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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619979
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hdac4
Name: histone deacetylase 4
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hdac4increases methylationEXP 6480464CTDbisphenol A results in increased methylation of HDAC4 genePMID:28505145
Hdac4affects methylationISOHdac4 (Mus musculus)6480464CTDbisphenol A affects the methylation of HDAC4 promoterPMID:27334623
Hdac4decreases expressionISOHdac4 (Mus musculus)6480464CTDbisphenol A results in decreased expression of HDAC4 mRNAPMID:32926169
Hdac4decreases methylationISOHDAC4 (Homo sapiens)6480464CTDbisphenol A results in decreased methylation of HDAC4 genePMID:31601247
Hdac4increases expressionISOHDAC4 (Homo sapiens)6480464CTDbisphenol A results in increased expression of HDAC4 mRNAPMID:32030086
Hdac4multiple interactionsISOHDAC4 (Homo sapiens)6480464CTD[bisphenol A co-treated with Fulvestrant] affects the methylation of HDAC4 genePMID:31601247
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