Aif1 (allograft inflammatory factor 1) - Rat Genome Database

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Gene: Aif1 (allograft inflammatory factor 1) Rattus norvegicus
Analyze
Symbol: Aif1
Name: allograft inflammatory factor 1
RGD ID: 61924
Description: Predicted to enable actin filament binding activity and calcium ion binding activity. Involved in several processes, including cellular response to morphine; positive regulation of muscle hyperplasia; and positive regulation of nitrogen compound metabolic process. Located in cytosol; lamellipodium; and perikaryon. Used to study type 1 diabetes mellitus. Biomarker of brain disease (multiple); glomerulonephritis; meningoencephalitis; and motor neuron disease. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human AIF1 (allograft inflammatory factor 1); INTERACTS WITH (+)-pilocarpine; (S)-colchicine; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AIF-1; balloon angioplasty responsive transcript; balloon angioplasty-responsive transcript 1; BART-1; Bart1; iba1; ionized calcium binding adapter molecule 1; ionized calcium-binding adapter molecule 1; microglia response factor; mrf-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Aif1tm(EGFP)Apps  
Genetic Models: SD-Aif1tm(EGFP)Apps/Mmmc
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2203,646,784 - 3,652,670 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl203,646,777 - 3,652,668 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx204,350,088 - 4,351,997 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0203,712,144 - 3,714,054 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0204,249,928 - 4,251,828 (+)NCBIRnor_WKY
Rnor_6.0205,161,350 - 5,167,176 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl205,161,333 - 5,166,448 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0207,234,609 - 7,240,454 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4203,714,428 - 3,716,327 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1203,714,654 - 3,716,552NCBI
Celera204,373,127 - 4,375,026 (-)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(S)-colchicine  (EXP)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,5-hexanedione  (EXP)
2-nitrofluorene  (EXP)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,3'-diindolylmethane  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
8-OH-DPAT  (ISO)
acetamide  (EXP)
aconitine  (EXP)
aflatoxin B1  (ISO)
agomelatine  (EXP)
all-trans-retinoic acid  (ISO)
allyl isothiocyanate  (EXP)
alpha-D-galactose  (EXP,ISO)
amentoflavone  (ISO)
aminoguanidine  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
apocynin  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzene  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
buspirone  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (EXP)
cannabidiol  (EXP)
carbon nanotube  (ISO)
chloroprene  (ISO)
chlorpyrifos  (EXP)
chrysene  (ISO)
cisplatin  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
Cuprizon  (EXP,ISO)
cyprodinil  (ISO)
dabigatran  (ISO)
decabromodiphenyl ether  (EXP)
diarsenic trioxide  (ISO)
diisopropyl fluorophosphate  (EXP)
diuron  (EXP)
doxorubicin  (ISO)
entinostat  (ISO)
ethanol  (EXP)
ethylmalonic acid  (EXP)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
galactose  (EXP,ISO)
gentamycin  (EXP)
ginsenoside Re  (ISO)
glyburide  (EXP,ISO)
hexachlorobenzene  (EXP)
Ibudilast  (EXP)
isoprenaline  (ISO)
kainic acid  (EXP,ISO)
ketamine  (EXP)
L-gamma-glutamyl-L-cysteine  (ISO)
lead diacetate  (EXP,ISO)
lipopolysaccharide  (EXP,ISO)
lycopene  (ISO)
Magnolol  (ISO)
maneb  (ISO)
manganese(II) chloride  (ISO)
medroxyprogesterone acetate  (ISO)
melatonin  (EXP)
mepanipyrim  (ISO)
methamphetamine  (ISO)
methylmalonic acid  (EXP)
methylmercury chloride  (ISO)
microcystin-LR  (ISO)
minocycline  (ISO)
morphine  (EXP)
Muraglitazar  (EXP)
mycophenolic acid  (EXP)
N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)cyclohexanecarboxamide  (ISO)
N-butylbenzenesulfonamide  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodimethylamine  (EXP)
NADP zwitterion  (EXP)
NADP(+)  (EXP)
nevirapine  (EXP)
nickel atom  (ISO)
nimesulide  (EXP)
nitrofen  (EXP)
Nonylphenol  (EXP)
Norbinaltorphimine  (ISO)
oxaliplatin  (EXP)
oxybenzone  (EXP)
p-menthan-3-ol  (ISO)
paraquat  (ISO)
permethrin  (ISO)
pirinixic acid  (EXP)
pravastatin  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (EXP)
Pyridostigmine bromide  (ISO)
pyrimethanil  (ISO)
quercetin  (EXP)
quinoline  (ISO)
resveratrol  (EXP,ISO)
rotenone  (EXP)
rottlerin  (ISO)
SCH 23390  (ISO)
senecionine  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (ISO)
sulpiride  (ISO)
tacrolimus hydrate  (ISO)
tadalafil  (ISO)
tamibarotene  (ISO)
Tesaglitazar  (EXP)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thioacetamide  (EXP,ISO)
titanium dioxide  (ISO)
tolcapone  (EXP)
toluene  (EXP,ISO)
topotecan  (EXP)
tributylstannane  (EXP)
trichloroethene  (EXP)
trimethyltin  (ISO)
valproic acid  (ISO)
vincaleukoblastine  (EXP)
zaragozic acid A  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin crosslink formation  (ISO)
actin filament bundle assembly  (IBA,ISO,ISS)
actin filament polymerization  (ISO,ISS)
cellular response to extracellular stimulus  (IEP)
cellular response to hormone stimulus  (IEP)
cellular response to hydroperoxide  (IEP)
cellular response to morphine  (IEP)
cellular response to oxidative stress  (ISO)
cellular response to type II interferon  (IEP,ISO)
cerebellum development  (IEP)
inflammatory response  (IEP)
macrophage activation  (NAS)
macrophage activation  (NAS)
negative regulation of apoptotic process  (IDA,IMP)
negative regulation of gene expression  (IMP)
negative regulation of smooth muscle cell chemotaxis  (ISO)
negative regulation of smooth muscle cell proliferation  (ISO)
parallel actin filament bundle assembly  (ISO)
phagocytosis, engulfment  (ISO,ISS)
positive regulation of cell migration  (IDA,IMP,ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of chemokine production  (ISO)
positive regulation of chemotaxis  (ISO)
positive regulation of fibroblast growth factor production  (ISO)
positive regulation of G1/S transition of mitotic cell cycle  (ISO,ISS)
positive regulation of interleukin-6 production  (ISO)
positive regulation of monocyte chemotaxis  (ISO,ISS)
positive regulation of mononuclear cell migration  (ISO)
positive regulation of muscle hyperplasia  (IMP)
positive regulation of nitric oxide biosynthetic process  (IDA,IMP)
positive regulation of protein phosphorylation  (IMP)
positive regulation of smooth muscle cell chemotaxis  (ISO,ISS)
positive regulation of smooth muscle cell proliferation  (IMP,ISO,ISS)
positive regulation of T cell migration  (ISO,ISS)
positive regulation of T cell proliferation  (ISO,ISS)
Rac protein signal transduction  (ISO,ISS)
response to axon injury  (IEP)
response to cytokine  (IEP)
response to electrical stimulus  (IEP)
response to glucocorticoid  (IEP)
ruffle assembly  (IBA,ISO,ISS)

Cellular Component
actin filament  (IBA,ISO,ISS)
cell projection  (IDA)
cytoplasm  (IDA,ISO)
cytoplasm  (ISO)
cytoplasm  (ISO)
cytosol  (IDA)
cytosol  (ISO)
cytosol  (ISO)
cytosol  (ISS)
glial cell projection  (ISO)
lamellipodium  (IDA,ISO,ISS)
nucleus  (ISO)
nucleus  (ISO)
nucleus  (ISO,ISS)
perikaryon  (IDA)
perinuclear region of cytoplasm  (ISO)
phagocytic cup  (ISO,ISS)
ruffle  (ISO)
ruffle membrane  (IBA,IEA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. CD4 microglial expression correlates with spontaneous clinical improvement in the acute Lewis rat EAE model. Almolda B, etal., J Neuroimmunol. 2009 Apr 30;209(1-2):65-80. Epub 2009 Feb 26.
2. Isolation and characterization of BART-1: A novel balloon angioplasty responsive transcript in rat carotid arteries. Autieri MV, etal., DNA Cell Biol 1996 Apr;15(4):297-304.
3. Use of differential display to identify differentially expressed mRNAs induced by rat carotid artery balloon angioplasty. Autieri MV, etal., Lab Invest 1995 Jun;72(6):656-61.
4. Experimental autoimmune neuritis induces differential microglia activation in the rat spinal cord. Beiter T, etal., J Neuroimmunol. 2005 Mar;160(1-2):25-31. Epub 2004 Dec 15.
5. Identification, isolation, and characterization of daintain (allograft inflammatory factor 1), a macrophage polypeptide with effects on insulin secretion and abundantly present in the pancreas of prediabetic BB rats. Chen ZW, etal., Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):13879-84.
6. Genetic variants of the HLA-A, HLA-B and AIF1 loci show independent associations with type 1 diabetes in Norwegian families. Eike MC, etal., Genes Immun. 2009 Mar;10(2):141-50. Epub 2008 Nov 6.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Developmental motor deficits induced by combined fetal exposure to lipopolysaccharide and early neonatal hypoxia/ischemia: a novel animal model for cerebral palsy in very premature infants. Girard S, etal., Neuroscience. 2009 Jan 23;158(2):673-82. Epub 2008 Oct 30.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Brief, low frequency stimulation of rat peripheral C-fibres evokes prolonged microglial-induced central sensitization in adults but not in neonates. Hathway GJ, etal., Pain. 2009 Apr 30.
11. Expression of allograft inflammatory factor-1 and haeme oxygenase-1 in brains of rats infected with the neurotropic Borna disease virus. Herden C, etal., Neuropathol Appl Neurobiol. 2005 Oct;31(5):512-21.
12. Warm ischemia-induced alterations in oxidative and inflammatory proteins in hepatic Kupffer cells in rats. Hirsch J, etal., Mol Cell Proteomics. 2006 Jun;5(6):979-86. Epub 2006 Feb 24.
13. Morphine enhances microglial migration through modulation of P2X4 receptor signaling. Horvath RJ and DeLeo JA, J Neurosci. 2009 Jan 28;29(4):998-1005.
14. Differential migration, LPS-induced cytokine, chemokine, and NO expression in immortalized BV-2 and HAPI cell lines and primary microglial cultures. Horvath RJ, etal., J Neurochem. 2008 Oct;107(2):557-69. Epub 2008 Sep 18.
15. Inflammation regulates functional integration of neurons born in adult brain. Jakubs K, etal., J Neurosci. 2008 Nov 19;28(47):12477-88.
16. Environment matters: synaptic properties of neurons born in the epileptic adult brain develop to reduce excitability. Jakubs K, etal., Neuron. 2006 Dec 21;52(6):1047-59.
17. Irradiation-induced loss of microglia in the young brain. Kalm M, etal., J Neuroimmunol. 2009 Jan 3;206(1-2):70-5. Epub 2008 Dec 13.
18. Bone marrow-derived mesenchymal stem cells reduce brain amyloid-beta deposition and accelerate the activation of microglia in an acutely induced Alzheimer's disease mouse model. Lee JK, etal., Neurosci Lett. 2009 Jan 30;450(2):136-41. Epub 2008 Dec 6.
19. Focal transplantation-based astrocyte replacement is neuroprotective in a model of motor neuron disease. Lepore AC, etal., Nat Neurosci. 2008 Nov;11(11):1294-301. Epub 2008 Oct 19.
20. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
21. Allograft inflammatory factor-1 augments macrophage phagocytotic activity and accelerates the progression of atherosclerosis in ApoE-/- mice. Mishima T, etal., Int J Mol Med. 2008 Feb;21(2):181-7.
22. Brain trauma induces expression of diacylglycerol kinase zeta in microglia. Nakano T, etal., Neurosci Lett. 2009 Sep 18;461(2):110-5. Epub 2009 Jun 9.
23. Involvement of microglia in the ethanol-induced neuropathic pain-like state in the rat. Narita M, etal., Neurosci Lett. 2007 Feb 27;414(1):21-5. Epub 2006 Dec 15.
24. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
25. Distinct cell proliferation events during abstinence after alcohol dependence: microglia proliferation precedes neurogenesis. Nixon K, etal., Neurobiol Dis. 2008 Aug;31(2):218-29. Epub 2008 May 3.
26. Cytoskeletal and activity-related changes in spinal motoneurons after root avulsion. Penas C, etal., J Neurotrauma. 2009 May;26(5):763-79.
27. Allograft-inflammatory-factor-1 is upregulated in microglial cells in human cerebral infarctions. Postler E, etal., J Neuroimmunol. 2000 Apr 3;104(1):85-91.
28. P2X7 receptor immunoreactive profile confined to resting and activated microglia in the epileptic brain. Rappold PM, etal., Brain Res. 2006 May 17;1089(1):171-8. Epub 2006 Apr 25.
29. GOA pipeline RGD automated data pipeline
30. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
31. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
32. Insulin and insulin-like growth factor expression and function deteriorate with progression of Alzheimer's disease: link to brain reductions in acetylcholine. Rivera EJ, etal., J Alzheimers Dis. 2005 Dec;8(3):247-68.
33. Sleep-dependent gene expression in the hippocampus and prefrontal cortex following long-term potentiation. Romcy-Pereira RN, etal., Physiol Behav. 2009 Aug 4;98(1-2):44-52. Epub 2009 Apr 20.
34. Time dependent changes of striatal interneurons after focal cerebral ischemia in rats. Sakuma M, etal., J Neural Transm. 2008;115(3):413-22. Epub 2008 Feb 26.
35. Retinal microglial activation and chemotaxis by docosahexaenoic acid hydroperoxide. Saraswathy S, etal., Invest Ophthalmol Vis Sci. 2006 Aug;47(8):3656-63.
36. Morphological and ultrastructural features of Iba1-immunolabeled microglial cells in the hippocampal dentate gyrus. Shapiro LA, etal., Brain Res. 2009 Apr 17;1266:29-36. Epub 2009 Feb 26.
37. Inhibition of allograft inflammatory factor-1 expression reduces development of neointimal hyperplasia and p38 kinase activity. Sommerville LJ, etal., Cardiovasc Res. 2009 Jan 1;81(1):206-15. Epub 2008 Sep 8.
38. Upregulation of a new microglial gene, mrf-1, in response to programmed neuronal cell death and degeneration. Tanaka S, etal., J Neurosci 1998 Aug 15;18(16):6358-69.
39. Long-term accumulation of microglia with proneurogenic phenotype concomitant with persistent neurogenesis in adult subventricular zone after stroke. Thored P, etal., Glia. 2009 Jun;57(8):835-49.
40. Expression of allograft inflammatory factor-1 in kidneys: A novel molecular component of podocyte. Tsubata Y, etal., Kidney Int. 2006 Dec;70(11):1948-54. Epub 2006 Oct 11.
41. Activation of dorsal horn microglia contributes to diabetes-induced tactile allodynia via extracellular signal-regulated protein kinase signaling. Tsuda M, etal., Glia. 2008 Mar;56(4):378-86.
42. Cloning and characterization of allograft inflammatory factor-1: a novel macrophage factor identified in rat cardiac allografts with chronic rejection. Utans U, etal., J Clin Invest 1995 Jun;95(6):2954-62.
43. Age-related changes in the spinal cord microglial and astrocytic response profile to nerve injury. Vega-Avelaira D, etal., Brain Behav Immun. 2007 Jul;21(5):617-23. Epub 2006 Dec 8.
44. Neuronal injury induces the release of pro-interleukin-1beta from activated microglia in vitro. Wang P, etal., Brain Res. 2008 Oct 21;1236:1-7. Epub 2008 Aug 8.
45. Delayed P2X4R expression after hypoxia-ischemia is associated with microglia in the immature rat brain. Wixey JA, etal., J Neuroimmunol. 2009 Jul 25;212(1-2):35-43. Epub 2009 May 17.
46. Allograft inflammatory factor-1 (AIF-1) is crucial for the survival and pro-inflammatory activity of macrophages. Yang ZF, etal., Int Immunol. 2005 Nov;17(11):1391-7. Epub 2005 Sep 12.
47. Antiinflammatory properties of IL-10 rescue small-for-size liver grafts. Yang ZF, etal., Liver Transpl. 2007 Apr;13(4):558-65.
48. Dexamethasone attenuates early expression of three molecules associated with microglia/macrophages activation following rat traumatic brain injury. Zhang Z, et al., Acta Neuropathol. 2007 Jun;113(6):675-82. Epub 2007 Jan 31.
Additional References at PubMed
PMID:8713135   PMID:9614071   PMID:10934045   PMID:11500035   PMID:11557666   PMID:12477932   PMID:12887599   PMID:14756805   PMID:15060004   PMID:15117732   PMID:15575896   PMID:16049345  
PMID:16987989   PMID:17011575   PMID:17565360   PMID:18699778   PMID:19745784   PMID:19815232   PMID:19861972   PMID:20572385   PMID:22116621   PMID:23701965   PMID:24571083   PMID:24796669  
PMID:26713069   PMID:28601280   PMID:29864618   PMID:33343805   PMID:34576050   PMID:35913387  


Genomics

Comparative Map Data
Aif1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2203,646,784 - 3,652,670 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl203,646,777 - 3,652,668 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx204,350,088 - 4,351,997 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0203,712,144 - 3,714,054 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0204,249,928 - 4,251,828 (+)NCBIRnor_WKY
Rnor_6.0205,161,350 - 5,167,176 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl205,161,333 - 5,166,448 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0207,234,609 - 7,240,454 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4203,714,428 - 3,716,327 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1203,714,654 - 3,716,552NCBI
Celera204,373,127 - 4,375,026 (-)NCBICelera
Cytogenetic Map20p12NCBI
AIF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38631,615,234 - 31,617,015 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl631,615,217 - 31,617,021 (+)EnsemblGRCh38hg38GRCh38
GRCh37631,583,011 - 31,584,792 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36631,691,012 - 31,692,777 (+)NCBINCBI36Build 36hg18NCBI36
Build 34631,691,767 - 31,692,777NCBI
Celera633,181,222 - 33,183,026 (+)NCBICelera
Cytogenetic Map6p21.33NCBI
HuRef631,369,335 - 31,370,975 (+)NCBIHuRef
CHM1_1631,585,130 - 31,586,934 (+)NCBICHM1_1
T2T-CHM13v2.0631,468,284 - 31,470,065 (+)NCBIT2T-CHM13v2.0
Aif1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391735,389,962 - 35,395,050 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1735,389,967 - 35,395,044 (-)EnsemblGRCm39 Ensembl
GRCm381735,170,986 - 35,176,083 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1735,170,991 - 35,176,068 (-)EnsemblGRCm38mm10GRCm38
MGSCv371735,307,937 - 35,312,946 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361734,779,048 - 34,784,057 (-)NCBIMGSCv36mm8
Celera1738,267,928 - 38,272,936 (-)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1718.59NCBI
Aif1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955437157,509 - 158,919 (+)NCBIChiLan1.0ChiLan1.0
AIF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1632,166,301 - 32,168,125 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl632,166,301 - 32,168,125 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0631,276,215 - 31,278,051 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
AIF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1121,104,350 - 1,106,179 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl121,104,394 - 1,106,177 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha121,240,799 - 1,242,629 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0121,249,600 - 1,251,430 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl121,249,645 - 1,251,403 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1121,108,905 - 1,110,735 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0121,176,225 - 1,178,056 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0121,243,086 - 1,244,917 (+)NCBIUU_Cfam_GSD_1.0
Aif1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494635,651,964 - 35,653,851 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367271,907,505 - 1,909,338 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049367271,907,493 - 1,909,350 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AIF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl723,726,787 - 23,731,671 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1723,711,752 - 23,731,191 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2727,520,797 - 27,540,237 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AIF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366604431,525,412 - 31,527,245 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Aif1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475424,590,071 - 24,591,904 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475424,590,071 - 24,591,913 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Aif1
79 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:115
Count of miRNA genes:82
Interacting mature miRNAs:88
Transcripts:ENSRNOT00000001135, ENSRNOT00000001138
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125159026Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
2306850Pia40Pristane induced arthritis QTL 400.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2015279595304575Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
61448Ciaa1CIA Autoantibody QTL 1300.001blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)2026463954597031Rat
61472Aia1Adjuvant induced arthritis QTL 1180.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2026463954597031Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20289259726381954Rat
1300152Bp195Blood pressure QTL 1953.46arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2036216499243559Rat
1331772Cdexp2CD45RC expression in CD8 T cells QTL 25.7CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)20362164910078919Rat
737973Pia21Pristane induced arthritis QTL 214.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2036216564606812Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20362165614101050Rat

Markers in Region
RH135373  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2203,651,910 - 3,652,637 (-)MAPPERmRatBN7.2
Rnor_6.0205,161,383 - 5,162,109NCBIRnor6.0
Rnor_5.0207,234,642 - 7,235,368UniSTSRnor5.0
RGSC_v3.4203,715,568 - 3,716,294UniSTSRGSC3.4
Celera204,373,160 - 4,373,886UniSTS
RH 3.4 Map2053.6UniSTS
Cytogenetic Map20p12UniSTS
MARC_5857-5858:997299374:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2203,651,240 - 3,651,828 (-)MAPPERmRatBN7.2
Rnor_6.0205,162,192 - 5,162,779NCBIRnor6.0
Rnor_5.0207,235,451 - 7,236,038UniSTSRnor5.0
RGSC_v3.4203,714,898 - 3,715,485UniSTSRGSC3.4
Celera204,373,969 - 4,374,556UniSTS
Cytogenetic Map20p12UniSTS
Aif1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2203,651,059 - 3,651,818 (-)MAPPERmRatBN7.2
Rnor_6.0205,162,202 - 5,162,960NCBIRnor6.0
Rnor_5.0207,235,461 - 7,236,219UniSTSRnor5.0
RGSC_v3.4203,714,717 - 3,715,475UniSTSRGSC3.4
Celera204,373,979 - 4,374,737UniSTS
Cytogenetic Map20p12UniSTS


Genetic Models
This gene Aif1 is modified in the following models/strains

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 1 47 36 19 36 19 10 21 11
Low 1 36 10 5 5 8 11 53 25 20 8
Below cutoff 6 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_017196 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006256061 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006256062 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006256063 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006256065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039098495 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB000818 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC094348 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF299328 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC081822 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX883046 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474121 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D82069 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM053942 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231499 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000323 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U10894 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U17919 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U33471 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000001135   ⟹   ENSRNOP00000001135
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl203,650,771 - 3,652,668 (+)Ensembl
Rnor_6.0 Ensembl205,161,356 - 5,163,247 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000001138   ⟹   ENSRNOP00000001138
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl203,649,975 - 3,652,668 (+)Ensembl
Rnor_6.0 Ensembl205,161,333 - 5,166,252 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000076331   ⟹   ENSRNOP00000068279
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl203,647,572 - 3,652,668 (+)Ensembl
Rnor_6.0 Ensembl205,161,350 - 5,166,448 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000076979
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl203,650,360 - 3,652,668 (+)Ensembl
Rnor_6.0 Ensembl205,161,350 - 5,163,660 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000097547   ⟹   ENSRNOP00000085491
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl203,646,777 - 3,652,668 (+)Ensembl
RefSeq Acc Id: NM_017196   ⟹   NP_058892
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2203,650,771 - 3,652,670 (+)NCBI
Rnor_6.0205,161,350 - 5,163,249 (-)NCBI
Rnor_5.0207,234,609 - 7,240,454 (-)NCBI
RGSC_v3.4203,714,428 - 3,716,327 (+)RGD
Celera204,373,127 - 4,375,026 (-)RGD
Sequence:
RefSeq Acc Id: XM_006256061   ⟹   XP_006256123
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2203,650,718 - 3,652,670 (+)NCBI
Rnor_6.0205,161,350 - 5,163,366 (-)NCBI
Rnor_5.0207,234,609 - 7,240,454 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006256062   ⟹   XP_006256124
