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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2282
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Runx2
Name: RUNX family transcription factor 2
Acc ID: CHEBI:17234
Term: glucose
Definition: An aldohexose used as a source of energy and metabolic intermediate.
Chemical ID: MESH:D005947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Runx2decreases expressionEXP 6480464CTDGlucose results in decreased expression of RUNX2 mRNA; Glucose results in decreased expression of RUNX2 proteinPMID:32643284
Runx2multiple interactionsEXP 6480464CTDmorroniside inhibits the reaction [Glucose results in decreased expression of RUNX2 mRNA]; morroniside inhibits the reaction [Glucose results in decreased expression of RUNX2 protein]PMID:32643284
Runx2decreases expressionISORUNX2 (Homo sapiens)6480464CTDGlucose results in decreased expression of RUNX2 mRNA; Glucose results in decreased expression of RUNX2 proteinPMID:38000455
Runx2decreases expressionISORunx2 (Mus musculus)6480464CTDGlucose results in decreased expression of RUNX2 mRNA; Glucose results in decreased expression of RUNX2 proteinPMID:33450223
Runx2increases expressionISORunx2 (Mus musculus)6480464CTDGlucose results in increased expression of RUNX2 mRNAPMID:17178593
Runx2multiple interactionsISORUNX2 (Homo sapiens)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phytic Acid inhibits the reaction [Glucose results in decreased expression of RUNX2 mRNA]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phytic Acid inhibits the reaction [Glucose results in decreased expression of RUNX2 protein]]; [EPO protein co-treated with Glucose] results in increased expression of RUNX2 mRNA; [EPO protein co-treated with Glucose] results in increased expression of RUNX2 protein; Melatonin inhibits the reaction [Glucose results in decreased expression of RUNX2 mRNA]; Melatonin inhibits the reaction [Glucose results in decreased expression of RUNX2 protein]; Phytic Acid inhibits the reaction [Glucose results in decreased expression of RUNX2 mRNA]; Phytic Acid inhibits the reaction [Glucose results in decreased expression of RUNX2 protein]PMID:30894315 PMID:38000455
Runx2multiple interactionsISORunx2 (Mus musculus)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Calcitriol inhibits the reaction [Glucose results in decreased expression of RUNX2 protein]]; Calcitriol inhibits the reaction [Glucose results in decreased expression of RUNX2 mRNA]; Calcitriol inhibits the reaction [Glucose results in decreased expression of RUNX2 protein]; FOXO1 protein inhibits the reaction [Calcitriol inhibits the reaction [Glucose results in decreased expression of RUNX2 mRNA]]; FOXO1 protein inhibits the reaction [Calcitriol inhibits the reaction [Glucose results in decreased expression of RUNX2 protein]]; Sirolimus inhibits the reaction [Calcitriol inhibits the reaction [Glucose results in decreased expression of RUNX2 mRNA]]; Sirolimus inhibits the reaction [Calcitriol inhibits the reaction [Glucose results in decreased expression of RUNX2 protein]]PMID:33450223
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