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Gene: Rnf8 (ring finger protein 8) Rattus norvegicus

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Symbol:

Rnf8

Name:

ring finger protein 8

RGD ID:

1308035

Description:

Predicted to enable several functions, including protein homodimerization activity; ubiquitin protein ligase binding activity; and zinc ion binding activity. Predicted to be involved in several processes, including DNA metabolic process; chromatin remodeling; and protein ubiquitination. Predicted to be located in chromosome, telomeric region; cytoplasm; and nucleoplasm. Predicted to be part of ubiquitin ligase complex. Predicted to be active in cytosol; nucleus; and site of double-strand break. Orthologous to human RNF8 (ring finger protein 8); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; INTERACTS WITH 4,4'-sulfonyldiphenol; 6-propyl-2-thiouracil; allethrin.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

E3 ubiquitin-protein ligase RNF8; LOC361815; MGC116114; ring finger protein 8, E3 ubiquitin protein ligase; RING-type E3 ubiquitin transferase RNF8

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	RNF8 (ring finger protein 8)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther
Mus musculus (house mouse):	Rnf8 (ring finger protein 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Rnf8 (ring finger protein 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	RNF8 (ring finger protein 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	RNF8 (ring finger protein 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Rnf8 (ring finger protein 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	RNF8 (ring finger protein 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	RNF8 (ring finger protein 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Rnf8 (ring finger protein 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	C5orf24 (chromosome 5 open reading frame 24)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	RNF8 (ring finger protein 8)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Rnf8 (ring finger protein 8)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	rnf8 (ring finger protein 8, E3 ubiquitin protein ligase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	rnf8	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	20	7,683,890 - 7,708,437 (+)	NCBI		GRCr8
mRatBN7.2	20	7,682,258 - 7,710,448 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	7,682,322 - 7,708,491 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	20	8,385,289 - 8,409,776 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	7,746,451 - 7,770,938 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	8,219,662 - 8,243,816 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	20	8,285,380 - 8,309,858 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	8,285,296 - 8,309,908 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	20	10,484,857 - 10,509,126 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	20	7,929,802 - 7,954,697 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	20	7,930,028 - 7,954,924 (+)	NCBI
Celera	20	9,219,236 - 9,244,017 (+)	NCBI		Celera
Cytogenetic Map	20	p12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autistic disorder (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (EXP)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

allethrin (EXP)

amiodarone (ISO)

amitrole (EXP)

arsane (ISO)

arsenic atom (ISO)

atrazine (EXP)

bisphenol A (EXP,ISO)

bisphenol F (EXP,ISO)

cadmium atom (ISO)

caffeine (ISO)

carbon nanotube (ISO)

chlordecone (ISO)

choline (ISO)

cisplatin (ISO)

clotrimazole (EXP)

copper(II) sulfate (ISO)

coumarin (ISO)

cyhalothrin (EXP)

cypermethrin (EXP)

Dibutyl phosphate (ISO)

dibutyl phthalate (EXP)

dicrotophos (ISO)

doxorubicin (ISO)

fenthion (ISO)

fenvalerate (EXP)

folic acid (ISO)

fulvestrant (ISO)

furan (EXP)

genistein (EXP)

gentamycin (EXP)

ketoconazole (ISO)

L-methionine (ISO)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

methapyrilene (EXP)

methidathion (ISO)

methimazole (EXP)

methoxychlor (EXP)

ochratoxin A (ISO)

paracetamol (EXP)

perfluorohexanesulfonic acid (ISO)

pyrethrins (EXP)

resveratrol (EXP)

Salinomycin (ISO)

sodium arsenate (ISO)

sulfadimethoxine (EXP)

temozolomide (ISO)

thioacetamide (EXP)

triphenyl phosphate (EXP,ISO)

triptonide (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

cell division (IEA)

chromatin organization (IEA)

DNA damage response (IEA,ISO,ISS)

DNA repair (IEA)

DNA repair-dependent chromatin remodeling (ISO,ISS)

double-strand break repair (IBA,IEA,ISO,ISS)

double-strand break repair via nonhomologous end joining (ISO,ISS)

epigenetic regulation of gene expression (ISO,ISS)

isotype switching (ISO,ISS)

negative regulation of transcription elongation by RNA polymerase II (ISO,ISS)

positive regulation of DNA repair (IEA,ISO,ISS)

positive regulation of double-strand break repair via homologous recombination (ISO,ISS)

protein autoubiquitination (ISO)

protein K48-linked ubiquitination (IBA,ISO,ISS)

protein K6-linked ubiquitination (ISO,ISS)

protein K63-linked ubiquitination (ISO,ISS)

protein ubiquitination (IEA)

response to ionizing radiation (IEA,ISO,ISS)

signal transduction in response to DNA damage (ISO)

sperm DNA condensation (ISO,ISS)

ubiquitin-dependent protein catabolic process (IBA,ISO,ISS)

Cellular Component

chromosome (IEA)

chromosome, telomeric region (IEA,ISO,ISS)

cytoplasm (IEA,ISO,ISS)

cytosol (IBA,ISO)

midbody (IEA)

nucleoplasm (ISO)

nucleus (IBA,IEA,ISO,ISS)

site of double-strand break (IBA,ISO,ISS)

ubiquitin ligase complex (IBA,IEA,ISO,ISS)

Molecular Function

chromatin binding (IEA,ISO,ISS)

histone binding (IBA,IEA,ISO,ISS)

identical protein binding (ISO)

metal ion binding (IEA)

protein binding (ISO)

protein homodimerization activity (ISO,ISS)

transferase activity (IEA)

ubiquitin binding (IEA)

ubiquitin protein ligase activity (IBA,ISO,ISS)

ubiquitin protein ligase binding (ISO)

ubiquitin-protein transferase activity (IEA,ISO)

zinc ion binding (IEA,ISO,ISS)

Molecular Pathway Annotations Click to see Annotation Detail View

ataxia telangiectasia-mutated (ATM) signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	ATM protein kinase: the linchpin of cellular defenses to stress.	Bhatti S, etal., Cell Mol Life Sci. 2011 Sep;68(18):2977-3006. doi: 10.1007/s00018-011-0683-9. Epub 2011 May 2.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	Double-strand break repair: 53BP1 comes into focus.	Panier S and Boulton SJ, Nat Rev Mol Cell Biol. 2014 Jan;15(1):7-18. doi: 10.1038/nrm3719. Epub 2013 Dec 11.
5.	GOA pipeline	RGD automated data pipeline
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
7.	Comprehensive gene review and curation	RGD comprehensive gene curation

Additional References at PubMed

PMID:12477932	PMID:18001824	PMID:18001825	PMID:18948756	PMID:19015238	PMID:20080757	PMID:20153262	PMID:20550933	PMID:21857671	PMID:21911360	PMID:22266820	PMID:22373579
PMID:22980979	PMID:28552346	PMID:29097665

Genomics

Comparative Map Data

Rnf8
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	20	7,683,890 - 7,708,437 (+)	NCBI		GRCr8
mRatBN7.2	20	7,682,258 - 7,710,448 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	7,682,322 - 7,708,491 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	20	8,385,289 - 8,409,776 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	7,746,451 - 7,770,938 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	8,219,662 - 8,243,816 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	20	8,285,380 - 8,309,858 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	8,285,296 - 8,309,908 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	20	10,484,857 - 10,509,126 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	20	7,929,802 - 7,954,697 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	20	7,930,028 - 7,954,924 (+)	NCBI
Celera	20	9,219,236 - 9,244,017 (+)	NCBI		Celera
Cytogenetic Map	20	p12	NCBI

RNF8
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	37,353,983 - 37,394,734 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	37,353,979 - 37,394,734 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	37,321,759 - 37,362,510 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	37,429,726 - 37,470,492 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	6	37,429,768 - 37,470,491	NCBI
Celera	6	38,876,721 - 38,917,497 (+)	NCBI		Celera
Cytogenetic Map	6	p21.2	NCBI
HuRef	6	37,040,684 - 37,081,344 (+)	NCBI		HuRef
CHM1_1	6	37,323,524 - 37,364,290 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	6	37,177,541 - 37,218,292 (+)	NCBI		T2T-CHM13v2.0

Rnf8
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	29,833,763 - 29,860,638 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	29,833,764 - 29,863,965 (+)	Ensembl		GRCm39 Ensembl
GRCm38	17	29,614,789 - 29,641,664 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	29,614,790 - 29,644,991 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	29,751,776 - 29,778,604 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	28,828,664 - 28,855,463 (+)	NCBI		MGSCv36	mm8
MGSCv36	17	29,341,843 - 29,368,671 (+)	NCBI		MGSCv36	mm8
Celera	17	30,155,441 - 30,176,366 (+)	NCBI		Celera
Cytogenetic Map	17	A3.3	NCBI
cM Map	17	15.45	NCBI

Rnf8
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955437	5,809,082 - 5,832,057 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955437	5,807,592 - 5,832,213 (-)	NCBI	ChiLan1.0	ChiLan1.0

RNF8
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	51,825,574 - 51,862,276 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	47,695,597 - 47,732,307 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	36,918,705 - 36,955,380 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	38,108,414 - 38,145,949 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	38,108,414 - 38,145,949 (+)	Ensembl	panpan1.1		panPan2

RNF8
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	12	6,380,365 - 6,415,407 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	12	6,292,459 - 6,415,382 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	12	6,398,291 - 6,433,355 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	12	6,844,755 - 6,879,956 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	12	6,844,708 - 6,970,087 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	12	6,381,196 - 6,416,424 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	12	6,463,623 - 6,498,627 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	12	6,562,602 - 6,597,564 (+)	NCBI		UU_Cfam_GSD_1.0

Rnf8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	41,838,907 - 41,886,084 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936476	22,074,146 - 22,121,286 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RNF8
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	32,931,786 - 32,970,585 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	32,931,786 - 32,969,536 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	37,836,029 - 37,874,578 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

RNF8
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	17	34,754,186 - 34,787,676 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	17	34,751,945 - 34,787,632 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666044	37,301,000 - 37,337,835 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Rnf8
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624754	20,679,867 - 20,714,522 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624754	20,683,133 - 20,714,469 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Rnf8
179 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	56
Count of miRNA genes:	50
Interacting mature miRNAs:	51
Transcripts:	ENSRNOT00000065629
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1641915	Colcr9	Colorectal carcinoma resistance QTL 9	2.97	0.0024	intestine integrity trait (VT:0010554)	benign colorectal tumor number (CMO:0001795)	20	1530655	46530655	Rat
2317057	Aia27	Adjuvant induced arthritis QTL 27	2.83		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	20	2892597	26381954	Rat
7387283	Uae44	Urinary albumin excretion QTL 44		0.1712	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	20	1	26123605	Rat
7411668	Foco32	Food consumption QTL 32	8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	20	1	36600972	Rat
2305926	Iddm37	Insulin dependent diabetes mellitus QTL 37	6		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	20	1527842	46527842	Rat
1354642	Despr15	Despair related QTL 15		0.0027	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	20	1	24159021	Rat
1600382	Edcs3	Endometrial carcinoma susceptibility QTL3	3.5	0.003	uterus morphology trait (VT:0001120)	percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)	20	1	25159026	Rat
1558640	Prcs2	Prostate cancer susceptibility QTL 2	3.3		prostate integrity trait (VT:0010571)	percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)	20	4606607	17617956	Rat
1331772	Cdexp2	CD45RC expression in CD8 T cells QTL 2	5.7		CD8-positive T cell quantity (VT:0008077)	blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)	20	3621649	10078919	Rat
8694189	Bw153	Body weight QTL 153	3.13	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	20	1	29191651	Rat
1300152	Bp195	Blood pressure QTL 195	3.46		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	20	3621649	9243559	Rat
4889857	Pur27	Proteinuria QTL 27	12.2	0.001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	20	4606607	17617956	Rat
70154	Insul2	Insulin level QTL 2	3.75		blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	20	6691706	17489458	Rat
9590109	Sffal8	Serum free fatty acids level QTL 8	5.32	0.01	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	20	1	29191651	Rat
9590275	Scort15	Serum corticosterone level QTL 15	3.48	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	20	1	29191651	Rat
9589155	Insul32	Insulin level QTL 32	6.38	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	20	1	29191651	Rat
7411650	Foco23	Food consumption QTL 23	20.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	20	1	29191651	Rat
2317851	Alcrsp22	Alcohol response QTL 22	3.2	0.05	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	20	1	27339237	Rat
1598816	Memor12	Memory QTL 12	2.4		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	20	2606836	47606836	Rat
61432	Cia1	Collagen induced arthritis QTL 1			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	20	3621656	14101050	Rat
1641893	Alcrsp7	Alcohol response QTL 7			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	20	1	27339237	Rat
6893685	Bw111	Body weight QTL 111	2.7	0.004	body mass (VT:0001259)	body weight (CMO:0000012)	20	1	32578807	Rat
9590252	Scort12	Serum corticosterone level QTL 12	20.46	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	20	1	36600972	Rat

Markers in Region

BF387562

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	20	7,704,894 - 7,705,086 (+)	MAPPER	mRatBN7.2
Rnor_6.0	20	8,307,903 - 8,308,094	NCBI	Rnor6.0
Rnor_5.0	20	10,507,171 - 10,507,362	UniSTS	Rnor5.0
RGSC_v3.4	20	7,952,742 - 7,952,933	UniSTS	RGSC3.4
Celera	20	9,242,062 - 9,242,253	UniSTS
RH 3.4 Map	20	81.5	UniSTS
Cytogenetic Map	20	p12	UniSTS

RH137336

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	20	7,706,540 - 7,706,728 (+)	MAPPER	mRatBN7.2
Rnor_6.0	20	8,309,549 - 8,309,736	NCBI	Rnor6.0
Rnor_5.0	20	10,508,817 - 10,509,004	UniSTS	Rnor5.0
RGSC_v3.4	20	7,954,388 - 7,954,575	UniSTS	RGSC3.4
Celera	20	9,243,708 - 9,243,895	UniSTS
RH 3.4 Map	20	91.8	UniSTS
Cytogenetic Map	20	p12	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001025727	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006256226	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017601685	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063279229	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063279230	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC099079	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473988	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000020	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000065629 ⟹ ENSRNOP00000059852

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	20	7,682,322 - 7,706,854 (+)	Ensembl
Rnor_6.0 Ensembl	20	8,285,296 - 8,309,908 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000081715 ⟹ ENSRNOP00000074480

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	20	7,682,322 - 7,708,491 (+)	Ensembl
Rnor_6.0 Ensembl	20	8,285,502 - 8,304,733 (+)	Ensembl

RefSeq Acc Id:

NM_001025727 ⟹ NP_001020898

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	7,683,965 - 7,708,425 (+)	NCBI
mRatBN7.2	20	7,682,389 - 7,706,850 (+)	NCBI
Rnor_6.0	20	8,285,418 - 8,309,858 (+)	NCBI
Rnor_5.0	20	10,484,857 - 10,509,126 (+)	NCBI
RGSC_v3.4	20	7,929,802 - 7,954,697 (+)	RGD
Celera	20	9,219,236 - 9,244,017 (+)	RGD

Sequence:

show sequence

TGCGCGAGAGGCGCCTCGGAAGCGATCGGAGCCCAGGCTGGAGTTTGGCTGGTTACTGAAAGTT
GCCCCGGTGCCGAGCGGGCTATGGGCGAGCCCGACCCCTTGGTCTCGGGGCAGCTCGCGGCCCG
CCGGAGCTGGTGCTTGCGGCGGCTGGGGATGGACCGCGAGTGGCTACAGCTGGAGGCTGGGAGT
GAGGTGACCATAGGACGGGGATTCAGTGTCACGTACCAGCTGATCTCAAAGGTGTGCCCTCTGA
TGATTTCTCGAAACCACTGCGTTCTGAAGCAGAATCCTGAGGGACAATGGACGATTATGGACAA
TAAGAGTCTGAATGGTGTTTGGCTGAACAGAGAGCGTCTGGCGCCGTTACAGGGTTACTGCATC
CGTAAGGGAGACCACATCCAGCTCGGAGTGCCTCTGGAAAGCAAGGAGCATGCGGAGTACGAAT
ACGAAGTTATCGAAGAAGACCGGGAGAGTCTGGCTCCCTGCCTTGCCCCCAAGAATGACCACAC
AACGGAAAAACATAAAGGCTTGAGAACTAAGAGGAAGTTCAGTTCGGATGGGGTAGAGAGTCTT
CCAGCCGAGGGCCCCTCAGATCTCAGGTGCCCACTGGCTAAAGGCTCCAGTAAACCCGCTGAGC
CAGAGAAGTTACACGGCAAAGGTGAAGCGGCAAGTCAGCCCTTGGGATGTTTGTGCCCTACCTT
GGCGTCTCTTGAGGCGAGTGAGAGGACCGCGGGGCCTCATGCTTGCTCTACTCTTCCTAAGGTC
CTCGAACTCTATCCTAAGAAGCAGAAGGCCTGCAGCCCATCAGCATCTCAGAGCAGCTTAGAAC
TGTTTAAGATGACCATGTCCAGGATGCTCAAGCTGAAAACCCAGATGCAAGAAAAGCAGATTGC
TGTCCTGAACGTCAAGAGGCAGGCCCGGAAGGGGAGCTCAAAGAAAGTCGTGAGGATGGAGAAG
GAGCTGCGAGACCTACAGTCCCAGCTGTACGCAGAGCAGGCTCAGCAGCAGGCAAGAGTGGAGC
AGCTGGAGAAGACGTTCCAGGAGGAGGAGCAGCACCTCCAGGGTTTGGAGAAAGAGCAAGGAGA
GTGTGATCTGAAGCAACAGCTGCTGCAGGCTCTGCAGGAGCATCGCGCTCTAATGGAAGAACTA
GATCGCAGCAAGAAGGACTTTGAGAAAATCATTCAAGCCAAGAACAAAGAATTGGAGCGGACCA
AGGAAGAAAAGGACAAGGTCCAAGCACAGAAGGAGGAAGTTCTCAGCCACATGAACGACGTGCT
GGAGAACGAGCTCCAGTGCATCATCTGCTCAGAGTACTTCATCGAGGCTGTCACCCTGAACTGT
GCCCACAGTTTCTGCTCCTTCTGCATCAGTGAGTGGATGAAGCGGAAAGTGGAGTGTCCCATCT
GTCGGAAGGACATTGAGTCCAGAACCAACTCGCTGGTTCTGGACAACTGCATCAGTAAGATGGT
GGAACGCCTGAGCTCAGACGTGAAGGAGAGGAGAAGCGTCCTCATTAGGGAACGAAGAGCAAAG
AGACTGTTATGAAGGTCATGCTCCAAGGACATGTGAGAGACTAGGAGGATGGCAGCTTGGCGCG
TTCTAGAGGATTCCCTTTGGCTGCTCTGGACATCATCGGAAGCCGTGTGCTGCAGAGACTTAGG
AAGTCTGTGTCACTGGCCTTCTGTCTGCTGGCCCTGCTGCTGACATCACCGTCTACAGTGCTGC
TGGGACACCCACTTGGAGTGACTGCCTCACTACGTGTTAAATGAGTTGAGTTCTGTGTTTCTTC
ATTTGTTGATTGTTTTTGATACCTCATGCACCCTGTTGACATCGCCTTGGACACTTGGGTGCGC
CCTATGGCTGCATGGAAGGTGGCCTGCATTTTGAGAGTCTGGTTTACCTTTTAATGAAAACAAG
ATGTCATTTCTTGGAAATAAATATATAAAACCCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_006256226 ⟹ XP_006256288

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	7,683,890 - 7,699,970 (+)	NCBI
mRatBN7.2	20	7,682,258 - 7,698,394 (+)	NCBI
Rnor_6.0	20	8,285,380 - 8,301,423 (+)	NCBI
Rnor_5.0	20	10,484,857 - 10,509,126 (+)	NCBI

Sequence:

