Runx2 (RUNX family transcription factor 2) - Rat Genome Database

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Gene: Runx2 (RUNX family transcription factor 2) Rattus norvegicus
Analyze
Symbol: Runx2
Name: RUNX family transcription factor 2
RGD ID: 2282
Description: Enables DNA-binding transcription factor binding activity; general transcription initiation factor binding activity; and histone deacetylase binding activity. Involved in several processes, including cellular response to zinc ion starvation; positive regulation of ossification; and response to insulin. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of chromatin and transcription regulator complex. Human ortholog(s) of this gene implicated in cleidocranial dysplasia; lung non-small cell carcinoma; and metaphyseal dysplasia-maxillary hypoplasia-brachydactyly syndrome. Orthologous to human RUNX2 (RUNX family transcription factor 2); PARTICIPATES IN fibroblast growth factor signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; INTERACTS WITH (20S)-ginsenoside Rg3; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CBF-alpha-1; Cbfa1; core-binding factor subunit alpha-1; OSF-2; osteoblast-specific transcription factor 2; runt related transcription factor 2; runt-related transcription factor 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8923,661,278 - 23,990,248 (+)NCBIGRCr8
mRatBN7.2916,167,504 - 16,492,826 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl916,167,482 - 16,492,167 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx924,761,163 - 24,969,039 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0929,823,843 - 30,032,066 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0928,124,579 - 28,332,468 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0918,564,743 - 18,773,092 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl918,564,927 - 18,773,092 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0917,448,142 - 17,658,373 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4911,869,234 - 12,025,219 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1911,867,896 - 11,943,304 (+)NCBI
Celera913,904,221 - 14,111,920 (+)NCBICelera
Cytogenetic Map9q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(20S)-ginsenoside Rg3  (EXP)
(R)-camphor  (ISO)
1,4-benzoquinone  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-di-tert-butylphenol  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid  (ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
2-trans,6-trans-farnesyl diphosphate  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-methyladenine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-fluorouracil  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP)
6alpha-methylprednisolone  (EXP)
acetamide  (EXP)
adenine  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
alendronic acid  (EXP)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP,ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
apocynin  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
aucubin  (ISO)
azadirachtin A  (ISO)
bafilomycin A1  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
berberine  (ISO)
beta-D-glucosamine  (ISO)
bezafibrate  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
boric acid  (ISO)
Butylparaben  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP)
calcidiol  (ISO)
calciol  (ISO)
calcitriol  (EXP,ISO)
Calphostin C  (ISO)
camphor  (ISO)
cannabidiol  (ISO)
captopril  (ISO)
celecoxib  (ISO)
CGP 52608  (ISO)
CHIR 99021  (ISO)
chitosan  (ISO)
chloroacetaldehyde  (ISO)
chloroquine  (ISO)
chlorpyrifos  (EXP)
choline  (ISO)
chromium(3+) trichloride  (ISO)
cidofovir anhydrous  (ISO)
cisplatin  (ISO)
clodronic acid  (ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP)
colforsin daropate hydrochloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
cordycepin  (ISO)
corticosterone  (EXP)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cycloheximide  (ISO)
D-glucose  (EXP,ISO)
DDT  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (EXP,ISO)
