Gene: Prf1 (perforin 1) Rattus norvegicus
Analyze
Symbol:
Prf1
Name:
perforin 1
RGD ID:
708463
Description:
Predicted to have calcium ion binding activity; identical protein binding activity; and wide pore channel activity. Involved in apoptotic process; circadian rhythm; and response to ethanol. Localizes to cytoplasmic vesicle and extracellular space. Used to study asthma; colon carcinoma; and glomerulonephritis. Biomarker of membranoproliferative glomerulonephritis. Human ortholog(s) of this gene implicated in several diseases, including Crohn's disease; familial hemophagocytic lymphohistiocytosis 2; human immunodeficiency virus infectious disease; multiple sclerosis; and non-Langerhans-cell histiocytosis. Orthologous to human PRF1 (perforin 1); PARTICIPATES IN allograft rejection pathway; autoimmune thyroiditis pathway; graft-versus-host disease pathway; INTERACTS WITH 1,2-dimethylhydrazine; 1-naphthyl isothiocyanate; 2,6-dinitrotoluene.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
Cyta; cytolysin; lymphocyte pore-forming protein; MGC108712; P1; perforin 1 (pore forming protein); perforin-1; RATCYTA
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
PRF1 (perforin 1) HGNC
Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):
Prf1 (perforin 1 (pore forming protein)) HGNC
Treefam, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Prf1 (perforin 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
PRF1 (perforin 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
PRF1 (perforin 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Prf1 (perforin 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
PRF1 (perforin 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):
PRF1 (perforin 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Prf1 (perforin 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Homo sapiens (human):
PRF1 (perforin 1)
Alliance
DIOPT (HGNC|Hieranoid|InParanoid|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB)
Mus musculus (house mouse):
Prf1 (perforin 1 (pore forming protein))
Alliance
DIOPT (Hieranoid|InParanoid|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB)
Danio rerio (zebrafish):
prf1.7 (perforin 1.7)
Alliance
DIOPT (InParanoid|OrthoFinder|OrthoInspector|PANTHER)
Danio rerio (zebrafish):
prf1.8 (perforin 1.8)
Alliance
DIOPT (InParanoid|OrthoFinder|OrthoInspector|PANTHER)
Danio rerio (zebrafish):
prf1.2 (perforin 1.2)
Alliance
DIOPT (InParanoid|OrthoFinder|OrthoInspector|PANTHER)
Danio rerio (zebrafish):
prf1.9 (perforin 1.9)
Alliance
DIOPT (Hieranoid|InParanoid|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB)
Danio rerio (zebrafish):
prf1.1 (perforin 1.1)
Alliance
DIOPT (Hieranoid|InParanoid|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 20 30,915,294 - 30,920,804 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 20 30,915,213 - 30,921,382 (+) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 20 32,706,313 - 32,711,823 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 20 28,658,367 - 28,663,877 (+) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 20 28,672,166 - 28,677,670 (+) NCBI Celera 20 30,679,378 - 30,684,888 (+) NCBI Celera Cytogenetic Map 20 q11 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Disease Annotations
RGD Manual Annotations
asthma ISO RGD:1553597 6482815 RGD asthma IDA 6482818 RGD Brain Injuries ISO RGD:1350272 6482807 RGD chronic fatigue syndrome ISO RGD:1350272 6482801 RGD Chronic Hepatitis C disease_progression ISO RGD:1350272 40813739 protein:increased expression:peripheral blood mononuclear cell (human) RGD colon carcinoma IDA 6482822 RGD Colonic Neoplasms ISO RGD:1553597 6482812 associated with Colitis RGD Crohn's disease ISO RGD:1350272 6482789 DNA:hypermethylation RGD Experimental Autoimmune Encephalomyelitis ISO RGD:1553597 6482806 RGD familial hemophagocytic lymphohistiocytosis 2 ISO RGD:1350272 6482809 DNA:missense mutations, nonsense mutations: :multiple RGD Fanconi anemia ISO RGD:1350272 6482802 RGD Flavivirus Infections ISO RGD:1553597 6482795 mRNA:increased expression:brain, spleen RGD glomerulonephritis IMP 6482824 RGD hemophagocytic lymphohistiocytosis ISO RGD:1553597 6482810 associated with Lymphocytic Choriomeningitis RGD human immunodeficiency virus infectious disease ISO RGD:1350272 6482808 RGD human immunodeficiency virus infectious disease ISO RGD:1350272 6482819 DNA:SNP: :rs885822 (human) RGD Macrophage Activation Syndrome ISO RGD:1350272 6482811 associated with Arthritis, Juvenile Rheumatoid, DNA:missense mutation:cds:p.A91V (human) RGD malaria ISO RGD:1553597 6482803 RGD membranoproliferative glomerulonephritis IEP 1599935 mRNA:increased expression:glomerulus RGD milker's nodule ISO RGD:1553597 6482788 RGD multiple sclerosis ISO RGD:1350272 6482817 protein:increased expression:blood, T cell RGD multiple sclerosis ISO RGD:1350272 6482820 DNA:SNPs:introns:c.-5+321C>T, c.539+82C>T (rs3758562, rs10999426) (human) RGD multiple sclerosis ISO RGD:1553597 6482805 RGD myocarditis ISO RGD:1553597 6482790 RGD non-Langerhans-cell histiocytosis ISO RGD:1350272 1599929 DNA:deletion, nonsense mutation, missense mutations: , Lymphohistiocytosis, Hemophagocytic, OMIM:603553 RGD systemic lupus erythematosus severity ISO RGD:1350272 6482798 RGD trypanosomiasis ISO RGD:1553597 6482814 RGD
Imported Annotations - ClinVar
aplastic anemia ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Aplastic anemia ClinVar PMID:17311987 more ... aplastic anemia ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Aplastic anemia ClinVar PMID:17311987 breast carcinoma ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Breast carcinoma ClinVar PMID:30311386 Familial Hemophagocytic Lymphohistiocytoses ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Familial hemophagocytic lymphohistiocytosis ClinVar PMID:10583959 more ... Familial Hemophagocytic Lymphohistiocytoses ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Familial hemophagocytic lymphohistiocytosis ClinVar PMID:11179007 more ... Familial Hemophagocytic Lymphohistiocytoses ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Familial hemophagocytic lymphohistiocytosis ClinVar Familial Hemophagocytic Lymphohistiocytoses ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Familial hemophagocytic lymphohistiocytosis ClinVar PMID:24033266 familial hemophagocytic lymphohistiocytosis 2 ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Familial hemophagocytic lymphohistiocytosis 2 ClinVar PMID:21674762 more ... familial hemophagocytic lymphohistiocytosis 2 ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Familial hemophagocytic lymphohistiocytosis 2 ClinVar PMID:26221353 , PMID:28492532 familial hemophagocytic lymphohistiocytosis 2 ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Familial hemophagocytic lymphohistiocytosis 2 ClinVar PMID:16860143 more ... familial hemophagocytic lymphohistiocytosis 2 ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Familial hemophagocytic lymphohistiocytosis 2 ClinVar PMID:21157294 familial hemophagocytic lymphohistiocytosis 2 ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Familial hemophagocytic lymphohistiocytosis 2 ClinVar PMID:16860143 , PMID:28492532 familial hemophagocytic lymphohistiocytosis 2 ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Familial hemophagocytic lymphohistiocytosis 2 ClinVar PMID:14757862 more ... familial hemophagocytic lymphohistiocytosis 2 ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Familial hemophagocytic lymphohistiocytosis 2 ClinVar PMID:25741868 , PMID:32963807 familial hemophagocytic lymphohistiocytosis 2 ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Familial hemophagocytic lymphohistiocytosis 2 ClinVar PMID:11179007 more ... familial hemophagocytic lymphohistiocytosis 2 ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Familial hemophagocytic lymphohistiocytosis 2 ClinVar PMID:15077010 more ... familial hemophagocytic lymphohistiocytosis 2 ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Hemophagocytic lymphohistiocytosis, familial, 2 ClinVar PMID:16278825 more ... familial hemophagocytic lymphohistiocytosis 2 ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Hemophagocytic lymphohistiocytosis, familial, 2 ClinVar PMID:11565555 more ... familial hemophagocytic lymphohistiocytosis 2 ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Hemophagocytic lymphohistiocytosis, familial, 2 ClinVar PMID:24033266 , PMID:25741868 familial hemophagocytic lymphohistiocytosis 2 ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Hemophagocytic lymphohistiocytosis, familial, 2 ClinVar PMID:26450956 , PMID:28492532 familial hemophagocytic lymphohistiocytosis 2 ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Familial hemophagocytic lymphohistiocytosis 2 ClinVar PMID:20638125 familial hemophagocytic lymphohistiocytosis 2 ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Familial hemophagocytic lymphohistiocytosis 2 ClinVar PMID:23592409 , PMID:28492532 familial hemophagocytic lymphohistiocytosis 2 ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Familial hemophagocytic lymphohistiocytosis 2 ClinVar PMID:10583959 more ... familial hemophagocytic lymphohistiocytosis 2 ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Familial hemophagocytic lymphohistiocytosis 2 ClinVar PMID:11179007 more ... familial hemophagocytic lymphohistiocytosis 2 ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Hemophagocytic lymphohistiocytosis, familial, 2 ClinVar PMID:17674359 familial hemophagocytic lymphohistiocytosis 2 ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Hemophagocytic lymphohistiocytosis, familial, 2 ClinVar PMID:10583959 more ... familial hemophagocytic lymphohistiocytosis 2 ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Familial hemophagocytic lymphohistiocytosis 2 ClinVar PMID:12060139 more ... familial hemophagocytic lymphohistiocytosis 2 ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Hemophagocytic lymphohistiocytosis, familial, 2 ClinVar PMID:21881043 more ... familial hemophagocytic lymphohistiocytosis 2 ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Familial hemophagocytic lymphohistiocytosis 2 ClinVar PMID:15728124 more ... familial hemophagocytic lymphohistiocytosis 2 ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Familial hemophagocytic lymphohistiocytosis 2 ClinVar PMID:18496551 more ... familial hemophagocytic lymphohistiocytosis 2 ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Hemophagocytic lymphohistiocytosis, familial, 2 ClinVar PMID:25326635 , PMID:25741868 familial hemophagocytic lymphohistiocytosis 2 ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Familial hemophagocytic lymphohistiocytosis 2 ClinVar PMID:25215106 more ... familial hemophagocytic lymphohistiocytosis 2 ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Hemophagocytic lymphohistiocytosis, familial, 2 ClinVar PMID:10583959 more ... familial hemophagocytic lymphohistiocytosis 2 ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Hemophagocytic lymphohistiocytosis, familial, 2, susceptibility to ClinVar PMID:12229880 more ... familial hemophagocytic lymphohistiocytosis 2 ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Hemophagocytic lymphohistiocytosis, familial, 2 ClinVar PMID:15632205 more ... familial hemophagocytic lymphohistiocytosis 2 ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Hemophagocytic lymphohistiocytosis, familial, 2 ClinVar PMID:25741868 familial hemophagocytic lymphohistiocytosis 2 ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Familial hemophagocytic lymphohistiocytosis 2 ClinVar PMID:17674359 , PMID:28492532 familial hemophagocytic lymphohistiocytosis 2 ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Familial hemophagocytic lymphohistiocytosis 2 ClinVar PMID:14757862 more ... familial hemophagocytic lymphohistiocytosis 2 ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Familial hemophagocytic lymphohistiocytosis 2 ClinVar PMID:21881043 more ... familial hemophagocytic lymphohistiocytosis 2 ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Familial hemophagocytic lymphohistiocytosis 2 ClinVar PMID:11565555 more ... familial hemophagocytic lymphohistiocytosis 2 ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Familial hemophagocytic lymphohistiocytosis 2 ClinVar PMID:10583959 more ... familial hemophagocytic lymphohistiocytosis 2 ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Familial hemophagocytic lymphohistiocytosis 2 ClinVar PMID:21881043 more ... familial hemophagocytic lymphohistiocytosis 2 ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Familial hemophagocytic lymphohistiocytosis 2 ClinVar PMID:11756153 more ... familial hemophagocytic lymphohistiocytosis 2 ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Familial hemophagocytic lymphohistiocytosis 2 ClinVar PMID:15755897 more ... familial hemophagocytic lymphohistiocytosis 2 ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Familial hemophagocytic lymphohistiocytosis 2 ClinVar PMID:28492532 , PMID:29665027 familial hemophagocytic lymphohistiocytosis 2 ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Hemophagocytic lymphohistiocytosis, familial, 2 ClinVar familial hemophagocytic lymphohistiocytosis 2 ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Familial hemophagocytic lymphohistiocytosis 2 ClinVar PMID:15632205 more ... familial hemophagocytic lymphohistiocytosis 2 ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Familial hemophagocytic lymphohistiocytosis 2 ClinVar PMID:25326637 more ... familial hemophagocytic lymphohistiocytosis 2 ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Familial hemophagocytic lymphohistiocytosis 2 ClinVar PMID:14757862 more ... familial hemophagocytic lymphohistiocytosis 2 ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Familial hemophagocytic lymphohistiocytosis 2 ClinVar PMID:26184781 , PMID:28492532 familial hemophagocytic lymphohistiocytosis 2 ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Hemophagocytic lymphohistiocytosis, familial, 2 ClinVar PMID:15609274 familial hemophagocytic lymphohistiocytosis 2 ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Familial hemophagocytic lymphohistiocytosis 2 ClinVar PMID:28492532 , PMID:29357941 familial hemophagocytic lymphohistiocytosis 2 ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Hemophagocytic lymphohistiocytosis, familial, 2 ClinVar PMID:17311987 more ... familial hemophagocytic lymphohistiocytosis 2 ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Familial hemophagocytic lymphohistiocytosis 2 ClinVar PMID:10583959 more ... familial hemophagocytic lymphohistiocytosis 2 ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Familial hemophagocytic lymphohistiocytosis 2 ClinVar PMID:15728124 more ... familial hemophagocytic lymphohistiocytosis 2 ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Hemophagocytic lymphohistiocytosis, familial, 2 ClinVar PMID:25741868 , PMID:28492532 familial hemophagocytic lymphohistiocytosis 2 ISO RGD:1350272 8554872 ClinVar Annotator: match by OMIM:603553 ClinVar PMID:10583959 , PMID:11179007 familial hemophagocytic lymphohistiocytosis 2 ISO RGD:1350272 8554872 ClinVar Annotator: match by OMIM:603553 ClinVar PMID:12716377 familial hemophagocytic lymphohistiocytosis 2 ISO RGD:1350272 8554872 ClinVar Annotator: match by OMIM:603553 ClinVar PMID:10583959 familial hemophagocytic lymphohistiocytosis 2 ISO RGD:1350272 8554872 ClinVar Annotator: match by OMIM:603553 ClinVar PMID:12599189 , PMID:7851014 familial hemophagocytic lymphohistiocytosis 2 ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Hemophagocytic lymphohistiocytosis, familial, 2 ClinVar PMID:28492532 genetic disease ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Inborn genetic diseases ClinVar PMID:15755897 more ... Visceral Heterotaxy 5, Autosomal ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Visceral heterotaxy 5, autosomal ClinVar PMID:28492532
Gene-Chemical Interaction Annotations
