Nus1 (NUS1 dehydrodolichyl diphosphate synthase subunit) - Rat Genome Database

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Gene: Nus1 (NUS1 dehydrodolichyl diphosphate synthase subunit) Rattus norvegicus
Analyze
Symbol: Nus1
Name: NUS1 dehydrodolichyl diphosphate synthase subunit
RGD ID: 1307879
Description: Predicted to contribute to dehydrodolichyl diphosphate synthase activity. Predicted to be involved in dolichol metabolic process; positive regulation of blood vessel endothelial cell migration; and vascular endothelial growth factor signaling pathway. Predicted to act upstream of or within cholesterol homeostasis; protein mannosylation; and regulation of intracellular cholesterol transport. Predicted to be located in membrane. Predicted to be part of dehydrodolichyl diphosphate synthase complex. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 55 and congenital disorder of glycosylation Iaa. Orthologous to human NUS1 (NUS1 dehydrodolichyl diphosphate synthase subunit); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: dehydrodolichyl diphosphate synthase complex subunit NUS1; LOC294400; nogo-B receptor; nuclear undecaprenyl pyrophosphate synthase 1; nuclear undecaprenyl pyrophosphate synthase 1 homolog; nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae); RGD1307879; similar to hypothetical protein D10Ertd438e
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82032,354,519 - 32,381,265 (+)NCBIGRCr8
mRatBN7.22031,811,817 - 31,838,562 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2031,811,817 - 31,838,561 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2032,816,930 - 32,844,014 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02032,207,839 - 32,234,926 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02032,937,789 - 32,964,535 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02033,557,052 - 33,584,011 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2033,557,052 - 33,584,010 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02035,336,831 - 35,363,790 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42031,143,886 - 31,170,668 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12031,144,058 - 31,181,953 (+)NCBI
Celera2033,209,636 - 33,236,417 (+)NCBICelera
Cytogenetic Map20q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:12947022   PMID:19723497   PMID:25066056   PMID:28602162   PMID:28842490   PMID:31154456   PMID:31442237   PMID:34662809  


Genomics

Comparative Map Data
Nus1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82032,354,519 - 32,381,265 (+)NCBIGRCr8
mRatBN7.22031,811,817 - 31,838,562 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2031,811,817 - 31,838,561 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2032,816,930 - 32,844,014 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02032,207,839 - 32,234,926 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02032,937,789 - 32,964,535 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02033,557,052 - 33,584,011 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2033,557,052 - 33,584,010 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02035,336,831 - 35,363,790 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42031,143,886 - 31,170,668 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12031,144,058 - 31,181,953 (+)NCBI
Celera2033,209,636 - 33,236,417 (+)NCBICelera
Cytogenetic Map20q11NCBI
NUS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386117,675,469 - 117,710,727 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6117,675,469 - 117,710,727 (+)EnsemblGRCh38hg38GRCh38
GRCh376117,996,632 - 118,031,890 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366118,103,310 - 118,138,583 (+)NCBINCBI36Build 36hg18NCBI36
Build 346118,103,362 - 118,136,441NCBI
Celera6118,739,521 - 118,774,823 (+)NCBICelera
Cytogenetic Map6q22.1NCBI
HuRef6115,577,729 - 115,612,992 (+)NCBIHuRef
CHM1_16118,260,511 - 118,295,775 (+)NCBICHM1_1
T2T-CHM13v2.06118,859,707 - 118,894,963 (+)NCBIT2T-CHM13v2.0
Nus1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391052,293,643 - 52,316,288 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1052,293,643 - 52,316,279 (+)EnsemblGRCm39 Ensembl
GRCm381052,417,547 - 52,440,192 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1052,417,547 - 52,440,183 (+)EnsemblGRCm38mm10GRCm38
MGSCv371052,137,353 - 52,159,998 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361052,106,015 - 52,125,181 (+)NCBIMGSCv36mm8
Celera1053,256,151 - 53,278,472 (+)NCBICelera
Cytogenetic Map10B3NCBI
cM Map1026.64NCBI
Nus1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955436825,387 - 850,558 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955436825,387 - 850,558 (+)NCBIChiLan1.0ChiLan1.0
NUS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25137,691,995 - 137,726,079 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16135,585,206 - 135,619,090 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06115,486,422 - 115,521,317 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16119,626,895 - 119,661,552 (+)NCBIpanpan1.1PanPan1.1panPan2
NUS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1157,866,760 - 57,895,505 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl157,866,879 - 57,893,077 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha158,669,766 - 58,698,455 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0158,050,809 - 58,079,510 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl158,050,871 - 58,079,506 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1157,952,148 - 57,980,842 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0157,793,092 - 57,821,772 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0158,424,589 - 58,453,383 (+)NCBIUU_Cfam_GSD_1.0
Nus1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946108,588,710 - 108,612,028 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936658695,609 - 718,746 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936658695,431 - 718,891 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NUS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl144,156,778 - 44,186,194 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1144,156,771 - 44,186,224 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2149,503,144 - 49,532,778 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NUS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11356,115,581 - 56,147,918 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1356,113,428 - 56,147,982 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604028,444,435 - 28,478,805 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nus1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479812,130,569 - 12,154,314 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479812,132,570 - 12,154,252 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nus1
444 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:229
Count of miRNA genes:152
Interacting mature miRNAs:168
Transcripts:ENSRNOT00000000467
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
7411652Foco24Food consumption QTL 240.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)201175751554435887Rat
9590092Insglur9Insulin/glucose ratio QTL 918.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)201175751554435887Rat
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)201761783247606836Rat
2317880Alcrsp25Alcohol response QTL 252.3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)201769755054435887Rat
2303626Vencon10Ventilatory control QTL 100.001respiration trait (VT:0001943)respiration rate (CMO:0000289)201919072154435887Rat
2303578Gluco50Glucose level QTL 502blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)202510672254435887Rat
2303587Bw93Body weight QTL 9313body mass (VT:0001259)body weight (CMO:0000012)202510672254435887Rat
2300188Bmd68Bone mineral density QTL 686.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)202510672254435887Rat
1331747Hrtrt16Heart rate QTL 163.163heart pumping trait (VT:2000009)heart rate (CMO:0000002)202520973454435887Rat
1598869Memor6Memory QTL 63.1exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)202924438854435887Rat
70158Bp60Blood pressure QTL 603arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)203161428444396023Rat

