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Gene: Runx2 (RUNX family transcription factor 2) Rattus norvegicus
Symbol: Runx2
Name: RUNX family transcription factor 2
Description: Exhibits histone deacetylase binding activity and transcription factor binding activity. Involved in cellular response to fibroblast growth factor stimulus; osteoblast differentiation; and positive regulation of ossification. Localizes to nucleus. Human ortholog(s) of this gene implicated in cleidocranial dysplasia and metaphyseal dysplasia-maxillary hypoplasia-brachydacty syndrome. Orthologous to human RUNX2 (RUNX family transcription factor 2); PARTICIPATES IN fibroblast growth factor signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; INTERACTS WITH (20S)-ginsenoside Rg3; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
Also known as: CBF-alpha-1; Cbfa1; core-binding factor subunit alpha-1; OSF-2; osteoblast-specific transcription factor 2; runt related transcription factor 2; runt-related transcription factor 2
Homo sapiens (human) : RUNX2 (RUNX family transcription factor 2)  HGNC  Alliance
Mus musculus (house mouse) : Runx2 (runt related transcription factor 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Runx2 (RUNX family transcription factor 2)
Pan paniscus (bonobo/pygmy chimpanzee) : RUNX2 (RUNX family transcription factor 2)
Canis lupus familiaris (dog) : RUNX2 (RUNX family transcription factor 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Runx2 (RUNX family transcription factor 2)
Sus scrofa (pig) : RUNX2 (RUNX family transcription factor 2)
Chlorocebus sabaeus (African green monkey) : RUNX2 (RUNX family transcription factor 2)
Heterocephalus glaber (naked mole-rat) : Runx2 (RUNX family transcription factor 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0918,564,743 - 18,773,092 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl918,564,927 - 18,773,092 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0917,448,142 - 17,658,373 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4911,869,234 - 12,025,219 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1911,867,896 - 11,943,304 (+)NCBI
Celera913,904,221 - 14,111,920 (+)NCBICelera
Cytogenetic Map9q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Runx2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2282
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.