Srf (serum response factor) - Rat Genome Database

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Gene: Srf (serum response factor) Rattus norvegicus
Analyze
Symbol: Srf
Name: serum response factor
RGD ID: 1559787
Description: Enables histone deacetylase binding activity and sequence-specific DNA binding activity. Involved in several processes, including cellular response to glucose stimulus; long-term memory; and positive regulation of transcription by glucose. Predicted to be located in chromatin; cytoplasm; and nucleus. Used to study hepatocellular carcinoma and hypertension. Human ortholog(s) of this gene implicated in cardiomyopathy and lymphangioleiomyomatosis. Orthologous to human SRF (serum response factor); PARTICIPATES IN platelet-derived growth factor signaling pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH (S)-amphetamine; 2,3,7,8-tetrachlorodibenzodioxine; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC501099; RGD1559787; serum response factor (c-fos serum response element-binding transcription factor); similar to serum response factor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8921,924,050 - 21,933,338 (+)NCBIGRCr8
mRatBN7.2914,426,453 - 14,435,734 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl914,426,472 - 14,435,733 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx923,010,176 - 23,019,436 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0928,073,247 - 28,082,508 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0926,373,557 - 26,382,817 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0916,737,637 - 16,747,226 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl916,737,642 - 16,747,225 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0915,642,584 - 15,652,178 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.499,788,378 - 9,797,639 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera912,173,971 - 12,183,234 (+)NCBICelera
Cytogenetic Map9q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-anisomycin  (ISO)
(S)-amphetamine  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
3-Nitrobenzanthrone  (ISO)
4,4'-sulfonyldiphenol  (ISO)
8-(4-chlorophenylthio)-cGMP  (ISO)
8-bromo-3',5'-cyclic GMP  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
butanal  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cadmium sulfate  (ISO)
caffeine  (ISO)
chlorpyrifos  (EXP,ISO)
chromium(6+)  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibutyl phthalate  (EXP,ISO)
dieldrin  (ISO)
dioxygen  (ISO)
endosulfan  (EXP,ISO)
ethanol  (ISO)
folic acid  (ISO)
FR900359  (ISO)
gefitinib  (ISO)
gentamycin  (EXP)
hydrogen peroxide  (ISO)
jaspamide  (ISO)
latrunculin B  (ISO)
lead(0)  (ISO)
lead(II) chloride  (ISO)
leflunomide  (ISO)
mangiferin  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methamphetamine  (ISO)
morphine  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
phencyclidine  (EXP)
rac-lactic acid  (ISO)
resveratrol  (EXP,ISO)
rotenone  (EXP)
SB 203580  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
tert-butyl hydroperoxide  (ISO)
Tetrachlorobisphenol A  (EXP,ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trimethyltin  (ISO)
triphenyl phosphate  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
wortmannin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (IEA,ISO)
actin filament organization  (IEA,ISO)
associative learning  (IEA,ISO)
axon extension  (IEA,ISO)
bicellular tight junction assembly  (IEA,ISO)
branching involved in blood vessel morphogenesis  (IEA,ISO)
bronchus cartilage development  (IEA,ISO)
cardiac muscle cell myoblast differentiation  (IEA,ISO)
cardiac myofibril assembly  (IEA,ISO)
cardiac vascular smooth muscle cell differentiation  (IEA,ISO)
cell migration involved in sprouting angiogenesis  (IEA,ISO)
cell-cell adhesion  (IEA,ISO)
cell-matrix adhesion  (IEA,ISO)
cellular response to glucose stimulus  (IEP)
cellular senescence  (IEA,ISO)
contractile actin filament bundle assembly  (IEA,ISO)
developmental growth  (IEA,ISO)
dorsal aorta morphogenesis  (IEA,ISO)
epithelial cell-cell adhesion  (IEA,ISO)
epithelial structure maintenance  (IEA,ISO)
erythrocyte development  (IEA,ISO)
establishment of skin barrier  (IEA,ISO)
eyelid development in camera-type eye  (IEA,ISO)
face development  (IEA,ISO)
filopodium assembly  (IEA,ISO)
forebrain development  (IEA,ISO)
gastrulation  (IEA,ISO)
heart development  (IEA,ISO)
heart looping  (IEA,ISO)
heart trabecula formation  (IEA,ISO)
hematopoietic stem cell differentiation  (IEA,ISO)
hippocampus development  (IEA,ISO)
in utero embryonic development  (IEA,ISO)
leukocyte differentiation  (IEA,ISO)
long-term memory  (IMP)
long-term synaptic depression  (IEA,ISO)
lung morphogenesis  (IEA,ISO)
lung smooth muscle development  (IEA,ISO)
megakaryocyte development  (IEA,ISO)
mesoderm formation  (IEA,ISO)
morphogenesis of an epithelial sheet  (IEA,ISO)
muscle cell cellular homeostasis  (IEA,ISO)
negative regulation of amyloid-beta clearance  (IEA,ISO)
negative regulation of cell migration  (IMP)
negative regulation of cell population proliferation  (IMP)
negative regulation of miRNA transcription  (IEA,ISO)
neuron migration  (IEA,ISO)
neuron projection development  (IEA,ISO)
platelet activation  (IEA,ISO)
platelet formation  (IEA,ISO)
positive regulation of axon extension  (IEA,ISO)
positive regulation of cell differentiation  (IEA,ISO)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of DNA-templated transcription  (IEA,IMP,ISO)
positive regulation of filopodium assembly  (IEA,ISO)
positive regulation of miRNA transcription  (IEA,ISO)
positive regulation of smooth muscle contraction  (IEA,ISO)
positive regulation of transcription by glucose  (IMP)
positive regulation of transcription by RNA polymerase II  (IBA,IEA,ISO)
positive regulation of transcription initiation by RNA polymerase II  (IEA,ISO)
positive thymic T cell selection  (IEA,ISO)
primitive streak formation  (IEA,ISO)
regulation of cell adhesion  (IEA,ISO)
regulation of DNA-templated transcription  (IEA,ISO)
response to cytokine  (IEA,ISO)
response to hormone  (IEA,ISO)
response to hypoxia  (IEA,ISO)
sarcomere organization  (IEA,ISO)
skin morphogenesis  (IEA,ISO)
stress fiber assembly  (IEA,ISO)
tangential migration from the subventricular zone to the olfactory bulb  (IEA,ISO)
thymus development  (IEA,ISO)
thyroid gland development  (IEA,ISO)
trachea cartilage development  (IEA,ISO)
transcription by RNA polymerase II  (IEA,ISO)
trophectodermal cell differentiation  (IEA,ISO)

Cellular Component
chromatin  (IEA,ISO)
cytoplasm  (IEA,ISO)
nucleus  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Inhibitory cardiac transcription factor, SRF-N, is generated by caspase 3 cleavage in human heart failure and attenuated by ventricular unloading. Chang J, etal., Circulation. 2003 Jul 29;108(4):407-13. Epub 2003 Jul 21.
2. Sequestration of serum response factor in the hippocampus impairs long-term spatial memory. Dash PK, etal., J Neurochem. 2005 Apr;93(2):269-78.
3. Increased expression of alternatively spliced dominant-negative isoform of SRF in human failing hearts. Davis FJ, etal., Am J Physiol Heart Circ Physiol. 2002 Apr;282(4):H1521-33.
4. Calcium/calmodulin-dependent protein kinase activates serum response factor transcription activity by its dissociation from histone deacetylase, HDAC4. Implications in cardiac muscle gene regulation during hypertrophy. Davis FJ, etal., J Biol Chem. 2003 May 30;278(22):20047-58. Epub 2003 Mar 26.
5. A role in learning for SRF: deletion in the adult forebrain disrupts LTD and the formation of an immediate memory of a novel context. Etkin A, etal., Neuron. 2006 Apr 6;50(1):127-43.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Increased Myosin Light Chain Kinase Expression in Hypertension: Regulation by SRF via an Insertion Mutation in the Promoter. Han YJ, etal., Mol Biol Cell. 2006 Jul 5;.
8. Depletion of serum response factor by RNA interference mimics the mitogenic effects of platelet derived growth factor-BB in vascular smooth muscle cells. Kaplan-Albuquerque N, etal., Circ Res. 2005 Sep 2;97(5):427-33. Epub 2005 Aug 4.
9. Activation of serum response factor in the liver of Long-Evans Cinnamon (LEC) rat. Maeda Y, etal., Cancer Lett. 1997 Nov 11;119(2):137-41.
10. Restricted inactivation of serum response factor to the cardiovascular system. Miano JM, etal., Proc Natl Acad Sci U S A. 2004 Dec 7;101(49):17132-7. Epub 2004 Nov 29.
11. Conditional inactivation of the murine serum response factor in the pancreas leads to severe pancreatitis. Miralles F, etal., Lab Invest. 2006 Oct;86(10):1020-36. Epub 2006 Aug 7.
12. Liver X receptor activation enhances CVB3 viral replication during myocarditis by stimulating lipogenesis. Papageorgiou AP, etal., Cardiovasc Res. 2015 Jul 1;107(1):78-88. doi: 10.1093/cvr/cvv157. Epub 2015 May 21.
13. Temporally controlled onset of dilated cardiomyopathy through disruption of the SRF gene in adult heart. Parlakian A, etal., Circulation. 2005 Nov 8;112(19):2930-9. Epub 2005 Oct 31.
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
16. GOA pipeline RGD automated data pipeline
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. miR-1/miR-206 regulate Hsp60 expression contributing to glucose-mediated apoptosis in cardiomyocytes. Shan ZX, etal., FEBS Lett. 2010 Aug 20;584(16):3592-600. Epub 2010 Jul 24.
19. TGFbeta1-induced Baf60c regulates both smooth muscle cell commitment and quiescence. Sohni A, etal., PLoS One. 2012;7(10):e47629. doi: 10.1371/journal.pone.0047629. Epub 2012 Oct 26.
20. Model of functional cardiac aging: young adult mice with mild overexpression of serum response factor. Zhang X, etal., Am J Physiol Regul Integr Comp Physiol. 2003 Sep;285(3):R552-60.
21. Tissue inhibitor of metalloproteinase-3 downregulation in lymphangioleiomyomatosis: potential consequence of abnormal serum response factor expression. Zhe X, etal., Am J Respir Cell Mol Biol. 2003 Apr;28(4):504-11.
Additional References at PubMed
PMID:2062642   PMID:2108863   PMID:3203386   PMID:8887666   PMID:8900044   PMID:9799237   PMID:11060034   PMID:11278942   PMID:11439182   PMID:12486129   PMID:12525493   PMID:12732141  
PMID:14999078   PMID:15169892   PMID:15180964   PMID:15256479   PMID:15282327   PMID:15550677   PMID:15647354   PMID:15837932   PMID:15857835   PMID:15929941   PMID:15950986   PMID:16054032  
PMID:16395403   PMID:16427017   PMID:16510470   PMID:16824956   PMID:16987998   PMID:17030628   PMID:17215356   PMID:17576768   PMID:17975004   PMID:18035064   PMID:18296735   PMID:18458156  
PMID:18511849   PMID:18804439   PMID:18945672   PMID:18952847   PMID:19098903   PMID:19357276   PMID:19578358   PMID:19778940   PMID:19783823   PMID:19797053   PMID:20047077   PMID:20525922  
PMID:20534669   PMID:20709909   PMID:20808827   PMID:21098124   PMID:21303526   PMID:21379568   PMID:21393865   PMID:21401944   PMID:21525490   PMID:21940949   PMID:22049076   PMID:22106411  
PMID:22157009   PMID:22454534   PMID:22907787   PMID:23553788   PMID:23935853   PMID:24088304   PMID:24218621   PMID:24385487   PMID:24623780   PMID:24732378   PMID:26408645   PMID:26719331  
PMID:27260841   PMID:27565710   PMID:27861881   PMID:28003268   PMID:28062493   PMID:28165114   PMID:28176371   PMID:28715805   PMID:28816418   PMID:29196028   PMID:31668740   PMID:31774735  
PMID:33406503   PMID:36527644   PMID:36801840   PMID:38421133  


Genomics

Comparative Map Data
Srf
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8921,924,050 - 21,933,338 (+)NCBIGRCr8
mRatBN7.2914,426,453 - 14,435,734 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl914,426,472 - 14,435,733 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx923,010,176 - 23,019,436 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0928,073,247 - 28,082,508 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0926,373,557 - 26,382,817 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0916,737,637 - 16,747,226 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl916,737,642 - 16,747,225 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0915,642,584 - 15,652,178 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.499,788,378 - 9,797,639 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera912,173,971 - 12,183,234 (+)NCBICelera
Cytogenetic Map9q12NCBI
SRF
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38643,171,269 - 43,181,506 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl643,171,269 - 43,181,506 (+)EnsemblGRCh38hg38GRCh38
GRCh37643,139,007 - 43,149,244 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36643,246,898 - 43,257,222 (+)NCBINCBI36Build 36hg18NCBI36
Build 34643,247,014 - 43,257,221NCBI
Celera644,691,142 - 44,701,465 (+)NCBICelera
Cytogenetic Map6p21.1NCBI
HuRef642,855,575 - 42,865,934 (+)NCBIHuRef
CHM1_1643,141,808 - 43,152,132 (+)NCBICHM1_1
T2T-CHM13v2.0643,000,031 - 43,010,279 (+)NCBIT2T-CHM13v2.0
Srf
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391746,857,764 - 46,869,194 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1746,859,255 - 46,867,101 (-)EnsemblGRCm39 Ensembl
GRCm381746,546,838 - 46,558,267 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1746,548,329 - 46,556,175 (-)EnsemblGRCm38mm10GRCm38
MGSCv371746,683,788 - 46,693,111 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361746,010,028 - 46,019,351 (-)NCBIMGSCv36mm8
Celera1749,982,837 - 49,992,041 (-)NCBICelera
Cytogenetic Map17CNCBI
cM Map1722.9NCBI
Srf
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554379,098,968 - 9,107,057 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554379,100,546 - 9,109,305 (+)NCBIChiLan1.0ChiLan1.0
SRF
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2557,671,108 - 57,681,467 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1653,541,022 - 53,551,267 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0642,763,099 - 42,773,332 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1644,057,192 - 44,066,768 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl644,057,192 - 44,066,768 (+)Ensemblpanpan1.1panPan2
SRF
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11211,664,441 - 11,673,846 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1211,664,527 - 11,671,533 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1211,691,502 - 11,700,834 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01212,146,868 - 12,156,424 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1212,146,882 - 12,156,417 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11211,674,421 - 11,683,753 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01211,758,840 - 11,768,172 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01211,853,634 - 11,862,966 (+)NCBIUU_Cfam_GSD_1.0
Srf
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494647,170,709 - 47,180,262 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647616,782,233 - 16,789,130 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647616,779,941 - 16,789,499 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SRF
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl738,213,487 - 38,222,144 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1738,213,300 - 38,223,686 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2743,712,387 - 43,724,048 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SRF
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11728,983,161 - 28,993,465 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1728,983,002 - 28,992,995 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604443,231,123 - 43,241,353 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Srf
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475416,371,995 - 16,381,287 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Srf
16 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:369
Count of miRNA genes:192
Interacting mature miRNAs:256
Transcripts:ENSRNOT00000061430
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9510982650109826Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9125408446254084Rat
7411609Foco16Food consumption QTL 1625.60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9895256053952560Rat
61450Ciaa3CIA Autoantibody QTL 36.5blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)9795472022071169Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)9137999212Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9143718459Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9125408446254084Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9140594091Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9510982642921101Rat
70226Eae4Experimental allergic encephalomyelitis QTL 4nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)9125661317Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)9137999212Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
1600365Mcs20Mammary carcinoma susceptibility QTL 203mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)91353377042791750Rat
11353947Bp392Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)9728325252283252Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9137999212Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9143718459Rat
9589133Insul26Insulin level QTL 2617.960.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)9895256053952560Rat

Markers in Region
RH127508  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2914,435,418 - 14,435,628 (+)MAPPERmRatBN7.2
Rnor_6.0916,746,911 - 16,747,120NCBIRnor6.0
Rnor_5.0915,651,863 - 15,652,072UniSTSRnor5.0
RGSC_v3.499,797,325 - 9,797,534UniSTSRGSC3.4
Celera912,182,920 - 12,183,129UniSTS
RH 3.4 Map955.0UniSTS
Cytogenetic Map9q12UniSTS
AW049942  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2914,435,239 - 14,435,328 (+)MAPPERmRatBN7.2
Rnor_6.0916,746,732 - 16,746,820NCBIRnor6.0
Rnor_5.0915,651,684 - 15,651,772UniSTSRnor5.0
RGSC_v3.499,797,146 - 9,797,234UniSTSRGSC3.4
Celera912,182,741 - 12,182,829UniSTS
Cytogenetic Map9q12UniSTS
SRF_3467  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2914,433,530 - 14,434,260 (+)MAPPERmRatBN7.2
Rnor_6.0916,745,023 - 16,745,752NCBIRnor6.0
Rnor_5.0915,649,975 - 15,650,704UniSTSRnor5.0
RGSC_v3.499,795,437 - 9,796,166UniSTSRGSC3.4
Celera912,181,030 - 12,181,759UniSTS
Cytogenetic Map9q12UniSTS
PMC305791P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2914,427,189 - 14,427,903 (+)MAPPERmRatBN7.2
mRatBN7.2914,427,232 - 14,427,903 (+)MAPPERmRatBN7.2
Rnor_6.0916,738,403 - 16,739,395NCBIRnor6.0
Rnor_6.0916,738,725 - 16,739,395NCBIRnor6.0
Rnor_5.0915,643,677 - 15,644,347UniSTSRnor5.0
Rnor_5.0915,643,355 - 15,644,347UniSTSRnor5.0
RGSC_v3.499,789,139 - 9,789,809UniSTSRGSC3.4
Celera912,174,732 - 12,175,402UniSTS
Cytogenetic Map9q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000061430   ⟹   ENSRNOP00000058149
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl914,426,472 - 14,435,733 (+)Ensembl
Rnor_6.0 Ensembl916,737,642 - 16,747,225 (+)Ensembl
RefSeq Acc Id: NM_001109302   ⟹   NP_001102772
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8921,924,076 - 21,933,337 (+)NCBI
mRatBN7.2914,426,472 - 14,435,733 (+)NCBI
Rnor_6.0916,737,642 - 16,747,225 (+)NCBI
Rnor_5.0915,642,584 - 15,652,178 (+)NCBI
RGSC_v3.499,788,378 - 9,797,639 (+)RGD
Celera912,173,971 - 12,183,234 (+)RGD
Sequence:
RefSeq Acc Id: XM_039084061   ⟹   XP_038939989
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8921,924,050 - 21,933,338 (+)NCBI
mRatBN7.2914,426,453 - 14,435,734 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001102772 (Get FASTA)   NCBI Sequence Viewer  
  XP_038939989 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM18828 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000058149
  ENSRNOP00000058149.3
RefSeq Acc Id: NP_001102772   ⟸   NM_001109302
- UniProtKB: D3ZHH8 (UniProtKB/TrEMBL),   A6JIQ4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000058149   ⟸   ENSRNOT00000061430
RefSeq Acc Id: XP_038939989   ⟸   XM_039084061
- Peptide Label: isoform X1
Protein Domains
MADS-box

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZHH8-F1-model_v2 AlphaFold D3ZHH8 1-504 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696516
Promoter ID:EPDNEW_R7040
Type:initiation region
Name:Srf_1
Description:serum response factor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0916,737,635 - 16,737,695EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1559787 AgrOrtholog
BioCyc Gene G2FUF-28230 BioCyc
Ensembl Genes ENSRNOG00000018232 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000061430 ENTREZGENE
  ENSRNOT00000061430.4 UniProtKB/TrEMBL
Gene3D-CATH 3.40.1810.10 UniProtKB/TrEMBL
InterPro MADS-box/MEF2_TF UniProtKB/TrEMBL
  MADS_SRF-like UniProtKB/TrEMBL
  TF_MADSbox UniProtKB/TrEMBL
  TF_MADSbox_sf UniProtKB/TrEMBL
KEGG Report rno:501099 UniProtKB/TrEMBL
NCBI Gene 501099 ENTREZGENE
PANTHER SERUM RESPONSE FACTOR HOMOLOG UniProtKB/TrEMBL
Pfam SRF-TF UniProtKB/TrEMBL
PhenoGen Srf PhenoGen
PRINTS MADSDOMAIN UniProtKB/TrEMBL
PROSITE MADS_BOX_1 UniProtKB/TrEMBL
  MADS_BOX_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018232 RatGTEx
SMART MADS UniProtKB/TrEMBL
Superfamily-SCOP TF_MADSbox UniProtKB/TrEMBL
UniProt A6JIQ4 ENTREZGENE, UniProtKB/TrEMBL
  D3ZHH8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-09-23 Srf  serum response factor  Srf  serum response factor (c-fos serum response element-binding transcription factor)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-18 Srf  serum response factor (c-fos serum response element-binding transcription factor)  Srf  serum response factor   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Srf  serum response factor   Srf_predicted  serum response factor (predicted)  'predicted' is removed 2292626 APPROVED
2006-08-22 Srf_predicted  serum response factor (predicted)  RGD1559787_predicted  similar to serum response factor (predicted)  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1559787_predicted  similar to serum response factor (predicted)  LOC501099  similar to serum response factor  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC501099  similar to serum response factor      Symbol and Name status set to provisional 70820 PROVISIONAL