Rnf8 (ring finger protein 8) - Rat Genome Database

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Gene: Rnf8 (ring finger protein 8) Rattus norvegicus
Analyze
Symbol: Rnf8
Name: ring finger protein 8
RGD ID: 1308035
Description: Predicted to enable several functions, including protein homodimerization activity; ubiquitin protein ligase activity; and ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including DNA metabolic process; protein ubiquitination; and regulation of nucleobase-containing compound metabolic process. Predicted to be located in chromosome, telomeric region; cytoplasm; and nucleoplasm. Predicted to be part of ubiquitin ligase complex. Predicted to be active in cytosol; nucleus; and site of double-strand break. Orthologous to human RNF8 (ring finger protein 8); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; INTERACTS WITH atrazine; bisphenol A; dibutyl phthalate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: E3 ubiquitin-protein ligase RNF8; LOC361815; MGC116114; ring finger protein 8, E3 ubiquitin protein ligase; RING-type E3 ubiquitin transferase RNF8
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2207,682,258 - 7,710,448 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl207,682,322 - 7,708,491 (+)Ensembl
Rnor_6.0208,285,380 - 8,309,858 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl208,285,296 - 8,309,908 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02010,484,857 - 10,509,126 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4207,929,802 - 7,954,697 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1207,930,028 - 7,954,924 (+)NCBI
Celera209,219,236 - 9,244,017 (+)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cellular_component  (ND)
chromosome, telomeric region  (IEA,ISO,ISS)
cytoplasm  (IEA,ISO,ISS)
cytosol  (IBA,ISO)
midbody  (IEA)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IEA,ISO,ISS)
site of double-strand break  (IBA,ISO,ISS)
ubiquitin ligase complex  (IBA,IEA,ISO,ISS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. ATM protein kinase: the linchpin of cellular defenses to stress. Bhatti S, etal., Cell Mol Life Sci. 2011 Sep;68(18):2977-3006. doi: 10.1007/s00018-011-0683-9. Epub 2011 May 2.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Double-strand break repair: 53BP1 comes into focus. Panier S and Boulton SJ, Nat Rev Mol Cell Biol. 2014 Jan;15(1):7-18. doi: 10.1038/nrm3719. Epub 2013 Dec 11.
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:12477932   PMID:18001824   PMID:18001825   PMID:18948756   PMID:19015238   PMID:20080757   PMID:20153262   PMID:20550933   PMID:21857671   PMID:21911360   PMID:22266820   PMID:22373579  
PMID:22980979   PMID:28552346   PMID:29097665  


Genomics

Comparative Map Data
Rnf8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2207,682,258 - 7,710,448 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl207,682,322 - 7,708,491 (+)Ensembl
Rnor_6.0208,285,380 - 8,309,858 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl208,285,296 - 8,309,908 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02010,484,857 - 10,509,126 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4207,929,802 - 7,954,697 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1207,930,028 - 7,954,924 (+)NCBI
Celera209,219,236 - 9,244,017 (+)NCBICelera
Cytogenetic Map20p12NCBI
RNF8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38637,353,983 - 37,394,734 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl637,353,979 - 37,394,734 (+)EnsemblGRCh38hg38GRCh38
GRCh37637,321,759 - 37,362,510 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36637,429,726 - 37,470,492 (+)NCBINCBI36hg18NCBI36
Build 34637,429,768 - 37,470,491NCBI
Celera638,876,721 - 38,917,497 (+)NCBI
Cytogenetic Map6p21.2NCBI
HuRef637,040,684 - 37,081,344 (+)NCBIHuRef
CHM1_1637,323,524 - 37,364,290 (+)NCBICHM1_1
T2T-CHM13v2.0637,177,541 - 37,218,292 (+)NCBI
Rnf8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391729,833,763 - 29,860,638 (+)NCBIGRCm39mm39
GRCm39 Ensembl1729,833,764 - 29,863,965 (+)Ensembl
GRCm381729,614,789 - 29,641,664 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1729,614,790 - 29,644,991 (+)EnsemblGRCm38mm10GRCm38
MGSCv371729,751,776 - 29,778,604 (+)NCBIGRCm37mm9NCBIm37
MGSCv361728,828,664 - 28,855,463 (+)NCBImm8
MGSCv361729,341,843 - 29,368,671 (+)NCBImm8
Celera1730,155,441 - 30,176,366 (+)NCBICelera
Cytogenetic Map17A3.3NCBI
Rnf8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554375,809,082 - 5,832,057 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554375,807,592 - 5,832,213 (-)NCBIChiLan1.0ChiLan1.0
RNF8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1638,108,414 - 38,145,949 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl638,108,414 - 38,145,949 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0636,918,705 - 36,955,380 (+)NCBIMhudiblu_PPA_v0panPan3
RNF8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1126,380,365 - 6,415,407 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl126,292,459 - 6,415,382 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha126,398,291 - 6,433,355 (+)NCBI
ROS_Cfam_1.0126,844,755 - 6,879,956 (+)NCBI
ROS_Cfam_1.0 Ensembl126,844,708 - 6,970,087 (+)Ensembl
UMICH_Zoey_3.1126,381,196 - 6,416,424 (+)NCBI
UNSW_CanFamBas_1.0126,463,623 - 6,498,627 (+)NCBI
UU_Cfam_GSD_1.0126,562,602 - 6,597,564 (+)NCBI
Rnf8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494641,838,907 - 41,886,084 (+)NCBI
SpeTri2.0NW_00493647622,074,146 - 22,121,286 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RNF8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl732,931,786 - 33,063,739 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1732,931,786 - 32,969,536 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2737,836,029 - 37,874,578 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RNF8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11734,754,186 - 34,787,676 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1734,751,945 - 34,787,632 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604437,301,000 - 37,337,835 (+)NCBIVero_WHO_p1.0
Rnf8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475420,679,867 - 20,714,522 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462475420,683,133 - 20,714,469 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
BF387562  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2207,704,894 - 7,705,086 (+)MAPPERmRatBN7.2
Rnor_6.0208,307,903 - 8,308,094NCBIRnor6.0
Rnor_5.02010,507,171 - 10,507,362UniSTSRnor5.0
RGSC_v3.4207,952,742 - 7,952,933UniSTSRGSC3.4
Celera209,242,062 - 9,242,253UniSTS
RH 3.4 Map2081.5UniSTS
Cytogenetic Map20p12UniSTS
RH137336  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2207,706,540 - 7,706,728 (+)MAPPERmRatBN7.2
Rnor_6.0208,309,549 - 8,309,736NCBIRnor6.0
Rnor_5.02010,508,817 - 10,509,004UniSTSRnor5.0
RGSC_v3.4207,954,388 - 7,954,575UniSTSRGSC3.4
Celera209,243,708 - 9,243,895UniSTS
RH 3.4 Map2091.8UniSTS
Cytogenetic Map20p12UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125159026Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20289259726381954Rat
1300152Bp195Blood pressure QTL 1953.46arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2036216499243559Rat
1331772Cdexp2CD45RC expression in CD8 T cells QTL 25.7CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)20362164910078919Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20362165614101050Rat
4889857Pur27Proteinuria QTL 2712.20.001total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20460660717617956Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20460660717617956Rat
70154Insul2Insulin level QTL 23.75blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20669170617489458Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:56
Count of miRNA genes:50
Interacting mature miRNAs:51
Transcripts:ENSRNOT00000065629
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 29 45 37 7 37 2 70 21 40 3
Low 1 14 12 4 12 4 8 9 4 14 1 8 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000065629   ⟹   ENSRNOP00000059852
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl207,682,322 - 7,706,854 (+)Ensembl
Rnor_6.0 Ensembl208,285,296 - 8,309,908 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000081715   ⟹   ENSRNOP00000074480
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl207,682,322 - 7,708,491 (+)Ensembl
Rnor_6.0 Ensembl208,285,502 - 8,304,733 (+)Ensembl
RefSeq Acc Id: NM_001025727   ⟹   NP_001020898
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2207,682,389 - 7,706,850 (+)NCBI
Rnor_6.0208,285,418 - 8,309,858 (+)NCBI
Rnor_5.02010,484,857 - 10,509,126 (+)NCBI
RGSC_v3.4207,929,802 - 7,954,697 (+)RGD
Celera209,219,236 - 9,244,017 (+)RGD
Sequence:
RefSeq Acc Id: XM_006256225   ⟹   XP_006256287
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2207,682,273 - 7,706,420 (+)NCBI
Rnor_6.0208,285,380 - 8,309,430 (+)NCBI
Rnor_5.02010,484,857 - 10,509,126 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006256226   ⟹   XP_006256288
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2207,682,258 - 7,698,394 (+)NCBI
Rnor_6.0208,285,380 - 8,301,423 (+)NCBI
Rnor_5.02010,484,857 - 10,509,126 (+)NCBI
Sequence:
RefSeq Acc Id: XR_005497281
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2207,682,277 - 7,710,448 (+)NCBI
RefSeq Acc Id: XR_597347
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2207,682,260 - 7,700,366 (+)NCBI
Rnor_6.0208,285,380 - 8,303,374 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001020898   ⟸   NM_001025727
- UniProtKB: Q4KLN8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006256287   ⟸   XM_006256225
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006256288   ⟸   XM_006256226
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000059852   ⟸   ENSRNOT00000065629
RefSeq Acc Id: ENSRNOP00000074480   ⟸   ENSRNOT00000081715
Protein Domains
FHA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q4KLN8-F1-model_v2 AlphaFold Q4KLN8 1-487 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701463
Promoter ID:EPDNEW_R11987
Type:initiation region
Name:Rnf8_1
Description:ring finger protein 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0208,285,399 - 8,285,459EPDNEW

Strain Variation

Strain Sequence Variants (MRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
Damaging Variants


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
20 8291578 8291579 C T snv CDR
20 8297059 8297060 G A snv SHRSP/Gcrc (RGD), SHR/OlalpcvMcwi (2019), BXH2/CubMcwi (2020), HXB31/IpcvMcwi (2019), SHRSP/A3NCrl (2019), SHR/NHsd (RGD), WKY/Gcrc (RGD)


Assembly: Rnor_5.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
20 10491055 10491056 C T snv DOB/Oda (KyushuU)
20 10496233 10496234 T G snv BDIX/NemOda (KyushuU), BDIX.Cg-Tal/NemOda (KyushuU)
20 10496536 10496537 G A snv SHR/OlaIpcvPrin (KNAW), WKY/Gcrc (KNAW), IS/Kyo (KyushuU), IS-Tlk/Kyo (KyushuU), SHR/OlaIpcv (KNAW), SHR/NHsd (KNAW), SHR/NCrlPrin (KNAW), SHRSP/Gcrc (KNAW)


Assembly: RGSC_v3.4

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
20 7941446 7941447 G A snv SHR/OlaIpcv (ICL), SHRSP/Gcrc (MDC), SHR/OlaIpcv (KNAW), WKY/Gcrc (ICL), SHR/NHsd (ICL), SHRSP/Gcrc (ICL), SHR/OlaIpcv (ICL)


Assembly: mRatBN7.2

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
20 7694030 7694031 G A snv BXH2/CubMcwi (2020), SHR/OlalpcvMcwi (2019), SHRSP/A3NCrl (2019), HXB31/IpcvMcwi (2019)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308035 AgrOrtholog
BioCyc Gene G2FUF-4366 BioCyc
Ensembl Genes ENSRNOG00000047171 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000059852 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000074480.2 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000065629 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000081715.2 UniProtKB/TrEMBL
Gene3D-CATH 3.30.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7443362 IMAGE-MGC_LOAD
InterPro FHA_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RNF8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SMAD_FHA_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_C3HC4_RING-type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:361815 UniProtKB/Swiss-Prot
MGC_CLONE MGC:116114 IMAGE-MGC_LOAD
NCBI Gene 361815 ENTREZGENE
Pfam FHA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-C3HC4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Rnf8 PhenoGen
PIRSF E3_ubiquit_lig_RNF8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE FHA_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_RING_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_RING_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART FHA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49879 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K858_RAT UniProtKB/TrEMBL
  Q4KLN8 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-16 Rnf8  ring finger protein 8  Rnf8  ring finger protein 8, E3 ubiquitin protein ligase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-10-15 Rnf8  ring finger protein 8, E3 ubiquitin protein ligase  Rnf8  ring finger protein 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Rnf8  ring finger protein 8  Rnf8_predicted  ring finger protein 8 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Rnf8_predicted  ring finger protein 8 (predicted)      Symbol and Name status set to approved 70820 APPROVED