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Gene: Prf1 (perforin 1) Rattus norvegicus
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Symbol: Prf1
Name: perforin 1
Description: Predicted to have calcium ion binding activity; identical protein binding activity; and wide pore channel activity. Involved in apoptotic process; circadian rhythm; and response to ethanol. Localizes to the cytoplasmic vesicle and extracellular space. Used to study asthma; colon carcinoma; and glomerulonephritis. Biomarker of membranoproliferative glomerulonephritis. Human ortholog(s) of this gene implicated in several diseases, including Crohn's disease; familial hemophagocytic lymphohistiocytosis 2; human immunodeficiency virus infectious disease; multiple sclerosis; and non-Langerhans-cell histiocytosis. Orthologous to human PRF1 (perforin 1); PARTICIPATES IN allograft rejection pathway; autoimmune thyroiditis pathway; graft-versus-host disease pathway; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 1,2-dimethylhydrazine; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Cyta; cytolysin; lymphocyte pore-forming protein; MGC108712; P1; perforin 1 (pore forming protein); perforin-1; RATCYTA
Orthologs:
Homo sapiens (human) : PRF1 (perforin 1)  HGNC  Alliance
Mus musculus (house mouse) : Prf1 (perforin 1 (pore forming protein))  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Prf1 (perforin 1)
Pan paniscus (bonobo/pygmy chimpanzee) : PRF1 (perforin 1)
Canis lupus familiaris (dog) : PRF1 (perforin 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Prf1 (perforin 1)
Sus scrofa (pig) : PRF1 (perforin 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.02030,915,294 - 30,920,804 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02032,706,313 - 32,711,823 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42028,658,367 - 28,663,877 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12028,672,166 - 28,677,670 (+)NCBI
Celera2030,679,378 - 30,684,888 (+)NCBICelera
Cytogenetic Map20q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Prf1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 708463
Created: 2003-09-23
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.