Abcg1 (ATP binding cassette subfamily G member 1) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Abcg1 (ATP binding cassette subfamily G member 1) Rattus norvegicus
Analyze
Symbol: Abcg1
Name: ATP binding cassette subfamily G member 1
RGD ID: 620294
Description: Predicted to enable several functions, including adenyl ribonucleotide binding activity; protein dimerization activity; and sterol transporter activity. Involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus and positive regulation of secretory granule organization. Predicted to be located in external side of plasma membrane; mitochondrion; and recycling endosome. Predicted to be active in plasma membrane. Biomarker of end stage renal disease. Orthologous to human ABCG1 (ATP binding cassette subfamily G member 1); INTERACTS WITH (S)-nicotine; 1,2-dimethylhydrazine; 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Abc8; ATP-binding cassette sub-family G member 1; ATP-binding cassette, sub-family G (WHITE), member 1; ATP-binding cassette, subfamily G (WHITE), member 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8209,128,056 - 9,184,312 (+)NCBIGRCr8
mRatBN7.2209,126,687 - 9,182,948 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl209,126,687 - 9,182,948 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx209,822,332 - 9,878,177 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0209,183,506 - 9,239,357 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0209,658,037 - 9,713,910 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0209,743,269 - 9,842,735 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl209,743,269 - 9,840,489 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02011,922,393 - 12,022,892 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4209,390,485 - 9,459,574 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1209,390,711 - 9,459,801 (+)NCBI
Celera2010,652,719 - 10,708,365 (+)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
(24S)-24-hydroxycholesterol  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(S)-nicotine  (EXP,ISO)
1,2-dimethylhydrazine  (EXP)
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine  (EXP)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
22-Hydroxycholesterol  (ISO)
25-hydroxycholesterol  (ISO)
26-hydroxycholesterol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (EXP,ISO)
5-aza-2'-deoxycytidine  (ISO)
8-Br-cAMP  (ISO)
9-cis-retinoic acid  (ISO)
acetamide  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucosamine  (EXP)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphotericin B  (ISO)
antirheumatic drug  (ISO)
arachidonic acid  (ISO)
Aroclor 1254  (ISO)
atrazine  (EXP)
beauvericin  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
beta-D-glucosamine  (EXP)
beta-hexachlorocyclohexane  (ISO)
beta-naphthoflavone  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroacetaldehyde  (ISO)
cholesterol  (ISO)
cholic acid  (ISO)
cidofovir anhydrous  (ISO)
cisplatin  (ISO)
clodronic acid  (ISO)
clofibrate  (ISO)
clofibric acid  (EXP)
clothianidin  (ISO)
clozapine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumestrol  (ISO)
curcumin  (ISO)
cyclosporin A  (EXP,ISO)
cypermethrin  (ISO)
D-glucose  (ISO)
decabromodiphenyl ether  (EXP)
dextran sulfate  (ISO)
diazinon  (ISO)
dibutyl phthalate  (EXP,ISO)
dioxygen  (ISO)
disulfiram  (ISO)
diuron  (ISO)
endosulfan  (EXP)
enniatin  (ISO)
Enterolactone  (ISO)
entinostat  (ISO)
ethanol  (EXP,ISO)
fenofibrate  (EXP)
fenvalerate  (EXP)
flusilazole  (EXP)
gamma-hexachlorocyclohexane  (ISO)
gentamycin  (EXP)
glucose  (ISO)
graphene oxide  (ISO)
GW 3965  (ISO)
Heptachlor epoxide  (ISO)
hexadecanoic acid  (ISO)
high-density lipoprotein cholesterol  (ISO)
ibuprofen  (ISO)
ifosfamide  (ISO)
isotretinoin  (EXP)
ketamine  (EXP)
kuwanone G  (ISO)
linoleic acid  (ISO)
lipopolysaccharide  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methamphetamine  (EXP)
methapyrilene  (ISO)
methoxychlor  (EXP)
Morroniside  (ISO)
N-acetyl-L-cysteine  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
nickel atom  (ISO)
nickel dichloride  (ISO)
nicotine  (EXP,ISO)
nicotinic acid  (EXP,ISO)
obeticholic acid  (ISO)
ochratoxin A  (ISO)
octadecanoic acid  (ISO)
oleic acid  (ISO)
oxycodone  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pentachlorophenol  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
phenytoin  (ISO)
pirinixic acid  (ISO)
progesterone  (EXP,ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rifampicin  (ISO)
rosuvastatin calcium  (ISO)
rotenone  (EXP)
scopolamine  (EXP)
silicon dioxide  (ISO)
simvastatin  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
succimer  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tebuconazole  (ISO)
telmisartan  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
triadimefon  (ISO)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (EXP)
valproic acid  (ISO)
vecuronium bromide  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
xanthohumol  (ISO)
zinc atom  (EXP,ISO)
zinc sulfate  (EXP)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Niacin improves renal lipid metabolism and slows progression in chronic kidney disease. Cho KH, etal., Biochim Biophys Acta. 2010 Jan;1800(1):6-15. Epub 2009 Oct 28.
2. Xanthohumol ameliorates atherosclerotic plaque formation, hypercholesterolemia, and hepatic steatosis in ApoE-deficient mice. Doddapattar P, etal., Mol Nutr Food Res. 2013 Oct;57(10):1718-28. doi: 10.1002/mnfr.201200794. Epub 2013 May 3.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Specific gene expression of ATP-binding cassette transporters and nuclear hormone receptors in rat liver parenchymal, endothelial, and Kupffer cells. Hoekstra M, etal., J Biol Chem 2003 Jul 11;278(28):25448-53.
6. Control of insulin granule formation and function by the ABC transporters ABCG1 and ABCA1 and by oxysterol binding protein OSBP. Hussain SS, etal., Mol Biol Cell. 2018 May 15;29(10):1238-1257. doi: 10.1091/mbc.E17-08-0519. Epub 2018 Mar 22.
7. ABCG1 (ABC8), the human homolog of the Drosophila white gene, is a regulator of macrophage cholesterol and phospholipid transport. Klucken J, etal., Proc Natl Acad Sci U S A 2000 Jan 18;97(2):817-22.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Role of ABCG1 and other ABCG family members in lipid metabolism. Schmitz G, etal., J Lipid Res 2001 Oct;42(10):1513-20.
Additional References at PubMed
PMID:11500512   PMID:15210959   PMID:15319426   PMID:15994327   PMID:16556852   PMID:16702602   PMID:16780588   PMID:16870176   PMID:16941710   PMID:17241464   PMID:17293612   PMID:17408620  
PMID:17657311   PMID:17916878   PMID:21040802   PMID:21481393   PMID:21520072   PMID:21957962   PMID:22042635   PMID:22871113   PMID:24576892   PMID:24719980   PMID:25305669   PMID:25462452  
PMID:26707062   PMID:34256330   PMID:37972683  


Genomics

Comparative Map Data
Abcg1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8209,128,056 - 9,184,312 (+)NCBIGRCr8
mRatBN7.2209,126,687 - 9,182,948 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl209,126,687 - 9,182,948 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx209,822,332 - 9,878,177 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0209,183,506 - 9,239,357 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0209,658,037 - 9,713,910 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0209,743,269 - 9,842,735 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl209,743,269 - 9,840,489 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02011,922,393 - 12,022,892 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4209,390,485 - 9,459,574 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1209,390,711 - 9,459,801 (+)NCBI
Celera2010,652,719 - 10,708,365 (+)NCBICelera
Cytogenetic Map20p12NCBI
ABCG1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382142,199,689 - 42,297,244 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2142,199,689 - 42,297,244 (+)EnsemblGRCh38hg38GRCh38
GRCh372143,619,799 - 43,717,354 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362142,492,868 - 42,590,423 (+)NCBINCBI36Build 36hg18NCBI36
Build 342142,549,262 - 42,590,421NCBI
Celera2128,767,307 - 28,866,320 (+)NCBICelera
Cytogenetic Map21q22.3NCBI
HuRef2129,038,262 - 29,134,637 (+)NCBIHuRef
CHM1_12143,180,637 - 43,277,563 (+)NCBICHM1_1
T2T-CHM13v2.02140,589,747 - 40,686,722 (+)NCBIT2T-CHM13v2.0
Abcg1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391731,276,668 - 31,336,958 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1731,276,649 - 31,336,962 (+)EnsemblGRCm39 Ensembl
GRCm381731,057,694 - 31,117,984 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1731,057,675 - 31,117,988 (+)EnsemblGRCm38mm10GRCm38
MGSCv371731,194,639 - 31,254,929 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361730,777,799 - 30,842,789 (+)NCBIMGSCv36mm8
Celera1731,974,265 - 32,035,260 (+)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1715.8NCBI
Abcg1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540739,410,262 - 39,459,383 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540739,410,262 - 39,459,383 (-)NCBIChiLan1.0ChiLan1.0
ABCG1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22238,282,534 - 38,360,690 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12133,137,097 - 33,215,326 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02128,534,697 - 28,619,590 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12141,856,585 - 41,941,031 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2141,839,115 - 41,933,050 (+)Ensemblpanpan1.1panPan2
ABCG1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13136,574,406 - 36,627,598 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3136,553,380 - 36,620,043 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3135,705,119 - 35,775,022 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03136,070,404 - 36,140,582 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3136,070,329 - 36,137,398 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13135,963,992 - 36,033,708 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03135,943,824 - 36,013,708 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03136,438,763 - 36,508,785 (+)NCBIUU_Cfam_GSD_1.0
Abcg1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497135,789,248 - 35,844,939 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365001,620,641 - 1,678,607 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365001,620,763 - 1,678,561 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ABCG1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13205,561,951 - 205,628,425 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113205,561,897 - 205,628,428 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213215,898,408 - 215,965,031 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ABCG1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1286,098,818 - 86,176,101 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl286,099,414 - 86,179,949 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605413,960,459 - 14,143,791 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Abcg1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474528,104,744 - 28,188,704 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474528,137,140 - 28,188,670 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Abcg1
440 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:339
Count of miRNA genes:197
Interacting mature miRNAs:241
Transcripts:ENSRNOT00000001533
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125159026Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20289259726381954Rat
1300152Bp195Blood pressure QTL 1953.46arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2036216499243559Rat
1331772Cdexp2CD45RC expression in CD8 T cells QTL 25.7CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)20362164910078919Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20362165614101050Rat
4889857Pur27Proteinuria QTL 2712.20.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20460660717617956Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20460660717617956Rat
70154Insul2Insulin level QTL 23.75blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20669170617489458Rat
1581577Pur15Proteinuria QTL 154.380.0002urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)20804241017617956Rat
4889870Pur30Proteinuria QTL 30190.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20804241029322208Rat
631265Iresp1Immunoglobin response QTL18.3blood anti-double stranded DNA antibody amount (VT:0004762)serum anti-DNA antibody level (CMO:0001533)20903971913461775Rat

Markers in Region
RH141020  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2209,182,753 - 9,182,936 (+)MAPPERmRatBN7.2
Rnor_6.0209,840,295 - 9,840,477NCBIRnor6.0
Rnor_5.02012,020,452 - 12,020,634UniSTSRnor5.0
RGSC_v3.4209,459,380 - 9,459,562UniSTSRGSC3.4
Celera2010,708,171 - 10,708,353UniSTS
RH 3.4 Map20119.3UniSTS
Cytogenetic Map20p12UniSTS
BE119023  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2209,138,477 - 9,138,638 (+)MAPPERmRatBN7.2
Rnor_6.0209,796,553 - 9,796,713NCBIRnor6.0
Rnor_6.0209,755,105 - 9,755,265NCBIRnor6.0
Rnor_5.02011,976,710 - 11,976,870UniSTSRnor5.0
Rnor_5.02011,933,293 - 11,933,453UniSTSRnor5.0
RGSC_v3.4209,403,229 - 9,403,389UniSTSRGSC3.4
Celera2010,664,531 - 10,664,691UniSTS
RH 3.4 Map20117.7UniSTS
Cytogenetic Map20p12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 24 26 16 19 16 68 24 27 11
Low 1 19 31 25 25 8 10 6 11 14 8
Below cutoff 1

Sequence


RefSeq Acc Id: ENSRNOT00000001533   ⟹   ENSRNOP00000001533
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl209,126,687 - 9,182,948 (+)Ensembl
Rnor_6.0 Ensembl209,743,269 - 9,840,489 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000078031   ⟹   ENSRNOP00000074901
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl209,133,023 - 9,182,948 (+)Ensembl
Rnor_6.0 Ensembl209,791,171 - 9,839,038 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000083505   ⟹   ENSRNOP00000070267
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl209,126,687 - 9,151,422 (+)Ensembl
Rnor_6.0 Ensembl209,743,296 - 9,839,236 (+)Ensembl
RefSeq Acc Id: NM_053502   ⟹   NP_445954
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8209,128,056 - 9,184,312 (+)NCBI
mRatBN7.2209,126,687 - 9,182,948 (+)NCBI
Rnor_6.0209,743,269 - 9,840,489 (+)NCBI
Rnor_5.02011,922,393 - 12,022,892 (+)NCBI
RGSC_v3.4209,390,485 - 9,459,574 (+)RGD
Celera2010,652,719 - 10,708,365 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_445954 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAC21556 (Get FASTA)   NCBI Sequence Viewer  
  EDL96995 (Get FASTA)   NCBI Sequence Viewer  
  EDL96996 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000001533
  ENSRNOP00000001533.3
  ENSRNOP00000070267.2
  ENSRNOP00000074901.2
RefSeq Acc Id: NP_445954   ⟸   NM_053502
- UniProtKB: G3V642 (UniProtKB/TrEMBL),   A6JJX9 (UniProtKB/TrEMBL),   Q9EPG9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000074901   ⟸   ENSRNOT00000078031
RefSeq Acc Id: ENSRNOP00000070267   ⟸   ENSRNOT00000083505
RefSeq Acc Id: ENSRNOP00000001533   ⟸   ENSRNOT00000001533
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V642-F1-model_v2 AlphaFold G3V642 1-666 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701469
Promoter ID:EPDNEW_R11993
Type:initiation region
Name:Abcg1_1
Description:ATP binding cassette subfamily G member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0209,743,255 - 9,743,315EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620294 AgrOrtholog
BioCyc Gene G2FUF-4329 BioCyc
Ensembl Genes ENSRNOG00000001158 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000001533 ENTREZGENE
  ENSRNOT00000001533.5 UniProtKB/TrEMBL
  ENSRNOT00000078031.2 UniProtKB/TrEMBL
  ENSRNOT00000083505.2 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
InterPro ABC_2_trans UniProtKB/TrEMBL
  ABC_transporter-like UniProtKB/TrEMBL
  ABC_transporter_CS UniProtKB/TrEMBL
  ABCG_dom UniProtKB/TrEMBL
  ATPase_AAA+_core UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  Pigment_permease UniProtKB/TrEMBL
KEGG Report rno:85264 UniProtKB/TrEMBL
NCBI Gene 85264 ENTREZGENE
PANTHER ABC TRANSPORTER G FAMILY MEMBER 28 UniProtKB/TrEMBL
  PTHR48041:SF90 UniProtKB/TrEMBL
Pfam ABC2_membrane UniProtKB/TrEMBL
  ABC2_membrane_7 UniProtKB/TrEMBL
  ABC_tran UniProtKB/TrEMBL
PhenoGen Abcg1 PhenoGen
PROSITE ABC_TRANSPORTER_1 UniProtKB/TrEMBL
  ABC_TRANSPORTER_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000001158 RatGTEx
SMART AAA UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt A0A0G2JXH0_RAT UniProtKB/TrEMBL
  A0A0G2K987_RAT UniProtKB/TrEMBL
  A6JJX9 ENTREZGENE, UniProtKB/TrEMBL
  A6JJY0_RAT UniProtKB/TrEMBL
  G3V642 ENTREZGENE, UniProtKB/TrEMBL
  Q9EPG9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-09 Abcg1  ATP binding cassette subfamily G member 1  Abcg1  ATP-binding cassette, subfamily G (WHITE), member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-11-16 Abcg1  ATP-binding cassette, subfamily G (WHITE), member 1  Abcg1  ATP-binding cassette, sub-family G (WHITE), member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Abcg1  ATP-binding cassette, sub-family G (WHITE), member 1      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Abcg1  ATP-binding cassette, sub-family G (WHITE), member 1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression abundant in Kupffer and liver endothelial cells 632216
gene_product belongs to the ABCG (White) subfamily of transporters 634620
gene_regulation expression in liver parenchymal cells is induced by high cholesterol diet