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Gene: Hdac4 (histone deacetylase 4) Rattus norvegicus
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Symbol: Hdac4
Name: histone deacetylase 4
Description: Exhibits promoter-specific chromatin binding activity and transcription factor binding activity. Predicted to contribute to sequence-specific DNA binding activity and transcription regulatory region DNA binding activity. Involved in several processes, including cellular response to mechanical stimulus; cellular response to parathyroid hormone stimulus; and positive regulation of lamellipodium assembly. Localizes to the cytoplasm; nucleus; and protein-containing complex. Biomarker of middle cerebral artery infarction. Human ortholog(s) of this gene implicated in ataxia telangiectasia; eating disorder; and retinal degeneration. Orthologous to human HDAC4 (histone deacetylase 4); PARTICIPATES IN calcium/calmodulin dependent kinase 2 signaling pathway; histone modification pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',5,5'-tetrabromobisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: HD4; LOC363287
Orthologs:
Homo sapiens (human) : HDAC4 (histone deacetylase 4)  HGNC  Alliance
Mus musculus (house mouse) : Hdac4 (histone deacetylase 4)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hdac4 (histone deacetylase 4)
Pan paniscus (bonobo/pygmy chimpanzee) : HDAC4 (histone deacetylase 4)
Canis lupus familiaris (dog) : HDAC4 (histone deacetylase 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hdac4 (histone deacetylase 4)
Sus scrofa (pig) : HDAC4 (histone deacetylase 4)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0999,052,945 - 99,299,715 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0998,727,262 - 98,973,829 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4991,147,435 - 91,389,810 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1991,421,635 - 91,447,796 (+)NCBI
Celera990,047,090 - 90,289,214 (-)NCBICelera
Cytogenetic Map9q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
 
More on Hdac4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 619979
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-08-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.