Gene: Hdac4 (histone deacetylase 4) Rattus norvegicus
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Symbol:
Hdac4
Name:
histone deacetylase 4
RGD ID:
619979
Description:
Exhibits promoter-specific chromatin binding activity and transcription factor binding activity. Predicted to contribute to transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including cellular response to mechanical stimulus; cellular response to parathyroid hormone stimulus; and positive regulation of lamellipodium assembly. Localizes to several cellular components, including cytosol; nucleus; and sarcomere. Biomarker of middle cerebral artery infarction. Human ortholog(s) of this gene implicated in ataxia telangiectasia; chromosome 2q37 deletion syndrome; eating disorder; and retinal degeneration. Orthologous to human HDAC4 (histone deacetylase 4); PARTICIPATES IN calcium/calmodulin dependent kinase 2 signaling pathway; histone modification pathway; INTERACTS WITH (S)-nicotine; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
HD4; LOC363287
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
HDAC4 (histone deacetylase 4) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):
Hdac4 (histone deacetylase 4) HGNC
Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Hdac4 (histone deacetylase 4) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
HDAC4 (histone deacetylase 4) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
HDAC4 (histone deacetylase 4) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Hdac4 (histone deacetylase 4) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
HDAC4 (histone deacetylase 4) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):
HDAC4 (histone deacetylase 4) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Hdac4 (histone deacetylase 4) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
HDAC7 (histone deacetylase 7) HGNC
OrthoMCL
Homo sapiens (human):
HDAC9 (histone deacetylase 9) HGNC
OrthoMCL
Homo sapiens (human):
HDAC5 (histone deacetylase 5) HGNC
OrthoMCL
Alliance orthologs 3
Homo sapiens (human):
HDAC4 (histone deacetylase 4)
Alliance
DIOPT (Ensembl Compara|HGNC|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|TreeFam)
Mus musculus (house mouse):
Hdac4 (histone deacetylase 4)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|TreeFam)
Danio rerio (zebrafish):
hdac4 (histone deacetylase 4)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|TreeFam)
Drosophila melanogaster (fruit fly):
HDAC4
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|TreeFam)
Caenorhabditis elegans (roundworm):
hda-4
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OrthoFinder|OrthoInspector|PANTHER|TreeFam)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 9 99,052,945 - 99,299,715 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 9 99,057,089 - 99,299,715 (-) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 9 98,727,262 - 98,973,829 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 9 91,147,435 - 91,389,810 (-) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 9 91,421,635 - 91,447,796 (+) NCBI Celera 9 90,047,090 - 90,289,214 (-) NCBI Celera Cytogenetic Map 9 q36 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - ClinVar
chromosome 2q37 deletion syndrome ISO RGD:1316832 8554872 ClinVar Annotator: match by term: Brachydactyly-Mental Retardation syndrome ClinVar PMID:20691407 more ... chromosome 2q37 deletion syndrome ISO RGD:1316832 8554872 ClinVar Annotator: match by term: Brachydactyly-Mental Retardation syndrome ClinVar PMID:28492532 chromosome 2q37 deletion syndrome ISO RGD:1316832 8554872 ClinVar Annotator: match by term: Brachydactyly-Mental Retardation syndrome ClinVar genetic disease ISO RGD:1316832 8554872 ClinVar Annotator: match by term: Inborn genetic diseases ClinVar PMID:10523670 more ... intellectual disability ISO RGD:1316832 8554872 ClinVar Annotator: match by term: Intellectual disability ClinVar PMID:25741868 microcephaly ISO RGD:1316832 8554872 ClinVar Annotator: match by term: Microcephaly ClinVar PMID:25741868 multiple myeloma ISO RGD:1316832 8554872 ClinVar Annotator: match by term: Multiple myeloma ClinVar muscular dystrophy ISO RGD:1316832 8554872 ClinVar Annotator: match by term: Muscular dystrophy ClinVar PMID:30311386 Neurodevelopmental Disorders ISO RGD:1316832 8554872 ClinVar Annotator: match by term: Neurodevelopmental disorder ClinVar PMID:30311386 primary hyperoxaluria type 1 ISO RGD:1316832 8554872 ClinVar Annotator: match by term: Primary hyperoxaluria, type I ClinVar PMID:22821680
Imported Annotations - CTD
brachydactyly ISO RGD:1316832 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:20691407 Brachydactyly, Type E ISO RGD:1316832 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:24715439 chromosome 2q37 deletion syndrome ISO RGD:1316832 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:20691407 Cocaine-Related Disorders ISO RGD:1316832 11554173 CTD Direct Evidence: therapeutic CTD PMID:17988634 contact dermatitis ISO RGD:1316832 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:25724174 intellectual disability ISO RGD:1316832 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:20691407 malignant mesothelioma ISO RGD:1316832 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:25756049 primary pulmonary hypertension ISO RGD:1316832 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:22711276 urinary bladder cancer ISO RGD:1316832 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:21507255 Imported Annotations - MGI
eating disorder ISS RGD:1550759 13592920 MouseDO Imported Annotations - OMIM
chromosome 2q37 deletion syndrome ISO RGD:1316832 7240710 OMIM
(S)-nicotine multiple interactions ISO RGD:1550759 6480464 Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of HDAC4 mRNA], Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of HDAC4 protein] CTD PMID:31846720 (S)-nicotine increases expression ISO RGD:1550759 6480464 Nicotine results in increased expression of HDAC4 mRNA, Nicotine results in increased expression of HDAC4 protein CTD PMID:31846720 (S)-nicotine increases expression EXP 6480464 Nicotine results in increased expression of HDAC4 mRNA, Nicotine results in increased expression of HDAC4 protein CTD PMID:31846720 1,2-dimethylhydrazine increases expression ISO RGD:1550759 6480464 1, 2-Dimethylhydrazine results in increased expression of HDAC4 mRNA CTD PMID:22206623 17alpha-ethynylestradiol increases expression EXP 6480464 Ethinyl Estradiol results in increased expression of HDAC4 mRNA CTD PMID:29097150 17beta-estradiol multiple interactions ISO RGD:1316832 6480464 [Estradiol binds to ESR2 protein] which results in increased expression of HDAC4 mRNA CTD PMID:20404318 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1550759 6480464 Tetrachlorodibenzodioxin affects the expression of HDAC4 mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of HDAC4 mRNA CTD PMID:22493514 2,3,7,8-Tetrachlorodibenzofuran decreases expression EXP 6480464 2 more ... CTD PMID:32109520 3,3',5,5'-tetrabromobisphenol A decreases expression EXP 6480464 tetrabromobisphenol A results in decreased expression of HDAC4 mRNA CTD PMID:27914987 5-aza-2'-deoxycytidine increases expression ISO RGD:1550759 6480464 Decitabine results in increased expression of HDAC4 mRNA CTD PMID:27915011 5-fluorouracil decreases expression ISO RGD:1316832 6480464 Fluorouracil results in decreased expression of HDAC4 mRNA CTD PMID:16557594 acetylsalicylic acid increases expression ISO RGD:1316832 6480464 Aspirin results in increased expression of HDAC4 mRNA CTD PMID:15928584 aflatoxin B1 decreases expression ISO RGD:1316832 6480464 Aflatoxin B1 results in decreased expression of HDAC4 mRNA CTD PMID:21641981 aflatoxin B1 affects methylation ISO RGD:1316832 6480464 Aflatoxin B1 affects the methylation of HDAC4 intron CTD PMID:30157460 aflatoxin B2 affects methylation ISO RGD:1316832 6480464 aflatoxin B2 affects the methylation of HDAC4 intron CTD PMID:30157460 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of HDAC4 mRNA CTD PMID:16483693 ammonium chloride increases expression EXP 6480464 Ammonium Chloride results in increased expression of HDAC4 protein CTD PMID:16483693 arsane affects methylation ISO RGD:1316832 6480464 Arsenic affects the methylation of HDAC4 gene CTD PMID:25304211 arsane affects expression ISO RGD:1316832 6480464 Arsenic affects the expression of HDAC4 mRNA CTD PMID:25304211 arsenic atom affects methylation ISO RGD:1316832 6480464 Arsenic affects the methylation of HDAC4 gene CTD PMID:25304211 arsenic atom affects expression ISO RGD:1316832 6480464 Arsenic affects the expression of HDAC4 mRNA CTD PMID:25304211 arsenous acid increases expression ISO RGD:1316832 6480464 Arsenic Trioxide results in increased expression of HDAC4 mRNA CTD PMID:22521957 benzo[a]pyrene decreases expression ISO RGD:1550759 6480464 Benzo(a)pyrene results in decreased expression of HDAC4 mRNA CTD PMID:19770486 benzo[a]pyrene affects methylation ISO RGD:1316832 6480464 Benzo(a)pyrene affects the methylation of HDAC4 5' UTR, Benzo(a)pyrene affects the methylation of HDAC4 intron CTD PMID:27901495 , PMID:30157460 benzo[a]pyrene increases methylation ISO RGD:1316832 6480464 Benzo(a)pyrene results in increased methylation of HDAC4 promoter CTD PMID:27901495 benzo[a]pyrene decreases expression ISO RGD:1316832 6480464 Benzo(a)pyrene results in decreased expression of HDAC4 mRNA CTD PMID:20064835 more ... benzo[a]pyrene diol epoxide I decreases expression ISO RGD:1316832 6480464 7 more ... CTD PMID:26238291 benzo[e]pyrene decreases methylation ISO RGD:1316832 6480464 benzo(e)pyrene results in decreased methylation of HDAC4 intron CTD PMID:30157460 bis(2-chloroethyl) sulfide decreases expression ISO RGD:1550759 6480464 Mustard Gas results in decreased expression of HDAC4 mRNA CTD PMID:26392148 bis(2-ethylhexyl) phthalate increases expression EXP 6480464 Diethylhexyl Phthalate results in increased expression of HDAC4 protein CTD PMID:25068794 bis(2-ethylhexyl) phthalate multiple interactions ISO RGD:1316832 6480464 HDAC4 mutant form inhibits the reaction [Diethylhexyl Phthalate results in decreased acetylation of and results in increased ubiquitination of SP3 protein] CTD PMID:25068794 bis(2-ethylhexyl) phthalate multiple interactions EXP 6480464 HDAC4 mutant form inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SP3 protein] CTD PMID:25068794 bis(2-ethylhexyl) phthalate increases expression ISO RGD:1316832 6480464 Diethylhexyl Phthalate results in increased expression of HDAC4 mRNA, Diethylhexyl Phthalate results in increased expression of HDAC4 protein CTD PMID:25068794 bisphenol A affects methylation ISO RGD:1550759 6480464 bisphenol A affects the methylation of HDAC4 promoter CTD PMID:27334623 bisphenol A increases methylation EXP 6480464 bisphenol A results in increased methylation of HDAC4 gene CTD PMID:28505145 bortezomib decreases expression ISO RGD:1316832 6480464 Bortezomib results in decreased expression of HDAC4 mRNA CTD PMID:17659339 ciguatoxin CTX1B affects expression ISO RGD:1550759 6480464 Ciguatoxins affects the expression of HDAC4 mRNA CTD PMID:18353800 cisplatin decreases response to substance ISO RGD:1316832 6480464 HDAC4 results in decreased susceptibility to Cisplatin CTD PMID:21571862 cisplatin decreases expression ISO RGD:1316832 6480464 Cisplatin results in decreased expression of HDAC4 mRNA CTD PMID:19561079 cisplatin multiple interactions ISO RGD:1316832 6480464 [HDAC4 results in increased activity of STAT1] which results in decreased susceptibility to Cisplatin CTD PMID:21571862 curcumin decreases expression ISO RGD:1550759 6480464 Curcumin analog results in decreased expression of HDAC4 protein CTD PMID:26991801 , PMID:29228771 curcumin decreases expression ISO RGD:1316832 6480464 Curcumin analog results in decreased expression of HDAC4 mRNA CTD PMID:26409325 cyclosporin A decreases expression ISO RGD:1316832 6480464 Cyclosporine results in decreased expression of HDAC4 mRNA CTD PMID:25562108 dexamethasone increases expression ISO RGD:1316832 6480464 Dexamethasone results in increased expression of HDAC4 mRNA CTD PMID:19022236 diarsenic trioxide increases expression ISO RGD:1316832 6480464 Arsenic Trioxide results in increased expression of HDAC4 mRNA CTD PMID:22521957 dicrotophos increases expression ISO RGD:1316832 6480464 dicrotophos results in increased expression of HDAC4 mRNA CTD PMID:28302478 dorsomorphin multiple interactions ISO RGD:1316832 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 endosulfan increases expression EXP 6480464 Endosulfan results in increased expression of HDAC4 mRNA CTD PMID:29391264 endosulfan decreases expression ISO RGD:1316832 6480464 Endosulfan results in decreased expression of HDAC4 mRNA, Endosulfan results in decreased expression of HDAC4 protein CTD PMID:29054638 ethanol increases expression EXP 6480464 Ethanol results in increased expression of HDAC4 protein CTD PMID:23544086 ethanol increases expression ISO RGD:1550759 6480464 Ethanol results in increased expression of HDAC4 mRNA CTD PMID:30319688 ethanol multiple interactions EXP 6480464 Ethanol promotes the reaction [HDAC3 protein binds to HDAC4 protein binds to HDAC5 protein binds to HDAC7 protein] more ... CTD PMID:23544086 ethyl methanesulfonate decreases expression ISO RGD:1316832 6480464 Ethyl Methanesulfonate results in decreased expression of HDAC4 mRNA CTD PMID:23649840 etoposide affects response to substance ISO RGD:1316832 6480464 HDAC4 protein affects the susceptibility to Etoposide CTD PMID:16217747 fluoranthene multiple interactions ISO RGD:1550759 6480464 [1-methylanthracene co-treated with fluoranthene] results in increased expression of HDAC4 mRNA CTD PMID:28329830 formaldehyde decreases expression ISO RGD:1316832 6480464 Formaldehyde results in decreased expression of HDAC4 mRNA CTD PMID:23649840 gentamycin increases expression ISO RGD:1550759 6480464 Gentamicins results in increased expression of HDAC4 protein CTD PMID:19141081 , PMID:23558232 indole-3-methanol multiple interactions ISO RGD:1550759 6480464 indole-3-carbinol promotes the reaction [enterotoxin B, staphylococcal results in decreased expression of HDAC4 mRNA] CTD PMID:24200994 manganese(II) chloride increases expression EXP 6480464 manganese chloride results in increased expression of HDAC4 mRNA, manganese chloride results in increased expression of HDAC4 protein CTD PMID:29155171 manganese(II) chloride increases expression ISO RGD:1316832 6480464 manganese chloride results in increased expression of HDAC4 mRNA, manganese chloride results in increased expression of HDAC4 protein CTD PMID:29155171 MC1568 multiple interactions EXP 6480464 MC1568 inhibits the reaction [Thimerosal results in increased expression of HDAC4 protein] CTD PMID:27660204 MC1568 multiple interactions ISO RGD:1316832 6480464 MC1568 inhibits the reaction [Thimerosal results in increased expression of HDAC4 protein] CTD PMID:27660204 methapyrilene decreases methylation ISO RGD:1316832 6480464 Methapyrilene results in decreased methylation of HDAC4 intron CTD PMID:30157460 methotrexate affects response to substance ISO RGD:1316832 6480464 HDAC4 protein affects the susceptibility to Methotrexate CTD PMID:16217747 methyl methanesulfonate decreases expression ISO RGD:1316832 6480464 Methyl Methanesulfonate results in decreased expression of HDAC4 mRNA CTD PMID:23649840 methylmercury chloride decreases expression ISO RGD:1316832 6480464 methylmercuric chloride results in decreased expression of HDAC4 mRNA CTD PMID:28001369 methylmercury chloride multiple interactions EXP 6480464 methylmercuric chloride promotes the reaction [HDAC4 protein binds to BDNF promoter] more ... CTD PMID:29522201 methylmercury chloride increases expression EXP 6480464 methylmercuric chloride results in increased expression of HDAC4 mRNA, methylmercuric chloride results in increased expression of HDAC4 protein CTD PMID:29522201 mitoxantrone affects response to substance ISO RGD:1316832 6480464 HDAC4 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 N-acetyl-1,4-benzoquinone imine affects response to substance ISO RGD:1316832 6480464 HDAC4 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 nicotine increases expression ISO RGD:1550759 6480464 Nicotine results in increased expression of HDAC4 mRNA, Nicotine results in increased expression of HDAC4 protein CTD PMID:31846720 nicotine multiple interactions ISO RGD:1550759 6480464 Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of HDAC4 mRNA], Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of HDAC4 protein] CTD PMID:31846720 nicotine increases expression EXP 6480464 Nicotine results in increased expression of HDAC4 mRNA, Nicotine results in increased expression of HDAC4 protein CTD PMID:31846720 nifedipine affects localization EXP 6480464 Nifedipine affects the localization of HDAC4 protein CTD PMID:20559781 O-methyleugenol decreases expression ISO RGD:1316832 6480464 methyleugenol results in decreased expression of HDAC4 mRNA CTD PMID:32234424 paclitaxel decreases expression EXP 6480464 Paclitaxel results in decreased expression of HDAC4 protein CTD PMID:27474498 paracetamol affects expression ISO RGD:1550759 6480464 Acetaminophen affects the expression of HDAC4 mRNA CTD PMID:17562736 paraquat decreases expression EXP 6480464 Paraquat results in decreased expression of HDAC4 protein CTD PMID:21777615 pelargonidin decreases expression ISO RGD:1550759 6480464 pelargonidin results in decreased expression of HDAC4 protein CTD PMID:31181187 phenylmercury acetate decreases expression ISO RGD:1316832 6480464 Phenylmercuric Acetate results in decreased expression of HDAC4 mRNA CTD PMID:26272509 phenylmercury acetate multiple interactions ISO RGD:1316832 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HDAC4 mRNA CTD PMID:27188386 quercetin decreases expression ISO RGD:1316832 6480464 Quercetin results in decreased expression of HDAC4 mRNA CTD PMID:20596804 SB 431542 multiple interactions ISO RGD:1316832 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 sodium arsenite multiple interactions ISO RGD:1550759 6480464 [DOT1L protein affects the susceptibility to sodium arsenite] which results in decreased expression of HDAC4 mRNA CTD PMID:30130555 sunitinib increases expression ISO RGD:1316832 6480464 Sunitinib results in increased expression of HDAC4 mRNA CTD PMID:31533062 tamoxifen multiple interactions ISO RGD:1316832 6480464 HDAC4 protein inhibits the reaction [Tamoxifen results in increased activity of ESR1 protein] CTD PMID:16051668 tauroursodeoxycholic acid multiple interactions EXP 6480464 tauroursodeoxycholic acid inhibits the reaction [Ethanol promotes the reaction [HDAC3 protein binds to HDAC4 protein binds to HDAC5 protein binds to HDAC7 protein]], tauroursodeoxycholic acid inhibits the reaction [Ethanol results in increased expression of HDAC4 protein] CTD PMID:23544086 tetrachloromethane increases expression ISO RGD:1550759 6480464 Carbon Tetrachloride results in increased expression of HDAC4 mRNA CTD PMID:27396813 tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of HDAC4 mRNA CTD PMID:31150632 thimerosal multiple interactions EXP 6480464 MC1568 inhibits the reaction [Thimerosal results in increased expression of HDAC4 protein] CTD PMID:27660204 thimerosal increases expression EXP 6480464 Thimerosal results in increased expression of HDAC4 protein CTD PMID:27660204 thimerosal increases expression ISO RGD:1316832 6480464 Thimerosal results in increased expression of HDAC4 protein CTD PMID:27660204 thimerosal multiple interactions ISO RGD:1316832 6480464 MC1568 inhibits the reaction [Thimerosal results in increased expression of HDAC4 protein] CTD PMID:27660204 titanium dioxide increases expression ISO RGD:1550759 6480464 titanium dioxide results in increased expression of HDAC4 mRNA CTD PMID:23131501 trichostatin A decreases expression ISO RGD:1316832 6480464 trichostatin A results in decreased expression of HDAC4 mRNA CTD PMID:22723015 more ... trichostatin A multiple interactions ISO RGD:1316832 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HDAC4 mRNA CTD PMID:27188386 valproic acid increases methylation ISO RGD:1316832 6480464 Valproic Acid results in increased methylation of HDAC4 gene CTD PMID:29154799 valproic acid multiple interactions ISO RGD:1316832 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HDAC4 mRNA CTD PMID:27188386 valproic acid decreases expression ISO RGD:1316832 6480464 Valproic Acid results in decreased expression of HDAC4 mRNA CTD PMID:26272509 , PMID:28001369 vecuronium bromide multiple interactions ISO RGD:1550759 6480464 Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of HDAC4 mRNA], Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of HDAC4 protein] CTD PMID:31846720 vinclozolin affects expression EXP 6480464 vinclozolin affects the expression of HDAC4 mRNA CTD PMID:19015723 vinclozolin decreases expression EXP 6480464 vinclozolin results in decreased expression of HDAC4 mRNA CTD PMID:18042343 vincristine decreases expression EXP 6480464 Vincristine results in decreased expression of HDAC4 protein CTD PMID:27474498 vorinostat multiple interactions ISO RGD:1316832 6480464 [vorinostat co-treated with monomethylarsonous acid] results in decreased expression of HDAC4 mRNA CTD PMID:23891734 zinc atom multiple interactions ISO RGD:1316832 6480464 Zinc binds to and results in increased activity of HDAC4 protein CTD PMID:16439135 zinc(0) multiple interactions ISO RGD:1316832 6480464 Zinc binds to and results in increased activity of HDAC4 protein CTD PMID:16439135
Biological Process cellular response to mechanical stimulus IEP 9590196 RGD cellular response to parathyroid hormone stimulus IEP 9681006 RGD cellular response to tumor necrosis factor IEP 9681445 RGD chromatin remodeling ISO RGD:1316832 1624291 (PMID:18850004) RGD PMID:18850004 histone deacetylation ISO RGD:1316832 1624291 (PMID:10869435), (PMID:18850004) RGD PMID:10869435 , PMID:18850004 histone H3 deacetylation ISO RGD:1316832 1624291 (PMID:12590135) RGD PMID:12590135 histone H4 deacetylation ISO RGD:1316832 1624291 (PMID:12590135) RGD PMID:12590135 negative regulation of cell population proliferation ISO RGD:1550759 1624291 MGI:MGI:3525071 (MGI:MGI:3513625 , PMID:15537544) RGD MGI:MGI:3513625 , PMID:15537544 negative regulation of DNA-binding transcription factor activity ISO RGD:1316832 1624291 (PMID:18850004) RGD PMID:18850004 negative regulation of glycolytic process ISO RGD:1550759 1624291 (MGI:MGI:4365327, PMID:19109424) RGD MGI:MGI:4365327 , PMID:19109424 negative regulation of myotube differentiation ISO RGD:1316832 1624291 (PMID:10983972) RGD PMID:10983972 negative regulation of osteoblast differentiation ISO RGD:1550759 1624291 (MGI:MGI:3584056, PMID:15990875) RGD MGI:MGI:3584056 , PMID:15990875 negative regulation of pri-miRNA transcription by RNA polymerase II ISO RGD:1550759 1624291 UniProtKB:P70288 (MGI:MGI:5754467 , PMID:24675724) RGD MGI:MGI:5754467 , PMID:24675724 negative regulation of transcription by RNA polymerase II ISO RGD:1316832 1624291 UniProtKB:P10085 more ... RGD PMID:10869435 more ... negative regulation of transcription by RNA polymerase II ISO RGD:1550759 1624291 MGI:MGI:2137495 more ... RGD MGI:MGI:3513625 more ... negative regulation of transcription, DNA-templated ISO RGD:1316832 1624291 (PMID:10869435), (PMID:19276356) RGD PMID:10869435 , PMID:19276356 negative regulation of transcription, DNA-templated ISO RGD:1550759 1624291 (MGI:MGI:2684511 more ... RGD MGI:MGI:2684511 more ... osteoblast development ISO RGD:1550759 1624291 (MGI:MGI:3584056, PMID:15990875) RGD MGI:MGI:3584056 , PMID:15990875 peptidyl-lysine deacetylation ISO RGD:1316832 1624291 (PMID:18614528) RGD PMID:18614528 positive regulation of cell population proliferation ISO RGD:1316832 1624291 (PMID:18850004) RGD PMID:18850004 positive regulation of DNA-binding transcription factor activity ISO RGD:1316832 1624291 (PMID:19071119) RGD PMID:19071119 positive regulation of lamellipodium assembly IMP 9681442 RGD positive regulation of male mating behavior IMP 7241147 RGD positive regulation of neuron apoptotic process IMP 9681446 RGD positive regulation of protein sumoylation ISO RGD:1316832 1624291 (PMID:17696781) RGD PMID:17696781 positive regulation of reactive oxygen species biosynthetic process IMP 9681442 RGD positive regulation of smooth muscle cell migration IMP 9681442 RGD positive regulation of smooth muscle cell proliferation IMP 9681442 RGD positive regulation of transcription by RNA polymerase II ISO RGD:1316832 1624291 (PMID:19071119) RGD PMID:19071119 positive regulation of transcription by RNA polymerase II ISO RGD:1550759 1624291 (MGI:MGI:4365327, PMID:19109424) RGD MGI:MGI:4365327 , PMID:19109424 positive regulation of transcription, DNA-templated ISO RGD:1550759 1624291 (MGI:MGI:4365327, PMID:19109424) RGD MGI:MGI:4365327 , PMID:19109424 protein deacetylation ISO RGD:1316832 1624291 (PMID:27708256) RGD PMID:27708256 protein sumoylation IEA GO:0019789 1600115 GO_REF:0000108 GOC GO_REF:0000108 regulation of cardiac muscle contraction by calcium ion signaling ISO RGD:1550759 1624291 (MGI:MGI:3793386, PMID:18250163) RGD MGI:MGI:3793386 , PMID:18250163 regulation of gene expression, epigenetic ISO RGD:1316832 1624291 (PMID:24413532) RGD PMID:24413532 regulation of protein binding ISO RGD:1316832 1624291 (PMID:19071119) RGD PMID:19071119 regulation of skeletal muscle fiber development ISO RGD:1550759 1624291 MGI:MGI:1333784 more ... RGD MGI:MGI:3763703 , PMID:17786239 regulation of striated muscle cell differentiation ISO RGD:1550759 1624291 MGI:MGI:1333784 more ... RGD MGI:MGI:3763703 , PMID:17786239 response to denervation involved in regulation of muscle adaptation ISO RGD:1550759 1624291 (MGI:MGI:4365327, PMID:19109424) RGD MGI:MGI:4365327 , PMID:19109424 response to drug IDA 2306455 phenylephrine RGD response to interleukin-1 ISO RGD:1316832 1624291 (PMID:19281832) RGD PMID:19281832 skeletal system development ISO RGD:1550759 1624291 MGI:MGI:3525071 (MGI:MGI:3513625 , PMID:15537544) RGD MGI:MGI:3513625 , PMID:15537544 Cellular Component A band IDA 2306453 PMID:18250163 MGI actomyosin ISO RGD:1550759 1624291 (MGI:MGI:3793386, PMID:18250163) RGD MGI:MGI:3793386 , PMID:18250163 cytoplasm IDA 2306455 RGD cytoplasm ISO RGD:1550759 1624291 (MGI:MGI:4365327 more ... RGD MGI:MGI:4365327 more ... cytoplasm ISO RGD:1316832 1624291 (PMID:10869435), (PMID:19281832) RGD PMID:10869435 , PMID:19281832 cytosol IDA 7241148 RGD cytosol ISO RGD:1316832 1624291 RGD GO_REF:0000052 cytosol ISO RGD:1550759 1624291 (MGI:MGI:3790244, PMID:17761942) RGD MGI:MGI:3790244 , PMID:17761942 histone deacetylase complex ISO RGD:1316832 1624291 (PMID:11804585) RGD PMID:11804585 neuromuscular junction ISO RGD:1550759 1624291 (MGI:MGI:3766846, PMID:17873280) RGD MGI:MGI:3766846 , PMID:17873280 nuclear speck ISO RGD:1316832 1624291 RGD GO_REF:0000052 nuclear speck IEA UniProtKB:P56524 , ensembl:ENSP000002646061600115 GO_REF:0000107 Ensembl GO_REF:0000107 nucleoplasm ISO RGD:1316832 1624291 RGD GO_REF:0000052 nucleus IDA 7241148 ; 2306455 RGD nucleus ISO RGD:1316832 1624291 (PMID:10869435), (PMID:19281832), (PMID:23867755), (PMID:26019235) RGD PMID:10869435 more ... nucleus ISO RGD:1550759 1624291 (MGI:MGI:4365327 more ... RGD MGI:MGI:4365327 more ... protein-containing complex IDA 7241148 RGD sarcomere IDA 2306453 RGD transcription repressor complex ISO RGD:1316832 1624291 (PMID:11804585) RGD PMID:11804585 Z disc IDA 2306453 PMID:18250163 MGI Molecular Function activating transcription factor binding ISO RGD:1316832 1624291 UniProtKB:Q8CFN5 (PMID:10983972) RGD PMID:10983972 chromatin binding ISO RGD:1550759 1624291 (MGI:MGI:5604984, PMID:24768298) RGD MGI:MGI:5604984 , PMID:24768298 DNA binding ISO RGD:1550759 1624291 (MGI:MGI:3607445, PMID:16260608) RGD MGI:MGI:3607445 , PMID:16260608 histone deacetylase activity ISO RGD:1316832 1624291 (PMID:10220385), (PMID:10869435) RGD PMID:10220385 , PMID:10869435 histone deacetylase binding ISO RGD:1316832 1624291 UniProtKB:O15379 , UniProtKB:Q9UKV0 (PMID:10869435), (PMID:12590135) RGD PMID:10869435 , PMID:12590135 identical protein binding ISO RGD:1316832 1624291 UniProtKB:P56524 (PMID:17360518) RGD PMID:17360518 NAD-dependent histone deacetylase activity (H3-K14 specific) IEA EC:3.5.1.98 1600115 GO_REF:0000003 UniProt GO_REF:0000003 potassium ion binding ISO RGD:1316832 1624291 (PMID:18614528) RGD PMID:18614528 promoter-specific chromatin binding IDA 7241147 RGD protein binding IPI RGD:621199 7327144 RGD protein binding ISO RGD:1550759 1624291 PR:O54946 more ... RGD MGI:MGI:2684511 more ... protein binding ISO RGD:1316832 1624291 UniProtKB:A1L4K1 more ... RGD PMID:10869435 more ... protein deacetylase activity ISO RGD:1316832 1624291 (PMID:18614528) RGD PMID:18614528 protein deacetylase activity ISO RGD:1550759 1624291 (MGI:MGI:3793386, PMID:18250163) RGD MGI:MGI:3793386 , PMID:18250163 protein kinase binding ISO RGD:1550759 1624291 UniProtKB:Q60670 (MGI:MGI:3712602 , PMID:17468767) RGD MGI:MGI:3712602 , PMID:17468767 repressing transcription factor binding ISO RGD:1316832 1624291 UniProtKB:O75376 (PMID:11804585) RGD PMID:11804585 RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO RGD:1316832 1624291 (PMID:24413532) RGD PMID:24413532 RNA polymerase II transcription factor binding ISO RGD:1316832 1624291 UniProtKB:Q9NP62 (PMID:23867755) RGD PMID:23867755 sequence-specific DNA binding contributes_to ISO RGD:1316832 1624291 (PMID:19276356) RGD PMID:19276356 SUMO transferase activity ISO RGD:1316832 1624291 (PMID:17218271) RGD PMID:17218271 transcription corepressor activity ISO RGD:1550759 1624291 MGI:MGI:1201674 (MGI:MGI:3584056 , PMID:15990875) RGD MGI:MGI:3584056 , PMID:15990875 transcription factor binding IPI RGD:1559787 9681440 RGD transcription factor binding ISO RGD:1550759 1624291 UniProtKB:Q02078 (MGI:MGI:5009201 , PMID:10748098) RGD MGI:MGI:5009201 , PMID:10748098 transcription factor binding ISO RGD:1316832 1624291 UniProtKB:P08047 , UniProtKB:Q61221 (PMID:18850004), (PMID:19071119) RGD PMID:18850004 , PMID:19071119 transcription factor binding IPI RGD:2282 9681006 RGD transcription regulatory region sequence-specific DNA binding contributes_to ISO RGD:1316832 1624291 (PMID:18850004) RGD PMID:18850004 zinc ion binding ISO RGD:1316832 1624291 (PMID:18614528) RGD PMID:18614528
Gene-Chemical Interaction Annotations