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2203,647,747 - 3,652,670 (+)NCBI
Rnor_6.0205,161,350 - 5,166,254 (-)NCBI
Rnor_5.0207,234,609 - 7,240,454 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006256063   ⟹   XP_006256125
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2203,646,784 - 3,652,670 (+)NCBI
Rnor_6.0205,161,350 - 5,167,176 (-)NCBI
Rnor_5.0207,234,609 - 7,240,454 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006256065   ⟹   XP_006256127
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2203,647,577 - 3,652,670 (+)NCBI
Rnor_6.0205,161,350 - 5,166,443 (-)NCBI
Rnor_5.0207,234,609 - 7,240,454 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039098495   ⟹   XP_038954423
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2203,647,751 - 3,652,670 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_058892   ⟸   NM_017196
- UniProtKB: P70491 (UniProtKB/Swiss-Prot),   P55009 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006256125   ⟸   XM_006256063
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006256127   ⟸   XM_006256065
- Peptide Label: isoform X3
- UniProtKB: P55009 (UniProtKB/Swiss-Prot),   F1LRC2 (UniProtKB/TrEMBL),   A0A0G2JT08 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256124   ⟸   XM_006256062
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006256123   ⟸   XM_006256061
- Peptide Label: isoform X1
- UniProtKB: A0A8L2PZR6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000068279   ⟸   ENSRNOT00000076331
RefSeq Acc Id: ENSRNOP00000001135   ⟸   ENSRNOT00000001135
RefSeq Acc Id: ENSRNOP00000001138   ⟸   ENSRNOT00000001138
RefSeq Acc Id: XP_038954423   ⟸   XM_039098495
- Peptide Label: isoform X3
- UniProtKB: A0A0G2JT08 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000085491   ⟸   ENSRNOT00000097547
Protein Domains
EF-hand

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P55009-F1-model_v2 AlphaFold P55009 1-147 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701399
Promoter ID:EPDNEW_R11923
Type:initiation region
Name:Aif1_1
Description:allograft inflammatory factor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R11924  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0205,163,247 - 5,163,307EPDNEW
RGD ID:13701401
Promoter ID:EPDNEW_R11924
Type:initiation region
Name:Aif1_2
Description:allograft inflammatory factor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R11923  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0205,166,223 - 5,166,283EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61924 AgrOrtholog
BioCyc Gene G2FUF-4656 BioCyc
Ensembl Genes ENSRNOG00000000853 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000001135 ENTREZGENE
  ENSRNOP00000001135.4 UniProtKB/TrEMBL
  ENSRNOP00000001138.7 UniProtKB/TrEMBL
  ENSRNOP00000068279 ENTREZGENE
  ENSRNOP00000068279.1 UniProtKB/TrEMBL
  ENSRNOP00000085491.1 UniProtKB/TrEMBL
  ENSRNOP00000097049.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000001135 ENTREZGENE
  ENSRNOT00000001135.6 UniProtKB/TrEMBL
  ENSRNOT00000001138.7 UniProtKB/TrEMBL
  ENSRNOT00000076331 ENTREZGENE
  ENSRNOT00000076331.3 UniProtKB/TrEMBL
  ENSRNOT00000076979.2 UniProtKB/TrEMBL
  ENSRNOT00000097547.1 UniProtKB/TrEMBL
Gene3D-CATH EF-hand UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AIF1/AIF1L UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF-hand-dom_pair UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29427 UniProtKB/Swiss-Prot
NCBI Gene 29427 ENTREZGENE
PANTHER ALLOGRAFT INFLAMMATORY FACTOR 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10356 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Aif1 PhenoGen
PROSITE EF_HAND_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47473 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JT08 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A0A1_RAT UniProtKB/TrEMBL
  A0A8I6GLW1_RAT UniProtKB/TrEMBL
  A0A8L2PZR6 ENTREZGENE, UniProtKB/TrEMBL
  AIF1_RAT UniProtKB/Swiss-Prot
  F1LRC2 ENTREZGENE, UniProtKB/TrEMBL
  P55009 ENTREZGENE
  P70491 ENTREZGENE
UniProt Secondary P55007 UniProtKB/Swiss-Prot
  P70491 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-04-06 Aif1  allograft inflammatory factor 1   Bart1  balloon angioplasty responsive transcript  Data Merged 737654 APPROVED
2002-08-07 Bart1  balloon angioplasty responsive transcript      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Aif1  allograft inflammatory factor 1       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains two strongly hydrophilic and one hydrophobic region, suggesting a type II integral membrane protein 632014
gene_mapping found within the rat major histocompatibility RT1 complex 1300431
gene_process may play a role in macrophage activation and function 724707
gene_regulation transiently expressed in response to vascular trauma 632014
gene_regulation transiently expressed in response to vascular trauma 632015