show sequence

TCTCCGGGCGATTGCTTCTGTCTGGTGTTTAGGTATGGTGCGCGAGAGGCGCCTCGGAAGCGAT
CGGAGCCCAGGCTGGAGTTTGGCTGGTTACTGAAAGTTGCCCCGGTGCCGAGCGGGCTATGGGC
GAGCCCGACCCCTTGGTCTCGGGGCAGCTCGCGGCCCGCCGGAGCTGGTGCTTGCGGCGGCTGG
GGATGGACCGCGAGTGGCTACAGCTGGAGGCTGGGAGTGAGGTGACCATAGGACGGGGATTCAG
TGTCACGTACCAGCTGATCTCAAAGGTGTGCCCTCTGATGATTTCTCGAAACCACTGCGTTCTG
AAGCAGAATCCTGAGGGACAATGGACGATTATGGACAATAAGAGTCTGAATGGTGTTTGGCTGA
ACAGAGAGCGTCTGGCGCCGTTACAGGGTTACTGCATCCGTAAGGGAGACCACATCCAGCTCGG
AGTGCCTCTGGAAAGCAAGGAGCATGCGGAGTACGAATACGAAGTTATCGAAGAAGACCGGGAG
AGTCTGGCTCCCTGCCTTGCCCCCAAGAATGACCACACAACGGAAAAACATAAAGGCTTGAGAA
CTAAGAGGAAGTTCAGTTCGGATGGGGTAGAGAGTCTTCCAGCCGAGGGCCCCTCAGATCTCAG
GTGCCCACTGGCTAAAGGCTCCAGTAAACCCGCTGAGCCAGAGAAGTTACACGGCAAAGGTGAA
GCGGCAAGTCAGCCCTTGGGATGTTTGTGCCCTACCTTGGCGTCTCTTGAGGCGAGTGAGAGGA
CCGCGGGGCCTCATGCTTGCTCTACTCTTCCTAAGGTCCTCGAACTCTATCCTAAGAAGCAGAA
GGCCTGCAGCCCATCAGCATCTCAGAGCAGCTTAGAACTGTTTAAGATGACCATGTCCAGGATG
CTCAAGCTGAAAACCCAGATGCAAGAAAAGCAGATTGCTGTCCTGAACGTCAAGAGGCAGGCCC
GGAAGGGGAGCTCAAAGAAAGTCGTGAGGATGGAGAAGGAGCTGCGAGACCTACAGTCCCAGCT
GTACGCAGAGCAGGCTCAGCAGCAGGCAAGAGTGGAGCAGCTGGAGAAGACGTTCCAGGAGGAG
GAGCAGCACCTCCAGGGTTTGGAGAAAGAGCAAGGAGAGTGTGATCTGAAGCAACAGCTGCTGC
AGGCTCTGCAGGAGTCTGCAAACAGAACAGGTGCCAGATGCTCACACCATCCGGCTGGAGATTT
GGAGCCTCACAGATACGCACCAGATCTCAGGCGTGGAAGCGTATGTCTCCATCAAGCAGAAGGC
GCCCTGGTGATGACAGAGCAGCCTGGAGACGATCTCGGGATAGGGGCTCTACTTCAGAATAGCG
AGGGCAGCGGCGGGCAGAGCATCGCGCTCTAATGGAAGAACTAGATCGCAGCAAGAAGGACTTT
GAGAAAATCATTCAAGCCAAGAACAAAGAATTGGAGCGGACCAAGG

hide sequence

RefSeq Acc Id:

XM_063279229 ⟹ XP_063135299

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	7,683,890 - 7,708,437 (+)	NCBI

RefSeq Acc Id:

XM_063279230 ⟹ XP_063135300

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	7,683,890 - 7,708,437 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001020898	(Get FASTA)	NCBI Sequence Viewer
	XP_006256288	(Get FASTA)	NCBI Sequence Viewer
	XP_063135299	(Get FASTA)	NCBI Sequence Viewer
	XP_063135300	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH99079	(Get FASTA)	NCBI Sequence Viewer
	EDL96971	(Get FASTA)	NCBI Sequence Viewer
	EDL96972	(Get FASTA)	NCBI Sequence Viewer
	EDL96973	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000059852.1
	ENSRNOP00000074480.2
GenBank Protein	Q4KLN8	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001020898 ⟸ NM_001025727

- UniProtKB:

Q4KLN8 (UniProtKB/Swiss-Prot), A0A0G2K858 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MGEPDPLVSGQLAARRSWCLRRLGMDREWLQLEAGSEVTIGRGFSVTYQLISKVCPLMISRNHC
VLKQNPEGQWTIMDNKSLNGVWLNRERLAPLQGYCIRKGDHIQLGVPLESKEHAEYEYEVIEED
RESLAPCLAPKNDHTTEKHKGLRTKRKFSSDGVESLPAEGPSDLRCPLAKGSSKPAEPEKLHGK
GEAASQPLGCLCPTLASLEASERTAGPHACSTLPKVLELYPKKQKACSPSASQSSLELFKMTMS
RMLKLKTQMQEKQIAVLNVKRQARKGSSKKVVRMEKELRDLQSQLYAEQAQQQARVEQLEKTFQ
EEEQHLQGLEKEQGECDLKQQLLQALQEHRALMEELDRSKKDFEKIIQAKNKELERTKEEKDKV
QAQKEEVLSHMNDVLENELQCIICSEYFIEAVTLNCAHSFCSFCISEWMKRKVECPICRKDIES
RTNSLVLDNCISKMVERLSSDVKERRSVLIRERRAKRLL

hide sequence

RefSeq Acc Id:

XP_006256288 ⟸ XM_006256226

- Peptide Label:

isoform X3

- Sequence:

show sequence

MGEPDPLVSGQLAARRSWCLRRLGMDREWLQLEAGSEVTIGRGFSVTYQLISKVCPLMISRNHC
VLKQNPEGQWTIMDNKSLNGVWLNRERLAPLQGYCIRKGDHIQLGVPLESKEHAEYEYEVIEED
RESLAPCLAPKNDHTTEKHKGLRTKRKFSSDGVESLPAEGPSDLRCPLAKGSSKPAEPEKLHGK
GEAASQPLGCLCPTLASLEASERTAGPHACSTLPKVLELYPKKQKACSPSASQSSLELFKMTMS
RMLKLKTQMQEKQIAVLNVKRQARKGSSKKVVRMEKELRDLQSQLYAEQAQQQARVEQLEKTFQ
EEEQHLQGLEKEQGECDLKQQLLQALQESANRTGARCSHHPAGDLEPHRYAPDLRRGSVCLHQA
EGALVMTEQPGDDLGIGALLQNSEGSGGQSIAL

hide sequence

Ensembl Acc Id:

ENSRNOP00000059852 ⟸ ENSRNOT00000065629

Ensembl Acc Id:

ENSRNOP00000074480 ⟸ ENSRNOT00000081715

RefSeq Acc Id:	XP_063135299 ⟸ XM_063279229
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2K858 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063135300 ⟸ XM_063279230
- Peptide Label:	isoform X2
- UniProtKB:	Q4KLN8 (UniProtKB/Swiss-Prot), A0A0G2K858 (UniProtKB/TrEMBL)

Protein Domains

FHA

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q4KLN8-F1-model_v2	AlphaFold	Q4KLN8	1-487	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13701463

Promoter ID:

EPDNEW_R11987

Type:

initiation region

Name:

Rnf8_1

Description:

ring finger protein 8

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	20	8,285,399 - 8,285,459	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1308035	AgrOrtholog
BioCyc Gene	G2FUF-4366	BioCyc
Ensembl Genes	ENSRNOG00000047171	Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000065629.3	UniProtKB/Swiss-Prot
	ENSRNOT00000081715.2	UniProtKB/TrEMBL
Gene3D-CATH	1.20.5.170	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	2.60.200.20	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.30.40.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7443362	IMAGE-MGC_LOAD
InterPro	FHA_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	RNF8	UniProtKB/Swiss-Prot
	SMAD_FHA_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Znf_C3HC4_RING-type	UniProtKB/Swiss-Prot
	Znf_RING	UniProtKB/Swiss-Prot
	Znf_RING/FYVE/PHD	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Znf_RING_CS	UniProtKB/Swiss-Prot
KEGG Report	rno:361815	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:116114	IMAGE-MGC_LOAD
NCBI Gene	361815	ENTREZGENE
PANTHER	E3 UBIQUITIN-PROTEIN LIGASE RNF8	UniProtKB/Swiss-Prot
	E3 UBIQUITIN-PROTEIN LIGASE RNF8	UniProtKB/Swiss-Prot
	E3 UBIQUITIN-PROTEIN LIGASE RNF8	UniProtKB/TrEMBL
	E3 UBIQUITIN-PROTEIN LIGASE RNF8	UniProtKB/TrEMBL
Pfam	FHA	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	zf-C3HC4	UniProtKB/Swiss-Prot
PhenoGen	Rnf8	PhenoGen
PIRSF	E3_ubiquit_lig_RNF8	UniProtKB/Swiss-Prot
PROSITE	FHA_DOMAIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ZF_RING_1	UniProtKB/Swiss-Prot
	ZF_RING_2	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000047171	RatGTEx
SMART	FHA	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	RING	UniProtKB/Swiss-Prot
Superfamily-SCOP	RING/U-box	UniProtKB/Swiss-Prot
	SSF49879	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A0G2K858	ENTREZGENE, UniProtKB/TrEMBL
	A6JJV5_RAT	UniProtKB/TrEMBL
	A6JJV6_RAT	UniProtKB/TrEMBL
	A6JJV7_RAT	UniProtKB/TrEMBL
	Q4KLN8	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-03-16	Rnf8	ring finger protein 8	Rnf8	ring finger protein 8, E3 ubiquitin protein ligase	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2012-10-15	Rnf8	ring finger protein 8, E3 ubiquitin protein ligase	Rnf8	ring finger protein 8	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	Rnf8	ring finger protein 8	Rnf8_predicted	ring finger protein 8 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Rnf8_predicted	ring finger protein 8 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

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Imported Disease Annotations - CTD

RGD Manual Annotations