Hdac4 (histone deacetylase 4) - Rat Genome Database

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Gene: Hdac4 (histone deacetylase 4) Mus musculus
Analyze
Symbol: Hdac4
Name: histone deacetylase 4
RGD ID: 1550759
MGI Page MGI
Description: Enables several functions, including chromatin binding activity; protein kinase binding activity; and transcription corepressor activity. Involved in regulation of nucleobase-containing compound metabolic process and response to denervation involved in regulation of muscle adaptation. Acts upstream of or within several processes, including negative regulation of osteoblast differentiation; osteoblast development; and regulation of myotube differentiation. Located in several cellular components, including actomyosin; cytosol; and neuromuscular junction. Is expressed in several structures, including alimentary system; early embryo; forelimb; ganglia; and telencephalon. Used to study eating disorder. Human ortholog(s) of this gene implicated in ataxia telangiectasia; eating disorder; and retinal degeneration. Orthologous to human HDAC4 (histone deacetylase 4).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 4932408F19Rik; AI047285; HD4
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39191,856,501 - 92,123,424 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl191,856,501 - 92,123,421 (-)EnsemblGRCm39 Ensembl
GRCm38191,928,779 - 92,195,702 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl191,928,779 - 92,195,699 (-)EnsemblGRCm38mm10GRCm38
MGSCv37193,829,311 - 94,044,970 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36193,763,140 - 93,978,799 (-)NCBIMGSCv36mm8
Celera194,870,648 - 95,086,759 (-)NCBICelera
Cytogenetic Map1DNCBI
cM Map146.24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (EXP,ISO)
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
5-aza-2'-deoxycytidine  (EXP)
5-fluorouracil  (ISO)
acetylsalicylic acid  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
allethrin  (ISO)
ammonium chloride  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
caffeine  (ISO)
Chlamydocin  (ISO)
chlorpyrifos  (EXP)
ciguatoxin CTX1B  (EXP)
cisplatin  (ISO)
curcumin  (EXP,ISO)
cyclosporin A  (ISO)
cyhalothrin  (ISO)
cypermethrin  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dicrotophos  (ISO)
dorsomorphin  (ISO)
endosulfan  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
fenvalerate  (ISO)
fluoranthene  (EXP)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP,ISO)
indole-3-methanol  (EXP)
lead diacetate  (ISO)
lead(0)  (ISO)
manganese(II) chloride  (ISO)
MC1568  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methoxychlor  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
mitoxantrone  (ISO)
N-acetyl-1,4-benzoquinone imine  (ISO)
nicotine  (EXP,ISO)
nifedipine  (ISO)
O-methyleugenol  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
pelargonidin  (EXP)
perfluorohexanesulfonic acid  (EXP)
phenylmercury acetate  (ISO)
pyrethrins  (ISO)
quercetin  (ISO)
SB 431542  (ISO)
sodium arsenite  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
tangeretin  (EXP)
tauroursodeoxycholic acid  (ISO)
tetrachloromethane  (EXP,ISO)
thimerosal  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
trichloroethene  (ISO)
trichostatin A  (ISO)
valproic acid  (ISO)
vecuronium bromide  (EXP)
vinclozolin  (ISO)
vincristine  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell population proliferation  (IDA,IMP)
cellular response to mechanical stimulus  (ISO)
cellular response to parathyroid hormone stimulus  (ISO)
cellular response to tumor necrosis factor  (ISO)
chromatin organization  (IEA)
chromatin remodeling  (ISO)
negative regulation of cell population proliferation  (IDA,IMP)
negative regulation of DNA-binding transcription factor activity  (ISO)
negative regulation of DNA-templated transcription  (IDA,IMP)
negative regulation of gene expression, epigenetic  (ISO)
negative regulation of glycolytic process  (IMP)
negative regulation of miRNA transcription  (IGI,IMP)
negative regulation of myotube differentiation  (ISO)
negative regulation of osteoblast differentiation  (IMP)
negative regulation of transcription by competitive promoter binding  (ISO)
negative regulation of transcription by RNA polymerase II  (IDA,IGI,ISO)
osteoblast development  (IMP)
osteoblast differentiation  (IMP)
peptidyl-lysine deacetylation  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of DNA-templated transcription  (IMP)
positive regulation of lamellipodium assembly  (ISO)
positive regulation of male mating behavior  (ISO)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of protein sumoylation  (ISO)
positive regulation of reactive oxygen species biosynthetic process  (ISO)
positive regulation of smooth muscle cell migration  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of transcription by RNA polymerase II  (IMP,ISO)
protein deacetylation  (ISO)
regulation of cardiac muscle contraction by calcium ion signaling  (IMP)
regulation of skeletal muscle fiber development  (IGI)
regulation of skeletal muscle fiber differentiation  (IGI)
response to alcohol  (ISO)
response to denervation involved in regulation of muscle adaptation  (IMP)
response to interleukin-1  (ISO)
response to xenobiotic stimulus  (ISO)
skeletal system development  (IMP)
type I interferon-mediated signaling pathway  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Proteomics analysis of human obesity reveals the epigenetic factor HDAC4 as a potential target for obesity. Abu-Farha M, etal., PLoS One. 2013 Sep 24;8(9):e75342. doi: 10.1371/journal.pone.0075342. eCollection 2013.
2. Ca(2)(+)-calmodulin-dependent protein kinase II regulation of cardiac excitation-transcription coupling. Bers DM Heart Rhythm. 2011 Jul;8(7):1101-4. doi: 10.1016/j.hrthm.2011.01.030. Epub 2011 Jan 18.
3. Histone deacetylase inhibition suppresses myogenin-dependent atrogene activation in spinal muscular atrophy mice. Bricceno KV, etal., Hum Mol Genet. 2012 Oct 15;21(20):4448-59. Epub 2012 Jul 13.
4. Muscle histone deacetylase 4 upregulation in amyotrophic lateral sclerosis: potential role in reinnervation ability and disease progression. Bruneteau G, etal., Brain. 2013 Aug;136(Pt 8):2359-68. doi: 10.1093/brain/awt164. Epub 2013 Jul 3.
5. HDAC4 regulates neuronal survival in normal and diseased retinas. Chen B and Cepko CL, Science. 2009 Jan 9;323(5911):256-9. doi: 10.1126/science.1166226.
6. Eating disorder predisposition is associated with ESRRA and HDAC4 mutations. Cui H, etal., J Clin Invest. 2013 Nov 1;123(11):4706-13.
7. Epigenetic modulation of neuronal apoptosis and cognitive functions in sepsis-associated encephalopathy. Fang J, etal., Neurol Sci. 2014 Feb;35(2):283-8. doi: 10.1007/s10072-013-1508-4. Epub 2013 Aug 8.
8. Fetal Alcohol Exposure Reduces Dopamine Receptor D2 and Increases Pituitary Weight and Prolactin Production via Epigenetic Mechanisms. Gangisetty O, etal., PLoS One. 2015 Oct 28;10(10):e0140699. doi: 10.1371/journal.pone.0140699. eCollection 2015.
9. Protein kinase A-regulated assembly of a MEF2{middle dot}HDAC4 repressor complex controls c-Jun expression in vascular smooth muscle cells. Gordon JW, etal., J Biol Chem. 2009 Jul 10;284(28):19027-42. doi: 10.1074/jbc.M109.000539. Epub 2009 Apr 23.
10. The expression of histone deacetylase 4 is associated with prednisone poor-response in childhood acute lymphoblastic leukemia. Gruhn B, etal., Leuk Res. 2013 Oct;37(10):1200-7. doi: 10.1016/j.leukres.2013.07.016. Epub 2013 Aug 12.
11. Valproic acid prevents penile fibrosis and erectile dysfunction in cavernous nerve-injured rats. Hannan JL, etal., J Sex Med. 2014 Jun;11(6):1442-51. doi: 10.1111/jsm.12522. Epub 2014 Mar 18.
12. HDAC4/5-HMGB1 signalling mediated by NADPH oxidase activity contributes to cerebral ischaemia/reperfusion injury. He M, etal., J Cell Mol Med. 2013 Apr;17(4):531-42. doi: 10.1111/jcmm.12040. Epub 2013 Mar 11.
13. Histone deacetylase expression in white matter oligodendrocytes after stroke. Kassis H, etal., Neurochem Int. 2014 Nov;77:17-23. doi: 10.1016/j.neuint.2014.03.006. Epub 2014 Mar 19.
14. Nuclear accumulation of HDAC4 in ATM deficiency promotes neurodegeneration in ataxia telangiectasia. Li J, etal., Nat Med. 2012 May;18(5):783-90. doi: 10.1038/nm.2709.
15. MGDs mouse GO annotations MGD data from the GO Consortium
16. MGD IEA MGD IEA
17. Histone deacetylase-2 is a key regulator of diabetes- and transforming growth factor-beta1-induced renal injury. Noh H, etal., Am J Physiol Renal Physiol. 2009 Sep;297(3):F729-39. doi: 10.1152/ajprenal.00086.2009. Epub 2009 Jun 24.
18. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
19. Physical and functional HAT/HDAC interplay regulates protein acetylation balance. Peserico A and Simone C, J Biomed Biotechnol. 2011;2011:371832. doi: 10.1155/2011/371832. Epub 2010 Dec 5.
20. Loss of the putative catalytic domain of HDAC4 leads to reduced thermal nociception and seizures while allowing normal bone development. Rajan I, etal., PLoS One. 2009 Aug 12;4(8):e6612. doi: 10.1371/journal.pone.0006612.
21. Mouse MP Annotation Import Pipeline RGD automated import pipeline
22. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. Histone deacetylase 4 selectively contributes to podocyte injury in diabetic nephropathy. Wang X, etal., Kidney Int. 2014 Oct;86(4):712-25. doi: 10.1038/ki.2014.111. Epub 2014 Apr 9.
25. Knockdown of lncRNA H19 alleviates ox-LDL-induced HCAECs inflammation and injury by mediating miR-20a-5p/HDAC4 axis. Yang Y, etal., Inflamm Res. 2022 Sep;71(9):1109-1121. doi: 10.1007/s00011-022-01604-z. Epub 2022 Jul 19.
26. The histone deacetylase 4/SP1/microrna-200a regulatory network contributes to aberrant histone acetylation in hepatocellular carcinoma. Yuan JH, etal., Hepatology. 2011 Dec;54(6):2025-35. doi: 10.1002/hep.24606.
27. Histone deacetylation inhibition in pulmonary hypertension: therapeutic potential of valproic acid and suberoylanilide hydroxamic acid. Zhao L, etal., Circulation. 2012 Jul 24;126(4):455-67. doi: 10.1161/CIRCULATIONAHA.112.103176. Epub 2012 Jun 18.
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10512203   PMID:10737771   PMID:10748098   PMID:10958686   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:12520002  
PMID:12904583   PMID:14576337   PMID:14610273   PMID:15367668   PMID:15489334   PMID:15537544   PMID:15601857   PMID:15741177   PMID:15743821   PMID:15767461   PMID:15782199   PMID:15840001  
PMID:15990875   PMID:16141072   PMID:16141073   PMID:16166628   PMID:16203988   PMID:16236793   PMID:16260608   PMID:16293626   PMID:16397154   PMID:16602821   PMID:16873063   PMID:17038545  
PMID:17336904   PMID:17468767   PMID:17568773   PMID:17761942   PMID:17786239   PMID:17873280   PMID:17923476   PMID:17967808   PMID:18163532   PMID:18250163   PMID:18256189   PMID:18332106  
PMID:18555775   PMID:18632985   PMID:18780762   PMID:18799693   PMID:18824292   PMID:19015268   PMID:19109424   PMID:19412888   PMID:19463978   PMID:19704004   PMID:20007902   PMID:20034059  
PMID:20097749   PMID:20506506   PMID:20719946   PMID:20887891   PMID:20937823   PMID:21118993   PMID:21267068   PMID:21282606   PMID:21324893   PMID:21421818   PMID:21590736   PMID:21731673  
PMID:21873635   PMID:21884692   PMID:21953612   PMID:22318228   PMID:22403301   PMID:22549777   PMID:22648949   PMID:22658415   PMID:22700976   PMID:22730529   PMID:22875922   PMID:23141539  
PMID:23151343   PMID:23236169   PMID:23239283   PMID:23271793   PMID:23297420   PMID:23434587   PMID:23603510   PMID:23624624   PMID:23652597   PMID:23892436   PMID:23941879   PMID:24023888  
PMID:24043307   PMID:24166750   PMID:24278330   PMID:24302884   PMID:24483844   PMID:24579951   PMID:24675724   PMID:24768298   PMID:24934156   PMID:24944198   PMID:25011550   PMID:25142465  
PMID:25187650   PMID:25205686   PMID:25332236   PMID:25392500   PMID:25447540   PMID:25489064   PMID:25529628   PMID:25728750   PMID:25854767   PMID:25871848   PMID:25903105   PMID:26238735  
PMID:26273529   PMID:26305546   PMID:26357899   PMID:26372908   PMID:26414199   PMID:26437241   PMID:26491230   PMID:26641069   PMID:26969532   PMID:27068606   PMID:27239042   PMID:27320207  
PMID:27333946   PMID:27466189   PMID:27544482   PMID:27563877   PMID:27597886   PMID:27626651   PMID:27661135   PMID:27741240   PMID:27759007   PMID:27785754   PMID:27798109   PMID:27875543  
PMID:27884425   PMID:28028172   PMID:28106071   PMID:28177888   PMID:28409622   PMID:28548935   PMID:28588072   PMID:28635037   PMID:28671696   PMID:28688716   PMID:28882900   PMID:29184203  
PMID:29227474   PMID:29472387   PMID:29472596   PMID:29477142   PMID:29529137   PMID:29543863   PMID:29544022   PMID:29632070   PMID:30030465   PMID:30121575   PMID:30134825   PMID:30145794  
PMID:30284520   PMID:30319457   PMID:30713114   PMID:30843886   PMID:30951378   PMID:31040226   PMID:31169064   PMID:31195810   PMID:31223056   PMID:31273193   PMID:31375688   PMID:31430259  
PMID:31581792   PMID:31600191   PMID:31618641   PMID:32153359   PMID:32325033   PMID:32354322   PMID:32612176   PMID:32770227   PMID:32924161   PMID:33000215   PMID:33590335   PMID:34118928  
PMID:34139860   PMID:34321999   PMID:34369661   PMID:34374436   PMID:34492228   PMID:35076395   PMID:35142084   PMID:35170869   PMID:35242053   PMID:35318161   PMID:35439761   PMID:35780770  
PMID:36028735   PMID:36029930   PMID:36331820   PMID:36477539   PMID:36613534   PMID:36877841   PMID:37010483   PMID:37640194   PMID:38326336   PMID:38355793   PMID:38657041   PMID:38690732  


Genomics

Comparative Map Data
Hdac4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39191,856,501 - 92,123,424 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl191,856,501 - 92,123,421 (-)EnsemblGRCm39 Ensembl
GRCm38191,928,779 - 92,195,702 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl191,928,779 - 92,195,699 (-)EnsemblGRCm38mm10GRCm38
MGSCv37193,829,311 - 94,044,970 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36193,763,140 - 93,978,799 (-)NCBIMGSCv36mm8
Celera194,870,648 - 95,086,759 (-)NCBICelera
Cytogenetic Map1DNCBI
cM Map146.24NCBI
HDAC4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382239,048,168 - 239,401,649 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2239,048,168 - 239,401,654 (-)EnsemblGRCh38hg38GRCh38
GRCh372239,969,864 - 240,323,343 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362239,634,801 - 239,987,580 (-)NCBINCBI36Build 36hg18NCBI36
Build 342239,706,635 - 240,058,897NCBI
Celera2233,665,663 - 234,017,808 (-)NCBICelera
Cytogenetic Map2q37.3NCBI
HuRef2231,741,321 - 232,092,211 (-)NCBIHuRef
CHM1_12239,975,706 - 240,328,679 (-)NCBICHM1_1
T2T-CHM13v2.02239,539,541 - 239,892,233 (-)NCBIT2T-CHM13v2.0
Hdac4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8999,950,972 - 100,200,994 (-)NCBIGRCr8
mRatBN7.2992,503,467 - 92,750,164 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl992,507,611 - 92,750,164 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx9100,941,905 - 101,184,435 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09106,077,667 - 106,320,195 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09104,435,308 - 104,677,856 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0999,052,945 - 99,299,715 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl999,057,089 - 99,299,715 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0998,727,262 - 98,973,829 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4991,147,435 - 91,389,810 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1991,421,635 - 91,447,796 (+)NCBI
Celera990,047,090 - 90,289,214 (-)NCBICelera
Cytogenetic Map9q36NCBI
Hdac4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555421,629,691 - 1,886,210 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555421,629,691 - 1,886,160 (+)NCBIChiLan1.0ChiLan1.0
HDAC4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213141,692,632 - 142,055,693 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B141,707,597 - 142,070,660 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B126,287,745 - 126,649,815 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B245,123,061 - 245,428,441 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B245,123,061 - 245,427,054 (-)Ensemblpanpan1.1panPan2
HDAC4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12549,318,621 - 49,545,314 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2549,317,349 - 49,453,478 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2549,810,705 - 50,083,929 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02549,702,537 - 49,976,665 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2549,706,181 - 49,977,414 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12549,576,470 - 49,848,695 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02549,364,978 - 49,638,565 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02549,597,454 - 49,869,914 (-)NCBIUU_Cfam_GSD_1.0
Hdac4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303191,277,349 - 191,488,700 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367451,730,694 - 1,942,074 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367451,730,743 - 1,942,071 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HDAC4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15138,381,635 - 138,614,301 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115138,378,237 - 138,657,266 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215152,920,983 - 153,035,106 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HDAC4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110125,098,375 - 125,450,524 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10125,098,366 - 125,403,227 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604073,947,227 - 74,329,237 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hdac4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248473,845,858 - 4,101,487 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248473,846,196 - 4,101,537 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hdac4
6994 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:630
Count of miRNA genes:430
Interacting mature miRNAs:512
Transcripts:ENSMUST00000008995, ENSMUST00000097644
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11039528Ccc3_mcolitis susceptibility in the Collaborative Cross 3 (mouse)13680142195051546Mouse
15039333Nmrs1_mNAFLD-associated magnetic resonance shift 1 (mouse)189786512123786512Mouse
1357847Jckm2_mjuvenile cystic kidney modifier 2 (mouse)Not determined174991977133290937Mouse
4142394Mssq1_mmandible size and shape QTL 1 (mouse)Not determined73615692107615830Mouse
1300821Lore1_mloss of righting induced by ethanol 1 (mouse)Not determined17554919192941077Mouse
10412185Hcs9_mhepatocarcinogenesis susceptibility 9 (mouse)Not determined163854690189303617Mouse
1558928Mord2_mmodifier of retinal degeneration 2 (mouse)Not determined177123115110536075Mouse
1301722Cia9_mcollagen induced arthritis QTL 9 (mouse)Not determined145783900189303617Mouse
13824984Twq5_mtestis weight QTL 5 (mouse)13069992184732197Mouse
14697706Stsl3a_mSalmonella typhimurium susceptibility locus 3a (mouse)17747663795827725Mouse
12790991Aath1_maortic arch atherosclerosis 1 (mouse)186483929120483929Mouse
1357721Sle17_msystematic lupus erythematosus susceptibility 17 (mouse)Not determined139132808126445310Mouse
10412238Alpq5_malcohol preference QTL 5 (mouse)Not determined182832635116832635Mouse
1302146Cocrb1_mcocaine related behavior 1 (mouse)Not determined170133533104139557Mouse
14746998Mancz1_mmandible centroid size 1 (mouse)15794135191941351Mouse
1301444Alcw5_malcohol withdrawal 5 (mouse)Not determined15854919192549443Mouse
1300746Skl1_mskeletal size (tail length) 1 (mouse)Not determined15799197791992080Mouse
1558860W10q7_mweight 10 weeks QTL 7 (mouse)Not determined134760138150193871Mouse
4141347Reb1_mrepetitive behavior 1 (mouse)Not determined91468266100413667Mouse
12791004Aath7_maortic arch atherosclerosis 7 (mouse)182832635116832635Mouse
14747009Manh49_mmandible shape 49 (mouse)15794135191941351Mouse
4141725Wbcq4_mwhite blood cell quantitative locus 4 (mouse)Not determined179858683113858791Mouse
12050069Nabq1_mnasal bone morphology QTL 1 (mouse)179858683113858791Mouse
1300976Bmd19_mbone mineral density 19 (mouse)Not determined173266214108838414Mouse
1357488Splq3_mspleen weight QTL 3 (mouse)Not determined134760138150193871Mouse
4141914Gcsfis_mG-CSF induced splenomegaly (mouse)Not determined74516235148715579Mouse
27095928Pglq6_mpelvic girdle length QTL 6, 10 week (mouse)175976637148775742Mouse
27095931Pglq1_mpelvic girdle length QTL 1, 5 week (mouse)175976637128527737Mouse
13452395Leusq2_mleucocytosis susceptibility QTL 2 (mouse)180245593126386517Mouse
1301748Abbp1_mA/J and C57BL/6 blood pressure 1 (mouse)Not determined162946755120529678Mouse
1301304Hrq3_mheart rate quantitative locus 3 (mouse)Not determined173615692107615830Mouse
1357439Popoa_mpremature ovulation and primary oocyte arrest (mouse)Not determined182643189135615379Mouse
4142291Aec2_mautoimmune exocrinopathy 2 (mouse)Not determined52457737182250592Mouse
1357753Kidq2_mkidney weight QTL 2 (mouse)Not determined134760138150193871Mouse
1300989Lrdg1_mlight induced retinal degeneration 1 (mouse)Not determined173755175147125370Mouse
4141329Mleu1_mmyeloid leukemia survival 1 (mouse)Not determined89786512123786512Mouse
1301667Lxw5_mlupus BXSB x NZW 5 (mouse)Not determined15854919192549443Mouse
11667074Led2_mlate embryonic death 2 (mouse)185696027117195081Mouse
27095918Ulnl1_mulna length 1, 5 week (mouse)167339159129727737Mouse
1301350Nidd4k_mNidd4 on KK-A (mouse)Not determined782291982147125370Mouse
1301162Skull1_mskull morphology 1 (mouse)Not determined15799197791992080Mouse
1300841Ssial1_msusceptibility to sialadenitis 1 (mouse)Not determined163920002153557562Mouse
26884448Sklq1_mskull length QTL 1, 5 week (mouse)175976637181327565Mouse
1357679Egrm1_mearly growth rate, maternal effect 1 (mouse)Not determined15799197791992080Mouse

Markers in Region
D1Mit365  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38192,129,184 - 92,129,282UniSTSGRCm38
MGSCv37194,025,761 - 94,025,859UniSTSGRCm37
Celera195,067,547 - 95,067,645UniSTS
Cytogenetic Map1DUniSTS
cM Map158.5UniSTS
Whitehead Genetic157.9UniSTS
Whitehead/MRC_RH11309.04UniSTS
Whitehead_YAC1 UniSTS
UniSTS:234174  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38191,932,806 - 91,932,930UniSTSGRCm38
MGSCv37193,829,383 - 93,829,507UniSTSGRCm37
Celera194,870,720 - 94,870,844UniSTS
Cytogenetic Map1DUniSTS
UniSTS:234175  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38191,929,336 - 91,929,598UniSTSGRCm38
MGSCv37193,825,913 - 93,826,175UniSTSGRCm37
Celera194,867,250 - 94,867,512UniSTS
Cytogenetic Map1DUniSTS
UniSTS:234176  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38192,039,579 - 92,039,710UniSTSGRCm38
MGSCv37193,936,156 - 93,936,287UniSTSGRCm37
Celera194,977,569 - 94,977,700UniSTS
Cytogenetic Map1DUniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_207225 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006529311 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006529312 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006529313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006529314 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006529315 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017319476 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017319477 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017319478 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017319479 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017319480 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017319482 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017319486 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017319487 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017319488 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017319498 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017319501 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030252529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030252531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030252541 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030252549 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030252550 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030252552 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036163125 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036163131 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC109197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC163436 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK029801 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK029933 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK155250 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK162369 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK164979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK170461 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK177302 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK201067 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK206621 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC066052 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY265337 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466520 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000008995   ⟹   ENSMUSP00000008995
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl191,860,479 - 92,076,115 (-)Ensembl
GRCm38.p6 Ensembl191,932,757 - 92,148,393 (-)Ensembl
Ensembl Acc Id: ENSMUST00000097644   ⟹   ENSMUSP00000095249
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl191,856,501 - 92,108,063 (-)Ensembl
GRCm38.p6 Ensembl191,928,779 - 92,180,341 (-)Ensembl
Ensembl Acc Id: ENSMUST00000185267
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl191,931,392 - 91,934,582 (-)Ensembl
GRCm38.p6 Ensembl192,003,670 - 92,006,860 (-)Ensembl
Ensembl Acc Id: ENSMUST00000185341
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl191,957,688 - 92,041,053 (-)Ensembl
GRCm38.p6 Ensembl192,029,966 - 92,113,331 (-)Ensembl
Ensembl Acc Id: ENSMUST00000186002   ⟹   ENSMUSP00000141018
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl191,957,677 - 92,108,019 (-)Ensembl
GRCm38.p6 Ensembl192,029,955 - 92,180,297 (-)Ensembl
Ensembl Acc Id: ENSMUST00000187308   ⟹   ENSMUSP00000140092
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl191,883,096 - 91,903,223 (-)Ensembl
GRCm38.p6 Ensembl191,955,374 - 91,975,501 (-)Ensembl
Ensembl Acc Id: ENSMUST00000187622
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl191,957,772 - 92,041,053 (-)Ensembl
GRCm38.p6 Ensembl192,030,050 - 92,113,331 (-)Ensembl
Ensembl Acc Id: ENSMUST00000189303
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl191,860,680 - 91,934,577 (-)Ensembl
GRCm38.p6 Ensembl191,932,958 - 92,006,855 (-)Ensembl
Ensembl Acc Id: ENSMUST00000189730
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl191,916,773 - 91,920,348 (-)Ensembl
GRCm38.p6 Ensembl191,989,051 - 91,992,626 (-)Ensembl
Ensembl Acc Id: ENSMUST00000191327
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl191,860,925 - 91,862,586 (-)Ensembl
GRCm38.p6 Ensembl191,933,203 - 91,934,864 (-)Ensembl
Ensembl Acc Id: ENSMUST00000212408
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl191,957,866 - 92,123,421 (-)Ensembl
GRCm38.p6 Ensembl192,030,144 - 92,195,699 (-)Ensembl
Ensembl Acc Id: ENSMUST00000212867
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl191,957,866 - 92,123,416 (-)Ensembl
GRCm38.p6 Ensembl192,030,144 - 92,195,694 (-)Ensembl
RefSeq Acc Id: NM_207225   ⟹   NP_997108
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39191,856,501 - 92,108,063 (-)NCBI
GRCm38191,928,779 - 92,180,341 (-)NCBI
MGSCv37193,829,311 - 94,044,970 (-)RGD
Celera194,870,648 - 95,086,759 (-)RGD
cM Map1 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006529311   ⟹   XP_006529374
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39191,856,501 - 91,977,801 (-)NCBI
GRCm38191,928,779 - 92,050,079 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006529312   ⟹   XP_006529375
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39191,856,501 - 92,108,045 (-)NCBI
GRCm38191,928,779 - 92,180,323 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006529313   ⟹   XP_006529376
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39191,856,501 - 92,108,011 (-)NCBI
GRCm38191,928,779 - 92,180,289 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006529314   ⟹   XP_006529377
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39191,856,501 - 92,042,362 (-)NCBI
GRCm38191,928,779 - 92,114,640 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006529315   ⟹   XP_006529378
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39191,856,501 - 92,108,068 (-)NCBI
GRCm38191,928,779 - 92,180,346 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017319476   ⟹   XP_017174965
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39191,856,501 - 92,108,058 (-)NCBI
GRCm38191,928,779 - 92,180,336 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017319477   ⟹   XP_017174966
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39191,856,501 - 92,108,058 (-)NCBI
GRCm38191,928,779 - 92,180,336 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017319478   ⟹   XP_017174967
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39191,856,501 - 92,108,058 (-)NCBI
GRCm38191,928,779 - 92,180,336 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017319479   ⟹   XP_017174968
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39191,856,501 - 92,108,058 (-)NCBI
GRCm38191,928,779 - 92,180,336 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017319480   ⟹   XP_017174969
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39191,856,501 - 92,123,424 (-)NCBI
GRCm38191,928,779 - 92,195,702 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017319482   ⟹   XP_017174971
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39191,856,501 - 92,108,068 (-)NCBI
GRCm38191,928,779 - 92,180,346 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017319486   ⟹   XP_017174975
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39191,856,501 - 92,123,424 (-)NCBI
GRCm38191,928,779 - 92,195,702 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017319487   ⟹   XP_017174976
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39191,856,501 - 92,123,424 (-)NCBI
GRCm38191,928,779 - 92,195,702 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017319488   ⟹   XP_017174977
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39191,856,501 - 92,123,424 (-)NCBI
GRCm38191,928,779 - 92,195,702 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017319498   ⟹   XP_017174987
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39191,856,501 - 92,123,412 (-)NCBI
GRCm38191,928,779 - 92,195,652 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017319501   ⟹   XP_017174990
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39191,856,501 - 92,108,011 (-)NCBI
GRCm38191,928,779 - 92,180,289 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030252529   ⟹   XP_030108389
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39191,856,501 - 92,108,600 (-)NCBI
GRCm38191,928,779 - 92,180,878 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030252531   ⟹   XP_030108391
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39191,856,501 - 92,108,068 (-)NCBI
GRCm38191,928,779 - 92,180,346 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030252541   ⟹   XP_030108401
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39191,856,501 - 92,108,068 (-)NCBI
GRCm38191,928,779 - 92,180,346 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030252549   ⟹   XP_030108409
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39191,856,501 - 92,108,600 (-)NCBI
GRCm38191,928,779 - 92,180,878 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030252550   ⟹   XP_030108410
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39191,856,501 - 92,108,596 (-)NCBI
GRCm38191,928,779 - 92,180,878 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030252552   ⟹   XP_030108412
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39191,856,501 - 92,108,011 (-)NCBI
GRCm38191,928,779 - 92,180,289 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036163125   ⟹   XP_036019018
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39191,856,501 - 92,065,776 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036163131   ⟹   XP_036019024
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39191,856,501 - 92,042,362 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_997108 (Get FASTA)   NCBI Sequence Viewer  
  XP_006529374 (Get FASTA)   NCBI Sequence Viewer  
  XP_006529375 (Get FASTA)   NCBI Sequence Viewer  
  XP_006529376 (Get FASTA)   NCBI Sequence Viewer  
  XP_006529377 (Get FASTA)   NCBI Sequence Viewer  
  XP_006529378 (Get FASTA)   NCBI Sequence Viewer  
  XP_017174965 (Get FASTA)   NCBI Sequence Viewer  
  XP_017174966 (Get FASTA)   NCBI Sequence Viewer  
  XP_017174967 (Get FASTA)   NCBI Sequence Viewer  
  XP_017174968 (Get FASTA)   NCBI Sequence Viewer  
  XP_017174969 (Get FASTA)   NCBI Sequence Viewer  
  XP_017174971 (Get FASTA)   NCBI Sequence Viewer  
  XP_017174975 (Get FASTA)   NCBI Sequence Viewer  
  XP_017174976 (Get FASTA)   NCBI Sequence Viewer  
  XP_017174977 (Get FASTA)   NCBI Sequence Viewer  
  XP_017174987 (Get FASTA)   NCBI Sequence Viewer  
  XP_017174990 (Get FASTA)   NCBI Sequence Viewer  
  XP_030108389 (Get FASTA)   NCBI Sequence Viewer  
  XP_030108391 (Get FASTA)   NCBI Sequence Viewer  
  XP_030108401 (Get FASTA)   NCBI Sequence Viewer  
  XP_030108409 (Get FASTA)   NCBI Sequence Viewer  
  XP_030108410 (Get FASTA)   NCBI Sequence Viewer  
  XP_030108412 (Get FASTA)   NCBI Sequence Viewer  
  XP_036019018 (Get FASTA)   NCBI Sequence Viewer  
  XP_036019024 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH66052 (Get FASTA)   NCBI Sequence Viewer  
  BAE33147 (Get FASTA)   NCBI Sequence Viewer  
  BAE36877 (Get FASTA)   NCBI Sequence Viewer  
  BAE37989 (Get FASTA)   NCBI Sequence Viewer  
  BAE43272 (Get FASTA)   NCBI Sequence Viewer  
  EDL40017 (Get FASTA)   NCBI Sequence Viewer  
  EDL40018 (Get FASTA)   NCBI Sequence Viewer  
  EDL40019 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000008995.9
  ENSMUSP00000095249
  ENSMUSP00000095249.4
  ENSMUSP00000140092.2
  ENSMUSP00000141018.2
GenBank Protein Q6NZM9 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_997108   ⟸   NM_207225
- UniProtKB: Q3TRZ9 (UniProtKB/Swiss-Prot),   Q3U2J3 (UniProtKB/Swiss-Prot),   Q3V3Y4 (UniProtKB/Swiss-Prot),   Q6NZM9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006529376   ⟸   XM_006529313
- Peptide Label: isoform X8
- Sequence:
RefSeq Acc Id: XP_006529375   ⟸   XM_006529312
- Peptide Label: isoform X8
- Sequence:
RefSeq Acc Id: XP_006529378   ⟸   XM_006529315
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006529377   ⟸   XM_006529314
- Peptide Label: isoform X8
- Sequence:
RefSeq Acc Id: XP_006529374   ⟸   XM_006529311
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_017174976   ⟸   XM_017319487
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_017174987   ⟸   XM_017319498
- Peptide Label: isoform X10
- Sequence:
RefSeq Acc Id: XP_017174977   ⟸   XM_017319488
- Peptide Label: isoform X7
- UniProtKB: Q3U2J3 (UniProtKB/Swiss-Prot),   Q3TRZ9 (UniProtKB/Swiss-Prot),   Q3V3Y4 (UniProtKB/Swiss-Prot),   Q6NZM9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017174975   ⟸   XM_017319486
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017174969   ⟸   XM_017319480
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017174968   ⟸   XM_017319479
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_017174966   ⟸   XM_017319477
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017174967   ⟸   XM_017319478
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_017174965   ⟸   XM_017319476
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017174990   ⟸   XM_017319501
- Peptide Label: isoform X11
- Sequence:
RefSeq Acc Id: XP_017174971   ⟸   XM_017319482
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_030108410   ⟸   XM_030252550
- Peptide Label: isoform X9
RefSeq Acc Id: XP_030108389   ⟸   XM_030252529
- Peptide Label: isoform X1
RefSeq Acc Id: XP_030108409   ⟸   XM_030252549
- Peptide Label: isoform X8
RefSeq Acc Id: XP_030108401   ⟸   XM_030252541
- Peptide Label: isoform X7
- UniProtKB: Q6NZM9 (UniProtKB/Swiss-Prot),   Q3U2J3 (UniProtKB/Swiss-Prot),   Q3TRZ9 (UniProtKB/Swiss-Prot),   Q3V3Y4 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_030108391   ⟸   XM_030252531
- Peptide Label: isoform X2
RefSeq Acc Id: XP_030108412   ⟸   XM_030252552
- Peptide Label: isoform X10
Ensembl Acc Id: ENSMUSP00000141018   ⟸   ENSMUST00000186002
Ensembl Acc Id: ENSMUSP00000008995   ⟸   ENSMUST00000008995
Ensembl Acc Id: ENSMUSP00000140092   ⟸   ENSMUST00000187308
Ensembl Acc Id: ENSMUSP00000095249   ⟸   ENSMUST00000097644
RefSeq Acc Id: XP_036019018   ⟸   XM_036163125
- Peptide Label: isoform X6
RefSeq Acc Id: XP_036019024   ⟸   XM_036163131
- Peptide Label: isoform X8
Protein Domains
Histone deacetylase   Histone deacetylase glutamine rich N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6NZM9-F1-model_v2 AlphaFold Q6NZM9 1-1076 view protein structure

Promoters
RGD ID:6874496
Promoter ID:EPDNEW_M699
Type:initiation region
Name:Hdac4_1
Description:Mus musculus histone deacetylase 4 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38192,180,299 - 92,180,359EPDNEW
RGD ID:6817872
Promoter ID:MM_KWN:1637
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:ENSMUST00000097644
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36193,826,736 - 93,827,236 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3036234 AgrOrtholog
Ensembl Genes ENSMUSG00000026313 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000008995.15 UniProtKB/Swiss-Prot
  ENSMUST00000097644 ENTREZGENE
  ENSMUST00000097644.9 UniProtKB/Swiss-Prot
  ENSMUST00000186002.3 UniProtKB/TrEMBL
  ENSMUST00000187308.2 UniProtKB/TrEMBL
Gene3D-CATH 3.40.800.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6.10.250.1550 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro HDAC4/5/7/9 UniProtKB/Swiss-Prot
  HDAC_PDAC UniProtKB/TrEMBL
  His_deacetylse UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  His_deacetylse_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  His_deacetylse_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hist_deacetylase_Gln_rich_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ureohydrolase_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:208727 UniProtKB/Swiss-Prot
MGD MGI:3036234 ENTREZGENE
NCBI Gene 208727 ENTREZGENE
PANTHER HISTONE DEACETYLASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HISTONE DEACETYLASE 4 UniProtKB/TrEMBL
  HISTONE DEACETYLASE HDAC1-RELATED UniProtKB/TrEMBL
  PTHR45364 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam HDAC4_Gln UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hist_deacetyl UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hdac4 PhenoGen
PIRSF HDAC_II_euk UniProtKB/Swiss-Prot
PRINTS HDASUPER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52768 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A087WQ92_MOUSE UniProtKB/TrEMBL
  A0A087WSF0_MOUSE UniProtKB/TrEMBL
  HDAC4_MOUSE UniProtKB/Swiss-Prot
  Q3TNU8_MOUSE UniProtKB/TrEMBL
  Q3TRZ9 ENTREZGENE
  Q3U2J3 ENTREZGENE
  Q3V3Y4 ENTREZGENE
  Q6NZM9 ENTREZGENE
UniProt Secondary Q3TRZ9 UniProtKB/Swiss-Prot
  Q3U2J3 UniProtKB/Swiss-Prot
  Q3V3Y4 UniProtKB/Swiss-Prot