(S)-nicotine multiple interactions ISO RGD:1550759 6480464 Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of HDAC4 mRNA], Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of HDAC4 protein] CTD PMID:31846720 (S)-nicotine increases expression ISO RGD:1550759 6480464 Nicotine results in increased expression of HDAC4 mRNA, Nicotine results in increased expression of HDAC4 protein CTD PMID:31846720 (S)-nicotine increases expression EXP 6480464 Nicotine results in increased expression of HDAC4 mRNA, Nicotine results in increased expression of HDAC4 protein CTD PMID:31846720 1,2-dimethylhydrazine increases expression ISO RGD:1550759 6480464 1, 2-Dimethylhydrazine results in increased expression of HDAC4 mRNA CTD PMID:22206623 17alpha-ethynylestradiol increases expression EXP 6480464 Ethinyl Estradiol results in increased expression of HDAC4 mRNA CTD PMID:29097150 17beta-estradiol multiple interactions ISO RGD:1316832 6480464 [Estradiol binds to ESR2 protein] which results in increased expression of HDAC4 mRNA CTD PMID:20404318 17beta-estradiol increases expression ISO RGD:1316832 6480464 Estradiol results in increased expression of HDAC4 mRNA CTD PMID:31614463 , PMID:32030086 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1550759 6480464 Tetrachlorodibenzodioxin affects the expression of HDAC4 mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of HDAC4 mRNA CTD PMID:22493514 , PMID:33387578 2,3,7,8-Tetrachlorodibenzofuran decreases expression EXP 6480464 2 more ... CTD PMID:32109520 3,3',5,5'-tetrabromobisphenol A decreases expression EXP 6480464 tetrabromobisphenol A results in decreased expression of HDAC4 mRNA CTD PMID:27914987 5-aza-2'-deoxycytidine increases expression ISO RGD:1550759 6480464 Decitabine results in increased expression of HDAC4 mRNA CTD PMID:27915011 5-fluorouracil decreases expression ISO RGD:1316832 6480464 Fluorouracil results in decreased expression of HDAC4 mRNA CTD PMID:16557594 acetylsalicylic acid increases expression ISO RGD:1316832 6480464 Aspirin results in increased expression of HDAC4 mRNA CTD PMID:15928584 acrylamide increases expression ISO RGD:1316832 6480464 Acrylamide results in increased expression of HDAC4 mRNA CTD PMID:32763439 aflatoxin B1 decreases expression ISO RGD:1316832 6480464 Aflatoxin B1 results in decreased expression of HDAC4 mRNA CTD PMID:21641981 aflatoxin B1 affects methylation ISO RGD:1316832 6480464 Aflatoxin B1 affects the methylation of HDAC4 intron CTD PMID:30157460 Aflatoxin B2 alpha affects methylation ISO RGD:1316832 6480464 aflatoxin B2 affects the methylation of HDAC4 intron CTD PMID:30157460 all-trans-retinoic acid increases expression ISO RGD:1316832 6480464 Tretinoin results in increased expression of HDAC4 mRNA CTD PMID:33167477 allethrin multiple interactions EXP 6480464 [Allethrins co-treated with cyhalothrin co-treated with cypermethrin co-treated with decamethrin co-treated with fenvalerate] affects the expression of HDAC4 mRNA, [cypermethrin co-treated with decamethrin co-treated with fenvalerate co-treated with cyhalothrin co-treated with Allethrins] affects the expression of HDAC4 mRNA CTD PMID:33051911 , PMID:33396045 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of HDAC4 mRNA CTD PMID:16483693 ammonium chloride increases expression EXP 6480464 Ammonium Chloride results in increased expression of HDAC4 protein CTD PMID:16483693 aristolochic acid A decreases expression ISO RGD:1316832 6480464 aristolochic acid I results in decreased expression of HDAC4 mRNA CTD PMID:33212167 arsane affects methylation ISO RGD:1316832 6480464 Arsenic affects the methylation of HDAC4 gene CTD PMID:25304211 arsane affects expression ISO RGD:1316832 6480464 Arsenic affects the expression of HDAC4 mRNA CTD PMID:25304211 arsenic atom affects methylation ISO RGD:1316832 6480464 Arsenic affects the methylation of HDAC4 gene CTD PMID:25304211 arsenic atom affects expression ISO RGD:1316832 6480464 Arsenic affects the expression of HDAC4 mRNA CTD PMID:25304211 arsenous acid increases expression ISO RGD:1316832 6480464 Arsenic Trioxide results in increased expression of HDAC4 mRNA CTD PMID:22521957 benzene decreases expression ISO RGD:1316832 6480464 Benzene results in decreased expression of HDAC4 mRNA CTD PMID:33064461 benzo[a]pyrene decreases expression ISO RGD:1550759 6480464 Benzo(a)pyrene results in decreased expression of HDAC4 mRNA CTD PMID:19770486 benzo[a]pyrene affects methylation ISO RGD:1316832 6480464 Benzo(a)pyrene affects the methylation of HDAC4 5' UTR, Benzo(a)pyrene affects the methylation of HDAC4 intron CTD PMID:27901495 , PMID:30157460 benzo[a]pyrene increases methylation ISO RGD:1316832 6480464 Benzo(a)pyrene results in increased methylation of HDAC4 promoter CTD PMID:27901495 benzo[a]pyrene decreases expression ISO RGD:1316832 6480464 Benzo(a)pyrene results in decreased expression of HDAC4 mRNA CTD PMID:20064835 more ... benzo[a]pyrene diol epoxide I decreases expression ISO RGD:1316832 6480464 7 more ... CTD PMID:26238291 benzo[e]pyrene decreases methylation ISO RGD:1316832 6480464 benzo(e)pyrene results in decreased methylation of HDAC4 intron CTD PMID:30157460 bis(2-chloroethyl) sulfide decreases expression ISO RGD:1550759 6480464 Mustard Gas results in decreased expression of HDAC4 mRNA CTD PMID:26392148 bis(2-ethylhexyl) phthalate increases expression EXP 6480464 Diethylhexyl Phthalate results in increased expression of HDAC4 protein CTD PMID:25068794 bis(2-ethylhexyl) phthalate multiple interactions ISO RGD:1316832 6480464 HDAC4 mutant form inhibits the reaction [Diethylhexyl Phthalate results in decreased acetylation of and results in increased ubiquitination of SP3 protein] CTD PMID:25068794 bis(2-ethylhexyl) phthalate multiple interactions EXP 6480464 HDAC4 mutant form inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SP3 protein] CTD PMID:25068794 bis(2-ethylhexyl) phthalate increases expression ISO RGD:1316832 6480464 Diethylhexyl Phthalate results in increased expression of HDAC4 mRNA, Diethylhexyl Phthalate results in increased expression of HDAC4 protein CTD PMID:25068794 bisphenol A affects methylation ISO RGD:1550759 6480464 bisphenol A affects the methylation of HDAC4 promoter CTD PMID:27334623 bisphenol A increases expression ISO RGD:1316832 6480464 bisphenol A results in increased expression of HDAC4 mRNA CTD PMID:32030086 bisphenol A decreases methylation ISO RGD:1316832 6480464 bisphenol A results in decreased methylation of HDAC4 gene CTD PMID:31601247 bisphenol A multiple interactions ISO RGD:1316832 6480464 [bisphenol A co-treated with Fulvestrant] affects the methylation of HDAC4 gene CTD PMID:31601247 bisphenol A decreases expression ISO RGD:1550759 6480464 bisphenol A results in decreased expression of HDAC4 mRNA CTD PMID:32926169 bisphenol A increases methylation EXP 6480464 bisphenol A results in increased methylation of HDAC4 gene CTD PMID:28505145 bortezomib decreases expression ISO RGD:1316832 6480464 Bortezomib results in decreased expression of HDAC4 mRNA CTD PMID:17659339 caffeine affects phosphorylation ISO RGD:1316832 6480464 Caffeine affects the phosphorylation of HDAC4 protein CTD PMID:35688186 ciguatoxin CTX1B affects expression ISO RGD:1550759 6480464 Ciguatoxins affects the expression of HDAC4 mRNA CTD PMID:18353800 cisplatin decreases response to substance ISO RGD:1316832 6480464 HDAC4 results in decreased susceptibility to Cisplatin CTD PMID:21571862 cisplatin decreases expression ISO RGD:1316832 6480464 Cisplatin results in decreased expression of HDAC4 mRNA CTD PMID:19561079 cisplatin multiple interactions ISO RGD:1316832 6480464 [HDAC4 results in increased activity of STAT1] which results in decreased susceptibility to Cisplatin CTD PMID:21571862 curcumin decreases expression ISO RGD:1550759 6480464 Curcumin analog results in decreased expression of HDAC4 protein CTD PMID:26991801 , PMID:29228771 curcumin decreases expression ISO RGD:1316832 6480464 Curcumin analog results in decreased expression of HDAC4 mRNA CTD PMID:26409325 cyclosporin A decreases expression ISO RGD:1316832 6480464 Cyclosporine results in decreased expression of HDAC4 mRNA CTD PMID:25562108 cyhalothrin multiple interactions EXP 6480464 [Allethrins co-treated with cyhalothrin co-treated with cypermethrin co-treated with decamethrin co-treated with fenvalerate] affects the expression of HDAC4 mRNA, [cypermethrin co-treated with decamethrin co-treated with fenvalerate co-treated with cyhalothrin co-treated with Allethrins] affects the expression of HDAC4 mRNA CTD PMID:33051911 , PMID:33396045 cypermethrin multiple interactions EXP 6480464 [Allethrins co-treated with cyhalothrin co-treated with cypermethrin co-treated with decamethrin co-treated with fenvalerate] affects the expression of HDAC4 mRNA, [cypermethrin co-treated with decamethrin co-treated with fenvalerate co-treated with cyhalothrin co-treated with Allethrins] affects the expression of HDAC4 mRNA CTD PMID:33051911 , PMID:33396045 dexamethasone increases expression ISO RGD:1316832 6480464 Dexamethasone results in increased expression of HDAC4 mRNA CTD PMID:19022236 diarsenic trioxide increases expression ISO RGD:1316832 6480464 Arsenic Trioxide results in increased expression of HDAC4 mRNA CTD PMID:22521957 dicrotophos increases expression ISO RGD:1316832 6480464 dicrotophos results in increased expression of HDAC4 mRNA CTD PMID:28302478 dorsomorphin multiple interactions ISO RGD:1316832 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 endosulfan increases expression EXP 6480464 Endosulfan results in increased expression of HDAC4 mRNA CTD PMID:29391264 endosulfan decreases expression ISO RGD:1316832 6480464 Endosulfan results in decreased expression of HDAC4 mRNA, Endosulfan results in decreased expression of HDAC4 protein CTD PMID:29054638 ethanol increases expression EXP 6480464 Ethanol results in increased expression of HDAC4 protein CTD PMID:23544086 ethanol increases expression ISO RGD:1550759 6480464 Ethanol results in increased expression of HDAC4 mRNA CTD PMID:30319688 ethanol multiple interactions EXP 6480464 Ethanol promotes the reaction [HDAC3 protein binds to HDAC4 protein binds to HDAC5 protein binds to HDAC7 protein] more ... CTD PMID:23544086 ethyl methanesulfonate decreases expression ISO RGD:1316832 6480464 Ethyl Methanesulfonate results in decreased expression of HDAC4 mRNA CTD PMID:23649840 etoposide affects response to substance ISO RGD:1316832 6480464 HDAC4 protein affects the susceptibility to Etoposide CTD PMID:16217747 fenvalerate multiple interactions EXP 6480464 [Allethrins co-treated with cyhalothrin co-treated with cypermethrin co-treated with decamethrin co-treated with fenvalerate] affects the expression of HDAC4 mRNA, [cypermethrin co-treated with decamethrin co-treated with fenvalerate co-treated with cyhalothrin co-treated with Allethrins] affects the expression of HDAC4 mRNA CTD PMID:33051911 , PMID:33396045 fluoranthene multiple interactions ISO RGD:1550759 6480464 [1-methylanthracene co-treated with fluoranthene] results in increased expression of HDAC4 mRNA CTD PMID:28329830 formaldehyde decreases expression ISO RGD:1316832 6480464 Formaldehyde results in decreased expression of HDAC4 mRNA CTD PMID:23649840 fulvestrant multiple interactions ISO RGD:1316832 6480464 [bisphenol A co-treated with Fulvestrant] affects the methylation of HDAC4 gene CTD PMID:31601247 fulvestrant increases methylation ISO RGD:1316832 6480464 Fulvestrant results in increased methylation of HDAC4 gene CTD PMID:31601247 gentamycin increases expression ISO RGD:1550759 6480464 Gentamicins results in increased expression of HDAC4 protein CTD PMID:19141081 , PMID:23558232 gentamycin increases expression EXP 6480464 Gentamicins results in increased expression of HDAC4 mRNA CTD PMID:33387578 indole-3-methanol multiple interactions ISO RGD:1550759 6480464 indole-3-carbinol promotes the reaction [enterotoxin B, staphylococcal results in decreased expression of HDAC4 mRNA] CTD PMID:24200994 lead diacetate multiple interactions EXP 6480464 [lead acetate results in increased abundance of Lead] which results in increased expression of and affects the localization of HDAC4 protein more ... CTD PMID:33080273 lead(0) multiple interactions EXP 6480464 [lead acetate results in increased abundance of Lead] which results in increased expression of and affects the localization of HDAC4 protein more ... CTD PMID:33080273 lead(2+) multiple interactions EXP 6480464 [lead acetate results in increased abundance of Lead] which results in increased expression of and affects the localization of HDAC4 protein more ... CTD PMID:33080273 manganese(II) chloride increases expression EXP 6480464 manganese chloride results in increased expression of HDAC4 mRNA, manganese chloride results in increased expression of HDAC4 protein CTD PMID:29155171 manganese(II) chloride increases expression ISO RGD:1316832 6480464 manganese chloride results in increased expression of HDAC4 mRNA, manganese chloride results in increased expression of HDAC4 protein CTD PMID:29155171 MC1568 multiple interactions EXP 6480464 MC1568 inhibits the reaction [Thimerosal results in increased expression of HDAC4 protein] CTD PMID:27660204 MC1568 multiple interactions ISO RGD:1316832 6480464 MC1568 inhibits the reaction [Thimerosal results in increased expression of HDAC4 protein] CTD PMID:27660204 methapyrilene decreases methylation ISO RGD:1316832 6480464 Methapyrilene results in decreased methylation of HDAC4 intron CTD PMID:30157460 methotrexate affects response to substance ISO RGD:1316832 6480464 HDAC4 protein affects the susceptibility to Methotrexate CTD PMID:16217747 methyl methanesulfonate decreases expression ISO RGD:1316832 6480464 Methyl Methanesulfonate results in decreased expression of HDAC4 mRNA CTD PMID:23649840 methylmercury chloride decreases expression ISO RGD:1316832 6480464 methylmercuric chloride results in decreased expression of HDAC4 mRNA CTD PMID:28001369 methylmercury chloride multiple interactions EXP 6480464 methylmercuric chloride promotes the reaction [HDAC4 protein binds to BDNF promoter] more ... CTD PMID:29522201 methylmercury chloride increases expression EXP 6480464 methylmercuric chloride results in increased expression of HDAC4 mRNA, methylmercuric chloride results in increased expression of HDAC4 protein CTD PMID:29522201 mitoxantrone affects response to substance ISO RGD:1316832 6480464 HDAC4 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 N-acetyl-1,4-benzoquinone imine affects response to substance ISO RGD:1316832 6480464 HDAC4 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 nicotine increases expression ISO RGD:1550759 6480464 Nicotine results in increased expression of HDAC4 mRNA, Nicotine results in increased expression of HDAC4 protein CTD PMID:31846720 nicotine multiple interactions ISO RGD:1550759 6480464 Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of HDAC4 mRNA], Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of HDAC4 protein] CTD PMID:31846720 nicotine increases expression EXP 6480464 Nicotine results in increased expression of HDAC4 mRNA, Nicotine results in increased expression of HDAC4 protein CTD PMID:31846720 nifedipine affects localization EXP 6480464 Nifedipine affects the localization of HDAC4 protein CTD PMID:20559781 O-methyleugenol decreases expression ISO RGD:1316832 6480464 methyleugenol results in decreased expression of HDAC4 mRNA CTD PMID:32234424 paclitaxel decreases expression EXP 6480464 Paclitaxel results in decreased expression of HDAC4 protein CTD PMID:27474498 paracetamol affects expression ISO RGD:1550759 6480464 Acetaminophen affects the expression of HDAC4 mRNA CTD PMID:17562736 paracetamol increases expression EXP 6480464 Acetaminophen results in increased expression of HDAC4 mRNA CTD PMID:33387578 paraquat decreases expression EXP 6480464 Paraquat results in decreased expression of HDAC4 protein CTD PMID:21777615 pelargonidin decreases expression ISO RGD:1550759 6480464 pelargonidin results in decreased expression of HDAC4 protein CTD PMID:31181187 phenylmercury acetate decreases expression ISO RGD:1316832 6480464 Phenylmercuric Acetate results in decreased expression of HDAC4 mRNA CTD PMID:26272509 phenylmercury acetate multiple interactions ISO RGD:1316832 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HDAC4 mRNA CTD PMID:27188386 quercetin decreases expression ISO RGD:1316832 6480464 Quercetin results in decreased expression of HDAC4 mRNA CTD PMID:20596804 SB 431542 multiple interactions ISO RGD:1316832 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 sodium arsenite multiple interactions ISO RGD:1550759 6480464 [DOT1L protein affects the susceptibility to sodium arsenite] which results in decreased expression of HDAC4 mRNA CTD PMID:30130555 sunitinib increases expression ISO RGD:1316832 6480464 Sunitinib results in increased expression of HDAC4 mRNA CTD PMID:31533062 tamoxifen multiple interactions ISO RGD:1316832 6480464 HDAC4 protein inhibits the reaction [Tamoxifen results in increased activity of ESR1 protein] CTD PMID:16051668 tauroursodeoxycholic acid multiple interactions EXP 6480464 ursodoxicoltaurine inhibits the reaction [Ethanol promotes the reaction [HDAC3 protein binds to HDAC4 protein binds to HDAC5 protein binds to HDAC7 protein]], ursodoxicoltaurine inhibits the reaction [Ethanol results in increased expression of HDAC4 protein] CTD PMID:23544086 tetrachloromethane increases expression ISO RGD:1550759 6480464 Carbon Tetrachloride results in increased expression of HDAC4 mRNA CTD PMID:27396813 tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of HDAC4 mRNA CTD PMID:31150632 thimerosal multiple interactions EXP 6480464 MC1568 inhibits the reaction [Thimerosal results in increased expression of HDAC4 protein] CTD PMID:27660204 thimerosal increases expression EXP 6480464 Thimerosal results in increased expression of HDAC4 protein CTD PMID:27660204 thimerosal increases expression ISO RGD:1316832 6480464 Thimerosal results in increased expression of HDAC4 protein CTD PMID:27660204 thimerosal multiple interactions ISO RGD:1316832 6480464 MC1568 inhibits the reaction [Thimerosal results in increased expression of HDAC4 protein] CTD PMID:27660204 thioacetamide increases expression EXP 6480464 Thioacetamide results in increased expression of HDAC4 mRNA CTD PMID:34492290 titanium dioxide increases expression ISO RGD:1550759 6480464 titanium dioxide results in increased expression of HDAC4 mRNA CTD PMID:23131501 trichloroethene increases expression EXP 6480464 Trichloroethylene results in increased expression of HDAC4 mRNA CTD PMID:33387578 trichostatin A decreases expression ISO RGD:1316832 6480464 trichostatin A results in decreased expression of HDAC4 mRNA CTD PMID:22723015 more ... trichostatin A multiple interactions ISO RGD:1316832 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HDAC4 mRNA CTD PMID:27188386 valproic acid increases methylation ISO RGD:1316832 6480464 Valproic Acid results in increased methylation of HDAC4 gene CTD PMID:29154799 valproic acid multiple interactions ISO RGD:1316832 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HDAC4 mRNA CTD PMID:27188386 valproic acid decreases expression ISO RGD:1316832 6480464 Valproic Acid results in decreased expression of HDAC4 mRNA CTD PMID:26272509 , PMID:28001369 vecuronium bromide multiple interactions ISO RGD:1550759 6480464 Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of HDAC4 mRNA], Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of HDAC4 protein] CTD PMID:31846720 vinclozolin affects expression EXP 6480464 vinclozolin affects the expression of HDAC4 mRNA CTD PMID:19015723 vinclozolin decreases methylation EXP 6480464 vinclozolin results in decreased methylation of HDAC4 gene CTD PMID:31079544 vinclozolin decreases expression EXP 6480464 vinclozolin results in decreased expression of HDAC4 mRNA CTD PMID:18042343 vincristine decreases expression EXP 6480464 Vincristine results in decreased expression of HDAC4 protein CTD PMID:27474498 vorinostat multiple interactions ISO RGD:1316832 6480464 [vorinostat co-treated with monomethylarsonous acid] results in decreased expression of HDAC4 mRNA CTD PMID:23891734 zinc atom multiple interactions ISO RGD:1316832 6480464 Zinc binds to and results in increased activity of HDAC4 protein CTD PMID:16439135 zinc(0) multiple interactions ISO RGD:1316832 6480464 Zinc binds to and results in increased activity of HDAC4 protein CTD PMID:16439135