Dibutyl phosphate  (ISO)
diclofenac  (EXP)
diethylstilbestrol  (EXP)
dioxygen  (ISO)
disodium selenite  (ISO)
disulfiram  (EXP)
dorsomorphin  (ISO)
enalapril  (EXP)
ethanol  (EXP,ISO)
Ethoxyacetic acid  (ISO)
Ethylenethiourea  (EXP)
farnesyl diphosphate  (ISO)
fasudil  (ISO)
ferric ammonium citrate  (ISO)
fisetin  (EXP)
flavonoids  (EXP)
folic acid  (ISO)
fulvestrant  (EXP,ISO)
gallocatechin  (EXP)
gamma-aminobutyric acid  (EXP)
gamma-Oryzanol (TN)  (EXP)
genistein  (EXP,ISO)
gentamycin  (EXP)
Ginkgoic acid  (ISO)
ginsenoside Rb1  (EXP)
glucose  (EXP,ISO)
glycerol 1-phosphate  (ISO)
glycerol 2-phosphate  (EXP,ISO)
glycidol  (EXP)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
hexaconazole  (ISO)
hexadecanoic acid  (EXP)
hydrogen chloride  (ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
hydroxyurea  (ISO)
icariin  (EXP,ISO)
Icaritin  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indole-3-methanol  (EXP)
ionomycin  (ISO)
isonicotinamide  (ISO)
kaempferol  (ISO)
ketoconazole  (EXP,ISO)
L-ascorbic acid  (EXP,ISO)
L-ascorbic acid 2-phosphate  (ISO)
L-methionine  (ISO)
lead nitrate  (ISO)
lead(0)  (EXP,ISO)
Licochalcone B  (ISO)
linalool  (EXP)
lipopolysaccharide  (ISO)
losartan  (EXP)
LY294002  (ISO)
manganese(II) chloride  (EXP)
melatonin  (EXP,ISO)
menaquinone  (EXP)
mercury dibromide  (ISO)
metformin  (EXP,ISO)
methotrexate  (ISO)
methoxychlor  (EXP)
methylmercury chloride  (EXP)
methylparaben  (ISO)
microcystin-LR  (EXP)
mifepristone  (EXP)
modafinil  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
Monobutylphthalate  (ISO)
montelukast  (ISO)
Morroniside  (EXP,ISO)
myo-inositol hexakisphosphate  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-nitrosodiethylamine  (EXP,ISO)
naringin  (EXP,ISO)
neoeriocitrin  (ISO)
niclosamide  (ISO)
nicotinamide  (EXP,ISO)
notoginsenoside R1  (ISO)
NS-398  (ISO)
ochratoxin A  (ISO)
Octicizer  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
PCB138  (EXP,ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenethyl caffeate  (EXP)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phylloquinone  (EXP)
picene  (ISO)
polaprezinc  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
prostaglandin E2  (ISO)
prostaglandin F2alpha  (ISO)
puerarin  (EXP)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-glucofuranoside  (EXP)
quercetin 3-O-beta-D-glucopyranoside  (EXP)
raloxifene  (ISO)
resveratrol  (EXP,ISO)
riboflavin  (ISO)
rotenone  (ISO)
rottlerin  (ISO)
rutin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
Salidroside  (ISO)
Sanggenon C  (ISO)
SB 203580  (EXP)
SB 431542  (ISO)
sclareol  (ISO)
silibinin  (ISO)
silicon dioxide  (ISO)
simvastatin  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
sodium chloride  (EXP)
sodium fluoride  (EXP,ISO)
sotorasib  (ISO)
streptozocin  (EXP)
succimer  (ISO)
T-2 toxin  (ISO)
tacrolimus hydrate  (EXP)
tamibarotene  (ISO)
tebuconazole  (ISO)
telmisartan  (EXP)
tetrachloromethane  (EXP,ISO)
Theaflavin 3,3'-digallate  (ISO)
thioacetamide  (EXP)
thromboxane A2  (ISO)
trametinib  (ISO)
tremolite asbestos  (ISO)
tributyl phosphate  (ISO)
tributylstannane  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triflumizole  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
tripotassium phosphate  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
tris(2-chloroethyl) phosphate  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
tungsten  (ISO)
tyrphostin AG 1478  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin K  (EXP)
warfarin  (EXP,ISO)
Y-27632  (ISO)
zinc atom  (EXP)
zinc dichloride  (ISO)
zinc sulfate  (ISO)
zinc(0)  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
BMP signaling pathway  (IEA,ISO)
bone mineralization  (IEA,ISO)
cell maturation  (IEA,ISO)
cell population proliferation  (ISO)
cellular response to fibroblast growth factor stimulus  (IEP)
cellular response to zinc ion starvation  (IEP)
chondrocyte development  (IEA,ISO)
chondrocyte differentiation  (ISO)
embryonic cranial skeleton morphogenesis  (IEA,ISO)
embryonic forelimb morphogenesis  (IEA,ISO)
endochondral ossification  (IEA,ISO)
epithelial cell proliferation  (IEA,ISO)
gene expression  (IEA,ISO)
ligamentous ossification  (IEA,ISO)
negative regulation of DNA-templated transcription  (IEA,ISO)
negative regulation of smoothened signaling pathway  (IEA,ISO)
odontogenesis of dentin-containing tooth  (IEA,ISO)
osteoblast development  (IEA,ISO)
osteoblast differentiation  (IMP,ISO)
osteoblast fate commitment  (IEA,ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of chondrocyte differentiation  (IEA,ISO)
positive regulation of developmental process  (IEA)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of epithelial cell proliferation  (IEA,ISO)
positive regulation of gene expression  (IEA,ISO)
positive regulation of multicellular organismal process  (IEA)
positive regulation of ossification  (IMP)
positive regulation of osteoblast differentiation  (IEA,ISO,ISS)
positive regulation of stem cell proliferation  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO,ISS)
regulation of DNA-templated transcription  (IEA)
regulation of fibroblast growth factor receptor signaling pathway  (IEA,ISO)
regulation of gene expression  (ISO)
regulation of odontogenesis of dentin-containing tooth  (IEA,ISO)
regulation of ossification  (IEA,ISO)
regulation of osteoblast differentiation  (ISO,TAS)
response to insulin  (IEP)
response to organic cyclic compound  (IEP)
response to sodium phosphate  (IEA,ISO)
skeletal system development  (ISO)
skeletal system morphogenesis  (ISO)
SMAD protein signal transduction  (IEA,ISO)
smoothened signaling pathway  (IEA,ISO)
stem cell differentiation  (IEA,ISO)
stem cell proliferation  (IEA,ISO)
T cell differentiation  (IEA,ISO)

Cellular Component
chromatin  (IEA,ISO)
cytoplasm  (IEA,ISO,ISS)
nucleoplasm  (ISO,TAS)
nucleus  (IEA,ISO,ISS)
transcription regulator complex  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Telmisartan Prevents Alveolar Bone Loss by Decreasing the Expression of Osteoclasts Markers in Hypertensive Rats With Periodontal Disease. Brito VGB, etal., Front Pharmacol. 2020 Nov 11;11:579926. doi: 10.3389/fphar.2020.579926. eCollection 2020.
2. Histone deacetylase 8 suppresses osteogenic differentiation of bone marrow stromal cells by inhibiting histone H3K9 acetylation and RUNX2 activity. Fu Y, etal., Int J Biochem Cell Biol. 2014 Sep;54:68-77. doi: 10.1016/j.biocel.2014.07.003. Epub 2014 Jul 11.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Increased expression of the receptor for activation of NF-kappaB and decreased runt-related transcription factor 2 expression in bone of rats with streptozotocin-induced diabetes. Hie M and Tsukamoto I, Int J Mol Med. 2010 Oct;26(4):611-8. doi: 10.3892/ijmm_00000506.
6. Zinc deficiency decreases osteoblasts and osteoclasts associated with the reduced expression of Runx2 and RANK. Hie M, etal., Bone. 2011 Dec;49(6):1152-9. doi: 10.1016/j.bone.2011.08.019. Epub 2011 Aug 26.
7. Osteogenic changes in kidneys of hyperoxaluric rats. Joshi S, etal., Biochim Biophys Acta. 2015 Sep;1852(9):2000-12. doi: 10.1016/j.bbadis.2015.06.020. Epub 2015 Jun 27.
8. Differential expressions of cancer-associated genes and their regulatory miRNAs in colorectal carcinoma. Kara M, etal., Gene. 2015 Aug 1;567(1):81-6. doi: 10.1016/j.gene.2015.04.065. Epub 2015 Apr 27.
9. The protein kinase C pathway plays a central role in the fibroblast growth factor-stimulated expression and transactivation activity of Runx2. Kim HJ, etal., J Biol Chem. 2003 Jan 3;278(1):319-26. Epub 2002 Oct 25.
10. SNHG20 knockdown suppresses proliferation, migration and invasion, and promotes apoptosis in non-small cell lung cancer through acting as a miR-154 sponge. Lingling J, etal., Biomed Pharmacother. 2019 Apr;112:108648. doi: 10.1016/j.biopha.2019.108648. Epub 2019 Feb 16.
11. Smad transcription factors. Massagué J, etal., Genes Dev. 2005 Dec 1;19(23):2783-810.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Mutations involving the transcription factor CBFA1 cause cleidocranial dysplasia. Mundlos S, etal., Cell. 1997 May 30;89(5):773-9.
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
16. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
17. GOA pipeline RGD automated data pipeline
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. How the Smads regulate transcription. Ross S and Hill CS, Int J Biochem Cell Biol. 2008;40(3):383-408. Epub 2007 Oct 7.
21. Olfactomedin 2 Regulates Smooth Muscle Phenotypic Modulation and Vascular Remodeling Through Mediating Runt-Related Transcription Factor 2 Binding to Serum Response Factor. Shi N, etal., Arterioscler Thromb Vasc Biol. 2017 Mar;37(3):446-454. doi: 10.1161/ATVBAHA.116.308606. Epub 2017 Jan 5.
22. HDAC4 represses matrix metalloproteinase-13 transcription in osteoblastic cells, and parathyroid hormone controls this repression. Shimizu E, etal., J Biol Chem. 2010 Mar 26;285(13):9616-26. doi: 10.1074/jbc.M109.094862. Epub 2010 Jan 22.
23. Sox9 expression during fracture repair. Shintaku Y, etal., Cells Tissues Organs. 2011;194(1):38-48. doi: 10.1159/000322557. Epub 2011 Jan 22.
24. Regulation of the bone-specific osteocalcin gene by p300 requires Runx2/Cbfa1 and the vitamin D3 receptor but not p300 intrinsic histone acetyltransferase activity. Sierra J, etal., Mol Cell Biol. 2003 May;23(9):3339-51.
25. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
26. Differential expression of RUNX genes in human esophageal squamous cell carcinoma: downregulation of RUNX3 worsens patient prognosis. Tonomoto Y, etal., Oncology. 2007;73(5-6):346-56. doi: 10.1159/000135350. Epub 2008 May 26.
27. Superoxide mediates shock wave induction of ERK-dependent osteogenic transcription factor (CBFA1) and mesenchymal cell differentiation toward osteoprogenitors. Wang FS, etal., J Biol Chem. 2002 Mar 29;277(13):10931-7. Epub 2002 Jan 9.
28. Genomic structure and isoform expression of the mouse, rat and human Cbfa1/Osf2 transcription factor. Xiao ZS, etal., Gene 1998 Jul 3;214(1-2):187-97.
29. Non-virus-mediated transfer of siRNAs against Runx2 and Smad4 inhibit heterotopic ossification in rats. Xue T, etal., Gene Ther. 2010 Mar;17(3):370-9. doi: 10.1038/gt.2009.154. Epub 2009 Nov 26.
30. Mitotic occupancy and lineage-specific transcriptional control of rRNA genes by Runx2. Young DW, etal., Nature. 2007 Jan 25;445(7126):442-6.
31. General transcription factor IIA-gamma increases osteoblast-specific osteocalcin gene expression via activating transcription factor 4 and runt-related transcription factor 2. Yu S, etal., J Biol Chem. 2008 Feb 29;283(9):5542-53. doi: 10.1074/jbc.M705653200. Epub 2008 Jan 2.
Additional References at PubMed
PMID:7862157   PMID:9182762   PMID:9632804   PMID:10072783   PMID:10213384   PMID:11965546   PMID:12112009   PMID:12369786   PMID:12434156   PMID:12551949   PMID:12807883   PMID:12815054  
PMID:12951324   PMID:14688224   PMID:14982932   PMID:15013103   PMID:15030764   PMID:15050892   PMID:15051730   PMID:15107406   PMID:15107836   PMID:15136142   PMID:15150273   PMID:15175325  
PMID:15225881   PMID:15389629   PMID:15456860   PMID:15537544   PMID:15537653   PMID:15565649   PMID:15668330   PMID:15668335   PMID:15990875   PMID:16099986   PMID:16115867   PMID:16443755  
PMID:16476422   PMID:16543677   PMID:16610234   PMID:16751105   PMID:17182356   PMID:17265428   PMID:17334410   PMID:17352693   PMID:17693062   PMID:17708712   PMID:17950631   PMID:18432284  
PMID:18487609   PMID:18701816   PMID:18804520   PMID:18986983   PMID:19075196   PMID:19121369   PMID:19124839   PMID:19144722   PMID:19170063   PMID:19423655   PMID:19739101   PMID:19822991  
PMID:19893245   PMID:20019778   PMID:20093419   PMID:20128911   PMID:20197312   PMID:20568992   PMID:20628571   PMID:20843790   PMID:21221986   PMID:21302441   PMID:21324897   PMID:21412826  
PMID:21628588   PMID:22008669   PMID:22009963   PMID:22407386   PMID:22547067   PMID:22713854   PMID:22827283   PMID:22873791   PMID:22906827   PMID:22916278   PMID:23517179   PMID:24042587  
PMID:24349534   PMID:24391920   PMID:24505141   PMID:24520423   PMID:24535991   PMID:24854956   PMID:25159845   PMID:25205373   PMID:25409708   PMID:25823394   PMID:26345541   PMID:26617945  
PMID:26666855   PMID:26743583   PMID:27178636   PMID:27184949   PMID:27216774   PMID:27281956   PMID:27321958   PMID:27503378   PMID:27748856   PMID:28125630   PMID:28290608   PMID:28419442  
PMID:28462510   PMID:28505335   PMID:28703881   PMID:28738062   PMID:30203400   PMID:30320897   PMID:30374602   PMID:30411113   PMID:30430007   PMID:30912295   PMID:31355604   PMID:31666602  
PMID:31715615   PMID:31960421   PMID:31970784   PMID:32096181   PMID:32459278   PMID:32910396   PMID:33187585   PMID:33485996   PMID:34245724   PMID:34463227   PMID:34643076   PMID:34845564  
PMID:34923106   PMID:36395739   PMID:36672941  


Genomics

Comparative Map Data
Runx2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8923,661,278 - 23,990,248 (+)NCBIGRCr8
mRatBN7.2916,167,504 - 16,492,826 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl916,167,482 - 16,492,167 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx924,761,163 - 24,969,039 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0929,823,843 - 30,032,066 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0928,124,579 - 28,332,468 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0918,564,743 - 18,773,092 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl918,564,927 - 18,773,092 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0917,448,142 - 17,658,373 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4911,869,234 - 12,025,219 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1911,867,896 - 11,943,304 (+)NCBI
Celera913,904,221 - 14,111,920 (+)NCBICelera
Cytogenetic Map9q13NCBI
RUNX2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38645,328,330 - 45,551,082 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl645,328,157 - 45,664,349 (+)EnsemblGRCh38hg38GRCh38
GRCh37645,296,067 - 45,518,819 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36645,404,032 - 45,626,797 (+)NCBINCBI36Build 36hg18NCBI36
Build 34645,498,291 - 45,623,020NCBI
Celera646,849,063 - 47,071,816 (+)NCBICelera
Cytogenetic Map6p21.1NCBI
HuRef645,018,738 - 45,241,794 (+)NCBIHuRef
CHM1_1645,298,649 - 45,521,390 (+)NCBICHM1_1
T2T-CHM13v2.0645,163,134 - 45,385,899 (+)NCBIT2T-CHM13v2.0
Runx2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391744,806,873 - 45,125,518 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1744,806,874 - 45,125,684 (-)EnsemblGRCm39 Ensembl
GRCm381744,495,987 - 44,814,797 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1744,495,987 - 44,814,797 (-)EnsemblGRCm38mm10GRCm38
MGSCv371744,740,950 - 44,951,746 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361744,067,056 - 44,277,682 (-)NCBIMGSCv36mm8
Celera1748,040,272 - 48,252,046 (-)NCBICelera
Cytogenetic Map17B3NCBI
cM Map1721.33NCBI
Runx2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543710,598,145 - 10,800,560 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543710,598,145 - 10,885,858 (+)NCBIChiLan1.0ChiLan1.0
RUNX2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2559,818,489 - 60,045,725 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1655,684,505 - 55,911,773 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0645,003,962 - 45,133,148 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1646,189,426 - 46,411,889 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl646,189,432 - 46,524,389 (+)Ensemblpanpan1.1panPan2
RUNX2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11213,723,535 - 13,842,565 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1213,628,539 - 13,840,785 (+)NCBICanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1213,628,539 - 13,840,785 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1213,657,403 - 13,875,716 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01214,116,775 - 14,343,464 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1214,117,254 - 14,450,732 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11213,641,535 - 13,967,483 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01213,729,537 - 14,055,648 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01213,825,170 - 14,151,515 (+)NCBIUU_Cfam_GSD_1.0
Runx2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494649,141,956 - 49,373,718 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647614,695,965 - 14,905,157 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647614,695,965 - 14,818,246 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RUNX2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl740,106,532 - 40,460,687 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1740,106,581 - 40,353,304 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2746,278,416 - 46,417,291 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RUNX2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11726,679,386 - 26,807,812 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1726,683,175 - 26,807,319 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604445,423,449 - 45,552,140 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Runx2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475414,679,974 - 14,867,729 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475414,601,574 - 14,868,469 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Runx2
1710 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1025
Count of miRNA genes:318
Interacting mature miRNAs:458
Transcripts:ENSRNOT00000061014
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9510982650109826Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9125408446254084Rat
7411609Foco16Food consumption QTL 1625.60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9895256053952560Rat
61450Ciaa3CIA Autoantibody QTL 36.5blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)9795472022071169Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)9137999212Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9143718459Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9125408446254084Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9140594091Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9510982642921101Rat
70226Eae4Experimental allergic encephalomyelitis QTL 4nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)9125661317Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)9137999212Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
1600365Mcs20Mammary carcinoma susceptibility QTL 203mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)91353377042791750Rat
11353947Bp392Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)9728325252283252Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9137999212Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9143718459Rat
9589133Insul26Insulin level QTL 2617.960.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)9895256053952560Rat

Markers in Region
BE116846  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2916,364,443 - 16,364,597 (+)MAPPERmRatBN7.2
Rnor_6.0918,761,793 - 18,761,946NCBIRnor6.0
Rnor_5.0917,647,074 - 17,647,227UniSTSRnor5.0
RGSC_v3.4912,013,930 - 12,014,083UniSTSRGSC3.4
Celera914,100,624 - 14,100,777UniSTS
RH 3.4 Map988.5UniSTS
Cytogenetic Map9q12UniSTS
PMC150810P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2916,371,765 - 16,371,868 (+)MAPPERmRatBN7.2
Rnor_6.0918,769,113 - 18,769,215NCBIRnor6.0
Rnor_5.0917,654,394 - 17,654,496UniSTSRnor5.0
RGSC_v3.4912,021,250 - 12,021,352UniSTSRGSC3.4
Celera914,107,941 - 14,108,043UniSTS
Cytogenetic Map9q12UniSTS
Runx2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2916,167,726 - 16,168,035 (+)MAPPERmRatBN7.2
Rnor_6.0918,565,038 - 18,565,346NCBIRnor6.0
Rnor_5.0917,451,099 - 17,451,407UniSTSRnor5.0
RGSC_v3.4911,792,215 - 11,792,523UniSTSRGSC3.4
Celera913,904,332 - 13,904,640UniSTS
Cytogenetic Map9q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2
Low 3 10 28 12 19 12 2 2 56 34 37 11 2
Below cutoff 33 29 29 29 6 9 18 1 2 6

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001278483 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001278484 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001415755 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006244549 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006244551 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006244554 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596547 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596548 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596549 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596551 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596552 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083954 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083955 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063267498 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010054619 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB025797 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB115745 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB115746 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB573881 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB573882 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF053950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF053953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF325502 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473987 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000061014   ⟹   ENSRNOP00000057733
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl916,167,482 - 16,375,745 (+)Ensembl
Rnor_6.0 Ensembl918,564,927 - 18,773,092 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000097660   ⟹   ENSRNOP00000079678
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl916,167,482 - 16,375,745 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000098417   ⟹   ENSRNOP00000077713
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl916,245,814 - 16,375,745 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000104855   ⟹   ENSRNOP00000079713
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl916,167,616 - 16,492,167 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000116490   ⟹   ENSRNOP00000097985
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl916,167,616 - 16,371,898 (+)Ensembl
RefSeq Acc Id: NM_001278483   ⟹   NP_001265412
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8923,665,058 - 23,873,182 (+)NCBI
mRatBN7.2916,167,612 - 16,375,735 (+)NCBI
Rnor_6.0918,564,927 - 18,773,092 (+)NCBI
Rnor_5.0917,448,142 - 17,658,373 (+)NCBI
Celera913,904,221 - 14,111,920 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001278484   ⟹   NP_001265413
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8923,743,240 - 23,873,182 (+)NCBI
mRatBN7.2916,245,799 - 16,375,735 (+)NCBI
Rnor_6.0918,643,570 - 18,773,092 (+)NCBI
Rnor_5.0917,448,142 - 17,658,373 (+)NCBI
Celera913,982,280 - 14,111,920 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001415755   ⟹   NP_001402684
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8923,665,058 - 23,873,182 (+)NCBI
mRatBN7.2916,167,612 - 16,375,735 (+)NCBI
RefSeq Acc Id: XM_006244549   ⟹   XP_006244611
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8923,665,057 - 23,880,005 (+)NCBI
mRatBN7.2916,167,650 - 16,382,560 (+)NCBI
Rnor_6.0918,565,007 - 18,773,083 (+)NCBI
Rnor_5.0917,448,142 - 17,658,373 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006244554   ⟹   XP_006244616
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8923,743,265 - 23,880,005 (+)NCBI
mRatBN7.2916,245,403 - 16,382,560 (+)NCBI
Rnor_6.0918,643,551 - 18,773,083 (+)NCBI
Rnor_5.0917,448,142 - 17,658,373 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017596547   ⟹   XP_017452036
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8923,665,057 - 23,880,005 (+)NCBI
mRatBN7.2916,167,649 - 16,382,560 (+)NCBI
Rnor_6.0918,565,007 - 18,773,083 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017596548   ⟹   XP_017452037
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8923,665,057 - 23,880,005 (+)NCBI
mRatBN7.2916,167,648 - 16,382,560 (+)NCBI
Rnor_6.0918,565,007 - 18,773,083 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017596549   ⟹   XP_017452038
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8923,665,057 - 23,880,005 (+)NCBI
mRatBN7.2916,167,647 - 16,382,560 (+)NCBI
Rnor_6.0918,565,007 - 18,773,083 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017596551   ⟹   XP_017452040
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8923,743,265 - 23,880,005 (+)NCBI
mRatBN7.2916,245,403 - 16,382,560 (+)NCBI
Rnor_6.0918,643,551 - 18,773,083 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017596552   ⟹   XP_017452041
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8923,743,265 - 23,880,005 (+)NCBI
mRatBN7.2916,245,403 - 16,382,560 (+)NCBI
Rnor_6.0918,643,551 - 18,773,083 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039083954   ⟹   XP_038939882
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8923,665,057 - 23,990,248 (+)NCBI
mRatBN7.2916,167,647 - 16,492,826 (+)NCBI
RefSeq Acc Id: XM_039083955   ⟹   XP_038939883
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8923,661,278 - 23,990,248 (+)NCBI
mRatBN7.2916,167,504 - 16,492,826 (+)NCBI
RefSeq Acc Id: XM_039083956   ⟹   XP_038939884
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8923,661,278 - 23,990,248 (+)NCBI
mRatBN7.2916,167,504 - 16,492,826 (+)NCBI
RefSeq Acc Id: XM_039083957   ⟹   XP_038939885
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8923,665,057 - 23,990,248 (+)NCBI
mRatBN7.2916,167,647 - 16,492,826 (+)NCBI
RefSeq Acc Id: XM_063267498   ⟹   XP_063123568
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8923,661,278 - 23,880,005 (+)NCBI
RefSeq Acc Id: XR_010054619
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8923,665,057 - 23,868,940 (+)NCBI
RefSeq Acc Id: NP_001265412   ⟸   NM_001278483
- Peptide Label: isoform 1
- UniProtKB: A0A8I6AS80 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001265413   ⟸   NM_001278484
- Peptide Label: isoform 2
- UniProtKB: A0A8I6AS80 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006244611   ⟸   XM_006244549
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AS80 (UniProtKB/TrEMBL),   A6JJ12 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006244616   ⟸   XM_006244554
- Peptide Label: isoform X11
- UniProtKB: A0A8I5Y1Y1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017452036   ⟸   XM_017596547
- Peptide Label: isoform X5
- UniProtKB: A0A8I6AS80 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017452037   ⟸   XM_017596548
- Peptide Label: isoform X7
- UniProtKB: F1M9C5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017452038   ⟸   XM_017596549
- Peptide Label: isoform X8
- UniProtKB: A0A8I6AS80 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017452040   ⟸   XM_017596551
- Peptide Label: isoform X10
- UniProtKB: A0A8I6AS80 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017452041   ⟸   XM_017596552
- Peptide Label: isoform X12
- UniProtKB: A0A8I5Y1Y1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000057733   ⟸   ENSRNOT00000061014
RefSeq Acc Id: XP_038939883   ⟸   XM_039083955
- Peptide Label: isoform X3
- UniProtKB: A0A8I6G3M7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038939884   ⟸   XM_039083956
- Peptide Label: isoform X4
- UniProtKB: A0A8I6G3M7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038939882   ⟸   XM_039083954
- Peptide Label: isoform X1
- UniProtKB: A0A8I6G3M7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038939885   ⟸   XM_039083957
- Peptide Label: isoform X6
- UniProtKB: A0A8I6G3M7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000097985   ⟸   ENSRNOT00000116490
Ensembl Acc Id: ENSRNOP00000079713   ⟸   ENSRNOT00000104855
Ensembl Acc Id: ENSRNOP00000079678   ⟸   ENSRNOT00000097660
Ensembl Acc Id: ENSRNOP00000077713   ⟸   ENSRNOT00000098417
RefSeq Acc Id: NP_001402684   ⟸   NM_001415755
- Peptide Label: isoform 1
- UniProtKB: A0A8I6AS80 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063123568   ⟸   XM_063267498
- Peptide Label: isoform X9
- UniProtKB: F1M9C5 (UniProtKB/TrEMBL),   A0A8I5ZNG8 (UniProtKB/TrEMBL)
Protein Domains
Runt

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z2J9-F1-model_v2 AlphaFold Q9Z2J9 1-218 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2282 AgrOrtholog
BioCyc Gene G2FUF-28148 BioCyc
Ensembl Genes ENSRNOG00000020193 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000061014.5 UniProtKB/TrEMBL
  ENSRNOT00000097660.1 UniProtKB/TrEMBL
  ENSRNOT00000098417.1 UniProtKB/TrEMBL
  ENSRNOT00000104855.1 UniProtKB/TrEMBL
  ENSRNOT00000116490.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.720 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AML1_Runt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  p53-like_TF_DNA-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  p53/RUNT-type_TF_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Runt_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Runx_central_dom UniProtKB/TrEMBL
  RunxI UniProtKB/TrEMBL
  TF_Runt-rel_RUNX UniProtKB/TrEMBL
NCBI Gene Runx2 ENTREZGENE
PANTHER PTHR11950 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RUNT-RELATED TRANSCRIPTION FACTOR 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Runt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RunxI UniProtKB/TrEMBL
PhenoGen Runx2 PhenoGen
PIRSF TF_Runt-rel_RUNX UniProtKB/TrEMBL
PRINTS ONCOGENEAML1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE RUNT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000020193 RatGTEx
Superfamily-SCOP beta-sandwich domain of Sec23/24 UniProtKB/TrEMBL
  SSF49417 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC202826
UniProt A0A8I5Y1Y1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZNG8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AS80 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6G3M7 ENTREZGENE, UniProtKB/TrEMBL
  A6JJ12 ENTREZGENE, UniProtKB/TrEMBL
  F1M9C5 ENTREZGENE, UniProtKB/TrEMBL
  Q9Z2J9 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q99NC7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-08-05 Runx2  RUNX family transcription factor 2  Runx2  runt-related transcription factor 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-17 Runx2  runt-related transcription factor 2  Runx2  runt related transcription factor 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Runx2  runt related transcription factor 2      Symbol and Name status set to approved 70586 APPROVED
2001-10-24 Runx2  runt related transcription factor 2      Symbol updated to reflect Human and Mouse nomenclature 68913 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function osteoblast-specific transcription factor 69800
gene_process involved in regulation of osteoblast differentiation 69800
gene_transcript has multiple splicing variant forms due to alternative use of transcription start sites 69800