Msl3l2 (male-specific lethal 3-like 2) - Rat Genome Database

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Gene: Msl3l2 (male-specific lethal 3-like 2) Rattus norvegicus
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Symbol: Msl3l2
Name: male-specific lethal 3-like 2
RGD ID: 1308699
Description: Predicted to be involved in chromatin organization and regulation of DNA-templated transcription. Predicted to be located in nucleus. Predicted to be part of MSL complex and NuA4 histone acetyltransferase complex. Human ortholog(s) of this gene implicated in Basilicata-Akhtar syndrome. Orthologous to human MSL3 (MSL complex subunit 3) and MSL3B (MSL complex subunit 3B); INTERACTS WITH aflatoxin B1 (ortholog); arsenite(3-) (ortholog); fipronil (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC309790; male-specific lethal 3-like 2 (Drosophila); RGD1308699; similar to 1700060H10Rik protein
RGD Orthologs
Human
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82036,011,381 - 36,019,529 (+)NCBIGRCr8
mRatBN7.22035,468,877 - 35,477,025 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2035,468,888 - 35,477,757 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2036,487,372 - 36,490,679 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02035,878,164 - 35,881,473 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02036,605,125 - 36,608,432 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02037,580,002 - 37,590,015 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2037,587,687 - 37,589,198 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02039,325,852 - 39,334,021 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42034,903,940 - 34,907,245 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12034,917,739 - 34,921,044 (+)NCBI
Celera2036,824,366 - 36,827,671 (+)NCBICelera
Cytogenetic Map20q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Genomics

Comparative Map Data
Msl3l2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82036,011,381 - 36,019,529 (+)NCBIGRCr8
mRatBN7.22035,468,877 - 35,477,025 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2035,468,888 - 35,477,757 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2036,487,372 - 36,490,679 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02035,878,164 - 35,881,473 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02036,605,125 - 36,608,432 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02037,580,002 - 37,590,015 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2037,587,687 - 37,589,198 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02039,325,852 - 39,334,021 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42034,903,940 - 34,907,245 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12034,917,739 - 34,921,044 (+)NCBI
Celera2036,824,366 - 36,827,671 (+)NCBICelera
Cytogenetic Map20q11NCBI
MSL3B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382233,864,663 - 233,868,386 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2233,864,663 - 233,868,386 (-)EnsemblGRCh38hg38GRCh38
GRCh372234,773,309 - 234,777,032 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362234,438,814 - 234,441,829 (-)NCBINCBI36Build 36hg18NCBI36
Celera2228,494,505 - 228,497,478 (-)NCBICelera
Cytogenetic Map2q37.1NCBI
HuRef2226,573,679 - 226,576,652 (-)NCBIHuRef
CHM1_12234,779,868 - 234,782,840 (-)NCBICHM1_1
T2T-CHM13v2.02234,353,465 - 234,357,190 (-)NCBIT2T-CHM13v2.0

Variants

.
Variants in Msl3l2
23 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:64
Count of miRNA genes:63
Interacting mature miRNAs:64
Transcripts:ENSRNOT00000001050
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)201761783247606836Rat
2303587Bw93Body weight QTL 9313body mass (VT:0001259)body weight (CMO:0000012)202510672254435887Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
2303626Vencon10Ventilatory control QTL 100.001respiration trait (VT:0001943)respiration rate (CMO:0000289)201919072154435887Rat
1598869Memor6Memory QTL 63.1exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)202924438854435887Rat
70158Bp60Blood pressure QTL 603arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)203161428444396023Rat
11528640Bss121Bone structure and strength QTL 1216.722e-07femur morphology trait (VT:0000559)femur length (CMO:0000442)203322147735747124Rat
7411652Foco24Food consumption QTL 240.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)201175751554435887Rat
1331747Hrtrt16Heart rate QTL 163.163heart pumping trait (VT:2000009)heart rate (CMO:0000002)202520973454435887Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
2303578Gluco50Glucose level QTL 502blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)202510672254435887Rat
2317880Alcrsp25Alcohol response QTL 252.3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)201769755054435887Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat
9590092Insglur9Insulin/glucose ratio QTL 918.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)201175751554435887Rat
2300188Bmd68Bone mineral density QTL 686.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)202510672254435887Rat

Markers in Region
RH131392  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22035,476,700 - 35,476,911 (+)MAPPERmRatBN7.2
Rnor_6.02037,589,223 - 37,589,433NCBIRnor6.0
Rnor_5.02039,333,685 - 39,333,895UniSTSRnor5.0
RGSC_v3.42034,907,450 - 34,907,660UniSTSRGSC3.4
Celera2036,827,876 - 36,828,086UniSTS
RH 3.4 Map20373.42UniSTS
Cytogenetic Map20q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000001050   ⟹   ENSRNOP00000001050
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2035,473,076 - 35,477,757 (+)Ensembl
Rnor_6.0 Ensembl2037,587,687 - 37,589,198 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000108572   ⟹   ENSRNOP00000084061
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2035,468,888 - 35,477,757 (+)Ensembl
RefSeq Acc Id: NM_001014032   ⟹   NP_001014054
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82036,015,695 - 36,019,529 (+)NCBI
mRatBN7.22035,473,191 - 35,477,025 (+)NCBI
Rnor_6.02037,585,713 - 37,589,018 (+)NCBI
Rnor_5.02039,325,852 - 39,334,021 (+)NCBI
RGSC_v3.42034,903,940 - 34,907,245 (+)RGD
Celera2036,824,366 - 36,827,671 (+)RGD
Sequence:
RefSeq Acc Id: NM_001419552   ⟹   NP_001406481
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82036,011,381 - 36,019,529 (+)NCBI
mRatBN7.22035,468,877 - 35,477,025 (+)NCBI
RefSeq Acc Id: NP_001014054   ⟸   NM_001014032
- UniProtKB: Q6AYG1 (UniProtKB/TrEMBL),   A6K4A8 (UniProtKB/TrEMBL),   A0A8I5ZYM3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000001050   ⟸   ENSRNOT00000001050
Ensembl Acc Id: ENSRNOP00000084061   ⟸   ENSRNOT00000108572
RefSeq Acc Id: NP_001406481   ⟸   NM_001419552
- UniProtKB: Q6AYG1 (UniProtKB/TrEMBL),   A6K4A8 (UniProtKB/TrEMBL),   A0A8I5ZYM3 (UniProtKB/TrEMBL)
Protein Domains
MRG

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6AYG1-F1-model_v2 AlphaFold Q6AYG1 1-371 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308699 AgrOrtholog
BioCyc Gene G2FUF-3607 BioCyc
Ensembl Genes ENSRNOG00000000801 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00055015316 UniProtKB/Swiss-Prot
  ENSRNOG00060007988 UniProtKB/Swiss-Prot
  ENSRNOG00065003310 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000001050.6 UniProtKB/Swiss-Prot
  ENSRNOT00000108572.1 UniProtKB/Swiss-Prot
  ENSRNOT00055026153 UniProtKB/Swiss-Prot
  ENSRNOT00055026158 UniProtKB/Swiss-Prot
  ENSRNOT00060013156 UniProtKB/Swiss-Prot
  ENSRNOT00060013185 UniProtKB/Swiss-Prot
  ENSRNOT00065004719 UniProtKB/Swiss-Prot
  ENSRNOT00065004720 UniProtKB/Swiss-Prot
Gene3D-CATH MRG domain UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7115468 IMAGE-MGC_LOAD
InterPro MRG UniProtKB/Swiss-Prot
  MRG_C_sf UniProtKB/Swiss-Prot
  MRG_dom UniProtKB/Swiss-Prot
KEGG Report rno:309790 UniProtKB/Swiss-Prot
MGC_CLONE MGC:94000 IMAGE-MGC_LOAD
NCBI Gene 309790 ENTREZGENE
PANTHER MORTALITY FACTOR 4-LIKE PROTEIN UniProtKB/Swiss-Prot
  MSL3-LIKE 2 UniProtKB/Swiss-Prot
Pfam MRG UniProtKB/Swiss-Prot
PhenoGen Msl3l2 PhenoGen
PROSITE MRG UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000000801 RatGTEx
  ENSRNOG00055015316 RatGTEx
  ENSRNOG00060007988 RatGTEx
  ENSRNOG00065003310 RatGTEx
UniProt A0A8I5ZYM3 ENTREZGENE
  A6K4A8 ENTREZGENE
  MS3L2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A0A8I5ZYM3 UniProtKB/Swiss-Prot
  A6K4A8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-10-01 Msl3l2  male-specific lethal 3-like 2  Msl3l2  male-specific lethal 3-like 2 (Drosophila)  Name changed 629549 APPROVED
2008-10-16 Msl3l2  male-specific lethal 3-like 2 (Drosophila)  RGD1308699  similar to 1700060H10Rik protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 RGD1308699  similar to 1700060H10Rik protein  RGD1308699_predicted  similar to 1700060H10Rik protein (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1308699_predicted  similar to 1700060H10Rik protein (predicted)  LOC309790_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC309790_predicted  similar to 1700060H10Rik protein (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL