Exhibits promoter-specific chromatin binding activity and transcription factor binding activity. Predicted to contribute to transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including cellular response to mechanical stimulus; cellular response to parathyroid hormone stimulus; and positive regulation of lamellipodium assembly. Localizes to several cellular components, including cytosol; nucleus; and sarcomere. Biomarker of middle cerebral artery infarction. Human ortholog(s) of this gene implicated in ataxia telangiectasia; chromosome 2q37 deletion syndrome; eating disorder; and retinal degeneration. Orthologous to human HDAC4 (histone deacetylase 4); PARTICIPATES IN calcium/calmodulin dependent kinase 2 signaling pathway; histone modification pathway; INTERACTS WITH (S)-nicotine; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of HDAC4 mRNA], Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of HDAC4 protein]
HDAC4 mutant form inhibits the reaction [Diethylhexyl Phthalate results in decreased acetylation of and results in increased ubiquitination of SP3 protein]
Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of HDAC4 mRNA], Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of HDAC4 protein]
[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-5-benzo1, 3dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-ylbenzamide] results in decreased expression of HDAC4 mRNA
ursodoxicoltaurine inhibits the reaction [Ethanol promotes the reaction [HDAC3 protein binds to HDAC4 protein binds to HDAC5 protein binds to HDAC7 protein]], ursodoxicoltaurine inhibits the reaction [Ethanol results in increased expression of HDAC4 protein]
[NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-5-benzo1, 3dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-ylbenzamide] results in decreased expression of HDAC4 mRNA
[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-5-benzo1, 3dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-ylbenzamide] results in decreased expression of HDAC4 mRNA
Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of HDAC4 mRNA], Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of HDAC4 protein]
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin