FOXO3 (forkhead box O3) - Rat Genome Database

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Gene: FOXO3 (forkhead box O3) Canis lupus familiaris
Analyze
Symbol: FOXO3
Name: forkhead box O3
RGD ID: 12096304
Description: ENCODES a protein that exhibits transcription coregulator binding (ortholog); INVOLVED IN antral ovarian follicle growth (ortholog); brain morphogenesis (ortholog); canonical Wnt signaling pathway (ortholog); PARTICIPATES IN insulin signaling pathway; phosphatidylinositol 3-kinase class I signaling pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; ASSOCIATED WITH adenoid cystic carcinoma (ortholog); Alzheimer's disease (ortholog); Brain Hypoxia-Ischemia (ortholog); FOUND IN RNA polymerase II transcription repressor complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: FKHRL1; forkhead box O3A; forkhead box protein O3; FOXO3A
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11265,552,455 - 65,673,467 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1265,552,310 - 65,670,198 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1265,368,393 - 65,489,406 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01266,431,072 - 66,552,185 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1266,430,400 - 66,552,181 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11265,781,942 - 65,903,154 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01265,630,050 - 65,751,117 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01265,902,223 - 66,023,273 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
antral ovarian follicle growth  (IEA,ISO)
brain morphogenesis  (IEA,ISO)
canonical Wnt signaling pathway  (IEA,ISO)
cellular response to amyloid-beta  (ISO)
cellular response to corticosterone stimulus  (ISO)
cellular response to glucose starvation  (IEA)
cellular response to glucose stimulus  (ISO)
cellular response to hypoxia  (ISO)
cellular response to nerve growth factor stimulus  (ISO)
cellular response to oxidative stress  (IEA,ISO)
DNA damage response, signal transduction by p53 class mediator  (IEA,ISO)
extrinsic apoptotic signaling pathway in absence of ligand  (IEA,ISO)
glucose homeostasis  (IEA,ISO)
initiation of primordial ovarian follicle growth  (IEA,ISO)
mitochondrial transcription  (IEA)
negative regulation of canonical Wnt signaling pathway  (IEA,ISO)
negative regulation of cell migration  (IEA)
negative regulation of neuron differentiation  (ISO)
negative regulation of transcription by RNA polymerase II  (IEA)
neuronal stem cell population maintenance  (IEA,ISO)
oocyte maturation  (IEA,ISO)
ovulation from ovarian follicle  (IEA,ISO)
positive regulation of apoptotic process  (IEA)
positive regulation of autophagy  (IEA)
positive regulation of DNA-templated transcription  (IEA,ISO)
positive regulation of endothelial cell apoptotic process  (ISO)
positive regulation of erythrocyte differentiation  (IEA,ISO)
positive regulation of hydrogen peroxide-mediated programmed cell death  (ISO)
positive regulation of miRNA transcription  (IEA)
positive regulation of muscle atrophy  (IEA)
positive regulation of neuron apoptotic process  (IEA)
positive regulation of reactive oxygen species biosynthetic process  (ISO)
positive regulation of regulatory T cell differentiation  (IEA)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
regulation of DNA-templated transcription  (IEA,ISO)
regulation of neural precursor cell proliferation  (IEA,ISO)
regulation of reactive oxygen species metabolic process  (IEA,ISO)
regulation of transcription by RNA polymerase II  (IEA)
regulation of translation  (IEA)
response to dexamethasone  (ISO)
response to fatty acid  (IEA)
response to nutrient levels  (ISO)
response to starvation  (IEA)
response to water-immersion restraint stress  (ISO)
response to xenobiotic stimulus  (ISO)
tumor necrosis factor-mediated signaling pathway  (IEA)

Cellular Component

References
Additional References at PubMed
PMID:12969136   PMID:30032202  


Genomics

Comparative Map Data
FOXO3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11265,552,455 - 65,673,467 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1265,552,310 - 65,670,198 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1265,368,393 - 65,489,406 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01266,431,072 - 66,552,185 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1266,430,400 - 66,552,181 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11265,781,942 - 65,903,154 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01265,630,050 - 65,751,117 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01265,902,223 - 66,023,273 (+)NCBIUU_Cfam_GSD_1.0
FOXO3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386108,559,825 - 108,684,774 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6108,559,835 - 108,684,774 (+)EnsemblGRCh38hg38GRCh38
GRCh376108,881,028 - 109,005,977 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366108,987,719 - 109,112,664 (+)NCBINCBI36Build 36hg18NCBI36
Build 346108,987,718 - 109,108,647NCBI
Celera6109,627,171 - 109,751,905 (+)NCBICelera
Cytogenetic Map6q21NCBI
HuRef6106,448,666 - 106,573,173 (+)NCBIHuRef
CHM1_16109,143,966 - 109,268,930 (+)NCBICHM1_1
T2T-CHM13v2.06109,737,167 - 109,862,124 (+)NCBIT2T-CHM13v2.0
Foxo3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391042,057,841 - 42,152,691 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1042,057,837 - 42,152,751 (-)EnsemblGRCm39 Ensembl
GRCm381042,181,845 - 42,276,695 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1042,181,841 - 42,276,755 (-)EnsemblGRCm38mm10GRCm38
MGSCv371041,905,592 - 41,996,548 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361041,874,201 - 41,965,157 (-)NCBIMGSCv36mm8
Celera1043,062,294 - 43,153,032 (-)NCBICelera
Cytogenetic Map10B2NCBI
cM Map1022.79NCBI
Foxo3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82047,251,968 - 47,348,254 (-)NCBIGRCr8
mRatBN7.22045,669,708 - 45,764,606 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2045,672,995 - 45,764,561 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2047,391,080 - 47,482,068 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02047,041,261 - 47,132,235 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02047,737,977 - 47,829,015 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02046,428,078 - 46,519,156 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2046,428,124 - 46,519,144 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02048,111,014 - 48,206,518 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42046,171,784 - 46,262,818 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12046,194,693 - 46,284,921 (-)NCBI
Celera2054,198,460 - 54,289,566 (+)NCBICelera
Cytogenetic Map20q12-q13NCBI
Foxo3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541133,655,958 - 33,770,829 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541133,655,958 - 33,770,829 (+)NCBIChiLan1.0ChiLan1.0
FOXO3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25128,566,148 - 128,691,309 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16126,458,644 - 126,582,871 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06106,360,519 - 106,485,676 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16110,406,265 - 110,536,967 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6110,406,266 - 110,516,272 (+)Ensemblpanpan1.1panPan2
Foxo3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946100,513,168 - 100,632,744 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365644,787,992 - 4,903,837 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365644,788,036 - 4,907,600 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FOXO3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl174,628,218 - 74,760,325 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1174,626,673 - 74,760,323 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2183,888,152 - 83,888,769 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.2184,047,498 - 84,048,900 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap1p13NCBI
FOXO3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11365,175,764 - 65,303,107 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1365,195,376 - 65,301,725 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604037,504,633 - 37,631,342 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Foxo3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478013,622,948 - 13,740,374 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478013,621,733 - 13,740,399 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in FOXO3
1228 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 22 6 6 6 6 6 12 10 6
Low 8
Below cutoff

Sequence


RefSeq Acc Id: ENSCAFT00000006080   ⟹   ENSCAFP00000005627
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1265,552,310 - 65,670,198 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845016873   ⟹   ENSCAFP00845013128
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1266,430,400 - 66,552,175 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845016904   ⟹   ENSCAFP00845013156
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1266,449,098 - 66,548,316 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845016921   ⟹   ENSCAFP00845013171
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1266,533,313 - 66,552,181 (+)Ensembl
RefSeq Acc Id: XM_003639400   ⟹   XP_003639448
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11265,552,455 - 65,673,467 (+)NCBI
Dog10K_Boxer_Tasha1265,368,393 - 65,489,406 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038492567   ⟹   XP_038348495
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11265,781,942 - 65,903,154 (+)NCBI
RefSeq Acc Id: XM_038554880   ⟹   XP_038410808
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01265,902,223 - 66,023,273 (+)NCBI
RefSeq Acc Id: XM_038618753   ⟹   XP_038474681
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01265,630,050 - 65,751,117 (+)NCBI
RefSeq Acc Id: XM_038684315   ⟹   XP_038540243
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01266,431,072 - 66,552,185 (+)NCBI
RefSeq Acc Id: XP_003639448   ⟸   XM_003639400
- UniProtKB: A0A8C0KZU3 (UniProtKB/TrEMBL),   A0A8C0YUF9 (UniProtKB/TrEMBL),   A0A8I3N2V0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000005627   ⟸   ENSCAFT00000006080
RefSeq Acc Id: XP_038348495   ⟸   XM_038492567
RefSeq Acc Id: XP_038474681   ⟸   XM_038618753
RefSeq Acc Id: XP_038540243   ⟸   XM_038684315
- UniProtKB: A0A8C0KZU3 (UniProtKB/TrEMBL),   A0A8C0YUF9 (UniProtKB/TrEMBL),   A0A8I3N2V0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038410808   ⟸   XM_038554880
- UniProtKB: A0A8C0KZU3 (UniProtKB/TrEMBL),   A0A8C0YUF9 (UniProtKB/TrEMBL),   A0A8I3N2V0 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845013128   ⟸   ENSCAFT00845016873
RefSeq Acc Id: ENSCAFP00845013156   ⟸   ENSCAFT00845016904
RefSeq Acc Id: ENSCAFP00845013171   ⟸   ENSCAFT00845016921
Promoters
RGD ID:13685527
Promoter ID:EPDNEW_C3594
Type:multiple initiation site
Name:FOXO3_1
Description:forkhead box O3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11265,552,288 - 65,552,348EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000003783 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00040010413 UniProtKB/TrEMBL
  ENSCAFG00845009586 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000006080.5 UniProtKB/TrEMBL
  ENSCAFT00000105051.1 UniProtKB/TrEMBL
  ENSCAFT00000109256.1 UniProtKB/TrEMBL
  ENSCAFT00040019271.1 UniProtKB/TrEMBL
  ENSCAFT00845016873 ENTREZGENE
  ENSCAFT00845016873.1 UniProtKB/TrEMBL
  ENSCAFT00845016904.1 UniProtKB/TrEMBL
  ENSCAFT00845016921.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/TrEMBL
  6.10.250.1690 UniProtKB/TrEMBL
InterPro Fork_head_dom UniProtKB/TrEMBL
  FOXO-TAD UniProtKB/TrEMBL
  FOXO_KIX-bd UniProtKB/TrEMBL
  TF_fork_head_CS_2 UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/TrEMBL
KEGG Report cfa:481954 UniProtKB/TrEMBL
NCBI Gene FOXO3 ENTREZGENE
PANTHER FORKHEAD BOX PROTEIN O UniProtKB/TrEMBL
  FORKHEAD BOX PROTEIN O3-RELATED UniProtKB/TrEMBL
Pfam Forkhead UniProtKB/TrEMBL
  FOXO-TAD UniProtKB/TrEMBL
  FOXO_KIX_bdg UniProtKB/TrEMBL
PRINTS FORKHEAD UniProtKB/TrEMBL
PROSITE FORK_HEAD_2 UniProtKB/TrEMBL
  FORK_HEAD_3 UniProtKB/TrEMBL
SMART SM00339 UniProtKB/TrEMBL
Superfamily-SCOP SSF46785 UniProtKB/TrEMBL
UniProt A0A8C0KZU3 ENTREZGENE
  A0A8C0YUF9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3N1R5_CANLF UniProtKB/TrEMBL
  A0A8I3N2V0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3RX02_CANLF UniProtKB/TrEMBL
  A0A8P0PJU3_CANLF UniProtKB/TrEMBL
  A0A8P0S9E7_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:40963 ENTREZGENE