Gene: Prf1 (perforin 1) Rattus norvegicus
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Symbol:
Prf1
Name:
perforin 1
Description:
Predicted to have calcium ion binding activity; identical protein binding activity; and wide pore channel activity. Involved in apoptotic process; circadian rhythm; and response to ethanol. Localizes to the cytoplasmic vesicle and extracellular space. Used to study asthma; colon carcinoma; and glomerulonephritis. Biomarker of membranoproliferative glomerulonephritis. Human ortholog(s) of this gene implicated in several diseases, including Crohn's disease; familial hemophagocytic lymphohistiocytosis 2; human immunodeficiency virus infectious disease; multiple sclerosis; and non-Langerhans-cell histiocytosis. Orthologous to human PRF1 (perforin 1); PARTICIPATES IN allograft rejection pathway; autoimmune thyroiditis pathway; graft-versus-host disease pathway; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 1,2-dimethylhydrazine; 1-naphthyl isothiocyanate.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
Cyta; cytolysin; lymphocyte pore-forming protein; MGC108712; P1; perforin 1 (pore forming protein); perforin-1; RATCYTA
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
PRF1 (perforin 1) HGNC
Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):
Prf1 (perforin 1 (pore forming protein)) HGNC
Treefam, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Prf1 (perforin 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
PRF1 (perforin 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
PRF1 (perforin 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Prf1 (perforin 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
PRF1 (perforin 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Homo sapiens (human):
PRF1 (perforin 1)
Alliance
DIOPT (HGNC, Hieranoid, InParanoid, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Mus musculus (house mouse):
Prf1 (perforin 1 (pore forming protein))
Alliance
DIOPT (Hieranoid, InParanoid, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Danio rerio (zebrafish):
prf1.2 (perforin 1.2)
Alliance
DIOPT (InParanoid, OrthoInspector, PANTHER)
Danio rerio (zebrafish):
prf1.9 (perforin 1.9)
Alliance
DIOPT (Hieranoid, InParanoid, OrthoInspector, PANTHER, PhylomeDB)
Danio rerio (zebrafish):
prf1.1 (perforin 1.1)
Alliance
DIOPT (Hieranoid, InParanoid, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 20 30,915,294 - 30,920,804 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_5.0 20 32,706,313 - 32,711,823 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 20 28,658,367 - 28,663,877 (+) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 20 28,672,166 - 28,677,670 (+) NCBI Celera 20 30,679,378 - 30,684,888 (+) NCBI Celera Cytogenetic Map 20 q11 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Disease Annotations
RGD Manual Annotations
asthma ISO RGD:1553597 6482815 RGD asthma IDA 6482818 RGD Brain Injuries ISO RGD:1350272 6482807 RGD chronic fatigue syndrome ISO RGD:1350272 6482801 RGD colon carcinoma IDA 6482822 RGD Colonic Neoplasms ISO RGD:1553597 6482812 associated with Colitis RGD Crohn's disease ISO RGD:1350272 6482789 DNA:hypermethylation RGD Experimental Autoimmune Encephalomyelitis ISO RGD:1553597 6482806 RGD familial hemophagocytic lymphohistiocytosis 2 ISO RGD:1350272 6482809 DNA:missense mutations, nonsense mutations: :multiple RGD Fanconi anemia ISO RGD:1350272 6482802 RGD Flavivirus Infections ISO RGD:1553597 6482795 mRNA:increased expression:brain, spleen RGD glomerulonephritis IMP 6482824 RGD hemophagocytic lymphohistiocytosis ISO RGD:1553597 6482810 associated with Lymphocytic Choriomeningitis RGD human immunodeficiency virus infectious disease ISO RGD:1350272 6482808 RGD human immunodeficiency virus infectious disease ISO RGD:1350272 6482819 DNA:SNP: :rs885822 (human) RGD Macrophage Activation Syndrome ISO RGD:1350272 6482811 associated with Arthritis, Juvenile Rheumatoid, DNA:missense mutation:cds:p.A91V (human) RGD malaria ISO RGD:1553597 6482803 RGD membranoproliferative glomerulonephritis IEP 1599935 mRNA:increased expression:glomerulus RGD milker's nodule ISO RGD:1553597 6482788 RGD multiple sclerosis ISO RGD:1350272 6482817 protein:increased expression:blood, T cell RGD multiple sclerosis ISO RGD:1350272 6482820 DNA:SNPs:introns:c.-5+321C>T, c.539+82C>T (rs3758562, rs10999426) (human) RGD multiple sclerosis ISO RGD:1553597 6482805 RGD myocarditis ISO RGD:1553597 6482790 RGD non-Langerhans-cell histiocytosis ISO RGD:1350272 1599929 DNA:deletion, nonsense mutation, missense mutations: , Lymphohistiocytosis, Hemophagocytic, OMIM:603553 RGD systemic lupus erythematosus severity ISO RGD:1350272 6482798 RGD trypanosomiasis ISO RGD:1553597 6482814 RGD
Imported Annotations - ClinVar
aplastic anemia ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Aplastic anemia, susceptibility to ClinVar PMID:12229880 more ... aplastic anemia ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Aplastic anemia ClinVar PMID:17311987 more ... aplastic anemia ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Aplastic anemia ClinVar PMID:17311987 Familial Hemophagocytic Lymphohistiocytoses ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Familial hemophagocytic lymphohistiocytosis ClinVar PMID:12060139 more ... Familial Hemophagocytic Lymphohistiocytoses ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Familial hemophagocytic lymphohistiocytosis ClinVar PMID:28492532 Familial Hemophagocytic Lymphohistiocytoses ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Familial hemophagocytic lymphohistiocytosis ClinVar PMID:21881043 more ... Familial Hemophagocytic Lymphohistiocytoses ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Familial hemophagocytic lymphohistiocytosis ClinVar PMID:24033266 , PMID:25741868 Familial Hemophagocytic Lymphohistiocytoses ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Familial hemophagocytic lymphohistiocytosis ClinVar PMID:17311987 more ... Familial Hemophagocytic Lymphohistiocytoses ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Familial hemophagocytic lymphohistiocytosis ClinVar PMID:25741868 , PMID:28492532 Familial Hemophagocytic Lymphohistiocytoses ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Familial hemophagocytic lymphohistiocytosis ClinVar Familial Hemophagocytic Lymphohistiocytoses ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Familial hemophagocytic lymphohistiocytosis ClinVar PMID:12229880 more ... Familial Hemophagocytic Lymphohistiocytoses ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Familial hemophagocytic lymphohistiocytosis ClinVar PMID:10583959 more ... familial hemophagocytic lymphohistiocytosis 2 ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Hemophagocytic lymphohistiocytosis, familial, 2 ClinVar PMID:16278825 more ... familial hemophagocytic lymphohistiocytosis 2 ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Hemophagocytic lymphohistiocytosis, familial, 2 ClinVar PMID:11565555 more ... familial hemophagocytic lymphohistiocytosis 2 ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Hemophagocytic lymphohistiocytosis, familial, 2 ClinVar PMID:24033266 , PMID:25741868 familial hemophagocytic lymphohistiocytosis 2 ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Hemophagocytic lymphohistiocytosis, familial, 2 ClinVar PMID:26450956 , PMID:28492532 familial hemophagocytic lymphohistiocytosis 2 ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Hemophagocytic lymphohistiocytosis, familial, 2 ClinVar PMID:15755897 more ... familial hemophagocytic lymphohistiocytosis 2 ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Hemophagocytic lymphohistiocytosis, familial, 2 ClinVar PMID:17674359 familial hemophagocytic lymphohistiocytosis 2 ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Hemophagocytic lymphohistiocytosis, familial, 2 ClinVar PMID:10583959 more ... familial hemophagocytic lymphohistiocytosis 2 ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Hemophagocytic lymphohistiocytosis, familial, 2 ClinVar PMID:21881043 more ... familial hemophagocytic lymphohistiocytosis 2 ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Hemophagocytic lymphohistiocytosis, familial, 2 ClinVar PMID:25326635 , PMID:25741868 familial hemophagocytic lymphohistiocytosis 2 ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Hemophagocytic lymphohistiocytosis, familial, 2 ClinVar PMID:10583959 more ... familial hemophagocytic lymphohistiocytosis 2 ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Hemophagocytic lymphohistiocytosis, familial, 2, susceptibility to ClinVar PMID:12229880 more ... familial hemophagocytic lymphohistiocytosis 2 ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Hemophagocytic lymphohistiocytosis, familial, 2 ClinVar PMID:15632205 more ... familial hemophagocytic lymphohistiocytosis 2 ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Hemophagocytic lymphohistiocytosis, familial, 2 ClinVar PMID:11756153 more ... familial hemophagocytic lymphohistiocytosis 2 ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Hemophagocytic lymphohistiocytosis, familial, 2 ClinVar PMID:25741868 familial hemophagocytic lymphohistiocytosis 2 ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Hemophagocytic lymphohistiocytosis, familial, 2 ClinVar PMID:12060139 more ... familial hemophagocytic lymphohistiocytosis 2 ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Hemophagocytic lymphohistiocytosis, familial, 2 ClinVar PMID:10583959 more ... familial hemophagocytic lymphohistiocytosis 2 ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Hemophagocytic lymphohistiocytosis, familial, 2 ClinVar familial hemophagocytic lymphohistiocytosis 2 ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Hemophagocytic lymphohistiocytosis, familial, 2 ClinVar PMID:19863536 more ... familial hemophagocytic lymphohistiocytosis 2 ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Hemophagocytic lymphohistiocytosis, familial, 2 ClinVar PMID:15609274 familial hemophagocytic lymphohistiocytosis 2 ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Hemophagocytic lymphohistiocytosis, familial, 2 ClinVar PMID:10583959 more ... familial hemophagocytic lymphohistiocytosis 2 ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Hemophagocytic lymphohistiocytosis, familial, 2 ClinVar PMID:17311987 more ... familial hemophagocytic lymphohistiocytosis 2 ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Hemophagocytic lymphohistiocytosis, familial, 2 ClinVar PMID:25741868 , PMID:28492532 familial hemophagocytic lymphohistiocytosis 2 ISO RGD:1350272 8554872 ClinVar Annotator: match by OMIM:603553 ClinVar PMID:10583959 , PMID:11179007 familial hemophagocytic lymphohistiocytosis 2 ISO RGD:1350272 8554872 ClinVar Annotator: match by OMIM:603553 ClinVar PMID:12716377 familial hemophagocytic lymphohistiocytosis 2 ISO RGD:1350272 8554872 ClinVar Annotator: match by OMIM:603553 ClinVar PMID:10583959 familial hemophagocytic lymphohistiocytosis 2 ISO RGD:1350272 8554872 ClinVar Annotator: match by OMIM:603553 ClinVar PMID:12599189 , PMID:7851014 familial hemophagocytic lymphohistiocytosis 2 ISO RGD:1350272 8554872 ClinVar Annotator: match by OMIM:603553 ClinVar PMID:25326637 familial hemophagocytic lymphohistiocytosis 2 ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Hemophagocytic lymphohistiocytosis, familial, 2 ClinVar PMID:28492532 genetic disease ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Inborn genetic diseases ClinVar PMID:15755897 more ... non-Hodgkin lymphoma ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Non-Hodgkin lymphoma ClinVar PMID:10583959 more ... non-Hodgkin lymphoma ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Lymphoma, non-hodgkin, susceptibility to ClinVar PMID:12229880 more ... non-Hodgkin lymphoma ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Familial non-Hodgkin lymphoma ClinVar PMID:10583959 more ... Visceral Heterotaxy 5, Autosomal ISO RGD:1350272 8554872 ClinVar Annotator: match by term: Visceral heterotaxy 5, autosomal ClinVar PMID:28492532
Imported Annotations - CTD
autistic disorder ISO RGD:1350272 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:18762240 non-alcoholic fatty liver disease ISO RGD:1350272 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:24211274 Imported Annotations - MGI
multiple sclerosis ISS RGD:1553597 13592920 OMIM:126200 more ... MouseDO type 1 diabetes mellitus ISS RGD:1553597 13592920 OMIM:222100 MouseDO Imported Annotations - OMIM
aplastic anemia ISO RGD:1350272 7240710 OMIM familial hemophagocytic lymphohistiocytosis 2 ISO RGD:1350272 7240710 OMIM non-Hodgkin lymphoma ISO RGD:1350272 7240710 OMIM
(S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE increases expression EXP 6480464 Topotecan results in increased expression of PRF1 mRNA CTD PMID:25729387 (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of PRF1 mRNA CTD PMID:25729387 1,2-dimethylhydrazine multiple interactions EXP 6480464 [APC protein affects the susceptibility to 1, 2-Dimethylhydrazine] which results in increased expression of PRF1 mRNA CTD PMID:27840820 1-naphthyl isothiocyanate decreases expression EXP 6480464 1-Naphthylisothiocyanate results in decreased expression of PRF1 mRNA CTD PMID:30723492 11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE decreases expression EXP 6480464 Nevirapine metabolite results in decreased expression of PRF1 mRNA CTD PMID:23947594 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1553597 6480464 Tetrachlorodibenzodioxin affects the expression of PRF1 mRNA CTD PMID:21570461 2,6-dinitrotoluene affects expression EXP 6480464 2, 6-dinitrotoluene affects the expression of PRF1 mRNA CTD PMID:21346803 2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione increases expression ISO RGD:1553597 6480464 Thalidomide results in increased expression of PRF1 CTD PMID:17089043 2-tert-butylhydroquinone multiple interactions ISO RGD:1553597 6480464 2-tert-butylhydroquinone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PRF1 protein] CTD PMID:30171972 3,4-methylenedioxymethamphetamine increases expression ISO RGD:1553597 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in increased expression of PRF1 mRNA CTD PMID:26251327 3,7-dihydropurine-6-thione increases expression EXP 6480464 Mercaptopurine results in increased expression of PRF1 mRNA CTD PMID:23358152 5-azacytidine multiple interactions ISO RGD:1350272 6480464 Azacitidine inhibits the reaction [IL2 protein results in increased secretion of PRF1 protein] CTD PMID:19394699 adenosine multiple interactions ISO RGD:1553597 6480464 [Adenosine co-treated with Coformycin] results in decreased expression of PRF1 mRNA CTD PMID:11992407 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of PRF1 mRNA CTD PMID:16483693 anthra[1,9-cd]pyrazol-6(2H)-one multiple interactions ISO RGD:1350272 6480464 pyrazolanthrone inhibits the reaction [resveratrol results in increased expression of PRF1 protein] CTD PMID:20082299 antirheumatic drug decreases expression ISO RGD:1350272 6480464 Antirheumatic Agents results in decreased expression of PRF1 mRNA CTD PMID:24449571 arsane affects expression ISO RGD:1350272 6480464 Arsenic affects the expression of PRF1 mRNA CTD PMID:18414638 arsenic atom affects expression ISO RGD:1350272 6480464 Arsenic affects the expression of PRF1 mRNA CTD PMID:18414638 arsenic(3+) affects expression ISO RGD:1350272 6480464 Arsenic affects the expression of PRF1 mRNA CTD PMID:18414638 benzo[a]pyrene increases expression ISO RGD:1553597 6480464 Benzo(a)pyrene results in increased expression of PRF1 mRNA CTD PMID:22228805 benzo[b]fluoranthene decreases expression ISO RGD:1553597 6480464 benzo(b)fluoranthene results in decreased expression of PRF1 mRNA CTD PMID:26377693 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of PRF1 mRNA CTD PMID:25181051 bisphenol A affects methylation EXP 6480464 bisphenol A affects the methylation of PRF1 promoter CTD PMID:27415467 bortezomib decreases expression ISO RGD:1350272 6480464 Bortezomib results in decreased expression of PRF1 mRNA CTD PMID:20977926 bromodichloromethane multiple interactions ISO RGD:1553597 6480464 [PRF1 protein co-treated with RAG2 protein] affects the reaction [[bromodichloromethane co-treated with Dietary Fats] results in increased expression of CASP3 protein modified form] more ... CTD PMID:24211274 carbon nanotube decreases expression ISO RGD:1553597 6480464 Nanotubes, Carbon analog results in decreased expression of PRF1 mRNA CTD PMID:25554681 chloroprene decreases expression ISO RGD:1553597 6480464 Chloroprene results in decreased expression of PRF1 mRNA CTD PMID:23125180 coformycin multiple interactions ISO RGD:1553597 6480464 [Adenosine co-treated with Coformycin] results in decreased expression of PRF1 mRNA CTD PMID:11992407 dichloroacetic acid increases expression ISO RGD:1553597 6480464 Dichloroacetic Acid results in increased expression of PRF1 mRNA CTD PMID:28962523 dichlorvos decreases expression ISO RGD:1350272 6480464 Dichlorvos results in decreased expression of PRF1 mRNA, Dichlorvos results in decreased expression of PRF1 protein CTD PMID:16002202 ethanol multiple interactions ISO RGD:1553597 6480464 Ethanol inhibits the reaction [IL2 protein results in increased expression of PRF1 mRNA] CTD PMID:12700414 ferric oxide decreases expression ISO RGD:1553597 6480464 ferric oxide analog results in decreased expression of PRF1 mRNA CTD PMID:24525745 formaldehyde decreases expression ISO RGD:1553597 6480464 Formaldehyde results in decreased expression of PRF1 mRNA, Formaldehyde results in decreased expression of PRF1 protein CTD PMID:24060340 fulvestrant decreases expression ISO RGD:1350272 6480464 Fulvestrant results in decreased expression of PRF1 mRNA, Fulvestrant results in decreased expression of PRF1 protein CTD PMID:20145137 fulvestrant increases expression ISO RGD:1350272 6480464 [fulvestrant results in increased expression of TGFB1 protein] which results in increased expression of PRF1 mRNA CTD PMID:20145137 gentamycin increases expression EXP 6480464 Gentamicins results in increased expression of PRF1 mRNA CTD PMID:22061828 halothane affects response to substance ISO RGD:1553597 6480464 PRF1 protein affects the susceptibility to Halothane CTD PMID:21245496 halothane multiple interactions ISO RGD:1553597 6480464 PRF1 protein affects the reaction [Halothane results in increased expression of IFNG protein] CTD PMID:21245496 ionomycin multiple interactions ISO RGD:1553597 6480464 2-tert-butylhydroquinone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PRF1 protein], [Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PRF1 protein CTD PMID:30171972 L-ascorbic acid decreases expression ISO RGD:1553597 6480464 Ascorbic Acid deficiency results in decreased expression of PRF1 mRNA CTD PMID:22306178 mercaptopurine increases expression EXP 6480464 Mercaptopurine results in increased expression of PRF1 mRNA CTD PMID:23358152 nevirapine decreases expression EXP 6480464 Nevirapine metabolite results in decreased expression of PRF1 mRNA CTD PMID:23947594 nickel atom decreases expression ISO RGD:1350272 6480464 Nickel results in decreased expression of PRF1 mRNA CTD PMID:23195993 nickel atom increases expression ISO RGD:1350272 6480464 Nickel results in increased expression of PRF1 mRNA CTD PMID:25583101 oxaliplatin increases expression EXP 6480464 oxaliplatin results in increased expression of PRF1 mRNA CTD PMID:25729387 oxaliplatin multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of PRF1 mRNA CTD PMID:25729387 p-menthan-3-ol decreases expression ISO RGD:1350272 6480464 Menthol results in decreased expression of PRF1 mRNA CTD PMID:26760959 Pentoxifylline decreases secretion ISO RGD:1350272 6480464 Pentoxifylline results in decreased secretion of PRF1 protein CTD PMID:17880773 phorbol 13-acetate 12-myristate multiple interactions ISO RGD:1553597 6480464 2-tert-butylhydroquinone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PRF1 protein], [Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PRF1 protein CTD PMID:30171972 poly(I:C) multiple interactions ISO RGD:1350272 6480464 Particulate Matter inhibits the reaction [Poly I-C results in increased expression of PRF1 protein], Vehicle Emissions inhibits the reaction [Poly I-C results in increased expression of PRF1 protein] CTD PMID:23618096 poly(I:C) increases expression ISO RGD:1350272 6480464 Poly I-C results in increased expression of PRF1 mRNA, Poly I-C results in increased expression of PRF1 protein CTD PMID:23618096 purine-6-thiol increases expression EXP 6480464 Mercaptopurine results in increased expression of PRF1 mRNA CTD PMID:23358152 pyrrolidine dithiocarbamate multiple interactions ISO RGD:1553597 6480464 pyrrolidine dithiocarbamic acid inhibits the reaction [IL2 protein results in increased expression of PRF1 mRNA] CTD PMID:12700414 resveratrol multiple interactions ISO RGD:1350272 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [resveratrol results in increased expression of PRF1 protein] more ... CTD PMID:20082299 resveratrol increases expression ISO RGD:1350272 6480464 resveratrol results in increased expression of PRF1 mRNA, resveratrol results in increased expression of PRF1 protein CTD PMID:20082299 serpentine asbestos decreases expression ISO RGD:1350272 6480464 Asbestos, Serpentine results in decreased expression of PRF1 protein CTD PMID:19822075 sirolimus decreases expression ISO RGD:1350272 6480464 Sirolimus results in decreased expression of PRF1 protein CTD PMID:16477233 tamoxifen decreases expression ISO RGD:1350272 6480464 Tamoxifen results in decreased expression of PRF1 mRNA, Tamoxifen results in decreased expression of PRF1 protein CTD PMID:20145137 tamoxifen increases expression ISO RGD:1350272 6480464 [Tamoxifen results in increased expression of TGFB1 protein] which results in increased expression of PRF1 mRNA CTD PMID:20145137 testosterone enanthate affects expression ISO RGD:1350272 6480464 testosterone enanthate affects the expression of PRF1 mRNA CTD PMID:17440010 tetrachloromethane decreases expression EXP 6480464 Carbon Tetrachloride results in decreased expression of PRF1 mRNA CTD PMID:31150632 thalidomide increases expression ISO RGD:1553597 6480464 Thalidomide results in increased expression of PRF1 CTD PMID:17089043 thioacetamide decreases expression EXP 6480464 Thioacetamide results in decreased expression of PRF1 mRNA CTD PMID:23411599 titanium dioxide increases expression ISO RGD:1553597 6480464 titanium dioxide analog results in increased expression of PRF1 mRNA, titanium dioxide results in increased expression of PRF1 mRNA CTD PMID:23557971 , PMID:25111187 topotecan increases expression EXP 6480464 Topotecan results in increased expression of PRF1 mRNA CTD PMID:25729387 topotecan multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of PRF1 mRNA CTD PMID:25729387 triclosan decreases expression ISO RGD:1350272 6480464 Triclosan results in decreased expression of PRF1 mRNA CTD PMID:30510588 tris(2-butoxyethyl) phosphate affects expression ISO RGD:1350272 6480464 tris(2-butoxyethyl) phosphate affects the expression of PRF1 mRNA CTD PMID:29024780 urethane decreases expression ISO RGD:1553597 6480464 Urethane results in decreased expression of PRF1 mRNA CTD PMID:12400877 urethane multiple interactions ISO RGD:1553597 6480464 [Urethane co-treated with Freund's Adjuvant] results in decreased expression of PRF1 mRNA CTD PMID:12400877 valproic acid increases methylation ISO RGD:1350272 6480464 Valproic Acid results in increased methylation of PRF1 gene CTD PMID:29154799 valproic acid increases expression ISO RGD:1350272 6480464 Valproic Acid results in increased expression of PRF1 mRNA CTD PMID:28001369 ziram decreases expression ISO RGD:1350272 6480464 Ziram results in decreased expression of PRF1 protein CTD PMID:21859362 , PMID:22038140
Biological Process apoptotic process IDA 6482825 RGD circadian rhythm IMP 1599931 RGD cytolysis IEA UniProtKB:P10820 , ensembl:ENSMUSP000001513541600115 GO_REF:0000107 Ensembl GO_REF:0000107 cytolysis ISO RGD:1553597 1624291 (MGI:MGI:66009, PMID:8164737) RGD MGI:MGI:66009 , PMID:8164737 cytolysis ISS UniProtKB:P10820 1600115 GO_REF:0000024 UniProt GO_REF:0000024 defense response to tumor cell ISO RGD:1553597 1624291 (MGI:MGI:66009, PMID:8164737) RGD MGI:MGI:66009 , PMID:8164737 defense response to tumor cell ISS UniProtKB:P10820 1600115 GO_REF:0000024 UniProt GO_REF:0000024 defense response to tumor cell IEA UniProtKB:P10820 , ensembl:ENSMUSP000001513541600115 GO_REF:0000107 Ensembl GO_REF:0000107 defense response to virus ISO RGD:1553597 1624291 (MGI:MGI:66009, PMID:8164737) RGD MGI:MGI:66009 , PMID:8164737 defense response to virus ISS UniProtKB:P10820 1600115 GO_REF:0000024 UniProt GO_REF:0000024 defense response to virus IEA UniProtKB:P10820 , ensembl:ENSMUSP000001513541600115 GO_REF:0000107 Ensembl GO_REF:0000107 immune response to tumor cell ISO RGD:1553597 1624291 (MGI:MGI:66009, PMID:8164737) RGD MGI:MGI:66009 , PMID:8164737 immune response to tumor cell ISS UniProtKB:P10820 1600115 GO_REF:0000024 UniProt GO_REF:0000024 immune response to tumor cell IEA UniProtKB:P10820 , ensembl:ENSMUSP000001513541600115 GO_REF:0000107 Ensembl GO_REF:0000107 immunological synapse formation ISO RGD:1350272 1624291 (PMID:21438968) RGD PMID:21438968 immunological synapse formation IEA UniProtKB:P14222 , ensembl:ENSP000003985681600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of killing of cells of other organism ISO RGD:1350272 1624291 (PMID:9756476) RGD PMID:9756476 positive regulation of killing of cells of other organism IEA UniProtKB:P14222 , ensembl:ENSP000003985681600115 GO_REF:0000107 Ensembl GO_REF:0000107 protein homooligomerization ISO RGD:1350272 1624291 (PMID:20889983) RGD PMID:20889983 protein homooligomerization ISS UniProtKB:P14222 1600115 GO_REF:0000024 UniProt GO_REF:0000024 protein homooligomerization IEA UniProtKB:P14222 , ensembl:ENSP000003985681600115 GO_REF:0000107 Ensembl GO_REF:0000107 protein homooligomerization IEA UniProtKB:P10820 , ensembl:ENSMUSP000001513541600115 GO_REF:0000107 Ensembl GO_REF:0000107 protein homooligomerization ISO RGD:1553597 1624291 (MGI:MGI:5285144, PMID:21037563) RGD MGI:MGI:5285144 , PMID:21037563 response to ethanol IEP 1599933 RGD T cell mediated cytotoxicity IEA UniProtKB:P10820 , ensembl:ENSMUSP000001513541600115 GO_REF:0000107 Ensembl GO_REF:0000107 T cell mediated cytotoxicity ISO RGD:1553597 1624291 (MGI:MGI:3531039, PMID:15454490) RGD MGI:MGI:3531039 , PMID:15454490 transmembrane transport IEA GO:0022829 1600115 GO_REF:0000108 GOC GO_REF:0000108 Cellular Component cytolytic granule ISO RGD:1350272 1624291 (PMID:9756476) RGD PMID:9756476 cytolytic granule ISS UniProtKB:P10820 1600115 GO_REF:0000024 UniProt GO_REF:0000024 cytolytic granule IEA UniProtKB:P14222 , ensembl:ENSP000003985681600115 GO_REF:0000107 Ensembl GO_REF:0000107 cytolytic granule IEA UniProtKB:P10820 , ensembl:ENSMUSP000001513541600115 GO_REF:0000107 Ensembl GO_REF:0000107 cytolytic granule ISO RGD:1553597 1624291 (MGI:MGI:4430768 more ... RGD MGI:MGI:4430768 more ... cytoplasmic vesicle IDA 6482824 RGD cytoplasmic vesicle IEA UniProtKB:P10820 , ensembl:ENSMUSP000001513541600115 GO_REF:0000107 Ensembl GO_REF:0000107 cytoplasmic vesicle ISO RGD:1553597 1624291 (MGI:MGI:2179173, PMID:11856751) RGD MGI:MGI:2179173 , PMID:11856751 cytosol ISO RGD:1350272 1624291 RGD GO_REF:0000052 cytosol IEA UniProtKB:P14222 , ensembl:ENSP000003985681600115 GO_REF:0000107 Ensembl GO_REF:0000107 endosome lumen IEA UniProtKB-SubCell:SL-0327 1600115 GO_REF:0000039 UniProt GO_REF:0000039 extracellular space IDA 6482824 RGD integral component of membrane ISO RGD:1350272 1624291 (PMID:20889983) RGD PMID:20889983 integral component of membrane ISS UniProtKB:P14222 1600115 GO_REF:0000024 UniProt GO_REF:0000024 integral component of membrane IEA UniProtKB:P14222 , ensembl:ENSP000003985681600115 GO_REF:0000107 Ensembl GO_REF:0000107 integral component of membrane IEA UniProtKB:P10820 , ensembl:ENSMUSP000001513541600115 GO_REF:0000107 Ensembl GO_REF:0000107 integral component of membrane ISO RGD:1553597 1624291 (MGI:MGI:5285144, PMID:21037563) RGD MGI:MGI:5285144 , PMID:21037563 plasma membrane IEA UniProtKB-SubCell:SL-0039 1600115 GO_REF:0000039 UniProt GO_REF:0000039 Molecular Function calcium ion binding ISO RGD:1553597 1624291 (MGI:MGI:5285144, PMID:21037563) RGD MGI:MGI:5285144 , PMID:21037563 calcium ion binding ISS UniProtKB:P10820 1600115 GO_REF:0000024 UniProt GO_REF:0000024 calcium ion binding IEA UniProtKB:P10820 , ensembl:ENSMUSP000001513541600115 GO_REF:0000107 Ensembl GO_REF:0000107 identical protein binding ISO RGD:1350272 1624291 UniProtKB:P14222 (PMID:21037563), (PMID:21685908) RGD PMID:21037563 , PMID:21685908 identical protein binding IEA UniProtKB:P14222 , ensembl:ENSP000003985681600115 GO_REF:0000107 Ensembl GO_REF:0000107 molecular_function ND 1598407 02/2007: no relevant rat data RGD protein binding ISO RGD:1350272 1624291 UniProtKB:P10144 , UniProtKB:Q15323 (PMID:11911826), (PMID:25416956) RGD PMID:11911826 , PMID:25416956 wide pore channel activity ISO RGD:1350272 1624291 (PMID:20889983) RGD PMID:20889983 wide pore channel activity ISS UniProtKB:P14222 1600115 GO_REF:0000024 UniProt GO_REF:0000024 wide pore channel activity IEA UniProtKB:P14222 , ensembl:ENSP000003985681600115 GO_REF:0000107 Ensembl GO_REF:0000107 wide pore channel activity IEA UniProtKB:P10820 , ensembl:ENSMUSP000001513541600115 GO_REF:0000107 Ensembl GO_REF:0000107 wide pore channel activity ISO RGD:1553597 1624291 (MGI:MGI:5285144, PMID:21037563) RGD MGI:MGI:5285144 , PMID:21037563
Gene-Chemical Interaction Annotations
