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Gene: HDAC4 (histone deacetylase 4) Homo sapiens
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Symbol: HDAC4
Name: histone deacetylase 4
Description: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AHO3; BDMR; brachydactyly-mental retardation syndrome; HA6116; HD4; HDAC-4; HDAC-A; HDACA; histone deacetylase A; KIAA0288
Orthologs:
Mus musculus (house mouse) : Hdac4 (histone deacetylase 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Hdac4 (histone deacetylase 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hdac4 (histone deacetylase 4)
Pan paniscus (bonobo/pygmy chimpanzee) : HDAC4 (histone deacetylase 4)
Canis lupus familiaris (dog) : HDAC4 (histone deacetylase 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hdac4 (histone deacetylase 4)
Sus scrofa (pig) : HDAC4 (histone deacetylase 4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382239,048,168 - 239,401,647 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372239,969,864 - 240,323,346 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362239,634,801 - 239,987,580 (-)NCBINCBI36hg18NCBI36
Build 342239,706,635 - 240,058,897NCBI
Celera2233,665,663 - 234,017,808 (-)NCBI
Cytogenetic Map2q37.3NCBI
HuRef2231,741,321 - 232,092,211 (-)NCBIHuRef
CHM1_12239,975,706 - 240,328,679 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on HDAC4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1316832
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-09-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.