Gene: Prf1 (perforin 1) Rattus norvegicus
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Symbol: Prf1
Name: perforin 1
Description: ENCODES a protein that exhibits calcium ion binding (ortholog); identical protein binding (ortholog); wide pore channel activity (ortholog); INVOLVED IN apoptotic process; circadian rhythm; response to ethanol; PARTICIPATES IN allograft rejection pathway; autoimmune thyroiditis pathway; graft-versus-host disease pathway; ASSOCIATED WITH asthma; Colonic Neoplasms; glomerulonephritis; FOUND IN cytoplasmic vesicle; extracellular space; cytolytic granule (ortholog); INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 1,2-dimethylhydrazine; 11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Cyta; cytolysin; lymphocyte pore-forming protein; MGC108712; P1; perforin 1 (pore forming protein); perforin-1; RATCYTA
Orthologs:
Homo sapiens (human) : PRF1 (perforin 1)  HGNC  Alliance
Mus musculus (house mouse) : Prf1 (perforin 1 (pore forming protein))  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Prf1 (perforin 1)
Pan paniscus (bonobo/pygmy chimpanzee) : PRF1 (perforin 1)
Canis lupus familiaris (dog) : PRF1 (perforin 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Prf1 (perforin 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.02030,915,294 - 30,920,804 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02032,706,313 - 32,711,823 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42028,658,367 - 28,663,877 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12028,672,166 - 28,677,670 (+)NCBI
Celera2030,679,378 - 30,684,888 (+)NCBICelera
Cytogenetic Map20q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model

Annotation    (Toggle Annotation Detail/Summary View)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
  
More on Prf1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 708463
Created: 2003-09-23
Species: Rattus norvegicus
Last Modified: 2018-08-14
Status: ACTIVE



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