Markers in Region
RH130480  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22031,836,471 - 31,836,652 (+)MAPPERmRatBN7.2
Rnor_6.02033,581,921 - 33,582,101NCBIRnor6.0
Rnor_5.02035,361,700 - 35,361,880UniSTSRnor5.0
RGSC_v3.42031,168,578 - 31,168,758UniSTSRGSC3.4
Celera2033,234,327 - 33,234,507UniSTS
RH 3.4 Map20310.84UniSTS
Cytogenetic Map20q11UniSTS
RH130660  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22031,838,196 - 31,838,383 (+)MAPPERmRatBN7.2
Rnor_6.02033,583,646 - 33,583,832NCBIRnor6.0
Rnor_5.02035,363,425 - 35,363,611UniSTSRnor5.0
RGSC_v3.42031,170,303 - 31,170,489UniSTSRGSC3.4
Celera2033,236,052 - 33,236,238UniSTS
RH 3.4 Map20316.5UniSTS
Cytogenetic Map20q11UniSTS
UniSTS:236351  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera1752,785 - 52,868UniSTS
Cytogenetic Map20q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 34 57 41 19 41 1 3 74 35 39 11 1
Low 9 7 8 2 7
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000000467   ⟹   ENSRNOP00000000467
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2031,811,817 - 31,838,561 (+)Ensembl
Rnor_6.0 Ensembl2033,557,052 - 33,584,010 (+)Ensembl
RefSeq Acc Id: NM_001164157   ⟹   NP_001157629
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82032,354,519 - 32,381,265 (+)NCBI
mRatBN7.22031,811,817 - 31,838,562 (+)NCBI
Rnor_6.02033,557,052 - 33,584,011 (+)NCBI
Rnor_5.02035,336,831 - 35,363,790 (+)NCBI
RGSC_v3.42031,143,886 - 31,170,668 (+)RGD
Celera2033,209,636 - 33,236,417 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001157629 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL92936 (Get FASTA)   NCBI Sequence Viewer  
  EDL92937 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000000467
  ENSRNOP00000000467.4
RefSeq Acc Id: NP_001157629   ⟸   NM_001164157
- UniProtKB: D3ZFM4 (UniProtKB/TrEMBL),   A6K485 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000000467   ⟸   ENSRNOT00000000467

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZFM4-F1-model_v2 AlphaFold D3ZFM4 1-293 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701625
Promoter ID:EPDNEW_R12149
Type:multiple initiation site
Name:Nus1_1
Description:NUS1 dehydrodolichyl diphosphate synthase subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02033,556,973 - 33,557,033EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307879 AgrOrtholog
BioCyc Gene G2FUF-3644 BioCyc
BioCyc Pathway PWY-6129 [dolichol and dolichyl phosphate biosynthesis] BioCyc
BioCyc Pathway Image PWY-6129 BioCyc
Ensembl Genes ENSRNOG00000000411 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000000467 ENTREZGENE
  ENSRNOT00000000467.7 UniProtKB/TrEMBL
Gene3D-CATH 3.40.1180.10 UniProtKB/TrEMBL
InterPro Nus1/NgBR UniProtKB/TrEMBL
  UPP_synth-like UniProtKB/TrEMBL
  UPP_synth-like_sf UniProtKB/TrEMBL
KEGG Report rno:294400 UniProtKB/TrEMBL
NCBI Gene 294400 ENTREZGENE
PANTHER DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT NUS1 UniProtKB/TrEMBL
  PTHR21528 UniProtKB/TrEMBL
Pfam Prenyltransf UniProtKB/TrEMBL
PhenoGen Nus1 PhenoGen
RatGTEx ENSRNOG00000000411 RatGTEx
Superfamily-SCOP UPP_synth UniProtKB/TrEMBL
UniProt A6K485 ENTREZGENE, UniProtKB/TrEMBL
  D3ZFM4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-07-01 Nus1  NUS1 dehydrodolichyl diphosphate synthase subunit  Nus1  nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-07 Nus1  nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae)  RGD1307879_predicted  similar to hypothetical protein D10Ertd438e (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 RGD1307879_predicted  similar to hypothetical protein D10Ertd438e (predicted)  LOC294400_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC294400_predicted  similar to hypothetical protein D10Ertd438e (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL