4204,201,184 - 4,201,397UniSTSRGSC3.4
Celera203,930,067 - 3,930,280UniSTS
Cytogenetic Map20p12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 26 13 13 13 2 72 26 38
Low 1 17 44 28 19 28 8 9 2 9 3 11 8
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000000494   ⟹   ENSRNOP00000000494
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl204,099,806 - 4,101,368 (-)Ensembl
Rnor_6.0 Ensembl204,411,876 - 4,413,366 (+)Ensembl
RefSeq Acc Id: NM_001002818   ⟹   NP_001002818
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8204,104,457 - 4,105,927 (-)NCBI
mRatBN7.2204,099,845 - 4,101,315 (-)NCBI
Rnor_6.0204,411,890 - 4,413,360 (+)NCBI
Rnor_5.0206,491,246 - 6,492,716 (+)NCBI
RGSC_v3.4204,201,108 - 4,202,576 (-)RGD
Celera203,928,889 - 3,930,356 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001002818 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH86532 (Get FASTA)   NCBI Sequence Viewer  
  CAE83965 (Get FASTA)   NCBI Sequence Viewer  
  EDL83421 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000000494
  ENSRNOP00000000494.3
  ENSRNOP00065039256
GenBank Protein Q6MG81 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001002818   ⟸   NM_001002818
- UniProtKB: Q6MG81 (UniProtKB/Swiss-Prot),   A6KTJ1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000000494   ⟸   ENSRNOT00000000494

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6MG81-F1-model_v2 AlphaFold Q6MG81 1-347 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701349
Promoter ID:EPDNEW_R11872
Type:initiation region
Name:Fkbpl_1
Description:FK506 binding protein-like
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0204,411,901 - 4,411,961EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1303227 AgrOrtholog
BioCyc Gene G2FUF-4590 BioCyc
Ensembl Genes ENSRNOG00000000432 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00065027763 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000000494 ENTREZGENE
  ENSRNOT00000000494.7 UniProtKB/Swiss-Prot
  ENSRNOT00065047846 UniProtKB/Swiss-Prot
Gene3D-CATH 1.25.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7305083 IMAGE-MGC_LOAD
InterPro TPR-like_helical_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TPR_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TPR_repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:406168 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:105545 IMAGE-MGC_LOAD
NCBI Gene 406168 ENTREZGENE
PANTHER FKBP PROLYL ISOMERASE-LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PEPTIDYLPROLYL ISOMERASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam TPR_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TPR_16 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Fkbpl PhenoGen
PROSITE TPR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TPR_REGION UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000000432 RatGTEx
  ENSRNOG00065027763 RatGTEx
SMART TPR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP FKBP-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48452 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6KTJ1 ENTREZGENE, UniProtKB/TrEMBL
  FKBPL_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-11-09 Fkbpl  FKBP prolyl isomerase like  Fkbpl  FK506 binding protein-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-10-12 Fkbpl        Symbol and Name status set to provisional 70820 PROVISIONAL